Traditional Chinese medicine sleep-aiding atomized liquid and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine sleep-aiding atomized liquid and a preparation method thereof, the traditional Chinese medicine sleep-aiding atomized liquid comprises the following traditional Chinese medicine raw materials: cortex albiziae, angelica sinensis, frankincense, valerian root, spina date seed, lily, radix rehmanniae recen and liquorice, all the raw materials basically have the effects of calming and soothing the nerves, and especially, the cortex albiziae can regulate the nervous system function of a human body, and can regulate the sleep-aiding function of the human body; according to the traditional Chinese medicine sleep-aiding atomized liquid, the sleep center of the brain is affected, the excitement degree of the nervous system is improved, people can fall asleep more easily and keep a deep sleep state, good sleep can improve the body immunity, compared with a traditional sleeping medicine, the traditional Chinese medicine does not contain any chemical component or additive, no toxic or side effect is caused to the human body, and by means of the atomization technology, the traditional Chinese medicine sleep-aiding atomized liquid is prepared. Active ingredients are delivered to the lung in an aerosol inhalation mode to enter blood circulation, the active ingredients are prevented from being decomposed by gastric acid, and the first-pass effect of the liver is avoided, so that a human body can fall asleep more quickly and safely and enter deep sleep.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine sleep-aiding atomized liquid and a preparation method thereof. Background Art

[0002] Insomnia, also known as sleep-disordered insomnia or simply insomnia, is characterized by difficulty falling asleep, staying asleep, or waking up early, leading to insufficient sleep or poor sleep quality, which can affect normal life, work, and study the next day. As a common sleep disorder, insomnia has a very high prevalence worldwide. According to the World Health Organization (WHO) and multiple epidemiological studies, approximately one-third of adults experience insomnia symptoms to varying degrees, and the prevalence of chronic insomnia ranges from 10% to 20%, with variations across countries and regions. With the accelerating pace of life, increasing work pressure, and the prevalence of electronic devices, the incidence of insomnia has been increasing year by year. Numerous studies have indicated that long-term, severe insomnia may increase the risk of chronic diseases such as cardiovascular disease, diabetes, and hypertension. With the accelerating pace of life and increasing social pressure, the prevalence of insomnia is expected to rise further, making it particularly important to take effective measures to improve sleep quality. Summary of the Invention

[0003] In order to improve the sleep quality of insomniacs, the present invention aims to provide a Chinese medicine sleep-aiding atomized liquid and a preparation method thereof.

[0004] To achieve the above object, the present invention adopts the following technical solutions:

[0005] In one aspect, the present invention provides a Chinese medicine sleep-aiding nebulized liquid, which is composed of the following raw materials: julibrissin bark, angelica, frankincense, valerian root, spinach seed, lily, raw rehmannia root, and licorice.

[0006] Preferably, the above-mentioned Chinese herbal sleep-inducing nebulized liquid contains the following weight ratios: 3-8g of Albizia Julibrissin bark, 5-10g of Chinese angelica, 1-5g of frankincense, 3-8g of valerian root, 8-15g of Ziziphus jujuba seeds, 10-15g of lily, 3-8g of Rehmannia glutinosa, and 6-12g of licorice. Preferably, the above-mentioned Chinese herbal sleep-inducing nebulized liquid contains the following weight ratios: 3g of Albizia Julibrissin bark, 5g of Chinese angelica, 1g of frankincense, 3g of valerian root, 8g of Ziziphus jujuba seeds, 10g of lily, 3g of Rehmannia glutinosa, and 6g of licorice.

[0007] Preferably, the above-mentioned Chinese medicine sleep-aiding nebulizer liquid contains the following weight ratios: 5g of Albizia Julibrissin bark, 8g of Angelica sinensis, 3g of frankincense, 5g of valerian root, 10g of Ziziphus jujuba seed, 12g of lily, 6g of Rehmannia glutinosa, and 10g of Licorice.

[0008] Preferably, the above-mentioned Chinese medicine sleep-aiding nebulizer liquid contains the following weight ratios: 8g of Albizia Julibrissin bark, 10g of Angelica sinensis, 5g of frankincense, 8g of valerian root, 15g of Ziziphus jujuba seed, 15g of lily, 8g of Rehmannia glutinosa, and 12g of Licorice.

[0009] Preferably, the pharmacological effects of the raw material components of the above-mentioned Chinese medicine sleep-aiding nebulizer liquid are as follows:

[0010] Albizia Julibrissin Bark: This product is the bark of the leguminous plant Albizia Julibrissin. It tastes sweet and is mild in nature. It has the effects of promoting blood circulation and removing blood stasis, soothing the liver and regulating qi, as well as calming the mind and promoting sleep. Its effect on the central nervous system is that it can prolong the sleep time of sodium pentobarbital, enhance immune function, and have anti-tumor effects.

