Heat-clearing and thirst-quenching granule and preparation method thereof

Abstract

The invention relates to heat-clearing and thirst-quenching granules and a preparation method thereof. The traditional Chinese medicine composition is prepared from radix trichosanthis, ginseng, fructus lycii, rhizoma coptidis, radix ophiopogonis, fructus schizandrae, fructus trichosanthis, radix astragali seu hedysari, radix puerariae, semen astragali complanati and salted rhizoma alismatis as raw materials through decoction, filtration, concentration and granulation, all the materials are selected from natural traditional Chinese medicine components, and the traditional Chinese medicine composition has the effects of clearing heat, purging fire, reinforcing qi, nourishing yin, promoting the production of body fluid and quenching thirst. The traditional Chinese medicine composition is used for treating qi-yin deficiency syndrome of diabetes, has obvious curative effects on symptoms such as dry mouth, liking to drink, spontaneous perspiration, night sweat, lassitude and hypodynamia, dysphoria in the heart and the like, has no side effect on the body, and is beneficial to health; the preparation method is simple and low in production cost.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, in particular to heat-clearing and thirst-quenching granules and a preparation method thereof. Background Art

[0002] Diabetes mellitus refers to a complex disease characterized by polydipsia, polyuria, polyphagia, weight loss, fatigue, and sweet urine. It is a common disease, and its incidence has been increasing in recent years, especially in middle-aged and elderly people. The "three mores" and the degree of weight loss are important indicators for judging the severity of the disease. Once discovered, lifestyle changes, including diet control, physical exercise, and weight loss, combined with certain medications, should be adopted to achieve the goal of controlling the disease. In addition, the susceptibility to numerous complications is another characteristic of this disease. Complications are important factors that affect the condition, damage the patient's labor force, and endanger the patient's life, so early prevention and treatment should be paid great attention. The cause of diabetes mellitus is relatively complex. Insufficient endowment, improper diet, emotional imbalance, excessive work and desire, etc. can all lead to diabetes mellitus.

[0003] Traditional Chinese Medicine (TCM) believes that diabetes primarily affects the lungs, stomach, and kidneys, with the underlying pathogenesis being yin and fluid depletion and excessive dryness and heat. Based on TCM theory, the treatment principles for diabetes are to clear heat and moisten the lungs, nourish yin and promote fluid production, nourish yin and benefit the kidneys, and clear the stomach and purge heat. This approach involves formulating prescriptions based on syndrome differentiation to achieve both symptomatic and fundamental treatment. Summary of the Invention

[0004] In view of the problems existing in the prior art, the present invention discloses a heat-clearing and thirst-quenching granule, whose main ingredients and weight ratios are: 145-150 parts of Radix Trichosanthis, 127-137 parts of Lycium barbarum, 115-120 parts of Rhizoma Coptidis, 100-105 parts of Radix Ophiopogonis, 99-105 parts of Fructus Schisandrae Chinensis, 90-110 parts of Fructus Trichosanthis, 83-93 parts of Ginseng, 83-93 parts of Radix Astragali, 60-70 parts of Radix Puerariae, 30-40 parts of Fructus Astragali, and 60-70 parts of Rhizoma Alisma.

[0005] As a preferred embodiment of the present invention, an appropriate amount of dextrin can be added as needed.

[0006] A method for preparing heat-clearing and thirst-quenching granules comprises the following steps: Step 1: grind Radix Trichosanthis and Radix Ginseng according to the proportion, pass through a 100-mesh sieve, and mix the fine powder evenly for later use; Step 2: Select wolfberry fruit, coptis root, ophiopogon japonicus, schisandra chinensis, trichosanthes root, astragalus root, kudzu root, complanatus chinensis, and salt alisma root according to the proportion, add 7 times the amount of water and decoct twice, each time for 1 hour, combine the decoctions, let stand and take the supernatant; Step 3: Filter the supernatant with a 100-mesh filter and concentrate it to a relative density of 1.20-1.30 at 70° C. After the extract is passed through a 100-mesh sieve, add an appropriate amount of dextrin and the mixed fine powder obtained in step 1 to make granules, and dry them at 60° C. to obtain heat-clearing and thirst-quenching granules.

