Reaction kettle for biological pharmacy

Abstract

The utility model relates to the technical field of reaction kettles, and discloses a biopharmaceutical reaction kettle which comprises a reaction kettle body, lug seats are fixed on the outer side of the reaction kettle body, a blanking pipe is mounted at the bottom of the reaction kettle body, and supporting legs are fixed at the bottom of the reaction kettle body. Through the arrangement of the auxiliary cleaning mechanism, one end of the rotating frame pokes the moving rod to move back and forth, the anti-falling sliding plate drives the cast iron frame and the rubber column to move back and forth, the rubber column impacts the outer side of the discharging pipe back and forth, adhesion materials can be stripped in an auxiliary mode, and the situation that the purity of the next batch is affected due to residue degradation is reduced; by arranging the stabilizing mechanism, fixing between the mounting sleeve and the corresponding supporting leg is conveniently completed, at the moment, the corresponding faces of the outer shell and the metal support are attached, fixing between the outer shell and the metal support can be completed through bolts, the outer shell is easy to position and easy and convenient to assemble in the assembling process, and the assembling stability of the outer shell is improved.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, and in particular to a reaction vessel for biopharmaceutical applications. Background Technology

[0002] Biopharmaceutical raw materials are primarily natural biological materials, including microorganisms, human organisms, animals, plants, and marine organisms. Furthermore, with the development of biotechnology, purposefully artificially produced biological raw materials are gradually becoming the main source of biopharmaceutical raw materials. Examples include animal raw materials obtained through immunoassay, and microorganisms or other cell raw materials obtained by altering their gene structure. Biopharmaceutical reaction vessels are devices used in biopharmaceutical processes to conduct chemical reactions, mainly for synthesizing drug raw materials and formulations.

[0003] For example, Chinese utility model patent application number 202020571986.9 discloses a biopharmaceutical reaction vessel, belonging to the field of pharmaceutical equipment. The biopharmaceutical reaction vessel includes a vessel body, serving as a container for biopharmaceuticals. The upper part of the vessel body is open, and a connecting flange is provided at the edge of the open end. An upper end cap is connected to the vessel body through this connecting flange, and screws are installed at the connecting flange. An inlet, a shaft through-hole, and an oxygen supply hole are drilled on the top of the upper end cap. An inlet pipe is installed at the inlet, and an oxygen supply pipe is installed at the oxygen supply hole. Hydrogen peroxide is introduced into the vessel body through the oxygen supply pipe, used for disinfection and sterilization before the reaction and for continuous oxygen supply during the reaction. This allows for pre-treatment of the vessel body's interior to prevent contamination of the bioreaction environment by bacteria, ensuring the purity of the biopharmaceutical product. Furthermore, it provides sufficient oxygen to the sealed vessel body during the reaction, ensuring the normal progress of the bioreaction.

[0004] However, during the use of the aforementioned reaction vessels, some biopharmaceutical materials are highly viscous and easily adhere to the inner wall of the vessel's feed pipes. The degradation of these residues affects the purity of subsequent batches. Therefore, those skilled in the art have provided a biopharmaceutical reaction vessel to address the problems mentioned in the background section. Utility Model Content

[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing a biopharmaceutical reaction vessel.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a biopharmaceutical reaction vessel, comprising a reaction vessel body, an ear seat fixed to the outside of the reaction vessel body, a feed pipe installed at the bottom of the reaction vessel body, a support leg fixed to the bottom of the reaction vessel body, a metal bracket fixed to the bottom of the reaction vessel body, an auxiliary cleaning mechanism fixed to the bottom of the metal bracket by bolts, and a stabilizing mechanism provided on the outside of the auxiliary cleaning mechanism;

[0007] The auxiliary cleaning mechanism includes an outer shell, a fixed frame is fixed to the inner bottom wall of the outer shell, a servo motor is fixed to one side inner wall of the outer shell, a rotating wheel is fixed to one end of the output shaft of the servo motor, a metal column is installed on the outer side of the rotating wheel, a rotating frame is rotatably connected to the outer side of the fixed frame through a rotating shaft, a limit sleeve is fixed to the outer side of the fixed frame, and an anti-detachment sliding plate is slidably connected inside the limit sleeve.

