Traditional Chinese medicine eye pad compound essential oil for treating xerophthalmia and preparation method thereof

Abstract

The invention discloses traditional Chinese medicine eye pad compound essential oil for treating xerophthalmia and a preparation method of the traditional Chinese medicine eye pad compound essential oil. The essential oil is prepared from 10-15 parts of butterflybush flower essential oil, 10-15 parts of chrysanthemum essential oil, 10-15 parts of radix salviae miltiorrhizae essential oil, 3-5 parts of fructus lycii essential oil, 3-5 parts of rose essential oil, 3-5 parts of honeysuckle essential oil, 1-3 parts of peppermint oil, 1-3 parts of jojoba oil, 1-3 parts of sweet almond oil, 10-19 parts of penetration enhancer and 600 parts of purified water. The traditional Chinese medicine composition is based on traditional Chinese medicine components and is combined with the modern medicine theory, tests prove that the tear secretion amount can be increased, the pathological change of conjunctival tissues can be well improved, and the xerophthalmia can be prevented and treated.

Description

Technical Field

[0001] The invention relates to the technical field of eye patches, in particular to a traditional Chinese medicine eye patch with composite essential oil for treating dry eyes and a preparation method thereof. Background Art

[0002] Dry eye is a disease caused by changes in the quantity and quality of tears or in the fluid dynamics, which leads to a decrease in the stability of the tear film, resulting in symptoms such as dry eyes, tearing, a foreign body sensation, blurred vision, and lower vision fatigue. Common clinical symptoms include dry eyes, a foreign body sensation, burning, itching, photophobia, red eyes, blurred vision, fluctuating vision, and visual fatigue. There are many ways to treat dry eyes, which are mainly divided into medication, physical therapy, and traditional Chinese medicine. Medication uses artificial tears such as sodium hyaluronate and polyvinyl alcohol, which need to be used frequently (4-6 times a day). Long-term use of products containing preservatives may damage the ocular surface and cannot solve the underlying causes such as inflammation. Physical therapy uses hot compresses and meibomian gland massage, which are suitable for evaporative dry eyes. They have limited effects on severe meibomian gland blockage and may damage the eyelids if not performed properly. Traditional Chinese medicine treatments, such as taking wolfberry and chrysanthemum tea internally, can improve systemic symptoms with minimal side effects, but the procedure is cumbersome and not suitable for the fast-paced urban life. Chinese herbal essential oil eye patches combine traditional Chinese medicine treatment with modern products, retaining the Chinese medicine's ability to treat both the symptoms and the root cause while also solving the problems of cumbersome decoction and difficulty in preservation, making them suitable for people with fast paces.

[0003] Patent CN108686129A discloses a Chinese herbal medicine Ganshenju essential oil eye patch for treating dry eye syndrome. The eye patch is made by extracting multiple Chinese herbal components into essential oils and combining them with a hydrophilic poultice. Experiments have shown that it has the function of promoting tear secretion in rats and is suitable for treating dry eye syndrome in humans. Because human skin has a natural barrier function, unlike Chinese medicine that can quickly reach the human body when taken orally, the eye patch composed only of the essential oil itself has a slow effect on the eyes and a poor therapeutic effect. The Chinese herbal essential oil components need to be further optimized. Summary of the Invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a traditional Chinese medicine eye patch with composite essential oil for treating dry eye and a preparation method thereof, so as to solve the problem that the essential oil eye patch in the prior art has slow skin action and poor therapeutic effect.

[0005] The objective of the present invention is achieved through the following technical scheme: a traditional Chinese medicine eye patch composite essential oil for treating dry eye, comprising the following components, measured by mass, 10-15 parts of buddlejac essential oil, 10-15 parts of chrysanthemum essential oil, 10-15 parts of salvia miltiorrhiza essential oil, 3-5 parts of wolfberry essential oil, 3-5 parts of rose essential oil, 3-5 parts of honeysuckle essential oil, 1-3 parts of peppermint oil, 1-3 parts of jojoba oil, 1-3 parts of sweet almond oil, 10-19 parts of a penetration enhancer, and 600 parts of purified water.

