Medicinal and edible preparation for panic attack of anxiety disorder and application of medicinal and edible preparation

Abstract

The invention belongs to the technical field of medicine and food homology, and particularly relates to a medicine and food homology preparation for panic attack of anxiety disorder and application of the medicine and food homology preparation. The medicinal and edible preparation for the panic attack of the anxiety disorder comprises raw astragalus membranaceus, codonopsis pilosula, radix bupleuri, platycodon grandiflorum, cimicifugae foetidae, ligusticum wallichii, gastrodia elata, bighead atractylodes rhizome and angelica sinensis, aims to solve the most common syndrome type of the panic attack of the anxiety disorder, namely panic attack accompanied by weakness and shortness of breath, is simple in prescription differentiation and remarkable in curative effect, can take effect within half an hour to one hour after being taken, and can be used for treating the panic attack of the anxiety disorder. The whole body function can be comprehensively improved, the life quality is remarkably improved, the probability of occurrence of other symptoms and diseases is reduced, and the defects existing in the existing traditional Chinese medicine and western medicine for treating anxiety panic attack can be well overcome.

Description

Technical Field

[0001] The present invention belongs to the technical field of medicine and food homology, and particularly relates to a medicine and food homology preparation for anxiety and panic attacks and application thereof. Background Art

[0002] Panic attacks are a hallmark of anxiety disorders, particularly panic disorder. They are characterized by sudden, intense feelings of fear or discomfort, often accompanied by a sense of loss of control or impending doom. Symptoms include palpitations, sweating, dyspnea, dizziness, tremors, and other manifestations of autonomic dysfunction, typically lasting from several minutes to tens of minutes. They are the result of a combination of physiological, psychological, and environmental factors. Modern medical analysis of the etiology and pathogenesis suggests that psychological factors such as excessive worry, catastrophic thinking, and sensitivity to physiological changes (such as abnormal respiratory regulation) are the primary contributing factors. Patients often misinterpret normal physiological reactions (such as a rapid heartbeat) as danger signals, triggering a vicious cycle. Secondly, biological factors are also involved, including neurotransmitters. For example, familial clustering suggests genetic susceptibility, while imbalances in neurotransmitters such as serotonin and norepinephrine may also play a role in the pathogenesis. Furthermore, metabolic and immune factors are involved. For example, studies have found that growth differentiation factor 15, released by the breakdown of adipose tissue, can trigger anxious behaviors through the brainstem receptor GFRAL, suggesting a complex interplay between metabolism and emotion. In addition, abnormal expression of neuronal chemokine CCL2 under hyperglycemic conditions aggravates anxiety through neuroinflammatory response.

[0003] Western medicine primarily focuses on symptom relief during the acute phase, while long-term treatment requires a combination of psychological intervention, medication, and lifestyle adjustments. Emerging research on biological mechanisms (such as the GDF15 and CCL2 pathways) has opened up new avenues for precision medicine. However, modern medicine still has some shortcomings in treating anxiety disorders and panic attacks, primarily manifested in: medication dependence and withdrawal reactions, side effects and tolerance issues, insufficiently personalized treatment, high relapse rates and long-term management challenges, and an inability to address underlying psychosocial factors.

[0004] Traditional Chinese Medicine (TCM) categorizes anxiety and panic attacks as "depression," "fear," and "fear," believing their core pathogenesis to be related to insufficient heart and gallbladder qi, phlegm and blood stasis blocking the collaterals, or qi imbalance. Treatment emphasizes syndrome differentiation and treatment, combining traditional Chinese medicine, acupuncture, and psychological interventions, focusing on holistic care and individualized approaches. While TCM emphasizes syndrome differentiation and treatment, panic attacks present complex and diverse syndromes (e.g., qi stagnation and blood stasis, heart and gallbladder qi deficiency, etc.), lacking unified diagnostic criteria and efficacy assessment indicators. Different physicians may discrepancy in their diagnosis of the same patient, making treatment plans difficult to generalize and replicate, and even worsening the condition due to inaccurate diagnosis. For sudden panic attacks (e.g., feelings of impending doom or loss of control), traditional Chinese medicine takes a long time to work (usually taking days to weeks), failing to quickly alleviate acute symptoms and requiring temporary intervention with Western medications (e.g., benzodiazepines). Summary of the Invention