[0007] Ginseng, also known as wild ginseng, blood ginseng, garden ginseng, yellow ginseng, earth spirit, earth spirit, divine grass, hundred-foot pestle, baby ginseng, and golden well jade railing, has the effects of tonifying vital energy, strengthening the body, promoting the production of body fluids, and calming the mind. It is mainly used to treat exhaustion, loss of appetite, fatigue, nausea and vomiting, loose stools, cough and shortness of breath, spontaneous sweating and sudden loss of consciousness, palpitations, forgetfulness, dizziness and headache, impotence, frequent urination, thirst, metrorrhagia in women, slow fright in children, and chronic deficiency, all symptoms of qi, blood, and body fluid deficiency. It tastes sweet and slightly bitter, and is slightly warm in nature. It enters the spleen and lung meridians.

[0008] Radix Trichosanthis (Trichosanthis root), also known as Tianguafen (Heavenly Melon Powder), Trichosanthes Root (Shit Melon Root), Trichosanthes Powder (White Medicine), Ruixue (Auspicious Snow), Pollen (Flower Pollen), and Weifen (Wilt Powder), has the effects of clearing heat and promoting fluid production, moistening the lungs and resolving phlegm, and reducing swelling and expelling pus. It is primarily used to treat fever-related thirst, polydipsia, lung heat-induced dry cough, and sores and swelling. It has a sweet, slightly bitter flavor and a slightly cold nature. It enters the lung and stomach meridians.

[0009] Lycium barbarum, also known as wolfberry, beet seed, red earring, and ground bone bark, has the benefits of improving eyesight and nourishing the liver and kidneys. It is mainly used to treat consumptive disease, spermatorrhea, lower back and knee pain, decreased vision, and vertigo and tinnitus. It has a sweet taste and a neutral nature. It enters the liver and kidney meridians.

[0010] Coptis chinensis (Coptis chinensis), also known as Chuanlian, Yuanlian, Jianglian, Chuanhuanglian, Jianghuanglian, Jiangchuanlian, Jiangzhihuanglian, Yulian, Yuhuanglian, and Chaohuanglian, has the effects of clearing heat and dampness, purging fire and detoxifying. It is used to treat damp-heat, fullness in the abdomen, vomiting, acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactive heart fire, restlessness and insomnia, vomiting and epistaxis due to blood heat, conjunctivitis, toothache, diabetes, and carbuncles. It is also used externally to treat eczema, eczema, and auricular abscesses. It has a bitter taste and cold properties. It enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians.

[0011] Ophiopogon japonicus, also known as Ophiopogon japonicus, Ophiopogon japonicus, and Ophiopogon japonicus, nourishes yin and promotes fluid production, moistening the lungs and clearing the heart. It is primarily used to treat dry coughs caused by lung dryness, consumptive coughs, thirst due to loss of fluid, restlessness and insomnia, internal heat and thirst, and constipation due to intestinal dryness. It has a sweet and slightly bitter flavor and a slightly cold nature. It enters the Heart, Lung, and Stomach meridians.

[0012] Schisandra chinensis, also known as Xuanji, Huiji, Wumeizi, and Shanhuajiao, has astringent properties, invigorates Qi and promotes fluid production, and calms the mind. It is primarily used to treat cough, asthma, nocturnal emission, spermatorrhea, excessive urination, chronic diarrhea, spontaneous sweating, night sweats, thirst due to fluid loss, palpitations, and insomnia. It has a sour flavor and warm properties. It enters the Lung and Kidney meridians.

[0013] Trichosanthes kirilowii, also known as Tianshe, bitter melon, mountain golden gourd, and medicinal melon peel, clears heat and eliminates phlegm, relieves chest tightness, and moistens the intestines. It is primarily used to treat lung-heat cough, thick, yellow phlegm, chest pain, and painful swelling and swelling caused by breast, lung, and intestinal abscesses. It has a sweet, slightly bitter flavor and a cold nature. It enters the lung, stomach, and large intestine meridians.