[0008] As a further description of the above technical solution:

[0009] A cast iron frame is fixed to the outside of the anti-detachment sliding plate, a rubber column is fixed to the outside of the cast iron frame, and a moving rod is fixed to the outside of the anti-detachment sliding plate.

[0010] By adopting the above technical solution, when the rotating wheel rotates, it drives the rotating frame to rotate through the metal column, so that one end of the rotating frame drives the moving rod and the anti-detachment sliding plate to move horizontally back and forth.

[0011] As a further description of the above technical solution:

[0012] One end of the rotating frame is provided with a groove, the size of which is adapted to the size of the moving rod.

[0013] By adopting the above technical solution, the rotating frame can be moved back and forth by moving the movable rod.

[0014] As a further description of the above technical solution:

[0015] The outer shell and the metal support are fixed together by bolts, and the inside of the rotating frame is provided with a through groove that matches the size of the metal column.

[0016] As a further description of the above technical solution:

[0017] The outer casing has a limiting hole inside, the size of which is adapted to the size of the rubber column.

[0018] As a further description of the above technical solution:

[0019] The stabilizing mechanism includes a mounting sleeve with a mounting groove inside. A mounting pad is fixed to the outside of one of the support legs, a positioning sleeve is fixed to the outside of the other support leg, and a positioning threaded post is fixed to the outside of the mounting pad.

[0020] As a further description of the above technical solution:

[0021] A washer is movably fitted to the outer side of the positioning threaded post, and a cast iron threaded sleeve is threadedly connected to the outer side of the positioning threaded post.

[0022] As a further description of the above technical solution:

[0023] The mounting sleeve is fixedly connected to the outer shell, and the mounting sleeve is movably fitted onto the outside of the positioning threaded post.

[0024] This utility model has the following beneficial effects:

[0025] 1. Compared with existing technologies, this biopharmaceutical reactor is equipped with an auxiliary cleaning mechanism. A servo motor drives the rotating wheel to rotate, and an eccentrically positioned metal column pushes the rotating frame to swing around the axis, which in turn drives the moving rod to make horizontal reciprocating motion. This causes the anti-detachment sliding plate to move the cast iron frame and rubber column back and forth. The rubber column hits the outside of the feed pipe back and forth, which can help peel off the adhering materials and reduce the impact of residue degradation on the purity of the next batch.

[0026] 2. Compared with the existing technology, this biopharmaceutical reactor is equipped with a stabilizing mechanism, which facilitates the fixing between the mounting sleeve and the corresponding support leg. At this time, the corresponding surfaces of the outer shell and the metal bracket are in contact, and bolts can be used to fix the outer shell and the metal bracket. This makes the outer shell easy to position during assembly, simplifies the assembly operation, and improves the assembly stability of the outer shell. Attached Figure Description

[0027] Figure 1 This is a perspective view of a biopharmaceutical reaction vessel proposed in this utility model;

[0028] Figure 2 This is a schematic diagram of an auxiliary cleaning mechanism for a biopharmaceutical reaction vessel proposed in this utility model;

[0029] Figure 3 This utility model Figure 2 Enlarged schematic diagram of region B;

[0030] Figure 4 This utility model Figure 1 A magnified diagram of region A.