[0005] The present invention aims to provide a medicinal and edible preparation for use in anxiety disorder and panic attacks, and its use. The medicinal and edible preparation is intended to address the most common syndrome type of anxiety disorder and panic attacks: panic attacks accompanied by fatigue and shortness of breath. The preparation has a simple formula and syndrome differentiation, and a significant therapeutic effect. The preparation usually takes effect within half an hour to an hour after taking the preparation, and can comprehensively improve the overall body function, significantly improve the quality of life, and reduce the probability of other symptoms and diseases. It can effectively address the shortcomings of current traditional Chinese medicine and Western medicine in the treatment of anxiety disorder and panic attacks.

[0006] According to one aspect of the present invention, a medicinal and edible preparation for anxiety and panic attacks is provided, which is prepared from the following raw materials in parts by weight: 20-40 parts of raw astragalus, 10-30 parts of codonopsis, 1-10 parts of bupleurum, 1-10 parts of platycodon, 1-10 parts of cimicifuga, 1-10 parts of ligusticum, 1-20 parts of ligusticum, 1-20 parts of gastrodia, 5-25 parts of atractylodes, and 1-10 parts of angelica.

[0007] Anxiety panic attacks accompanied by fatigue and shortness of breath are the most common syndromes in Traditional Chinese Medicine (TCM). Their pathogenesis is spleen and stomach deficiency, sinking of Zong Qi, insufficient Qi and blood, and poor circulation, which prevent them from ascending to nourish the heart, lungs, head, and other organs in the upper Jiao, leading to the corresponding symptoms. Spleen deficiency, insufficient Qi and blood, and sinking of Zong Qi are the fundamental pathological characteristics. According to TCM theory, the spleen governs transportation and transformation, generating Qi and blood, and ascending the clear. The rise of Yang Qi relies on the transportation and transformation of the spleen and stomach, transforming food into the essence of water and grain, which is then transformed into Qi and blood for distribution throughout the body. Spleen deficiency hinders the production of Qi and blood, and the ascending of the clear is impaired. Malnourished mind leads to insomnia and anxiety, lack of Qi and blood nourishment for the head leads to dizziness, and inadequate Qi and blood supply to the heart and lungs leads to chest tightness, palpitations, and shortness of breath.

[0008] Therefore, the present invention treats panic attacks of anxiety accompanied by fatigue and shortness of breath by strengthening the spleen and replenishing qi, raising yang and lifting the sunken, and nourishing blood. The method focuses on strengthening the spleen and replenishing qi, raising yang and promoting blood circulation, which can not only strengthen the spleen and generate qi and blood, but also unclog the channels of qi and blood, guide qi and blood upward and nourish the upper jiao to achieve the purpose of treatment. The present invention provides a medicinal and edible preparation formula that replenishes qi and blood and nourishes the mind, has good effect, is safe and reliable, and is a self-made formula.

[0009] In this formula, Astragalus nourishes Qi and raises Yang, particularly effective in elevating the vital energy in the chest, making it the main herb. Codonopsis replenishes vital Qi, enhancing the Qi-tonifying power of Astragalus. Atractylodes macrocephala strengthens the spleen, dissipates dampness, and aids the spleen in transporting and transforming Qi and blood, both serving as assistant herbs. Bupleurum guides the herbs upward, elevating the Qi of the Shaoyang meridian. Angelica sinensis nourishes the blood and harmonizes the vital energy, tonifying Qi without stagnating the blood. Cimicifuga ephedra elevates the Qi of the Yangming meridian and assists Astragalus in lifting the sunken Qi. Chuanxiong guides the herbs upward, activating Qi and blood circulation, allowing Qi and blood to flow smoothly to the upper Jiao and the head. Gastrodia elata promotes Qi without harming vital Qi, unblocking Qi and blood, and improving microcirculation. These five herbs serve as adjuvant herbs. Platycodon grandiflorum carries the herbs upward to the chest, acting like a boat, making it the guiding herb. The formula consists of only nine herbs, meticulously formulated to complement each other in tonifying and promoting Qi, nourishing and promoting blood circulation. While addressing the fundamental needs of the spleen and stomach, it also effectively utilizes meridian-guiding herbs to direct the flow of Qi and blood, helping the herbs reach the affected area directly.

