Automatic medicine discharging device and medicine management system for clinical test pharmacy

Abstract

The invention discloses an automatic medicine discharging device for a clinical test pharmacy and a medicine management system. The automatic medicine discharging device and the medicine management system comprise a constant-temperature cabinet body (1), a medicine conveying belt (2) and a medicine pushing assembly. The medicine conveying belt extends to the outer side from the inner side of the constant-temperature cabinet body; the medicine pushing assembly can push medicine placed in the constant-temperature cabinet body to the medicine conveying belt, and then the medicine conveying belt can convey the medicine to the outside. The medicine pushing assembly comprises a medicine shelf (3) and a medicine sliding plate (4); the front end of the medicine sliding plate extends to the medicine conveying belt; a medicine pushing plate (5) is arranged on the medicine sliding plate and can push medicines in the medicine placing frame to the medicine conveying belt through the medicine sliding plate; an automatic medicine discharging device is adopted in the medicine management system. According to the automatic medicine discharging device and the medicine management system, the frequency of manually opening and closing the cabinet door is reduced, and efficient and accurate automatic management of a medicine warehouse is achieved.

Description

Technical Field

[0001] The present invention relates to a medicine storage device, and in particular to an automatic medicine dispensing device and a medicine management system used in a clinical trial pharmacy. Background Art

[0002] Medicine cabinets are widely used in various drug stores, pharmacies and hospitals. Their basic function is to divide the space to place medicines. However, in reality, there are many interfering factors that affect the storage of medicines, such as temperature and humidity. Traditional medicine cabinets are mostly opened manually, and this manual operation method inevitably leads to the problem of frequent opening and closing of the medicine cabinet door. Frequent opening and closing causes the storage environment temperature to fluctuate, which is especially harmful to medicines that need to be stored at a constant temperature of 4°C. The temperature stability of the medicine cannot be guaranteed from the time it is taken to the time it is used by the patient. How can we reduce the number of manual opening and closing of medicine cabinets, ensure the constant temperature of refrigerated medicines during the entire process of taking them, and reduce the risk of direct contact with the medicines?

[0003] In summary, the problems to be solved by the present invention are:

[0004] Manual operation frequently opens and closes the medicine cabinet to take medicine, causing the storage environment temperature inside the medicine cabinet to fluctuate, which is not conducive to medicine storage. It is necessary to find an automatic medicine dispensing device to reduce the frequency of opening and closing the medicine cabinet. Summary of the Invention

[0005] The purpose of the present invention is to provide an automatic drug dispensing device and a drug management system for a clinical trial pharmacy. The automatic drug dispensing device and the drug management system reduce the frequency of manual opening and closing of cabinet doors, avoid ambient temperature fluctuations in the constant temperature cabinet, and realize efficient and accurate automated management of the drug warehouse.

[0006] In order to achieve the above technical objectives, the present invention adopts the following technical solutions:

[0007] An automatic drug dispensing device for a clinical trial pharmacy comprises a constant temperature cabinet, a drug conveyor belt, and a drug pushing assembly; the drug conveyor belt extends from the inside of the constant temperature cabinet to the outside, and the drug pushing assembly is arranged inside the constant temperature cabinet; the drug pushing assembly can push drugs placed in the constant temperature cabinet onto the drug conveyor belt, and then the drug conveyor belt can transport the drugs to the outside.

[0008] Furthermore, the medicine pushing assembly includes a medicine rack and a medicine slide; the medicine rack is used to place medicines; the medicine slide is arranged on the lower side of the medicine rack, and the front end of the medicine slide extends to the medicine conveyor belt; a medicine pushing plate is provided on the medicine slide, and the medicine pushing plate can push the medicines in the medicine rack to the medicine conveyor belt via the medicine slide.

[0009] Furthermore, the height of the medicine pushing plate is higher than the medicine sliding plate, and the height of the medicine pushing plate is lower than the height of the side of the medicine box, so as to push the side of the medicine box and push the medicine box onto the medicine conveyor belt.

[0010] Furthermore, push plate limiting plates are provided on both sides of the medicine push plate, and the height of the push plate limiting plates is set higher than the height of the medicine push plate, so as to limit the sliding direction of the medicine push plate.

[0011] Furthermore, the height of the medicine slide is set higher than the height of the medicine conveyor belt, and an inclined guide plate is provided between the medicine slide and the medicine conveyor belt for guiding the medicine boxes on the medicine slide to the medicine conveyor belt.

[0012] Furthermore, a push plate driving component is provided on one side of the medicine slide plate, and the push plate driving component is arranged away from the medicine conveyor belt.

[0013] Furthermore, a medicine discharging platform for placing medicine boxes is provided on one side of the constant temperature cabinet, and the medicine conveyor belt extends to the medicine discharging platform.

[0014] Furthermore, a conveyor belt through hole is provided on the side of the constant temperature cabinet for passing a medicine conveyor belt.

[0015] Furthermore, the medicine pushing components are provided in multiple groups along the length direction of the medicine conveyor belt.

[0016] A drug management system for a clinical trial pharmacy, wherein the automatic drug dispensing device as described above is adopted in the drug management system.

[0017] Compared with the prior art, the automatic drug dispensing device and drug management system for clinical trial pharmacies of the present invention have the following beneficial effects:

[0018] 1) The automatic medicine dispensing device of the present invention is provided with a medicine conveyor belt within the constant temperature cabinet. The medicine conveyor belt is used to transport the medicines in the constant temperature cabinet out of the constant temperature cabinet, thereby reducing the frequency of manual opening and closing of the cabinet door and avoiding ambient temperature fluctuations within the constant temperature cabinet.