[0031] Legend:

[0032] 1. Reactor body; 2. Ear seat; 3. Feed pipe; 4. Support leg; 5. Metal bracket; 6. Auxiliary cleaning mechanism; 61. Outer shell; 62. Fixing frame; 63. Servo motor; 64. Rotating wheel; 65. Metal column; 66. Rotating frame; 67. Limit sleeve; 68. Anti-detachment sliding plate; 69. Cast iron frame; 610. Rubber column; 611. Moving rod; 7. Stabilizing mechanism; 71. Mounting sleeve; 72. Mounting groove; 73. Mounting pad; 74. Positioning sleeve; 75. Positioning threaded column; 76. Gasket; 77. Cast iron threaded sleeve. Detailed Implementation

[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0034] Reference Figure 1-4 The present invention provides a biopharmaceutical reaction vessel, including a reaction vessel body 1, an ear seat 2 fixed on the outside of the reaction vessel body 1, a feed pipe 3 installed at the bottom of the reaction vessel body 1, a support leg 4 fixed at the bottom of the reaction vessel body 1, a metal bracket 5 fixed at the bottom of the reaction vessel body 1, an auxiliary cleaning mechanism 6 fixed at the bottom of the metal bracket 5 by bolts, and a stabilizing mechanism 7 provided on the outside of the auxiliary cleaning mechanism 6.

[0035] The auxiliary cleaning mechanism 6 includes a housing 61. A fixing frame 62 is fixed to the inner bottom wall of the housing 61. A servo motor 63 is fixed to one inner wall of the housing 61. A rotating wheel 64 is fixed to one end of the output shaft of the servo motor 63. A metal column 65 is mounted on the outer side of the rotating wheel 64. A rotating frame 66 is rotatably connected to the outer side of the fixing frame 62 via a rotating shaft. A limit sleeve 67 is fixed to the outer side of the fixing frame 62. An anti-detachment sliding plate 68 is slidably connected inside the limit sleeve 67. A cast iron frame 69 is fixed to the outer side of the anti-detachment sliding plate 68. A rubber column 610 is fixed to the outer side of the cast iron frame 69. A movable rod 611 is fixed. When the rotating wheel 64 rotates, it drives the rotating frame 66 to rotate through the metal column 65. This causes one end of the rotating frame 66 to drive the movable rod 611 and the anti-detachment sliding plate 68 to move horizontally back and forth. One end of the rotating frame 66 is provided with a groove whose size is adapted to the size of the movable rod 611, allowing the rotating frame 66 to move the movable rod 611 back and forth. The outer shell 61 and the metal bracket 5 are fixed together by bolts. The interior of the rotating frame 66 is provided with a through groove that is adapted to the size of the metal column 65. The interior of the outer shell 61 is provided with a limiting hole whose size is adapted to the size of the rubber column 610.

[0036] The stabilizing mechanism 7 includes a mounting sleeve 71, which has a mounting groove 72 inside. A mounting pad 73 is fixed to the outside of one support leg 4, and a positioning sleeve 74 is fixed to the outside of one support leg 4. A positioning threaded post 75 is fixed to the outside of the mounting pad 73. A washer 76 is movably sleeved on the outside of the positioning threaded post 75. A cast iron threaded sleeve 77 is threadedly connected to the outside of the positioning threaded post 75. The mounting sleeve 71 is fixedly connected to the outer shell 61, and the mounting sleeve 71 is movably sleeved on the outside of the positioning threaded post 75.