[0010] The sources of raw materials for this recipe are as follows: Raw Astragalus: the root of Astragalus membranaceus var.mongholicus (Bunge) PK Hsiao or Astragalus membranaceus (Fisch.) Bunge, both plants of the genus Astragalus in the Leguminosae family.

[0011] Codonopsis: The root of Codonopsis pilosula (Franch.) Nannf., C. pilosula Nannf. var. (Nannf.) LT Shen or C. tangshen Oliv. of the Campanulaceae family.

[0012] Atractylodes: The dried rhizome of Atractylodes macrocephala Koidz., a plant of the Asteraceae family.

[0013] Bupleurum: The dried root of Bupleurum chinense DC. or Bupleurumscorzonerifolium Willd. of the Apiaceae family.

[0014] Angelica: The dried root of Angelica sinensis (Oliv.) Diels, a plant of the Apiaceae family.

[0015] Cimicifuga: The dried rhizome of Cimicifuga heracleifolia Kom., Cimicifuga dahurica (Turcz.) Maxim. or Cimicifuga foetida L., all plants of the Ranunculaceae family.

[0016] Chuanxiong: The dried rhizome of the Umbelliferae plant Ligusticum chuanxiong Hort. or Ligusticum wallichiiFranch.

[0017] Gastrodia elata: the dried tuber of Gastrodia elata Bl., a plant of the Orchidaceae family.

[0018] Platycodon: The dried root of Platycodon grandiflorus (Jacq.) A.Dc., a plant of the Campanulaceae family.

[0019] In some embodiments, the ratio of the above raw materials can be preferably: 25-35 parts of raw astragalus, 25-35 parts of codonopsis, 2-8 parts of bupleurum, 2-8 parts of platycodon, 2-8 parts of cimicifuga, 5-15 parts of chuanxiong, 5-15 parts of gastrodia, 10-20 parts of atractylodes, and 2-8 parts of angelica.

[0020] In some embodiments, the ratio of the above raw materials can be further preferably: 30 parts of Astragalus, 20 parts of Codonopsis, 5 parts of Bupleurum, 5 parts of Platycodon, 5 parts of Cimicifuga, 10 parts of Chuanxiong, 10 parts of Gastrodia, 15 parts of Atractylodes, and 5 parts of Angelica.

[0021] In some embodiments, a medicinal and edible preparation for anxiety and panic attacks also includes 1-20 parts of Rhizoma Anemarrhenae, which is added to treat post-ingestion discomfort such as insomnia, dry mouth, and sore throat. Rhizoma Anemarrhenae is the dried rhizome of Anemarrhena asphodeloides Bunge. Preferably, the amount is 5-15 parts; more preferably, 10 parts.

[0022] In some embodiments, a medicinal and edible preparation for anxiety and panic attacks also includes 1-20 parts of Atractylodes lancea, a medicinal herb used to treat increased loose stools. Atractylodes lancea is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz., both of the Asteraceae family. Preferably, the amount is 5-15 parts; more preferably, 10 parts.

[0023] In some embodiments, the medicinal and edible preparations for anxiety and panic attacks may also include medically or food-acceptable excipients to prepare different dosage forms required by patients, which are convenient for use, storage and transportation, and meet clinical and market needs; wherein the excipients used are all excipients commonly used in the prior art.