[0006] Preferably, the penetration enhancer comprises, by weight, 2-5 parts of linseed oil, 5-7 parts of camellia oil, 1-2 parts of borneol or natural borneol, 1-2 parts of menthol, and 1-3 parts of linseed extract.

[0007] Preferably, the composition comprises the following components in parts by mass: 12 parts of buddleja essential oil, 12 parts of chrysanthemum essential oil, 12 parts of salvia miltiorrhiza essential oil, 4 parts of wolfberry essential oil, 4 parts of rose essential oil, 4 parts of honeysuckle, 2 parts of peppermint oil, 2 parts of jojoba oil, 2 parts of sweet almond oil), 18 parts of linseed oil, 6 parts of camellia seed oil, 1.5 parts of borneol or natural borneol, 1.5 parts of menthol, 2 parts of linseed extract, and 600 parts of purified water.

[0008] A method for preparing a traditional Chinese medicine eye patch containing compound essential oil for treating dry eyes comprises the following steps: S1. Weigh Buddleja essential oil, chrysanthemum essential oil, salvia miltiorrhiza essential oil, wolfberry essential oil, rose essential oil, honeysuckle essential oil, peppermint oil, jojoba oil, sweet almond oil in parts by mass and dissolve in a container, stir to make a compound essential oil; S2. Weigh flaxseed oil, camellia seed oil, menthol, borneol or natural borneol, flaxseed extract in parts by mass and stir to form a uniform liquid to form a penetration enhancer; S3. Add 5-10% water to the preparation tank, start stirring, add the penetration enhancer and compound essential oil in sequence, add the remaining amount of water according to the planned amount, emulsify and stir for 30 minutes to prepare the compound essential oil.

[0009] Preferably, the Buddleja buddleja essential oil, chrysanthemum essential oil, and salvia miltiorrhiza essential oil are prepared according to the following method: weigh the prescription amount of Chinese medicinal materials, put them into a volatile oil extraction tank, add 10 times the amount of water and soak for 12-18 hours, then heat to 100°C, reflux extraction for 3 hours, stop heating, and collect the volatile oil of the Chinese medicinal materials.

