Sublingual blood-activating collateral-dredging stasis-dispersing health-care spray

Abstract

The invention discloses a sublingual blood-activating collateral-dredging stasis-dispersing health-care spray which is prepared from lycopodium clavatum, sticktight, bamboo shavings, astragalus membranaceus, angelica sinensis, folium artemisiae argyi, fructus lycii, leech, tartary buckwheat, frankincense, dragon's blood, hawthorn, artificial musk, rhizoma zingiberis, pseudo-ginseng, borneol, camphor and white spirit. The product is prepared by a two-stage soaking and filtering process, is applied sublingually in a spray form, and aims to promote blood circulation and eliminate blood stasis. The spray is quick to absorb and convenient to use, fills the market blank of non-prescription external health care products, and provides a safe and effective conditioning mode for health of heart and cerebral vessels. The preparation process optimizes the extraction of effective components of traditional Chinese medicines, and ensures the stability and consistency of the product. The sublingual administration mode utilizes the quick absorption characteristic of mucous membranes, so that the active ingredients quickly enter blood, and is suitable for daily health care and first aid auxiliary scenes. The product design pays attention to user experience, the spray dosage form is convenient to carry, the dosage is controllable, and the efficient requirement of modern people for health management is met.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparations, and in particular to a sublingual blood circulation-activating, collateral-draining and blood stasis-removing health-care spray. Background Art

[0002] Traditional Chinese medicine theory believes that blood stasis is a major factor leading to various health problems, such as poor circulation and pain. Chinese medicines that promote blood circulation and remove blood stasis play an important role in maintaining cardiovascular health by improving blood flow and enhancing vascular elasticity. However, traditional Chinese medicines are mostly in the form of decoctions or pills, with slow oral absorption rates and the bioavailability of active ingredients may be reduced due to liver metabolism. In recent years, sublingual administration has become an innovative method of drug delivery due to its advantages of rapid absorption and avoidance of the first-pass effect. However, there has been little research on sublingual preparations in the field of traditional Chinese medicine, and products on the market are scarce.

[0003] This invention addresses the shortcomings of existing technologies by designing a sublingual spray that combines traditional Chinese medicine formulas with modern drug delivery methods. By carefully selecting 17 Chinese medicinal herbs and employing a liquor-soaking process to optimize the extraction of active ingredients, this spray formulation allows for convenient administration. This invention not only improves the absorption efficiency of Chinese medicine but also meets user needs for safe, fast, and portable healthcare products, providing a new option for health management. Summary of the Invention

[0004] The purpose of this section is to summarize some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract and title of this application to avoid obscuring the purpose of this section, the abstract and the title of the invention, and such simplifications or omissions should not be used to limit the scope of the present invention.

[0005] In view of the above problems in the prior art, the inventors proposed the present invention.

[0006] Therefore, the purpose of the present invention is to overcome the deficiencies in the prior art and provide a sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray.

[0007] To solve the above technical problems, the present invention provides the following technical solution: a sublingual blood circulation, meridian dredging and blood stasis removing health care spray, comprising: the following ingredients in parts by weight: 90-100g of striata herb, 90-100g of bidentata herb, 90-100g of bamboo shavings, 90-100g of astragalus, 90-100g of angelica, 90-100g of grass, 105-115g of wolfberry, 105-115g of leech, 105-115g of buckwheat, 105-115g of frankincense, 105-115g of blood clotting, 105-115g of hawthorn, 20-30g of artificial musk, 115-125g of dried ginger, 135-145g of Panax notoginseng, 145-155g of borneol, 15-25g of camphor, and 4800-5200ml of white wine.

[0008] As a preferred embodiment of the sublingual blood circulation, meridian dredgement and blood stasis removing health care spray described in the present invention, the spray comprises: 95g of Herba Lycopodii, 95g of Herba Bidens pilosa, 95g of Rhizoma Anemarrhenae, 95g of Radix Astragali, 95g of Radix Angelicae Sinensis, 95g of Herba Artemisiae Argyi, 110g of Fructus Lycii, 110g of Hirudo, 110g of Tartary Buckwheat, 110g of Frankincense, 110g of Sanguisorba Officinalis, 110g of Hawthorn, 25g of artificial musk, 120g of dried ginger, 140g of Panax notoginseng, 150g of borneol, 20g of camphor and 5000ml of liquor.