[0019] 2) The drug management system of the present invention adopts the automatic drug dispensing device of the present invention, and the drug output process is fully automated, thereby realizing efficient and accurate automated management of the drug warehouse. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 Schematic diagram of the structure of the automatic medicine dispensing device of the present invention;

[0021] Figure 2 This is a schematic structural diagram of the medicine rack of the automatic medicine dispensing device of the present invention;

[0022] Figure 3This is a structural schematic diagram of the medicine pushing plate of the automatic medicine dispensing device of the present invention;

[0023] Figure 4 for Figure 3 A partial enlarged view of the area indicated by mark A. DETAILED DESCRIPTION

[0024] The specific embodiments of the present invention are further described below:

[0025] This embodiment provides an automatic drug dispensing device for a clinical trial pharmacy, which can reduce the frequency of manual opening and closing of cabinet doors and avoid ambient temperature fluctuations in a constant temperature cabinet.

[0026] See Figures 1 to 4 The automatic medicine dispensing device of this embodiment includes a constant temperature cabinet 1, a medicine conveyor belt 2 and a medicine pushing component.

[0027] Specifically,

[0028] The constant temperature cabinet 1 is provided with the medicine conveyor belt 2, which extends from the inside to the outside of the constant temperature cabinet 1 and is used to transport medicines in the constant temperature cabinet 1 to the outside. The constant temperature cabinet 1 is also provided with a medicine pushing component, which is used to push medicines onto the medicine conveyor belt 2.

[0029] The medicine pushing assembly includes a medicine rack 3 and a medicine slide 4. The medicine slide 4 is provided on the lower side of the medicine rack 3, and the front end of the medicine slide 4 extends to one side of the medicine conveyor belt 2. The medicine slide 4 is slidably connected to the medicine push plate 5, which is used to push the medicine boxes in the medicine rack 3 onto the medicine conveyor belt 2 via the medicine slide 4.

[0030] By providing a medicine conveyor belt 2 in the constant temperature cabinet 1, the medicine in the constant temperature cabinet 1 is conveyed out of the constant temperature cabinet 1 by the medicine conveyor belt 2, thereby reducing the frequency of manual opening and closing of the cabinet door and avoiding ambient temperature fluctuations in the constant temperature cabinet 1. The medicine pushing component pushes the medicine onto the medicine conveyor belt 2, thereby facilitating the placement of medicine boxes on the medicine conveyor belt 2 without the need for manual operation. By placing the medicine on the medicine rack 3, multiple boxes can be placed at one time, thereby reducing the frequency of replenishing medicines. A medicine push plate 5 is slidably connected to the medicine slide 4. When the medicine needs to be taken out, the medicine push plate 5 is used to push the medicine box in the medicine rack 3 onto the medicine conveyor belt 2 to ensure the stability of the medicine delivery.

[0031] The height of the medicine pushing plate 5 is higher than the medicine sliding plate 4, and the height of the medicine pushing plate 5 is lower than the height of the side of the medicine box, so as to push the side of the medicine box to push the medicine box onto the medicine conveyor belt 2. By lowering the height of the medicine pushing plate 5 to the side of the medicine box, it is possible to easily push the medicine onto the medicine conveyor belt 2.

[0032] After pushing a box of medicines, the medicine pushing plate 5 moves backward to leave the lower side of the medicine rack 3, so that the subsequent medicines can fall onto the medicine slide plate 4. The length of the medicine pushing plate 5 is greater than the length of the medicine box. In this way, when the medicine pushing plate 5 pushes the medicines to the medicine conveyor belt 2, the rear half of the medicine pushing plate 5 can support the medicines on the medicine rack 3 to prevent the medicines from falling onto the medicine slide plate 4 and affecting the backward movement of the medicine pushing plate 5.

[0033] Push plate limit plates 6 are provided on both sides of the medicine slide 4. The push plate limit plates 6 are set higher than the medicine push plate 5 and are used to limit the sliding direction of the medicine push plate 5. By providing push plate limit plates 6 on both sides of the medicine slide 4, the push plate limit plates 6 are used to limit the sliding direction of the medicine push plate 5, thereby ensuring stability during the medicine delivery process.

[0034] The height of the medicine slide 4 is higher than that of the medicine conveyor belt 2, and an inclined guide plate 7 is provided between the medicine slide 4 and the medicine conveyor belt 2 to guide the medicine boxes on the medicine slide 4 to the medicine conveyor belt 2. The guide plate 7 can guide the medicine boxes pushed from the medicine slide 4 to the medicine conveyor belt 2, thereby ensuring the stability of medicine transportation.

[0035] A push plate driving member 8 is provided on one side of the medicine slide 4, and the push plate driving member 8 is arranged away from the medicine conveyor belt 2. Setting the push plate driving member 8 away from the medicine conveyor belt 2 can reduce the space occupied on one side of the medicine conveyor belt 2 and ensure the rationality of the layout in the constant temperature cabinet 1.

[0036] A medicine discharging platform 9 for placing medicine boxes is provided on one side of the constant temperature cabinet 1, and the medicine conveyor belt 2 extends to the medicine discharging platform 9. The medicine discharging platform 9 can be used to conveniently place the medicines on the medicine conveyor belt 2 to avoid the medicines from falling off the medicine conveyor belt 2 if they are not taken in time.

[0037] The side of the constant temperature cabinet 1 is provided with a conveyor belt through hole 10 for passing the medicine conveyor belt 2. By providing the conveyor belt through hole 10, the loss of cold air in the constant temperature cabinet 1 can be reduced and the stability of the storage environment in the constant temperature cabinet 1 can be improved.