[0014] Astragalus, also known as Jianqi, Baiben, Wangsun, Jinqi, Mianhuangqi, and Beiqi, has the effects of tonifying Qi and strengthening the exterior, expelling toxins and pus, promoting urination, and promoting tissue regeneration. It is primarily used to treat Qi deficiency and fatigue, chronic diarrhea and prolapse of the anus, spontaneous sweating, edema, uterine prolapse, proteinuria in chronic nephritis, diabetes, and persistent wounds. It has a sweet flavor and warm nature. It enters the Lung and Spleen meridians.

[0015] Pueraria root, also known as dried kudzu root, sweet kudzu root, powdered kudzu root, kudzu root, kudzu root, kudzu root, kudzu root, kudzu root, and kudzu root, has the effects of relieving muscles and reducing fever, promoting bowel movements, promoting fluid production and quenching thirst, and promoting yang and stopping diarrhea. It is primarily used to treat exogenous fever, stiff neck and headache, the initial onset of measles, delayed rash, thirst caused by febrile diseases, diabetes, diarrhea, dysentery, hypertension, and coronary heart disease. It has a sweet and pungent flavor and is neutral in nature. It enters the spleen and stomach meridians.

[0016] The invention has the following beneficial effects: The invention uses Radix Trichosanthis, ginseng, wolfberry, coptis root, ophiopogon, schisandra chinensis, trichosanthes root, astragalus root, kudzu root, astragalus root, salina fruit, and salina salsa as raw materials, which are boiled, filtered, concentrated, and then granulated. The materials are all natural Chinese medicinal ingredients, and have the effects of clearing heat and purging fire, replenishing qi and nourishing yin, and promoting body fluid and quenching thirst. It is used to treat the qi and yin deficiency syndrome of diabetes mellitus, and has obvious therapeutic effects on symptoms such as dry mouth and thirst, spontaneous sweating and night sweats, fatigue, and fever in the five parts of the body. It has no side effects and is beneficial to health. The preparation method is simple and the production cost is low. DETAILED DESCRIPTION

[0017] Example 1

[0018] The heat-clearing and thirst-quenching granules of the present invention mainly include Radix Trichosanthis, Radix Ginseng, Fructus Lycii, Rhizoma Coptidis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Fructus Trichosanthis, Radix Astragali, Radix Puerariae, Fructus Astragali, and Rhizoma Alismatis. The preparation method thereof comprises the following steps: Step 1: Select 145 parts of pollen and 83 parts of ginseng according to the proportion, grind them, pass them through a 100-mesh sieve, and mix them evenly to obtain a mixed fine powder for later use; Step 2: Select 127 parts of wolfberry, 115 parts of coptis root, 100 parts of ophiopogon, 99 parts of schisandra, 90 parts of trichosanthes, 83 parts of astragalus, 60 parts of kudzu root, 30 parts of complanatus, and 60 parts of salt alisma, add 7 times the amount of water and decoct twice, each time for 1 hour, combine the decoctions, let stand and take the supernatant; Step 3: Filter the supernatant with a 100-mesh filter and concentrate it to a relative density of 1.20 at 70° C. After the extract is passed through a 100-mesh sieve, add an appropriate amount of dextrin and the mixed fine powder obtained in step 1 to make granules, and dry them at 60° C. to obtain Qingrexiaoke granules.

[0019] Example 2

[0020] The heat-clearing and thirst-quenching granules of the present invention mainly include Radix Trichosanthis, Radix Ginseng, Fructus Lycii, Rhizoma Coptidis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Fructus Trichosanthis, Radix Astragali, Radix Puerariae, Fructus Astragali, and Rhizoma Alismatis. The preparation method thereof comprises the following steps: Step 1: Select 150 parts of pollen and 93 parts of ginseng according to the proportion, grind them, pass them through a 100-mesh sieve, and mix them evenly to obtain a mixed fine powder for later use; Step 2: Select 137 parts of wolfberry, 120 parts of coptis root, 105 parts of ophiopogon, 105 parts of schisandra chinensis, 110 parts of trichosanthes, 93 parts of astragalus, 70 parts of kudzu root, 40 parts of complanatus, and 70 parts of salt alisma root according to proportion, add 7 times the amount of water and decoct twice, each time for 1 hour, combine the decoctions, let stand and take the supernatant; Step 3: Filter the supernatant with a 100-mesh filter and concentrate it to a relative density of 1.30 at 70° C. After the extract is passed through a 100-mesh sieve, add an appropriate amount of dextrin and the mixed fine powder obtained in step 1 to make granules, and dry them at 60° C. to obtain heat-clearing and thirst-quenching granules.

