Composition for prophylactic treatment of hypocalcemia in ruminants

By using phosphate binding agents and zeolite compositions in ruminants, the problem of hypocalcemia before delivery was solved, and the stability of blood calcium levels and the improvement of milk production was achieved.

CN120417778APending Publication Date: 2025-08-01VILOFOSS AS
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Patent Information

Application Number
CN202280102564.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2022-12-12
Publication Date
2025-08-01

AI Technical Summary

Technical Problem

The prior art is difficult to effectively prevent hypocalcemia in ruminants before delivery, especially when calcium demand suddenly increases during calving, resulting in a decrease in plasma calcium levels and affecting animal production capacity.

Method used

One or more phosphate binding agents, such as aluminum citrate, aluminum chloride, aluminum sulfate, etc., are used as composition components, combined with zeolites for prophylactic treatment of ruminant hypocalcemia before delivery by manual administration of large doses or wet forms of unit dosage forms.

Benefits of technology

It significantly reduced the inorganic phosphate concentration in perinatal cattle, maintained total serum calcium levels, reduced the incidence of subclinical hypocalcemia, increased milk production and reduced the risk of clinical hypocalcemia.

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Abstract

The present application discloses compositions and principles for the prophylactic treatment of hypocalcemia in ruminants (e.g., cattle) prior to childbirth, i.e. Compositions comprising one or more phosphate binding agents for the prophylactic treatment of parturient hypocalcemia in ruminants (e.g., cattle), e.g., where the compositions are in one or more unit dosage forms, e.g., in one or more unit dosage forms. And wherein one or more unit dosage forms of the composition are manually administered per day to the gastrointestinal tract of the ruminant, or wherein the composition is provided in wet form. The present application also discloses compositions comprising one or more phosphate binding agents and one or more nutrients selected from the group consisting of minerals, vitamins and amino acids, and compositions comprising inhibitors of the small intestine Na-phosphate transporter for use in the prophylactic treatment of parturient hypocalcemia in ruminants, such as cattle. The phosphate binder is selected from aluminum salts, ferric salts, sevelamer salts and lanthanum salts formed with inorganic or organic acids, hydrates thereof or any mixture thereof.
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