[0010] The present invention has the following advantages: 1. The present invention is based on traditional Chinese medicine components and combines modern medical theory to produce a traditional Chinese medicine eye patch with compound essential oil that has therapeutic effect on dry eye; 2. The core pathogenesis of dry eye (called "white astringency syndrome" in traditional Chinese medicine) is yin deficiency and dry heat, liver blood deficiency, and blood stasis in the eye vessels. Among the Chinese medicinal components, Buddleja buddhistata can clear away heat and nourish the liver, improve eyesight and remove cataracts, and has the function of nourishing the liver and blood. It is suitable for both deficiency and excess eye diseases. Chrysanthemum can dispel wind and heat, clear the liver and purge fire, calm the liver and suppress yang, relieve liver fire and red eyes, clear away heat and detoxify. Salvia miltiorrhiza can promote blood circulation and remove blood stasis, promote menstruation and relieve pain, clear the heart and relieve vexation, cool blood and eliminate carbuncle. Lycium barbarum can nourish the liver and kidney, improve essence and improve eyesight. Rose can soothe the liver. It can relieve depression, harmonize blood and remove blood stasis, and alleviate liver depression and qi stagnation; honeysuckle can dispel wind and heat, fight inflammation and relieve itching; peppermint oil can dispel wind-heat and refresh the mind; jojoba oil nourishes yin and moisturizes dryness, shrinks and moisturizes; sweet almond oil has antioxidant and can repair the ocular surface; Buddleja bud, chrysanthemum, and wolfberry in this formula nourish the liver and kidneys, and promote the upward flow of body fluids; salvia miltiorrhiza and rose promote the circulation of qi and blood, remove blood stasis and promote new blood; honeysuckle and peppermint dispel wind and heat, and expel pathogens; jojoba oil and sweet almond oil nourish yin and moisturize dryness, and strengthen the soil and promote the production of body fluids; 3. This formula takes "clearing heat and nourishing yin as the main approach, and promoting blood circulation and soothing the liver as the auxiliary approach" as the treatment principle, taking into account both local symptom relief and systemic organ regulation, which is more in line with the complex pathogenesis of dry eye; 4. Buddleja buddhistata is the core drug, which can clear liver heat and nourish liver yin, in line with the essence of "nourishing yin and clearing heat"; chrysanthemum has strong liver-clearing effect, but weak yin-nourishing effect, and is combined with wolfberry to prevent its dryness; wolfberry replenishes the yin of the liver and kidneys, balancing the heat-clearing effect of chrysanthemum; the three drugs work together to regulate the insufficient body fluid production from the root according to the theory that "the liver opens the orifices to the eyes" and "the kidneys control body fluids"; salvia miltiorrhiza is mild and slightly cold in nature, and rose has a mild liver-clearing effect without drying out, preventing yin-nourishing drugs from being greasy. The combination of the two promotes "Qi circulation leads to blood circulation" and solves the problems caused by Qi and blood stasis. Tear distribution disorder; Amaranthus seeds have strong heat-clearing properties but are cold in nature. Long-term use can easily damage the spleen and stomach, so the dosage should be reduced and it needs to be harmonized with licorice. At the same time, Amaranthus seeds have a mydriatic effect and are contraindicated in patients with glaucoma. Long-term high-dose licorice may cause water and sodium retention; Inula flower is used to lower qi and resolve phlegm, and to dredge the meridians, which is inconsistent with the treatment principle; adding peppermint oil, a guiding drug, can dispel wind and heat, guide the drug upward to the head, and achieve a good targeted treatment effect; applying modern medical theory and selecting a variety of suitable penetration enhancers to shorten the time it takes for the drug to penetrate the skin and achieve the best therapeutic effect; 5. The compound essential oil of the Chinese medicine eye patch of the present invention has been verified by the Schirmer test to be able to increase tear secretion, play a good improvement role in the pathological changes of conjunctival tissue, and has a very good therapeutic effect on dry eye. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Figure 1 This is a diagram of the conjunctival tissue morphology of the dry eye model of the blank group rats of the present invention; Figure 2 This is a diagram of the conjunctival tissue morphology of the dry eye model rat model group of the present invention; Figure 3 This is a diagram of the conjunctival tissue morphology of a dry eye model rat in the formula essential oil group of the present invention. DETAILED DESCRIPTION

[0012] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0013] A traditional Chinese medicine eye patch with compound essential oil for treating dry eyes is prepared according to the following method, comprising the following steps: S1. Weigh 40 mesh filter bag fried Buddleja, chrysanthemum, Danshen prescription amount of Chinese herbal medicines, into the volatile oil extraction tank, add 10 times the amount of water after 12-18 hours, then heated to 100 ° C, reflux extraction for 3 hours, stop heating, collect Chinese volatile oil; S2. According to the mass ratio, 10-15 parts of Buddleja essential oil, 10-15 parts of chrysanthemum essential oil, 10-15 parts of salvia miltiorrhiza essential oil, 3-5 parts of wolfberry essential oil, 3-5 parts of rose essential oil, 3-5 parts of honeysuckle essential oil, 1-3 parts of peppermint oil, 1-3 parts of jojoba oil, 1-3 parts of sweet almond oil were added to the container and dissolved and stirred to prepare a compound essential oil, wherein wolfberry essential oil, rose essential oil, honeysuckle essential oil, peppermint oil, jojoba oil, sweet almond oil are commercially available; S3 weighed in parts by mass 2-5 parts of linseed oil, 5-7 parts of camellia oil, 1-2 parts of borneol or natural borneol, 1-2 parts of menthol, 1-3 parts of flaxseed extract, stirred and dispersed to form a uniform liquid to form a penetration enhancer; S4. Add 5-10% water to the preparation tank, start stirring, add the penetration enhancer and compound essential oil in sequence, add the remaining amount of water according to the planned amount, emulsify and stir for 30 minutes to prepare the compound essential oil.