[0021] Example 3

[0022] The heat-clearing and thirst-quenching granules of the present invention mainly include Radix Trichosanthis, Radix Ginseng, Fructus Lycii, Rhizoma Coptidis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Fructus Trichosanthis, Radix Astragali, Radix Puerariae, Fructus Astragali, and Rhizoma Alismatis. The preparation method thereof comprises the following steps: Step 1: Select 148 parts of pollen and 88 parts of ginseng according to the proportion, grind them, pass them through a 100-mesh sieve, and mix them evenly to obtain a mixed fine powder for later use; Step 2: Select 132 parts of wolfberry, 118 parts of coptis root, 102 parts of ophiopogon, 102 parts of schisandra chinensis, 100 parts of trichosanthes, 88 parts of astragalus, 66 parts of kudzu root, 34 parts of complanatus, and 66 parts of salt alisma root according to proportion, add 7 times the amount of water and decoct twice, each time for 1 hour, combine the decoctions, let stand and take the supernatant; Step 3: Filter the supernatant with a 100-mesh filter and concentrate it to a relative density of 1.20-1.30 at 70° C. After the extract is passed through a 100-mesh sieve, add an appropriate amount of dextrin and the mixed fine powder obtained in step 1 to make granules, and dry them at 60° C. to obtain heat-clearing and thirst-quenching granules.

[0023] This granule product complies with the provisions of various granule items specified in General Chapter 0104 of Appendix IV of the 2020 edition of the Chinese Pharmacopoeia.

[0024] Components not described in detail herein are prior art.

[0025] Although the specific embodiments of the present invention have been described in detail above, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by ordinary technicians in this field, various changes can be made without departing from the purpose of the present invention. Modifications or deformations that do not involve creative work are still within the scope of protection of the present invention.

Claims

1. A heat-clearing and thirst-quenching granule, characterized in that: Its main ingredients and weight proportions are: 145-150 parts of Radix Trichosanthis, 127-137 parts of Fructus Lycii, 115-120 parts of Rhizoma Coptidis, 100-105 parts of Radix Ophiopogonis, 99-105 parts of Fructus Schisandrae Chinensis, 90-110 parts of Fructus Trichosanthis, 83-93 parts of Ginseng, 83-93 parts of Radix Astragali, 60-70 parts of Radix Puerariae, 30-40 parts of Fructus Astragali, and 60-70 parts of Rhizoma Alisma.

2. The heat-clearing and thirst-quenching granules according to claim 1, characterized in that: The invention comprises 148 parts of Radix Trichosanthis, 132 parts of Fructus Lycii, 118 parts of Rhizoma Coptidis, 102 parts of Radix Ophiopogonis, 102 parts of Fructus Schisandrae Chinensis, 100 parts of Fructus Trichosanthis, 88 parts of Radix Ginseng, 88 parts of Radix Astragali, 66 parts of Radix Puerariae, 34 parts of Fructus Astragali and 66 parts of Rhizoma Alisma.

3. The method for preparing the heat-clearing and thirst-quenching granules according to claim 1, wherein: The steps are as follows: Step 1: grind Radix Trichosanthis and Radix Ginseng according to the proportion, pass through a 100-mesh sieve, and mix the fine powder evenly for later use; Step 2: Select wolfberry fruit, coptis root, ophiopogon japonicus, schisandra chinensis, trichosanthes root, astragalus root, kudzu root, complanatus chinensis, and salt alisma root according to the proportion, add 7 times the amount of water and decoct twice, each time for 1 hour, combine the decoctions, let stand and take the supernatant; Step 3: Filter the supernatant with a 100-mesh filter and concentrate it to a relative density of 1.20-1.30 at 70° C. After the extract is passed through a 100-mesh sieve, add the mixed fine powder obtained in step 1 to make granules, and dry them at 60° C. to obtain Qingrexiaoke granules.