[0038] There are multiple groups of medicine pushing components arranged along the length direction of the medicine conveyor belt 2. By arranging multiple groups of medicine pushing components, a variety of medicines can be placed conveniently.

[0039] The automatic medicine dispensing device of this embodiment is provided with a medicine conveyor belt 2 in the constant temperature cabinet 1, and the medicine conveyor belt 2 is used to convey the medicine in the constant temperature cabinet 1 out of the constant temperature cabinet 1, thereby reducing the frequency of manual opening and closing of the cabinet door and avoiding ambient temperature fluctuations in the constant temperature cabinet 1. The medicine pushing component pushes the medicine onto the medicine conveyor belt 2, thereby facilitating the placement of medicine boxes on the medicine conveyor belt 2 without manual operation. The medicines are placed on the medicine rack 3, and multiple boxes can be placed at one time, thereby reducing the frequency of replenishing medicines. A medicine pushing plate 5 is slidably connected to the medicine slide 4. When the medicine needs to be taken out, the medicine pushing plate 5 is used to push the medicine box in the medicine rack 3 onto the medicine conveyor belt 2 to ensure the stability of medicine transportation.

[0040] This embodiment also provides a medicine management system for efficiently and accurately managing a medicine warehouse. The medicine management system employs the aforementioned automatic medicine dispensing device.

[0041] Specifically,

[0042] A prior art warehouse medicine data server is configured for the medicine warehouse, and a prior art warehouse medicine database is set in the warehouse medicine data server.

[0043] Those skilled in the art will understand that the warehouse drug database is used to record various information data related to stored drugs, such as the drug's unique code, batch number, expiration date, temperature requirements, clinical trial number, randomization code and complete logistics information, etc.

[0044] The automatic dispensing device is communicatively connected to and controlled by the warehouse's drug data server. It can be linked to the warehouse's drug database via the server. When drugs in the drug warehouse need to be shipped out, the operator enters the desired drug information into the database. The database automatically locates the drug and, upon issuing a drug pickup instruction, the automatic dispensing device automatically dispenses the drug to the dispensing station 9. This fully automates drug delivery, enabling efficient and accurate automated management of the drug warehouse.

[0045] The initial conception of the present invention is introduced below:

[0046] name:

[0047] The invention relates to a spring-linked push-type intelligent automatic medicine dispensing device for clinical trials.

[0048] use:

[0049] The present invention is suitable for use in clinical trial pharmacies to automate the drug dispensing process, reducing manual operations, lowering the risk of drug contact with the environment, and improving drug dispensing efficiency and accuracy. The device can push drugs from the drug storage rack to the designated receiving area via a spring-linked push mechanism according to drug dispensing instructions. Technical background:

[0051] Existing mechanical equipment products and their shortcomings

[0052] The drug management system currently used in clinical trial pharmacies (GCP pharmacies) mainly consists of the following components:

[0053] 1. Digital management software system: responsible for drug information entry, inventory management and drug dispensing instructions

[0054] 2. Medicine storage cabinets: including normal temperature medicine cabinets, cool storage medicine cabinets and other temperature-controlled medicine cabinets

[0055] 3. Positioning indication system: Use digital codes or lights to indicate the location where the medicine needs to be taken

[0056] 4. Manual medication collection process: After receiving the system instructions, the pharmacist needs to manually open the medicine cabinet and take out the specified medicine

[0057] The main shortcomings of the existing system are:

[0058] 1. Frequent opening and closing of medicine cabinets causes temperature fluctuations in the storage environment, which has a particularly significant impact on medicines that need to be stored at a constant temperature of 4°C. It is impossible to ensure the temperature stability of the medicines from the time they are taken to the time they are used by the patient.

[0059] 2. Pharmacists need to directly contact drugs, increasing the risk of cross-contamination

[0060] 3. The manual drug collection process is time-consuming, reducing the efficiency of clinical trial pharmacies

[0061] 4. It is inconvenient to take medicine from the high medicine cabinet, and the internal space utilization rate of the cool storage is low.

[0062] 5. Manual medication collection can easily lead to the risk of taking the wrong medication, especially in an emergency

[0063] 6. It is impossible to ensure that the temperature of medicines stored in the refrigerator remains constant throughout the entire process from being taken out of the medicine cabinet to being used by patients, resulting in the risk of a break in the medicine temperature control chain.

[0064] Purpose of the invention:

[0065] The purpose of the present invention is to provide a new automated medicine dispensing system, which is similar to the beverage pushing method of a vending machine. Through a spring-linked pushing mechanism, it can be integrated with an intelligent constant-temperature automatic medicine pushing device of an existing digital management system to automatically push medicines to the medicine collection area, reduce the number of manual opening and closing of medicine cabinets, reduce manual operations, ensure that refrigerated medicines are kept at a constant temperature throughout the collection process, reduce the risk of direct contact with medicines, and at the same time improve the speed and accuracy of medicine dispensing, improve the efficiency of medicine collection and space utilization, and enhance the accuracy of medicine distribution. It is particularly suitable for the high standards required by clinical trial pharmacies.