[0037] Working principle: Chemical reactions and processing are carried out in the biopharmaceutical process using the reactor body 1. The processed materials are discharged through the feed pipe 3. Some biopharmaceutical materials are highly viscous and easily adhere to the inner wall of the feed pipe 3. The servo motor 63 drives the rotating wheel 64 to rotate, which pushes the rotating frame 66 to swing around the axis through the eccentrically set metal column 65. This, in turn, drives the moving rod 611 to perform horizontal reciprocating motion. One end of the rotating frame 66 moves the moving rod 611 back and forth, and the anti-detachment sliding plate 68 drives the cast iron frame 69 and the rubber column 610 to move back and forth. The rubber column 610 hits the outside of the feed pipe 3 back and forth, which can help peel off the adhered materials and reduce the impact of residue degradation on the purity of the next batch. By setting... With a stabilizing mechanism 7, when installing the outer shell 61, the mounting sleeve 71 on the outside of the outer shell 61 is first movably fitted onto the outside of the positioning threaded post 75, and one end of the mounting sleeve 71 is movably inserted into the positioning sleeve 74. The corresponding surface of the mounting sleeve 71 is in contact with the outside of the mounting pad 73. Then, the washer 76 is movably fitted onto the outside of the positioning threaded post 75, and the cast iron threaded sleeve 77 is threadedly connected to the positioning threaded post 75, which conveniently completes the fixing between the mounting sleeve 71 and the corresponding support leg 4. At this time, the corresponding surfaces of the outer shell 61 and the metal bracket 5 are in contact, and bolts can be used to fix the outer shell 61 and the metal bracket 5, making the outer shell 61 easy to position during assembly, simplifying the assembly operation, and improving the assembly stability of the outer shell 61.

[0038] Finally, it should be noted that the above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A biopharmaceutical reaction vessel comprising a reaction vessel body (1), characterized in that: The outer side of the reactor body (1) is fixed with an ear seat (2), the bottom of the reactor body (1) is installed with a feed pipe (3), the bottom of the reactor body (1) is fixed with a support leg (4), the bottom of the reactor body (1) is fixed with a metal bracket (5), the bottom of the metal bracket (5) is fixed with an auxiliary cleaning mechanism (6) by bolts, and the outer side of the auxiliary cleaning mechanism (6) is provided with a stabilizing mechanism (7). The auxiliary cleaning mechanism (6) includes an outer shell (61), a fixing frame (62) is fixed to the inner bottom wall of the outer shell (61), a servo motor (63) is fixed to one side inner wall of the outer shell (61), a rotating wheel (64) is fixed to one end of the output shaft of the servo motor (63), a metal column (65) is installed on the outer side of the rotating wheel (64), a rotating frame (66) is rotatably connected to the outer side of the fixing frame (62) through a rotating shaft, a limit sleeve (67) is fixed to the outer side of the fixing frame (62), and an anti-detachment sliding plate (68) is slidably connected inside the limit sleeve (67).

2. The biopharmaceutical reaction vessel of claim 1, wherein: A cast iron frame (69) is fixed to the outside of the anti-detachment sliding plate (68), a rubber column (610) is fixed to the outside of the cast iron frame (69), and a moving rod (611) is fixed to the outside of the anti-detachment sliding plate (68).

3. The biopharmaceutical reaction vessel of claim 2, wherein: One end of the rotating frame (66) is provided with a groove, the size of which is adapted to the size of the moving rod (611).

4. The biopharmaceutical reaction vessel of claim 1, wherein: The outer shell (61) and the metal bracket (5) are fixed together by bolts, and the rotating frame (66) has a through groove inside that matches the size of the metal column (65).

5. The biopharmaceutical reaction vessel of claim 1, wherein: The outer shell (61) has a limiting hole inside, the size of which is adapted to the size of the rubber column (610).

6. The biopharmaceutical reaction vessel of claim 1, wherein: The stabilizing mechanism (7) includes a mounting sleeve (71), the mounting sleeve (71) has a mounting groove (72) inside, a mounting pad (73) is fixed to the outside of one of the support legs (4), a positioning sleeve (74) is fixed to the outside of one of the support legs (4), and a positioning threaded post (75) is fixed to the outside of the mounting pad (73).

7. The biopharmaceutical reaction vessel of claim 6, wherein: A gasket (76) is movably sleeved on the outer side of the positioning threaded post (75), and a cast iron threaded sleeve (77) is threadedly connected to the outer side of the positioning threaded post (75).

8. The biopharmaceutical reaction vessel of claim 7, wherein: The mounting sleeve (71) and the outer shell (61) are fixedly connected, and the mounting sleeve (71) is movably sleeved on the outside of the positioning threaded post (75).

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