[0014] Example 1 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is prepared according to the above method. The composite essential oil comprises 15g of buddlejac essential oil, 15g of chrysanthemum essential oil, 10g of salvia miltiorrhiza essential oil, 3g of wolfberry essential oil, 3g of rose essential oil, 5g of honeysuckle, 3g of peppermint oil, 1g of jojoba oil, 1g of sweet almond oil, 2g of linseed oil, 7g of camellia seed oil, 1g of natural borneol, 1g of menthol, 3g of linseed extract, and 600g of purified water.

[0015] Example 2 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 14g of buddlejac essential oil, 14g of chrysanthemum essential oil, 11g of salvia miltiorrhiza essential oil, 4g of wolfberry essential oil, 4g of rose essential oil, 4g of honeysuckle, 2g of peppermint oil, 2g of jojoba oil, 2g of sweet almond oil, 3g of linseed oil, 6g of camellia seed oil, 1g of natural borneol, 2g of menthol, 2g of linseed extract, and 600g of purified water.

[0016] Example 3 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 13g of buddlejac essential oil, 13g of chrysanthemum essential oil, 12g of salvia miltiorrhiza essential oil, 5g of wolfberry essential oil, 5g of rose essential oil, 3g of honeysuckle, 1g of peppermint oil, 3g of jojoba oil, 2g of sweet almond oil, 4g of linseed oil, 5g of camellia seed oil, 2g of natural borneol, 1g of menthol, 1g of linseed extract, and 600g of purified water.

[0017] Example 4 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 12g of buddlejac essential oil, 12g of chrysanthemum essential oil, 13g of salvia miltiorrhiza essential oil, 3g of wolfberry essential oil, 3g of rose essential oil, 3g of honeysuckle, 3g of peppermint oil, 3g of jojoba oil, 3g of sweet almond oil, 5g of linseed oil, 5g of camellia seed oil, 1.5g of natural borneol, 1.5g of menthol, 3g of linseed extract, and 600g of purified water.

[0018] Example 5 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye, which differs from Example 1 in that its components include 11g of buddlejac essential oil, 11g of chrysanthemum essential oil, 14g of salvia miltiorrhiza essential oil, 4g of wolfberry essential oil, 4g of rose essential oil, 3g of honeysuckle, 2g of peppermint oil, 2g of jojoba oil, 2g of sweet almond oil, 3g of linseed oil, 6g of camellia seed oil, 1.5g of natural borneol, 1.5g of menthol, 3g of linseed extract, and 600g of purified water.

[0019] Example 6 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 10g of buddlejac essential oil, 10g of chrysanthemum essential oil, 15g of salvia miltiorrhiza essential oil, 5g of wolfberry essential oil, 5g of rose essential oil, 5g of honeysuckle, 1g of peppermint oil, 1g of jojoba oil, 1g of sweet almond oil, 2g of linseed oil, 7g of camellia seed oil, 2g of natural borneol, 2g of menthol, 1.5g of linseed extract, and 600g of purified water.

[0020] Example 7 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 15g of buddlejac essential oil, 15g of chrysanthemum essential oil, 15g of salvia miltiorrhiza essential oil, 5g of wolfberry essential oil, 5g of rose essential oil, 3g of honeysuckle, 1g of peppermint oil, 1g of jojoba oil, 1g of sweet almond oil, 1g of linseed oil, 1g of camellia seed oil, 1g of natural borneol, 1g of menthol, 1g of linseed extract, and 600g of purified water.

[0021] Example 8 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 12g of buddlejac essential oil, 12g of chrysanthemum essential oil, 12g of salvia miltiorrhiza essential oil, 4g of wolfberry essential oil, 4g of rose essential oil, 4g of honeysuckle, 2g of peppermint oil, 2g of jojoba oil, 2g of sweet almond oil, 3g of linseed oil, 6g of camellia seed oil, 1.5g of natural borneol, 1.5g of menthol, 2g of linseed extract, and 600g of purified water.

[0022] Example 9 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 10g of buddlejac essential oil, 10g of chrysanthemum essential oil, 10g of salvia miltiorrhiza essential oil, 3g of wolfberry essential oil, 3g of rose essential oil, 5g of honeysuckle, 3g of peppermint oil, 3g of jojoba oil, 3g of sweet almond oil, 5g of linseed oil, 7g of camellia seed oil, 2g of natural borneol, 2g of menthol, 3g of linseed extract, and 600g of purified water.