[0009] As a preferred embodiment of the sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray of the present invention, the liquor is a high-proof liquor with an alcohol content of more than 60%.

[0010] A preferred method for preparing a sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray, wherein:

[0011] a) placing Herba Lycopodii, Herba Bidens pilosae, Rhizoma Anemarrhenae, Radix Astragali, Radix Angelicae Sinensis, Herba Artemisiae Argyi, Fructus Lycii, Hirudo, Tartary Buckwheat, Frankincense, Dracaena Draconis, Fructus Hawthorne, artificial musk, dried ginger, and Radix Notoginseng in a container;

[0012] b) Add white wine, seal the container, and place it in a cool place at 15-25°C for 35 days;

[0013] c) filtering to obtain a filtrate, and adding borneol and camphor;

[0014] d) Seal and let stand for 7 days;

[0015] e) Filter again and fill into a medicinal spray container.

[0016] As a preferred solution for the preparation process of the sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray of the present invention, the standing temperature in step b) is 20°C.

[0017] As a preferred solution for the preparation process of the sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray of the present invention, the filtration in steps c) and e) uses a filter membrane with a pore size of 0.22-0.45 μm.

[0018] As a preferred embodiment of the sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray of the present invention, the spray remains stable when stored at room temperature for at least 24 months.

[0019] As a preferred embodiment of the sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray of the present invention, it further comprises one or more preservatives or stabilizers.

[0020] As a preferred embodiment of the sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray of the present invention, the composition is packaged in a quantitative spray bottle, and the spraying amount is fixed each time.

[0021] A method for promoting blood circulation and eliminating blood stasis, wherein: a sublingual blood circulation-activating, collateral-draining and stasis-removing health-care spray is applied sublingually in the form of a spray, 2-3 times per spray, repeated every 10 minutes, for 3-5 times in succession;

[0022] The sublingual blood circulation, collateral activating and blood stasis removing health care spray can control the three highs and prevent cerebral infarction and myocardial infarction and has an immediate conditioning effect.

[0023] Beneficial effects of the present invention: The present invention administers the drug through sublingual spray, which significantly improves the absorption rate of the active ingredients of traditional Chinese medicine, allowing users to feel the effect of improved blood circulation in a short period of time. The rapid absorption characteristics of the sublingual mucosa allow the active ingredients to directly enter the blood, bypassing the gastrointestinal tract and liver metabolism, improving bioavailability, reducing the burden on the digestive system, and is suitable for long-term use or sensitive people. The spray formulation is easy to carry and has precise dosage without the need for additional tools. It is suitable for home, travel or first aid scenarios, meeting the needs of modern people for convenient health management. The combination of traditional Chinese medicines in the formula has been optimized, and the synergistic effect promotes blood circulation, eliminates blood stasis, and gently regulates the body, which is in line with the traditional Chinese medicine concept of "preventive treatment". The stability of the product is guaranteed by a two-stage soaking process, and long-term storage does not affect the effect of the active ingredients. Compared with traditional oral preparations, the present invention has significant advantages in absorption efficiency, user experience and application scenarios, providing an innovative over-the-counter health care option for cardiovascular and cerebrovascular health. DETAILED DESCRIPTION

[0024] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0025] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0026] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it designate a separate or selective embodiment that is mutually exclusive with other embodiments.

[0027] Example 1

[0028] As a preferred embodiment, the present invention provides a preparation method of a sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray, the formula of which is: 95g of Herba Lycopodii, 95g of Herba Bidens pilosae, 95g of Rhizoma Anemarrhenae, 95g of Radix Astragali, 95g of Radix Angelicae Sinensis, 95g of Herba Artemisiae Argyi, 110g of Fructus Lycii, 110g of Hirudo, 110g of Tartary Buckwheat, 110g of Frankincense, 110g of Sanguisorba Officinalis, 110g of Hawthorn, 25g of artificial musk, 120g of dried ginger, 140g of Radix Notoginseng, 150g of borneol, 20g of camphor, and 5000ml of liquor with an alcohol content of more than 60%.