[0024] In some embodiments, the medicine-food homologous preparation for anxiety disorder panic attack can be an oral solution, powder (such as made into a solid beverage), granules, ointment, etc. The medicine-food homologous preparation for anxiety disorder panic attack of the present application can be prepared into the above-mentioned different dosage forms according to the existing method. For example, when making an oral solution or decoction, the raw materials can be added to water and soaked, and then heated to boiling and kept slightly boiling for 0.2h-2h, and the first decoction and the decoction residue are obtained after separation; the decoction residue is added with water, heated to boiling, and kept slightly boiling for 0.2h-2h hours, and the second decoction is taken after separation, and the first decoction and the second decoction are combined to obtain an oral solution. Wherein, 8-40 times the total weight of the raw materials are added to the raw materials and heated to boiling, and 6-30 times the total weight of the raw materials are added to the decoction residue and heated to boiling.

[0025] According to another aspect of the present invention, there is provided a use of the above-mentioned medicinal and edible preparation for anxiety and panic attacks in the preparation of a drug for preventing or treating anxiety, especially anxiety and panic attacks, especially anxiety and panic attacks accompanied by fatigue and shortness of breath. DETAILED DESCRIPTION

[0026] The present invention will be further described in detail below in conjunction with specific embodiments. Unless otherwise specified, the following raw materials are commercially available.

[0027] Example 1 A medicinal and edible preparation for panic attacks caused by anxiety disorders, comprising: 30g of Astragalus, 20g of Codonopsis, 10g of Atractylodes, 5g of Bupleurum, 5g of Angelica, 5g of Cimicifuga, 10g of Chuanxiong, 10g of Gastrodia, and 5g of Platycodon grandiflorum, and the preparation is a decoction-free granule prepared according to existing technology.

[0028] The existing method for preparing fry-free granules includes the following steps: (1) After processing astragalus, Codonopsis pilosula, Atractylodes macrocephala, Gastrodia elata, and Platycodon grandiflorum according to the standards of the Chinese Pharmacopoeia, they are crushed to an appropriate particle size. Bupleurum, Cimicifuga heracleifolia, and Angelica sinensis can be extracted for volatile oil by supercritical CO2 extraction or steam distillation. The remaining medicinal residues are retained for later use. (2) Combine the residues of Astragalus, Codonopsis, Atractylodes, Gastrodia, Platycodon, Bupleurum, Cimicifuga, and Angelica, and use a dynamic water extraction process to decoct them twice (the first time with 8 times the amount of water for 1.5 hours, and the second time with 6 times the amount of water for 1 hour). Combine the filtrates and filter through a 200-mesh sieve to remove impurities from the residues. The volatile oils of Bupleurum, Cimicifuga, and Angelica are recovered by condensation and then prepared into stable powders using β-cyclodextrin inclusion technology to prevent oxidation. (3) The aqueous extract is concentrated under vacuum to an extract with a relative density of 1.25-1.30 (60°C), spray-dried (inlet air temperature 180°C, outlet air temperature 80°C) to a fine powder, and then the aqueous extract dried fine powder and volatile oil inclusion powder are mixed, 10% dextrin is added as a binder, granulated, and low-temperature dried at 60°C to a moisture content of ≤5%.

[0029] Example 2 A medicinal and edible preparation for panic attacks caused by anxiety disorders is composed of: 30g of Astragalus, 20g of Codonopsis, 10g of Atractylodes, 5g of Bupleurum, 5g of Angelica, 5g of Cimicifuga, 10g of Chuanxiong, 10g of Gastrodia, and 5g of Platycodon grandiflorum, and is an oral solution prepared according to existing technology.

[0030] When preparing an oral solution according to the existing technology, the following steps can be taken: put the medicinal materials into a pot, add 500-800ml of cold water, boil over high heat, then adjust to low heat, simmer for 25-30 minutes, and filter out the medicinal liquid; add 300-400ml of hot water to the medicinal residue, boil, then adjust to low heat, simmer for 15-20 minutes, filter, combine the medicinal liquids, and mix the secondary medicinal liquid with the first decoction.

