Miniature implantable chip for regulating and controlling cells to secrete vesicles as well as preparation method and application of miniature implantable chip

CN120661842APending Publication Date: 2025-09-19NANJING UNIV OF POSTS & TELECOMM
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Patent Information

Application Number
CN202510899080.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-01
Publication Date
2025-09-19

AI Technical Summary

Technical Problem

In existing technologies, the preparation efficiency of extracellular vesicles (EVs) is low, electrical stimulation is highly invasive, and light regulation is insufficiently targeted, resulting in poor immunotherapy effects for bladder cancer.

Method used

A micro-implantable chip is designed, which uses wireless power supply equipment and wireless optical transmission equipment to stimulate DC cells in hydrogel through radio frequency fields and blue light to promote the release of extracellular vesicles. The wireless optical transmission equipment consists of a 3D spiral coil and a micro-printed circuit board, which is encapsulated in medical-grade silicone. Combined with the photoelectric conversion performance of WS2 quantum dots, precise electrical stimulation is achieved.

Benefits of technology

It significantly enhances the exocytosis activity of DC cells, induces T cell proliferation, activates specific anti-tumor responses, improves tumor suppression effects, has good biocompatibility and long-term implantation safety, and has synergistic immunotherapy potential.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention belongs to the field of implantable microchips, and particularly relates to a miniature implantable chip for regulating cells to secrete vesicles as well as a preparation method and application of the miniature implantable chip. The miniature implantable chip comprises an implantable device and a wireless power supply device. The implantable device comprises wireless light transmission equipment and hydrogel wrapping the wireless light transmission equipment; the hydrogel comprises dendritic cells and tungsten disulfide quantum dots. The wireless light transmission device is composed of a 3D spiral coil and a miniature printed circuit board. The 3D spiral coil and the micro printed circuit board are packaged in medical grade silica gel; the miniature printed circuit board comprises an integrated radio frequency rectifier and a blue LED chip.
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