[0011] Angelica: sweet and spicy in taste, warm in nature, it can replenish blood and promote blood circulation, regulate menstruation and relieve pain, moisten the intestines and promote bowel movements, enhance immune function, and has antioxidant, cholesterol-lowering, lipid-lowering, liver-protecting, analgesic, sedative, anti-tumor, and antibacterial effects.

[0012] Frankincense: It tastes spicy and bitter, and is warm in nature. It enters the heart, liver, and spleen meridians and has the effects of promoting blood circulation and qi, reducing swelling and promoting tissue regeneration, relieving pain, and having anti-inflammatory and antioxidant effects.

[0013] Valerian root: It has the effect of calming the mind and soothing the nerves, has the effect of temporarily lowering blood pressure and protecting the liver, can inhibit the central nervous system, reduce nerve excitability, improve myocardial ischemia and arrhythmia, has a sedative effect, can shorten the time to fall asleep and improve sleep quality.

[0014] Chinese jujube seeds: sweet in taste, neutral in nature, enter the heart, spleen, liver, and gallbladder meridians, and have multiple pharmacological effects such as sedation and hypnosis, antidepressant, anticonvulsant, memory improvement, and anti-myocardial ischemia.

[0015] Lily: sweet, slightly bitter, slightly cold in nature, enters the heart and lung meridians, moistens the lungs and relieves coughs, beautifies the skin, calms the mind, enhances immunity, and has anti-cancer effects.

[0016] Raw Rehmannia root: sweet and bitter in taste, cold in nature, has the effects of clearing heat and cooling blood, nourishing yin and promoting body fluid.

[0017] Licorice: It is neutral in nature, sweet in taste, and enters the twelve meridians. It has pharmacological effects such as detoxification, expectoration, analgesia, antispasmodic, and even anti-cancer. Modern pharmacological research shows that licorice has antibacterial, anti-allergic, anti-inflammatory, and anti-arrhythmic effects.

[0018] In another aspect, the present invention provides a Chinese medicine sleep-inducing aerosol liquid and a preparation method thereof, comprising the following steps:

[0019] S1 Weighing: Weigh the above-mentioned Chinese medicinal materials according to the weight ratio;

[0020] S2 Crushing: Pour the weighed Chinese medicine raw materials into the grinder and grind them into powder;

[0021] S3 sieving: the ground Chinese medicinal materials are passed through an 80-mesh sieve and subjected to boiling water reflux extraction for 1 hour;

[0022] S4 extraction: Filter the extract, add ethanol to the extract, and precipitate overnight to increase the ethanol concentration;

[0023] S5 concentration: The water-extracted alcohol precipitate is centrifuged to obtain a clear liquid, which is then vacuum concentrated to obtain an extract concentrate;

[0024] S6 dissolution: dissolving the extract with propylene glycol to prepare a propylene glycol solution;

[0025] S7 finished product: propylene glycol is added to the propylene glycol solution, with the propylene glycol accounting for 50%, and the remaining weight is supplemented with propylene glycol to prepare the atomized liquid.

[0026] Preferably, in step S4, ethanol is added twice, and the two alcohol precipitations are carried out overnight.

[0027] Preferably, in step S4, the ethanol concentration needs to be increased from 40% to 70%.

[0028] Preferably, glycerol is added in step S7, with the proportion of glycerol being 50%, and the remaining weight is supplemented by propylene glycol to prepare the atomized liquid.

[0029] Beneficial effects of the present invention

[0030] The present invention provides a Chinese herbal sleep-aiding nebulizer liquid and a preparation method thereof. Most of the selected Chinese herbal medicines have sedative and tranquilizing effects. In particular, the Chinese herbal medicine Albizia Julibrissin bark can also regulate the functions of the human nervous system, especially can affect the sleep center of the brain, and improve the excitability of the nervous system by adjusting the release and transmission of neurotransmitters, so that the brain is calmer, easier to fall asleep and maintain a deep sleep state. Good sleep helps to improve the body's immunity. At the same time, some Chinese herbal medicines also have anti-inflammatory and antibacterial effects, which can better protect physical health. Compared with traditional sleeping pills, the Chinese herbal medicines in the Chinese herbal sleep-aiding nebulizer liquid do not contain any chemical components and additives, and have no toxic side effects on the human body. By utilizing atomization technology, the active ingredients are delivered to the lungs through atomization inhalation to enter the blood circulation, avoiding the decomposition of the active ingredients by gastric acid and the first-pass effect of the liver, so that the human body can fall asleep and enter a deep sleep more quickly and safely. DETAILED DESCRIPTION

[0031] To make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the embodiments. The embodiments of the present invention are only used to explain the present invention and are not intended to limit the present invention.