[0029] Preparation method:

[0030] Raw Material Preparation: Accurately weigh schisandra chinensis, bidentata herba, bamboo shavings, astragalus, angelica, mugwort, wolfberry, leech, buckwheat, frankincense, dragon's blood, hawthorn, artificial musk, dried ginger, and Panax notoginseng and place in a clean, sealed glass container. Preferably, all Chinese medicinal materials comply with the standards of the Pharmacopoeia of the People's Republic of China to ensure raw material quality. Furthermore, the raw materials are screened and cleaned before weighing to remove impurities.

[0031] First soak: Add 5000ml of white wine with an alcohol content of at least 60% to the container. Seal the container and place it in a cool, dark place at 20°C for 35 days. Gently shake the container once a week to promote the dissolution of the active ingredients. Ideally, avoid direct sunlight to prevent degradation.

[0032] Furthermore, the container is made of medical-grade glass to ensure no chemical reactions.

[0033] First filtration: After standing for 35 days, filter using a filter membrane with a pore size of 0.22 μm, collect the clarified filtrate, and transfer it to another clean and sealed container. Preferably, the filtration operation is carried out under sterile conditions to ensure product hygiene.

[0034] Furthermore, the filtering equipment is made of stainless steel to avoid contamination.

[0035] Second soaking: Add 150g of borneol and 20g of camphor to the filtrate, seal it, and continue to stand at 20°C for 7 days. The addition of borneol and camphor helps to enhance the sublingual absorption efficiency and product stability.

[0036] Preferably, borneol and camphor are added with slow stirring to ensure uniform dissolution.

[0037] Second filtration and packaging: After standing for 7 days, filter again using a 0.22 μm filter membrane and fill the resulting clear liquid into a quantitative spray bottle (0.1 ml per spray).

[0038] Furthermore, the spray bottle is made of medical-grade materials to ensure tightness and dosage accuracy. Preferably, each bottle contains 10ml, suitable for single use.

[0039] Quality Control: Check the seal of the spray bottle and the uniformity of the spray. Store in a cool, dry place. Preferably, the product is stability tested after packaging to ensure that there is no obvious precipitation or deterioration after storage at room temperature for 24 months.

[0040] Furthermore, random sampling is conducted to test product clarity and microbial limits to ensure compliance with health product standards.

[0041] Instructions: As a preferred method of administration, spray 2-3 times (approximately 0.2-0.3 ml) sublingually, repeating every 10 minutes for 3-5 consecutive times. It is recommended to use 1-2 times daily for 7 consecutive days. Furthermore, users should clean their mouths before use to ensure that the sublingual mucosa is dry to improve absorption efficiency.

[0042] Effect Observation: In a volunteer test, 50 subjects aged 40-65 years with symptoms of sublingual veins or blood stasis were selected. Within 15 minutes of use, 80% of the subjects reported a significant reduction in sublingual veins and enhanced mental clarity. Furthermore, after 7 consecutive days of use, 98% of the subjects reported improved physical strength and reduced fatigue. Some subjects also observed improvements in the three high indicators (blood pressure, blood lipids, and blood sugar).

[0043] Example 2

[0044] As another embodiment, the present invention provides a preparation method for shortening the first soaking time to explore the possibility of process optimization.

[0045] Recipe: Same as Example 1.

[0046] Preparation method:

[0047] Raw material preparation: Weigh the Chinese medicinal materials according to step 1 of Example 1 and place them in a sealed container. Preferably, the raw materials are dried before weighing to ensure a moisture content of less than 5%. Furthermore, the container should be made of medical-grade glass to prevent chemical reactions.

[0048] First soak: Add 5000ml of liquor with an alcohol content of at least 60%. Seal the container and let it rest at 20°C for 30 days, shaking it weekly. Preferably, record the ambient temperature during the soaking process to ensure stability. Furthermore, check the container regularly to prevent alcohol evaporation.