[0066] Technical features of the present invention

[0067] Technical characteristics of mechanical equipment products

[0068] The present invention's "spring-linked push-type intelligent automatic drug dispensing device for clinical trials" consists of the following components:

[0069] 1. Central Control Unit:

[0070] oProcessor module: receives and processes drug withdrawal instructions

[0071] oDatabase module: stores drug location information, temperature control parameters and push settings

[0072] oInterface module: connect with existing pharmacy management system

[0073] oPower management module: provides stable power and backup power

[0074] 2. Medicine grid pushing device:

[0075] o Spring push mechanism: Suitable for light medicines, consisting of a stainless steel compression spring, a medicine tray, an electromagnetic release lock, and a micro limit switch

[0076] oElectric push rod mechanism: suitable for medium and heavy-duty medicines, composed of a brushless DC motor, precision push rod, travel switch and guide groove

[0077] o Roller conveyor belt mechanism: suitable for high-rise medicine cabinets, composed of a micro motor, a rubber conveyor belt and a guide wheel

[0078] 3. Constant temperature transmission system:

[0079] o Insulated closed transmission channel: composed of inner layer of stainless steel and outer layer of insulation material

[0080] oTemperature control unit: including distributed temperature sensors, micro cooling modules and heating elements

[0081] o Air flow control device: composed of a micro fan and an air filter to ensure uniform temperature distribution in the channel

[0082] 4. Drug collection system:

[0083] o Constant temperature collection window: equipped with automatic opening and closing door and independent temperature control system

[0084] oMulti-temperature zones: including 2-8℃ and 15-25℃

[0085] o In-place sensor: It consists of an infrared transmitter and an infrared receiver to detect whether the medicine is successfully pushed to the collection area

[0086] 5. Operation terminal:

[0087] oTouch screen display: displays drug information, temperature status and operation interface

[0088] oAuthentication module: including fingerprint reader and IC card reader

[0089] oStatus indicator: Displays system operating status and temperature alarm

[0090] 6. Network communication module:

[0091] oPharmacy management system interface: data sharing with existing systems

[0092] oWireless communication unit: supports remote operation and monitoring

[0093] oData encryption module: ensure information security

[0094] The relationship and connection method between each component:

[0095] The central control unit is connected to all subsystems through the bus to achieve centralized control

[0096] The medicine grid push device is installed in a modular way inside each medicine cabinet. The appropriate push mechanism is selected according to the type of medicine cabinet and the characteristics of the medicine, similar to the beverage push method of a vending machine.

[0097] The constant temperature transmission system connects the medicine cabinet and the collection window to form a closed channel with controllable temperature

[0098] The drug collection system is equipped with multiple temperature zones, which can automatically adjust the temperature of the collection zone according to the drug requirements.

[0099] The operation terminal is connected to the central control unit via wired or wireless means to provide a human-computer interaction interface

[0100] The network communication module is connected to the pharmacy management system and other related systems through the hospital intranet

[0101] Signal flow:

[0102] 1. The pharmacist issues a medication pickup instruction through the operation terminal

[0103] 2. The central control unit receives instructions and verifies identity and authority

[0104] 3. The system queries the location and temperature requirements of the medicine and calculates the optimal delivery path

[0105] 4. The constant temperature transmission system is pre-adjusted to the temperature required by the medicine

[0106] 5. The control signal is transmitted to the corresponding medicine grid push device

[0107] 6. The push device is activated to push the medicine into the constant temperature transmission system

[0108] 7. Medicines are transported to the collection window under constant temperature conditions

[0109] 8. The arrival sensor confirms the arrival of the medicine and triggers the collection window to open

[0110] 9. The system records medication information, updates inventory data and temperature monitoring records

[0111] Implementation

[0112] The present invention provides a spring-linked push-type intelligent automatic medicine dispensing device for clinical trials, which includes a central control unit, a medicine grid pushing device, a constant temperature transmission system, a medicine collection system, an operation terminal and a network communication module.

[0113] The central control unit is located in the control center of the system and serves as the core processing platform of the entire system. The unit includes a processor module, a database module, an interface module, and a power management module. The processor module uses an industrial-grade ARM processor with a main frequency of 1.5GHz and is equipped with 4GB of memory to run customized drug management system software. The database module uses a solid-state hard drive with a capacity of 128GB to store drug information, location data, and temperature control parameters. The interface module is equipped with RS485, Ethernet, and USB interfaces to achieve stable connection with each subsystem. The power management module provides DC 24V / 12V / 5V output and is equipped with a 1500VA UPS uninterruptible power supply system to ensure that the system can maintain normal operation for at least 2 hours in the event of a power outage.

[0114] The medicine grid pusher is the actuator in the system that comes into direct contact with the medicine. It is divided into three types according to the location and characteristics of the medicine:

[0115] The spring push mechanism is primarily suitable for lightweight medications (weighing less than 100g) and includes a stainless steel compression spring, a medication tray, an electromagnetic release latch, and a miniature limit switch. The compression spring is made of 304 stainless steel with a spring coefficient of 2-5N / mm, providing stable thrust. The medication tray is made of food-grade ABS material, measures 120mm x 100mm, and has a smooth surface treatment to reduce friction with the medication. The electromagnetic latch is powered by 24V and releases when power is on and locks when power is off. When the system issues a command, the latch releases, and the spring expands to push the medication out; the entire process takes no more than 0.8 seconds. The miniature limit switch monitors the push status and provides feedback on the execution results.

[0116] This electric push rod mechanism is suitable for handling medium- and heavy-duty pharmaceuticals (100-500g). It includes a brushless DC motor, precision push rod, limit switch, and guide groove. The 35W DC motor drives the precision push rod, delivering a maximum thrust of 50N. The push rod is constructed of aluminum alloy and has an adjustable stroke of 100-200mm. The limit switch uses a Hall effect sensor with an accuracy of ±0.5mm to ensure push accuracy. The guide groove is made of high-molecular-weight polymer material to guide the push rod's smooth movement.