[0032] Example 1

[0033] A traditional Chinese medicine sleep-inducing nebulized liquid comprises the following raw materials in parts by weight: 3g of julibrissin bark, 5g of angelica sinensis, 1g of frankincense, 3g of valerian root, 8g of spinach seed, 10g of lily, 3g of raw rehmannia root, and 6g of liquorice.

[0034] A Chinese medicine sleep-inducing nebulizer liquid and a preparation method thereof, comprising the following steps: weighing the above-mentioned Chinese medicine raw materials according to a weight ratio, pouring the weighed Chinese medicine raw materials into a grinder and grinding them into powder, passing the ground Chinese medicine raw materials through an 80-mesh sieve, extracting them under boiling water reflux for 1 hour, filtering the extract, adding ethanol to the extract twice, precipitating them with alcohol overnight twice, increasing the ethanol concentration from 40% to 70%, centrifuging the water-extracted ethanol precipitate to obtain a clarified liquid, vacuum concentrating the extract to obtain an extract extract, dissolving the extract with propylene glycol to obtain a propylene glycol solution, adding glycerol to the propylene glycol solution, wherein the glycerol accounts for 50%, and supplementing the remaining weight with propylene glycol to obtain the nebulizer liquid.

[0035] Example 2

[0036] A traditional Chinese medicine sleep-inducing nebulized liquid comprises the following raw materials in parts by weight: 5g of julibrissin bark, 8g of angelica sinensis, 3g of frankincense, 5g of valerian root, 10g of spinach seed, 12g of lily, 6g of raw rehmannia root, and 10g of liquorice.

[0037] The preparation method is the same as that of Example 1.

[0038] Example 3

[0039] A traditional Chinese medicine sleep-inducing nebulized liquid comprises the following raw materials in parts by weight: 8g of julibrissin bark, 10g of angelica sinensis, 5g of frankincense, 8g of valerian root, 15g of jujube seed, 15g of lily, 8g of raw rehmannia root, and 12g of liquorice.

[0040] The preparation method is the same as that of Example 1.

[0041] Comparative Example 1 (lacking Chinese medicinal material Albizia Julibrissin bark)

[0042] A traditional Chinese medicine sleep-inducing nebulized liquid comprises the following raw materials in parts by weight: 5g of angelica sinensis, 1g of frankincense, 3g of valerian root, 8g of spinach seed, 10g of lily, 3g of raw rehmannia root, and 6g of liquorice.

[0043] The preparation method is the same as that of Example 1.

[0044] Comparative Example 2 (lacking the Chinese medicinal material valerian root)

[0045] A Chinese medicine sleep-inducing nebulized liquid comprises the following raw materials in parts by weight: 5g of julibrissin bark, 8g of angelica sinensis, 3g of frankincense, 10g of spinach seed, 12g of lily, 6g of rehmannia root, and 10g of liquorice.

[0046] The preparation method is the same as that of Example 1.

[0047] Comparative Example 3 (reducing the weight ratio of Chinese medicinal materials Albizia Julibrissin bark and Valerian root)

[0048] A traditional Chinese medicine sleep-inducing nebulized liquid comprises the following raw materials in parts by weight: 1g of julibrissin bark, 10g of angelica sinensis, 5g of frankincense, 1g of valerian root, 15g of spinach seed, 15g of lily, 8g of raw rehmannia root, and 12g of liquorice.

[0049] The preparation method is the same as that of Example 1.

[0050] Experimental testing

[0051] 90 people with various sleep problems such as difficulty falling asleep, easy awakening, and intermittent insomnia were randomly selected, regardless of gender, and divided into 6 groups, 15 people in each group. The first group inhaled the atomized liquid prepared in Example 1, the second group inhaled the atomized liquid prepared in Example 2, the third group inhaled the atomized liquid prepared in Example 3, the fourth group inhaled the atomized liquid prepared in Comparative Example 1, the fifth group inhaled the atomized liquid prepared in Comparative Example 2, and the sixth group inhaled the atomized liquid prepared in Comparative Example 3.

[0052] Nebulization method: Nebulize 3 times a day, 10 minutes each time.

[0053] After inhalation of nebulized liquid, the subjects were followed up for 2 months and the number of people with significant effects, effective and ineffective effects was counted.

[0054] Detection tool: Wear a smart bracelet to monitor sleep quality

[0055] Significant effects: Fall asleep quickly, detection tools detect that the sleep time is more than 7 hours continuously and the deep sleep is more than 3 hours, and you will not feel tired after waking up the next day.

[0056] There is a slight effect: falling asleep quickly.

[0057] No effect: Difficulty falling asleep and easy to wake up in the middle of the night.