[0031] In other embodiments, the existing method for preparing decoction-free granules may also include the following steps: (1) Use water extraction or alcohol extraction or a combination of the two to extract the active ingredients; water extraction is to add 10-15 times the weight of the medicinal material in water, soak at 45-50 ° C for 6-12 hours, and ultrasonic assisted crushing (frequency 20-25kHz, power 550-750W); alcohol extraction is to add 65%-75% ethanol solution to fat-soluble components (such as Chuanxiong and Angelica sinensis), soak at 50-60 ° C for 3-6 hours; (2) After the extract is filtered through a 0.2-1.5 μm filter to remove impurities, it is concentrated to 10%-20% of the original volume at 65-75°C, and then spray-dried to make the concentrate into dry powder, which is then granulated with auxiliary materials such as maltodextrin.

[0032] In other embodiments, the edible and medicinal preparation for anxiety and panic attacks of the present invention can also be made into tea bags, which can be directly simmered in hot water for 10-30 minutes before drinking, or boiled in water for at least 5-20 minutes before drinking.

[0033] In other embodiments, the medicine-food preparation for anxiety and panic attacks may also be prepared by first using other commonly used preparations, such as ointments, powders, and the like.

[0034] In other embodiments, the medicine and food preparation for panic attacks of anxiety disorders includes, by weight, 40 parts of raw astragalus, 30 parts of codonopsis, 10 parts of bupleurum, 10 parts of platycodon, 10 parts of cimicifuga, 20 parts of chuanxiong, 20 parts of gastrodia, 25 parts of atractylodes, and 10 parts of angelica; or, 20 parts of raw astragalus, 10 parts of codonopsis, 3 parts of bupleurum, 2 parts of platycodon, 2 parts of cimicifuga, 6 parts of chuanxiong, 6 parts of gastrodia, 10 parts of atractylodes, and 3 parts of angelica; or, 25 parts of raw astragalus, 16 parts of codonopsis, 6 parts of bupleurum, 6 parts of platycodon, 6 parts of cimicifuga, 12 parts of chuanxiong, 12 parts of gastrodia, 20 parts of atractylodes, and 6 parts of angelica.

[0035] In other embodiments, if insomnia, dry mouth, sore throat and other discomforts occur after taking the medicine-food preparation, Rhizoma Anemarrhenae can be added, and the dosage of Rhizoma Anemarrhenae is 5 parts, 6 parts, 8 parts, 10 parts, 11 parts, 13 parts or 15 parts.

[0036] In other embodiments, if taking the medicine-food preparation is accompanied by discomfort such as loose stools, Atractylodes lancea can be added, and the amount of Atractylodes lancea used is 5 parts, 6 parts, 8 parts, 10 parts, 11 parts, 13 parts or 15 parts.

[0037] A multicenter randomized controlled trial method was used. According to the trial inclusion and exclusion criteria, 120 subjects treated in Huizhou Central People's Hospital from May 2022 to May 2025 were collected and randomly assigned to the treatment group and the control group. The relevant information of the subjects is shown in Table 1.

[0038] Table 1 Subject information

[0039] The inclusion criteria for the subjects were as follows: ①Meet the DSM-5 diagnostic criteria for anxiety disorders; ②Accompanied by physical symptoms such as fatigue and shortness of breath; ③ According to Chinese medicine, the syndrome is spleen deficiency and blood weakness.

[0040] The exclusion criteria for subjects are as follows: ①Organic cardiovascular and cerebrovascular diseases; ②Hemoglobin <110g / L; ③ALT>40U / L.

[0041] The medicinal and edible granules prepared in Example 1 for anxiety and panic attacks were used by the subjects in the treatment group, 3 times a day, 5 g each time; the control group (conventional treatment) was given sertraline 50 mg / d + cognitive behavioral therapy, and the treatment course was maintained for 4 weeks.