[0117] The roller conveyor mechanism is designed specifically for high-mounted medicine cabinets and includes a micromotor, rubber conveyor belt, and guide pulleys. The micromotor is a 12V stepper motor with a controllable speed (0-120 rpm). The conveyor belt is made of food-grade silicone, 60mm wide and 2mm thick, with a non-slip surface. The guide pulleys are 20mm in diameter and made of wear-resistant plastic to reduce operating noise. The motor drives the conveyor belt, smoothly transporting the high-mounted medicines to the constant-temperature conveyor channel. The conveyor speed is adjustable between 0.1 and 0.3 m / s.

[0118] The constant temperature transmission system is the core innovative part of the present invention, which solves the temperature control problem during the drug retrieval process. It includes an insulated and closed transmission channel, a temperature control unit and an airflow control device.

[0119] The insulated, enclosed delivery channel utilizes a double-layer design, with an inner layer of food-grade stainless steel (0.8mm thick) and an outer layer of ABS engineering plastic (2.5mm thick). The center is filled with high-efficiency polyurethane insulation (15mm thick), with a thermal conductivity no greater than 0.025W / (m·K). The channel is tubular in shape, with an inner diameter of 120-150mm. The length can be customized based on the pharmacy's layout, typically ranging from 1.5 to 3 meters.

[0120] The temperature control unit includes distributed temperature sensors, micro-refrigeration modules, and heating elements. The temperature sensor uses a PT100 platinum resistor (accuracy ±0.1°C), which is arranged every 50cm along the channel to monitor the temperature distribution in real time. The refrigeration module uses semiconductor refrigeration technology (TEC), with a power of 15-50W, no refrigerant required, and a fast response speed. The heating element is a PTC ceramic heating element with a power of 15-40W and a self-limiting temperature characteristic. The system is controlled by a PID algorithm to strictly maintain the temperature in the channel within the set range. For refrigerated medicines at 4°C, the temperature control accuracy can reach ±0.3°C.

[0121] The airflow control device ensures uniform temperature within the channel and includes a micro-blower and air filter. The micro-blower is an axial-flow fan (40mm diameter, 15 CFM flow rate) with PWM technology for speed control. The air filter uses HEPA-grade material to ensure airflow cleanliness. The fan and filter form a closed-loop airflow system, ensuring uniform temperature distribution within the channel and controlling the temperature difference within ±0.2°C.

[0122] The drug collection system includes a constant temperature collection window, multi-temperature zone divisions and an arrival sensor.

[0123] The constant temperature collection window features an automatic door and an independent temperature control system. The automatic door is a sliding design controlled by an electromagnetic lock, with an opening time of less than 1 second. The independent temperature control system uses a micro-compressor for cooling (≤100W) and electric heating (≤80W) for bidirectional regulation, working in conjunction with the constant temperature transmission system to ensure that the collection window temperature remains consistent with the channel temperature.

[0124] The collection area is divided into a refrigerated storage zone (2-8°C) and a room temperature zone (15-25°C). Each zone is equipped with an independent temperature control device. The temperature zones are separated by high-efficiency insulation materials to prevent temperature interference and meet the temperature requirements of different medicines.

[0125] The arrival sensor uses infrared beamforming technology, including an infrared transmitter and an infrared receiver. When the medicine reaches the collection window, the infrared beam is blocked, and the system detects the arrival signal (response time < 0.1 seconds), triggering the collection window to open and recording the time the medicine was removed.

[0126] The operation terminal serves as the system's human-machine interface and includes a touchscreen display, an authentication module, and status indicators. The touchscreen is a 10.1-inch capacitive screen (1280×800 resolution) that displays drug information, the user interface, and temperature data. The authentication module includes a fingerprint reader and an IC card reader for dual authentication. The status indicator uses an RGB LED, which displays the system's operating status based on different colors.

[0127] The network communication module includes a pharmacy management system interface, a wireless communication unit, and a data encryption module. The pharmacy management system interface supports both SOAP and REST protocols and is compatible with mainstream pharmacy management software. The wireless communication unit supports Wi-Fi and 4G / 5G mobile networks. The data encryption module uses the AES-256 algorithm to ensure data transmission security.

[0128] The present invention is based on the following principles:

[0129] 1. Principle of mechanical automation: Use mechanical force to replace manual operation to achieve automatic delivery of medicines

[0130] 2. Temperature control principle: Based on the principles of thermodynamics and heat transfer, a closed constant temperature transmission system is designed.

[0131] 3. Modular design principle: select appropriate push mechanism and temperature control scheme according to different drug characteristics and temperature requirements

[0132] 4. Closed circulation system principle: The entire process from drug storage to use is closed to reduce the impact of environmental variables

[0133] 5. Principle of human-computer interaction optimization: simplify the operation process, reduce the difficulty of operation and error rate

[0134] 6. Principle of drug quality assurance: Based on the drug storage temperature requirements (such as some drugs need to be kept at 4°C), design a full temperature control system

[0135] This invention adopts the idea of the push mechanism of vending machines, but is specially designed for the particularity of clinical trial drugs, especially in the constant temperature control system, to ensure that the drugs maintain the required temperature throughout the entire process from the storage cabinet to the patient's use.

[0136] advantage;

[0137] Compared with the prior art, the present invention has the following significant advantages:

[0138] 1. Constant Temperature Guarantee Throughout the Entire Process: This innovative solution addresses the challenge of temperature control during the "last mile" of drug delivery, enabling closed-loop temperature control throughout the entire drug storage and retrieval process. Especially for drugs refrigerated at 4°C, temperature deviation is controlled within ±0.5°C, ensuring the stable and reliable quality of drugs for clinical trials.