[0023] Example 10 A traditional Chinese medicine eye patch with composite essential oil for treating dry eye is different from Example 1 in that its components include 12g of buddlejac essential oil, 12g of chrysanthemum essential oil, 12g of salvia miltiorrhiza essential oil, 4g of wolfberry essential oil, 4g of rose essential oil, 4g of honeysuckle, 2g of peppermint oil, 2g of jojoba oil, 2g of sweet almond oil, 3g of linseed oil, 6g of camellia seed oil, 1.5g of borneol, 1.5g of menthol, 2g of linseed extract, and 600g of purified water.

[0024] Schirmer test was performed on rats: a disposable tear secretion ophthalmic test paper was used, which was cut in half longitudinally. One end of the filter paper strip was folded 5 mm and clamped in the conjunctival sac at the inner 1 / 3 of the rat's lower eyelid. The other end was hung on the outside of the lower eyelid. The eyes were gently closed. After 5 minutes, the filter paper strip was removed and the length of the wet filter paper (mm) was observed.

[0025] Experimental procedure: 72 rats, half male and half female, weighing 180-220 g, were randomly divided into 12 groups: blank group, model group, and essential oil group. Except for the blank group, each rat was given 5 μL of 2 g·L essential oil per eye. －1 Benzalkonium chloride was administered twice a day, at 9:00 a.m. and 9:00 p.m., for 15 consecutive days. Dry eye conditions were evaluated on the 10th day of the experiment. At 9:00 a.m. on the 11th day of the experiment, the essential oil group was coated around the eyes of the rats with the essential oil prepared in Examples 1-10 (0.1 ml / rat). The medication was continued for 12 consecutive days. On the 22nd day of the experiment, dry eye conditions were evaluated and tear secretion was recorded 1 hour after oral administration at 9:00 a.m. The results are as follows.

[0026] Group Number of cases left eye right eye Blank group 6 <![CDATA[10.38±1.42 ** ]]> <![CDATA[10.41±1.34 ** ]]> Model Group 6 2.13±1.22 2.06±1.46 Example 1 6 <![CDATA[7.32±0.87 ** ]]> <![CDATA[7.56±1.13 ** ]]> Example 2 6 <![CDATA[7.45±1.53 ** ]]> <![CDATA[7.39±2.66 ** ]]> Example 3 6 <![CDATA[7.75±1.23 ** ]]> <![CDATA[7.86±1.06 ** ]]> Example 4 6 <![CDATA[7.97±1.64 ** ]]> <![CDATA[7.77±2.15 ** <!-- 4 -->]]> Example 5 6 <![CDATA[7.62±1.52 ** ]]> <![CDATA[7.69±2.34 ** ]]> Example 6 6 <![CDATA[7.44±0.86 ** ]]> <![CDATA[7.53±1.45 ** ]]> Example 7 6 <![CDATA[7.11±0.83 ** ]]> <![CDATA[7.15±0.56 ** ]]> Example 8 6 <![CDATA[8.14±1.17 ** ]]> <![CDATA[8.09±0.96 ** ]]> Example 9 6 <![CDATA[7.55±1.42 ** ]]> <![CDATA[7.58±1.38 ** ]]> Example 10 6 <![CDATA[7.82±1.53 ** ]]> <![CDATA[7.75±2.27 ** ]]> Compared with the model group, *P<0.05, **P<0.01 As shown in the table above, compared with the blank group, the model group significantly reduced tear secretion in both left and right rats, indicating that the dry eye model was successfully established. Compared with the model group, the essential oil groups prepared in the examples all significantly increased tear secretion in both left and right rats, with Example 8 having the best combination ratio and the best therapeutic effect.

[0027] The rats were killed, and the intact eyeballs were removed, fixed with 4% formaldehyde, embedded in paraffin, sectioned, and stained with hematoxylin-eosin (HE) to observe the morphological changes of corneal tissue. Figures 1 to 3 shown.