[0049] First filtration: Filter using a 0.22 μm filter membrane and collect the filtrate. Preferably, filtration is performed in a sterile environment to ensure product hygiene.

[0050] Second soaking: Add 150g of borneol and 20g of camphor, seal and let stand for 7 days. Preferably, stir slowly when adding borneol and camphor to ensure uniform dissolution.

[0051] Second filtration and packaging: Filter again using a 0.22 μm filter membrane and fill into a quantitative spray bottle. Furthermore, after packaging, spray uniformity testing is performed.

[0052] Quality Control: Check product clarity and spray properties and store in a cool, dark place. Preferably, the product undergoes stability testing to ensure no deterioration after 24 months of storage.

[0053] Usage: Same as Example 1.

[0054] Effect Observation: Within 15 minutes after spraying, 70% of the volunteers reported a slightly lower reduction in sublingual veins than in Example 1, and a slightly weaker sense of mental clarity. Furthermore, 90% of the volunteers reported an overall acceptable effect, indicating that soaking time has a certain impact on ingredient extraction.

[0055] Comparative Example 1

[0056] This comparative example mainly compares the effects of missing key ingredients. The formula is as follows: leech, dragon's blood and Panax notoginseng are removed, and the rest is the same as Example 1.

[0057] Preparation method: same as Example 1.

[0058] Effect Observation: Volunteers reported that within 15 minutes after spraying, only 50% of the subjects reported a reduction in sublingual veins and a weaker sense of mental clarity, demonstrating the key role of leeches, dragon's blood, and Panax notoginseng in promoting blood circulation and removing blood stasis.

[0059] Comparative Example 2

[0060] This comparative example mainly verifies the single immersion process.

[0061] Recipe: Same as Example 1.

[0062] Preparation method: Add all ingredients into white wine at once, seal it and let it stand at 20℃ for 42 days, filter it and put it into a spray bottle.

[0063] Effect observation: Volunteers reported that the effect was lower than that of Example 1, and 60% of the subjects reported that the reduction of sublingual veins was limited and the stability was slightly poor.

[0064] This invention successfully integrates traditional Chinese medicine theory with modern pharmaceutical technology to design a sublingual blood circulation-activating, collateral-draining, and stasis-removing health spray, providing an innovative solution for cardiovascular health management. Its core advantage lies in its sublingual administration, which leverages the rapid absorption properties of the sublingual mucosa to rapidly allow the active ingredients of traditional Chinese medicine to enter the bloodstream, bypassing the gastrointestinal tract and liver for metabolism, thereby significantly improving bioavailability. This administration method not only improves absorption efficiency but also reduces the burden on the digestive system, making it particularly suitable for long-term use or those sensitive to oral medications. The formula incorporates 17 carefully selected traditional Chinese medicinal herbs, such as angelica sinensis, Panax notoginseng, and Sanguisorba officinalis, which promote blood circulation and remove stasis. Astragalus membranaceus and wolfberry fruit strengthen the body, while borneol and camphor, acting as transdermal enhancers, further accelerate absorption. The synergistic effect of these ingredients enables the spray to rapidly improve blood circulation and eliminate blood stasis, providing users with rapid health benefits. Furthermore, the use of baijiu (white wine) as a solvent not only effectively extracts both fat-soluble and water-soluble components from the traditional Chinese medicine but also provides a natural preservative, ensuring the product's stability during long-term storage. The combination of this formula and process fully reflects the innovation of the present invention in the fusion of tradition and modern technology.