[0139] 2. Maintain a stable storage environment: The automated medication retrieval mechanism significantly reduces the number of times the medicine cabinet door needs to be opened, reducing temperature fluctuations by over 90%, and further ensuring the consistency of the medication storage environment.

[0140] 3. Contactless operation: Pharmacists do not need to directly contact drugs throughout the entire process, reducing the risk of cross-contamination by more than 95%. It is especially suitable for the management of highly sensitive drugs such as immunosuppressants.

[0141] 4. Efficient medication collection process: The automated push mechanism reduces the average medication collection time from 45 seconds to 12 seconds, which is only 1 / 4 of the traditional time, greatly improving medication collection efficiency.

[0142] 5. Improved space utilization: Through roller conveyor and modular shelf design, the space utilization of high-rise medicine cabinets is increased by 75%, and the storage density of medicines in cool warehouses is increased by 25%, achieving larger capacity of medicine management within the same area.

[0143] 6. Reduce labor intensity: Pharmacists' labor intensity is reduced by 70%. The system can automatically process multiple medication requests simultaneously, greatly reducing manual pressure and improving work efficiency.

[0144] 7. Significantly improved drug collection accuracy: Combined with an intelligent control system and precise push device, the drug collection error rate has been reduced from 0.5% to 0.02%, comprehensively improving the safety and standardization of drug use in clinical trials.

[0145] 8. Intelligent temperature and operation traceability management: The system automatically records the temperature, personnel and operation time of each medication collection process, and generates a complete electronic log, which meets the full traceability requirements of GCP pharmacies.

[0146] 9. Energy-saving and environmentally friendly design: The use of zoned temperature control and high-efficiency thermal insulation materials reduces the overall energy consumption of the system by more than 30% compared with traditional solutions, saving approximately 5,000 kWh of electricity annually, which is green and energy-saving.

[0147] 10. Modular structure design: Each component of the system adopts standardized interfaces and modular design, which facilitates rapid maintenance and upgrades. The failure of a single module does not affect the overall operation, ensuring the stability and reliability of the system.

[0148] The manufacturing process of the "spring-linked push-type intelligent automatic drug dispensing device for clinical trials" of the present invention includes two parts: hardware assembly and software configuration.

[0149] Hardware Assembly

[0150] 1. Production of central control unit:

[0151] oInstall the processor module, configure the ARM processor (1.5GHz) and 4GB memory

[0152] oConnect database module (128GB solid state drive)

[0153] oInstall the interface module and set up the RS485, Ethernet and USB interfaces

[0154] oConnect the power management module and UPS uninterruptible power supply (1500VA capacity)

[0155] oInstall a fan cooling system to ensure a stable operating temperature for the system

[0156] 2. Assembly of the medicine rack push device:

[0157] oSpring push mechanism:

[0158] Select a 304 stainless steel compression spring with a suitable elastic coefficient (2-5N / mm) according to the weight of the drug

[0159] Install the medicine tray to ensure a smooth surface to reduce friction

[0160] Connect the electromagnetic release lock (24V) and the control circuit

[0161] Install micro limit switches and adjust positions to ensure accurate detection

[0162] Assemble the reset mechanism for spring compression and locking

[0163] oElectric push rod mechanism:

[0164] Install the brushless DC motor (24V / 35W) and connect the reducer

[0165] Connect the precision push rod to adjust the stroke range (100-200mm)

[0166] Install travel switches (Hall sensors) at the starting and end positions

[0167] Fixed guide groove to ensure accurate push rod movement trajectory

[0168] Connect control circuit and signal feedback line

[0169] oRoller conveyor mechanism:

[0170] Install the micro motor (12V stepper motor) and drive circuit

[0171] Connect the rubber conveyor belt (60mm width) and adjust the tension

[0172] Install guide wheels to ensure smooth running of the conveyor belt

[0173] Connect the control signal line and power line

[0174] 3. Assembly of constant temperature transmission system:

[0175] o Make a heat-insulated closed transmission channel, combining the inner layer of stainless steel, insulation material and outer layer of ABS to form a sandwich structure

[0176] oInstall the temperature control unit, including the temperature sensor, cooling module and heating element

[0177] o Place temperature sensors (PT100 platinum resistance) at key points in the channel, with a spacing of no more than 50 cm

[0178] oInstall air flow control devices, including micro fans and air filters

[0179] oConnect temperature control circuit and signal cable to achieve closed-loop control

[0180] 4. Assembly of drug collection system:

[0181] oInstall constant temperature collection windows, including automatic opening and closing doors and independent temperature control systems

[0182] o Establish multiple temperature zones, set up 2-8℃ refrigerated temperature zone and 15-25℃ normal temperature zone

[0183] oInstallation sensor, including infrared transmitter and receiver

[0184] oConnect the temperature control circuit and switch control circuit

[0185] oInstall thermal insulation materials to ensure independent temperature control in each temperature zone

[0186] 5. Assembly of the operating terminal:

[0187] o Install a 10.1-inch touchscreen display

[0188] oConnect authentication modules, including fingerprint readers and IC card readers

[0189] oInstallation status indicator (RGB LED)

[0190] oConnect internal control circuits and communication cables

[0191] 6. Installation of networking communication module:

[0192] o Install the pharmacy management system interface and configure the communication protocol o Connect the wireless communication unit (Wi-Fi and 4G / 5G module)

[0193] oInstall the data encryption module and configure secure communication parameters oConnect the antenna and signal cable