[0028] Figure 1-Figure 3 The results showed that: ① Blank group: The corneal epithelial layers were clear, the cell morphology was normal, the corneal layers were neatly arranged, and no obvious pathological changes were observed; ② Formula essential oil group: The corneal epithelial layers were clear, the nuclei of the surface cells were enlarged, the basal cells were loosely arranged, and the corneal layers were basically normal; ③ Model group: The corneal epithelial layers were thickened, vacuolar degeneration was common in the cells, the surface cells were reduced, a large number of nuclear fragmentation cells were visible, and mild edema and capillary dilation of the corneal stroma were occasionally observed. The anterior limiting layer, corneal stroma, posterior limiting layer and corneal endothelium were neatly arranged.

[0029] Summary: This study used benzalkonium chloride to induce a dry eye model in rats. The tear secretion of rats in the model group was significantly reduced, and significant pathological changes occurred in the conjunctival tissue, indicating that the model was successfully replicated. The external application of the formulated compound essential oil had a good intervention effect on dry eye rats, and also had a good improvement effect on the pathological changes of the rat conjunctival tissue.

[0030] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine eye patch containing compound essential oil for treating dry eyes, characterized by: The invention comprises the following components in parts by mass: 10-15 parts of buddleja flower essential oil, 10-15 parts of chrysanthemum essential oil, 10-15 parts of salvia miltiorrhiza essential oil, 3-5 parts of wolfberry essential oil, 3-5 parts of rose essential oil, 3-5 parts of honeysuckle essential oil, 1-3 parts of peppermint oil, 1-3 parts of jojoba oil, 1-3 parts of sweet almond oil, 10-19 parts of penetration enhancer and 600 parts of purified water.

2. A Chinese medicine eye patch composite essential oil for treating dry eye according to claim 1, characterized in that: Calculated by weight, the penetration enhancer includes 2-5 parts of linseed oil, 5-7 parts of camellia seed oil, 1-2 parts of borneol or natural borneol, 1-2 parts of menthol, and 1-3 parts of linseed extract.

3. A Chinese medicine eye patch composite essential oil for treating dry eye according to claim 2, characterized in that: The invention comprises the following components in parts by mass: 12 parts of buddleja flower essential oil, 12 parts of chrysanthemum essential oil, 12 parts of salvia miltiorrhiza essential oil, 4 parts of wolfberry fruit essential oil, 4 parts of rose essential oil, 4 parts of honeysuckle, 2 parts of peppermint oil, 2 parts of jojoba oil, 2 parts of sweet almond oil, 3 parts of linseed oil, 6 parts of camellia seed oil, 1.5 parts of borneol or natural borneol, 1.5 parts of menthol, 2 parts of linseed extract and 600 parts of purified water.

4. A method for preparing a traditional Chinese medicine eye patch compounded with essential oil for treating dry eye according to any one of claims 1 to 3, characterized in that: The following steps are included: S1. Weigh Buddleja essential oil, chrysanthemum essential oil, salvia miltiorrhiza essential oil, wolfberry essential oil, rose essential oil, honeysuckle essential oil, peppermint oil, jojoba oil, sweet almond oil in parts by mass and dissolve in a container, stir to make a compound essential oil; S2. Weigh flaxseed oil, camellia seed oil, menthol, borneol or natural borneol, flaxseed extract in parts by mass and stir to form a uniform liquid to form a penetration enhancer; S3. Add 5-10% water to the preparation tank, start stirring, add the penetration enhancer and compound essential oil in sequence, add the remaining amount of water according to the planned amount, emulsify and stir for 30 minutes to prepare the compound essential oil.

5. The method for preparing a traditional Chinese medicine eye patch containing compound essential oil for treating dry eye according to claim 4, characterized in that: The Buddleja buddleja essential oil, chrysanthemum essential oil and salvia miltiorrhiza essential oil are prepared according to the following method: the Chinese medicinal materials in the formula amount are weighed, put into the volatile oil extraction tank, 10 times the amount of water is added and soaked for 12-18 hours, then heated to 100°C, reflux extracted for 3 hours, stopped heating, and the volatile oil of the Chinese medicinal materials was collected.

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