[0065] The three examples demonstrate the feasibility and superiority of the technical solution from different perspectives. Example 1, using a standard formula and optimal preparation conditions, demonstrates the product's ideal effects. Volunteer tests show that the spray significantly improves sublingual veins and blood stasis symptoms within a short period of time, enhances mental clarity, and improves physical strength and reduces fatigue after long-term use. This rapid onset of action is due to the efficient absorption of sublingual administration and the synergistic effect of the various ingredients in the formula. Example 2 verifies the adaptability of the formula to different alcohol concentrations by reducing the alcohol concentration of the liquor to 52%. Although the effect is slightly lower than that of Example 1, its friendliness for alcohol-sensitive users demonstrates the flexibility and wide applicability of the formula. Example 3 explores the possibility of process optimization by shortening the first soaking time to 30 days. Although the effect is slightly lower than the standard process, it still meets basic functional requirements, demonstrating the robustness of the process and the potential for improving production efficiency. The setting of the comparative examples further highlights the necessity of the formula and process. The omission of key ingredients or the simplification of the process both lead to a significant decrease in effect, demonstrating the completeness and scientific nature of the technical solution of the present invention.

[0066] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray, characterized by: The invention comprises the following ingredients in parts by weight: 90-100g of striata herb, 90-100g of bidentata herb, 90-100g of bamboo shavings, 90-100g of astragalus, 90-100g of angelica, 90-100g of grass, 105-115g of wolfberry, 105-115g of leech, 105-115g of buckwheat, 105-115g of frankincense, 105-115g of dragon's blood, 105-115g of hawthorn, 20-30g of artificial musk, 115-125g of dried ginger, 135-145g of Panax notoginseng, 145-155g of borneol, 15-25g of camphor, and 4800-5200ml of white wine.

2. A sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray according to claim 1, characterized in that: It contains the following ingredients in parts by weight: 95g of Herba Lycopodii, 95g of Herba Bidens pilosa, 95g of Rhizoma Anemarrhenae, 95g of Astragalus, 95g of Radix Angelicae Sinensis, 95g of Artemisiae Argyi, 110g of Lycium barbarum, 110g of Leech, 110g of Tartary Buckwheat, 110g of Frankincense, 110g of Sanguisorba officinalis, 110g of Hawthorn, 25g of artificial musk, 120g of dried ginger, 140g of Panax notoginseng, 150g of borneol, 20g of camphor, and 5000ml of white wine.

3. A sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray according to claim 2, characterized in that: The liquor is a high-proof liquor with an alcohol content of more than 60%.

4. A method for preparing a sublingual blood-activating, collateral-draining and stasis-removing health-care spray according to any one of claims 1 to 3, characterized in that: a) placing Herba Lycopodii, Herba Bidens pilosae, Rhizoma Anemarrhenae, Radix Astragali, Radix Angelicae Sinensis, Herba Artemisiae Argyi, Fructus Lycii, Hirudo, Tartary Buckwheat, Frankincense, Dracaena Draconis, Fructus Hawthorne, artificial musk, dried ginger, and Radix Notoginseng in a container; b) Add white wine, seal the container, and place it in a cool place at 15-25°C for 35 days; c) filtering to obtain a filtrate, and adding borneol and camphor; d) Seal and let stand for 7 days; e) Filter again and fill into a medicinal spray container.

5. The preparation process of a sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray according to claim 4, characterized in that: The standing temperature in step b) is 20°C.

6. The preparation process of a sublingual blood-activating, collateral-draining and stasis-removing health-care spray according to claim 4 or 5, characterized in that: The filtration in steps c) and e) uses a filter membrane with a pore size of 0.22-0.45 μm.

7. The sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray according to claim 3, characterized in that: Stable for at least 24 months when stored at room temperature.

8. The sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray according to claim 3, characterized in that: One or more preservatives or stabilizers may also be included.

9. The sublingual blood-activating, collateral-draining and blood-stasis-removing health-care spray according to claim 3, characterized in that: The composition is packaged in a quantitative spray bottle, and the spraying amount each time is fixed.

10. A method for promoting blood circulation and eliminating blood stasis, characterized in that: The method comprises administering the sublingual blood circulation, meridian dredging and blood stasis removing health care spray according to any one of claims 1 to 3 in the form of a sublingual spray, spraying 2 to 3 times each time, repeating once every 10 minutes, for 3 to 5 times in a row; The sublingual blood circulation, collateral activating and blood stasis removing health care spray can control the three highs and prevent cerebral infarction and myocardial infarction and has an immediate conditioning effect.