[0194] Software Configuration

[0195] 1. System operating system installation:

[0196] oInstall a customized Linux operating system oConfigure system startup parameters and drivers oSet system security policies and access rights

[0197] 2. Database system configuration:

[0198] o Install the SQL database engine o Create drug information tables, location information tables, temperature parameter tables, and operation log tables o Configure data backup strategies and recovery mechanisms

[0199] 3. Control software installation:

[0200] o Install drug management control software o Configure control parameters of each subsystem o Set temperature control PID algorithm parameters o Configure push mechanism operating parameters (speed, acceleration, stroke)

[0201] 4. Communication interface configuration:

[0202] o Set up interface parameters with the pharmacy management system o Configure network communication protocols and encryption parameters o Establish communication links between subsystems o Set up data transmission formats and protocols

[0203] 5. User interface configuration:

[0204] o Install the touch screen operation interface software o Design the functional interface for drug query, drug collection, management, etc. o Configure the status display and alarm prompt interface o Set user permissions and authentication parameters

[0205] System debugging

[0206] 1. Hardware debugging:

[0207] o Check whether all electrical connections are secure o Test whether the action of each actuator is correct o Calibrate the temperature sensor (compared with the standard thermometer, the error is <±0.2℃)

[0208] oTest the force and stroke of the push mechanism (under no-load and loaded conditions)

[0209] 2. Software debugging:

[0210] o Check if all software modules are running properly o Test database read and write functions

[0211] o Verify the accuracy of data transmission on the communication interface o Adjust the control algorithm parameters to optimize the system response

[0212] 3. System joint debugging:

[0213] o Test the integrity of the drug delivery process o Verify temperature control accuracy and stability o Test the responsiveness of simultaneous access to multiple drugs o Verify the alarm and handling mechanism under abnormal conditions

[0214] 4. Performance testing:

[0215] o Continuous operation test (more than 24 hours) to verify system stability o Large-volume drug withdrawal test to verify system processing capacity o Power failure recovery test to verify UPS function and data security o Temperature fluctuation test to verify constant temperature control capability

[0216] The use process of the "spring-linked push-type intelligent automatic drug dispensing device for clinical trials" of the present invention is described in detail as follows: 1. System initialization

[0217] Startup preparation:

[0218] oCheck whether the power connection is normal

[0219] oTurn on the system main power switch

[0220] oThe system automatically performs a hardware self-test (approximately 30 seconds)

[0221] oEach temperature control zone automatically adjusts to the preset temperature

[0222] Administrator login:

[0223] o The administrator enters the account and password on the operation terminal o Authentication is performed using an IC card or fingerprint o Check the system status report to confirm that there are no abnormalities o Check the temperature records to confirm that the temperature in each temperature zone has reached the set value 2. Drug storage

[0224] Information entry:

[0225] o Pharmacists select the "Drug Storage" function on the operation terminal. o Enter drug information: name, batch number, specifications, quantity, temperature requirements, etc. o The system automatically assigns the most suitable storage location and displays the location number. o The display prompts you to specify the medicine cabinet and medicine grid location.

[0226] Physical storage:

[0227] o The pharmacist opens the designated medicine cabinet. o Place the medicine in the medicine compartment assigned by the system. o For the spring push mechanism, ensure that the medicine is placed on the medicine tray. o For the electric push rod mechanism, place the medicine at the front end of the push rod. o For the roller conveyor mechanism, place the medicine on the conveyor belt.

[0228] Confirm warehousing:

[0229] o Close the medicine cabinet door o Confirm the storage is complete at the operation terminal o The system records the storage time, operator and temperature data o Update the inventory database

[0230] 3. Medication Collection

[0231] Application for medication collection:

[0232] o Pharmacist logs into the system through dual identity authentication o Select the "Get Medicine" function and enter the medicine name / code o The system displays the medicine details and inventory location o Pharmacist confirms the quantity and purpose of the medicine

[0233] System Preparation:

[0234] o The system verifies the pharmacist's authority and drug access rights. o Pre-adjust the temperature of the constant temperature transmission system and the collection area according to the drug temperature requirements. o The touch screen displays the temperature adjustment progress and real-time temperature value. o When the temperature reaches the required range (deviation <±0.3℃), it displays "Ready". Drug push:

[0235] oThe pharmacist confirms the medication collection instruction and clicks "Start Collection"

[0236] oThe system activates the push device of the corresponding medicine compartment:

[0237] Light medicines: Activate the spring push mechanism, release the electromagnetic lock, and the spring pushes the medicine. Medium and heavy medicines: Start the electric push rod mechanism, and the motor drives the push rod to push the medicine. High medicines: Start the roller conveyor mechanism, and the motor drives the conveyor belt to transport the medicine. The medicine enters the constant temperature transmission system and is transported under constant temperature conditions. The touch screen displays the medicine delivery progress and real-time temperature curve.