[0042] The efficacy of the treatment was evaluated using HAMA (Hamilton Anxiety Rating Scale) scores, symptom improvement rate, and overall effectiveness rate as primary indicators, with the results shown in Tables 2-4. As shown in Table 2, the improvement in HAMA scores was significantly greater than that in the control group (P<0.05), with the HAMA score in the treatment group decreasing by 67.3%, while the score in the control group decreased by 48.6%, suggesting that a medicinal and edible preparation for panic attacks in anxiety disorders can significantly improve core symptoms of anxiety disorders.

[0043] Table 2 Changes in HAMA scores (mean ± SD)

[0044] Table 3 Symptom improvement rate (n / %)

[0045] Table 4 Total effective rate

[0046] The safety evaluation of the edible and medicinal preparation for anxiety disorder and panic attack of the present application was conducted using adverse reactions, liver function, gastrointestinal reactions, and dizziness as safety evaluation indicators. The results are shown in Table 5. As can be seen from Table 5, the edible and medicinal preparation for anxiety disorder and panic attack has good safety.

[0047] Table 5 Safety evaluation

[0048] In summary, the medicinal and edible preparation for anxiety and panic attacks provided in this application has significant efficacy in treating anxiety accompanied by fatigue and shortness of breath, has good safety, and can be promoted as a traditional Chinese medicine treatment plan.

[0049] The above are only some embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the inventive concept of the present invention, which all fall within the scope of protection of the present invention.

Claims

1. A medicinal and edible preparation for anxiety and panic attacks, characterized in that: The invention is prepared from the following raw materials in parts by weight: 20-40 parts of raw astragalus, 10-30 parts of codonopsis pilosula, 1-10 parts of bupleurum, 1-10 parts of platycodon, 1-10 parts of cimicifuga, 1-10 parts of ligusticum, 1-20 parts of ligusticum, 1-20 parts of gastrodia, 5-25 parts of atractylodes and 1-10 parts of angelica.

2. The medicinal and edible preparation for anxiety and panic attacks according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 25-35 parts of raw astragalus, 25-35 parts of codonopsis pilosula, 2-8 parts of bupleurum, 2-8 parts of platycodon, 2-8 parts of cimicifuga, 5-15 parts of chuanxiong, 5-15 parts of gastrodia, 10-20 parts of atractylodes and 2-8 parts of angelica.

3. The medicinal and edible preparation for anxiety and panic attacks according to claim 1, characterized in that: The medicine is prepared from the following raw materials in parts by weight: 30 parts of astragalus, 20 parts of codonopsis, 5 parts of bupleurum, 5 parts of platycodon, 5 parts of cimicifuga, 10 parts of ligusticum, 10 parts of gastrodia, 15 parts of atractylodes and 5 parts of angelica.

4. The medicinal and edible preparation for anxiety and panic attacks according to any one of claims 1 to 3, characterized in that: Calculated by weight, 1-20 parts of Anemarrhena Rhizoma are also included.

5. The medicinal and edible preparation for anxiety and panic attacks according to any one of claims 1 to 3, characterized in that: Calculated by weight, it also includes 1-20 parts of Atractylodes lancea.

6. The medicinal and edible preparation for anxiety and panic attacks according to any one of claims 1 to 3, characterized in that: The preparations include oral solutions, powders, granules or pastes.

7. The medicinal and edible preparation for anxiety and panic attacks according to claim 6, characterized in that: Also included are pharmaceutically or food-acceptable excipients.

8. Use of the medicine-food preparation for anxiety and panic attacks according to any one of claims 1 to 7 in the preparation of a drug for preventing or treating anxiety.

9. The use according to claim 8, characterized in that The anxiety disorder medication is a medication for anxiety disorder panic attacks.

10. The use according to claim 9, characterized in that The anxiety disorder drug is a drug for anxiety disorder and panic attacks accompanied by fatigue, shortness of breath.

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