[0058] Table 1 Statistics of test results of the test population after inhaling the nebulized liquid for 2 months

[0059]

[0060] It can be seen from the above statistical table that the sleep quality of the people who inhaled the nebulized liquid prepared in Examples 1, 2, and 3 was basically significantly improved. However, for the people who inhaled the nebulized liquid prepared in Comparative Examples 1 and 2, since the nebulized liquid lacked important Chinese medicinal raw materials for improving sleep, a very large proportion of the people who inhaled Comparative Examples 1 and 2 did not improve their sleep quality. For the people who inhaled the nebulized liquid prepared in Comparative Example 3, since the nebulized liquid prepared in Comparative Example 3 contained insufficient amount of important Chinese medicinal raw materials for improving sleep, the nebulized liquid also failed to significantly improve their sleep.

[0061] In summary, the Chinese medicine sleep-aiding nebulized liquid and its preparation method provided by the present invention have sedative and tranquilizing effects, can help people fall asleep quickly and enter a deep sleep state, and also have anti-inflammatory and antibacterial effects, which can better protect physical health. Compared with traditional sleeping pills, the Chinese medicinal materials in the Chinese medicine sleep-aiding nebulized liquid do not contain any chemical components and additives, and have no toxic side effects on the human body. By utilizing nebulization technology and administering the drug through atomized inhalation, the drug can directly act on the respiratory mucosa, avoiding irritation and burden on the gastrointestinal tract, so that the human body can fall asleep more quickly and safely and enter a deep sleep.

[0062] The embodiments of the present invention are only specific descriptions of the technical solutions, not limitations of the technical solutions. Any substitutions or modifications made by those skilled in the art without changing the essential contents of the present invention shall fall within the protection scope of the present invention.

Claims

1. A Chinese medicine sleep-aiding nebulized liquid, characterized in that: Contains the following Chinese medicinal ingredients: Albizia Julibrissin bark, Angelica sinensis, frankincense, valerian root, and Ziziphus jujuba seed.

2. The Chinese medicine sleep-aiding aerosol liquid according to claim 1, characterized in that: The Chinese medicine raw materials also include: lily, raw rehmannia root, and liquorice.

3. The Chinese medicine sleep-aiding aerosol liquid according to claim 2, characterized in that: The preparation is made according to the following weight ratio: 3-8g of Albizia Julibrissin bark, 5-10g of Chinese angelica, 1-5g of frankincense, 3-8g of valerian root, 8-15g of Ziziphus jujuba seed, 10-15g of lily, 3-8g of Rehmannia root, and 6-12g of liquorice.

4. The Chinese medicine sleep-aiding aerosol liquid according to claim 3, characterized in that: It is prepared according to the following weight ratio: 3 or 8g of Albizia Julibrissin bark, 5 or 10g of Angelica sinensis, 1 or 5g of frankincense, 3 or 8g of valerian root, 8 or 15g of Ziziphus jujuba seed, 10 or 15g of lily, 3 or 8g of Rehmannia root, and 6 or 12g of Licorice.

5. The Chinese medicine sleep-aiding aerosol liquid according to claim 3 or 4, characterized in that: It is prepared according to the following weight ratio: 5g of Albizia Julibrissin bark, 8g of Angelica sinensis, 3g of frankincense, 5g of valerian root, 10g of Ziziphus jujuba seed, 12g of lily, 6g of Rehmannia root, and 10g of Licorice.

6. The method for preparing the Chinese medicine sleep-aiding aerosol liquid according to claim 3, characterized in that: The following steps are involved: S1 Weighing: Weigh the above-mentioned Chinese medicinal materials according to the weight ratio; S2 Crushing: Pour the weighed Chinese medicine raw materials into the grinder and grind them into powder; S3 sieving: the ground Chinese medicinal materials are passed through an 80-mesh sieve and subjected to boiling water reflux extraction for 1 hour; S4 extraction: The extract is filtered, ethanol is added to the extract, and the extract is precipitated overnight to increase the ethanol concentration; S5 concentration: the water-extracted alcohol precipitate is centrifuged to obtain a clear liquid, which is then vacuum concentrated to obtain an extract concentrate; S6 dissolution: the extract is dissolved in propylene glycol to obtain a propylene glycol solution; S7 finished product: propylene glycol is added to the propylene glycol solution, with the propylene glycol accounting for 50%, and the remaining weight is supplemented with propylene glycol to prepare the atomized liquid.

7. The method for preparing the Chinese medicine sleep-aiding aerosol liquid according to claim 6, characterized in that: In step S4, ethanol needs to be added twice, and the two alcohol precipitations are carried out overnight.

8. The method for preparing the Chinese medicine sleep-aiding aerosol liquid according to claim 6, characterized in that: In step S4, the ethanol concentration needs to be increased from 40% to 70%.

9. The method for preparing the Chinese medicine sleep-aiding aerosol liquid according to claim 6, characterized in that: In step S7, glycerol is added, the glycerol accounts for 50%, and the remaining weight is supplemented by propylene glycol to prepare an atomized liquid.

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