[0238] Medicine collection:

[0239] o The medicine arrives at the collection window in the corresponding temperature zone o The arrival sensor detects the arrival of the medicine and triggers the collection window to open o The system emits an audible and visual prompt, and the screen displays the medicine information o The pharmacist takes the medicine from the collection window and verifies the medicine information o The collection window automatically closes after the medicine is taken away (no operation or manual confirmation for 3 seconds) Record update:

[0240] o The system automatically updates inventory data o Records medication collection time, operator, and temperature data throughout the process o Generates electronic medication collection records and synchronizes them to the pharmacy management system o Displays confirmation of operation completion on the screen

[0241] 4. Temperature monitoring and management

[0242] Real-time monitoring:

[0243] oThe system continuously monitors the temperature of each area (sampling frequency 10 seconds / time)

[0244] o Touch screen can display temperature history curve and real-time data o Administrators can set temperature alarm thresholds and response strategies o All temperature data are automatically recorded and stored for a long time (≥5 years)

[0245] Exception handling:

[0246] o When the temperature deviates from the set range, the system will issue a graded alarm based on the degree of deviation: Slight deviation (within ±0.5℃): the system will automatically adjust, with a yellow prompt; Moderate deviation (±0.5-1.0℃): increase the adjustment intensity, with an audible prompt; Severe deviation (>±1.0℃): a red alarm will be issued to notify the administrator; o The system will attempt to automatically restore the temperature to normal and will record any abnormalities; o If the abnormality persists, the affected area can be isolated and the drug retrieval task can be transferred; 5. System Maintenance

[0247] Daily maintenance:

[0248] o Clean the collection window and operation interface daily o Check the sealing status of each medicine cabinet door o Confirm that the push device is working properly o Check the UPS power status and power

[0249] Regular maintenance:

[0250] o Clean the transmission channel weekly to ensure there is no drug residue o Test each push device monthly and perform no-load tests o Calibrate the temperature sensor quarterly o Update software and back up data every six months

[0251] Professional maintenance:

[0252] o Annual comprehensive inspection by professional technicians o Replacement of wearing parts (springs, sensors, etc.)

[0253] o System software upgrade and database optimization o Refrigeration system inspection and maintenance

[0254] 6. Troubleshooting

[0255] Push failure handling:

[0256] oSystem automatically retries (up to 3 times)

[0257] o After continuous failure, the fault location and possible cause are displayed. o Provide manual medication dispensing option to guide pharmacists. o Record fault information and notify maintenance personnel.

[0258] Temperature control troubleshooting:

[0259] oStart the backup temperature control module

[0260] o Transfer medicines to affected areas if necessary

[0261] oSend out a fault alarm to notify maintenance personnel

[0262] oRecord fault time and temperature data for subsequent analysis

[0263] System crash handling:

[0264] oUPS ensures continuous operation of core functions

[0265] oThe system automatically saves key data

[0266] oStart the automatic recovery process

[0267] o Provide manual emergency operation plan in serious cases

[0268] The above are only preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Therefore, any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An automatic drug dispensing device for a clinical trial pharmacy, characterized by: The automatic medicine dispensing device comprises a constant temperature cabinet (1), a medicine conveyor belt (2) and a medicine pushing component; The medicine conveyor belt (2) extends from the inner side to the outer side of the constant temperature cabinet (1), and the medicine pushing component is arranged inside the constant temperature cabinet (1); The medicine pushing component can push the medicine placed in the constant temperature cabinet (1) onto the medicine conveyor belt (2), and then the medicine conveyor belt (2) can convey the medicine to the outside.

2. The automatic drug dispensing device for a clinical trial pharmacy according to claim 1, characterized in that: The medicine pushing component comprises a medicine rack (3) and a medicine slide plate (4); The medicine rack (3) is used for placing medicines; The medicine slide plate (4) is arranged on the lower side of the medicine rack (3), and the front end of the medicine slide plate (4) extends to the medicine conveyor belt (2); A medicine push plate (5) is provided on the medicine slide plate (4), and the medicine push plate (5) can push the medicine in the medicine rack (3) onto the medicine conveyor belt (2) via the medicine slide plate (4).

3. The automatic drug dispensing device for a clinical trial pharmacy according to claim 2, characterized in that: The height of the medicine pushing plate (5) is higher than that of the medicine sliding plate (4), and the height of the medicine pushing plate (5) is lower than that of the side of the medicine box, so as to push the side of the medicine box and push the medicine box onto the medicine conveyor belt (2).

4. The automatic drug dispensing device for a clinical trial pharmacy according to claim 2, characterized in that: Push plate limiting plates (6) are provided on both sides of the medicine slide plate (4). The height of the push plate limiting plates (6) is higher than the height of the medicine push plate (5) and is used to limit the sliding direction of the medicine push plate (5).

5. The automatic drug dispensing device for a clinical trial pharmacy according to claim 2, characterized in that: The height of the medicine slide (4) is higher than that of the medicine conveyor belt (2), and an inclined guide plate (7) is provided between the medicine slide (4) and the medicine conveyor belt (2) for guiding the medicine boxes on the medicine slide (4) to the medicine conveyor belt (2).

6. The automatic drug dispensing device for a clinical trial pharmacy according to claim 2, characterized in that: A push plate driving member (8) is provided on one side of the medicine slide plate (4), and the push plate driving member (8) is arranged away from the medicine conveyor belt (2).

7. The automatic drug dispensing device for a clinical trial pharmacy according to claim 1, characterized in that: A medicine discharging platform (9) for placing medicine boxes is provided on one side of the constant temperature cabinet (1), and the medicine conveyor belt (2) extends to the medicine discharging platform (9).

8. The automatic drug dispensing device for a clinical trial pharmacy according to claim 1, characterized in that: A conveyor belt through hole (10) is provided on the side of the constant temperature cabinet (1) for passing a medicine conveyor belt (2).

9. The automatic drug dispensing device for a clinical trial pharmacy according to claim 1, characterized in that: The medicine pushing components are arranged in multiple groups along the length direction of the medicine conveyor belt (2).

10. A drug management system for a clinical trial pharmacy, characterized by: The medicine management system adopts the automatic medicine dispensing device according to any one of claims 1 to 9.

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