Traditional Chinese medicine preparation for treating viral pneumonia

Abstract

The invention discloses a traditional Chinese medicine preparation for treating viral pneumonia. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of ginseng, 9-15 parts of parasitic loranthus, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cassia twig, 6-9 parts of divaricate saposhnikovia root, 3-4.5 parts of prepared fructus evodiae, 10-20 parts of salvia miltiorrhiza, 6-9 parts of angelica sinensis, 6-9 parts of ligusticum wallichii, 8-12 parts of cortex moutan, 6-9 parts of radix paeoniae rubra, 6-9 parts of pericarpium citri reticulatae, 6-9 parts of rhizoma pinellinae praeparata and 6-9 parts of honey-fried The traditional Chinese medicine preparation disclosed by the invention is high in effective rate, can quickly relieve inflammatory response and remarkably reduce release of inflammatory mediators, and can quickly bring down a fever of a patient, and the average time is about 29 hours.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine preparation for treating viral pneumonia, belonging to the technical field of traditional Chinese medicines. Background Art

[0002] Viral pneumonia is a common viral respiratory illness in clinical practice, presenting with symptoms such as fever, cough and sputum, and even chest tightness, shortness of breath, and dyspnea. Severe cases can be life-threatening. Viral pneumonia can be caused by various respiratory viruses, leading to damage to the bronchi and alveoli, causing lung inflammation and other respiratory infection symptoms, and even secondary respiratory failure and pulmonary fibrosis. Viral pneumonia is highly epidemic, seasonal, and contagious. Clinically, its occurrence is often closely linked to the patient's immune function and inflammatory factors. When the immune system is compromised, the virus is more likely to breach the immune barrier, invade lung tissue, trigger a series of inflammatory reactions, and release large amounts of inflammatory mediators. Currently, the diagnostic and treatment guidelines and expert consensus for viral pneumonia are not fully systematic and comprehensive. Clinically, the treatment of viral pneumonia still primarily relies on anti-influenza drugs, supplemented by symptomatic management. The "Chinese Expert Consensus on the Treatment and Prevention of Influenza with Antiviral Drugs" advocates the use of oseltamivir as a first-line treatment for influenza. In clinical practice, influenza-associated pneumonia often develops secondary to influenza, and therefore oseltamivir is also suitable for the treatment of influenza-associated pneumonia. However, with the continuous mutation of viruses, the efficacy of antiviral drugs like oseltamivir is becoming increasingly uncertain, and treatment may also be associated with various adverse reactions. Traditional Chinese medicine currently has some clinical experience in treating viral pneumonia. Previously, most traditional Chinese medicine practitioners believed that viral pneumonia was primarily caused by exposure to warm and hot pathogens, which were believed to be most susceptible to affecting the lungs. Clinically, treatment often used heat-clearing and cooling herbs such as Yinqiao Powder and Maxing Shigan Decoction. The current status of both traditional Chinese and Western medicine in treating viral pneumonia is generally unsatisfactory, with limited success in rapidly alleviating fever and cough, and in significantly shortening treatment courses. Currently, there is still a lack of a universally used and effective traditional Chinese medicine preparation for viral pneumonia. Summary of the Invention

[0003] In order to overcome the drawbacks of the existing technology, the present invention provides a traditional Chinese medicine preparation for treating viral pneumonia, which has a high efficacy, can quickly alleviate the inflammatory response and significantly reduce the release of inflammatory mediators, and can quickly reduce the patient's fever, with an average duration of about 29 hours.

[0004] The technical solution adopted by the present invention to solve its technical problem is: A traditional Chinese medicine preparation for treating viral pneumonia, comprising the following components in parts by weight: 10-20 parts of ginseng, 9-15 parts of mistletoe, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cinnamon twig, 6-9 parts of siler, 3-4.5 parts of processed evodia rutaecarpa, 10-20 parts of salvia miltiorrhiza, 8-12 parts of moutan bark, 6-9 parts of red peony root, 6-9 parts of dried tangerine peel, 6-9 parts of pinellia ternata, and 6-9 parts of roasted liquorice.

[0005] The above-mentioned traditional Chinese medicine preparation for treating viral pneumonia further comprises the following components in parts by weight: 6-9 parts of angelica sinensis and 6-9 parts of ligusticum chuanxiong.

[0006] The above-mentioned traditional Chinese medicine preparation for treating viral pneumonia comprises the following components in parts by weight: 12-18 parts of ginseng, 10-14 parts of mistletoe, 4-6 parts of schisandra chinensis, 7-9 parts of gastrodia elata, 7-9 parts of cinnamon twig, 7-9 parts of siler, 3.5-4.5 parts of processed evodia rutaecarpa, 12-18 parts of salvia miltiorrhiza, 7-9 parts of angelica sinensis, 7-9 parts of ligusticum chuanxiong, 9-11 parts of moutan bark, 7-9 parts of red peony root, 7-9 parts of dried tangerine peel, 7-9 parts of pinellia ternata, and 7-9 parts of roasted liquorice.

[0007] The above-mentioned traditional Chinese medicine preparation for treating viral pneumonia comprises the following components in parts by weight: 15 parts of ginseng, 12 parts of mistletoe, 5 parts of schisandra chinensis, 8 parts of gastrodia elata, 8 parts of cinnamon twigs, 8 parts of siler, 4 parts of processed evodia rutaecarpa, 15 parts of salvia miltiorrhiza, 10 parts of moutan bark, 8 parts of red peony root, 8 parts of angelica sinensis, 8 parts of ligusticum chuanxiong, 8 parts of dried tangerine peel, 8 parts of pinellia tuber, and 8 parts of prepared liquorice.

[0008] The common pharmacological effects of the Chinese medicinal raw materials selected in the present invention are as follows: Ginseng: Sweet, slightly bitter, and warm in nature. It enters the spleen and lung meridians. It significantly replenishes vital energy, benefits the lungs and spleen, promotes fluid production and nourishes blood, and calms the mind. It is used for symptoms of physical weakness, shortness of breath, spontaneous sweating, cold limbs, fatigue, loss of appetite, vomiting and diarrhea, wheezing due to qi deficiency, chronic cough, thirst due to fluid deficiency, and any other deficiency of qi, blood, and body fluids. Ginseng has anti-shock and cardiotonic effects; it also fights fatigue, promotes protein, DNA, and RNA synthesis, stimulates the hematopoietic system, and enhances the immune system. It also has anti-inflammatory, anti-allergic, and blood sugar-lowering properties.

[0009] Mulberry parasite: Bitter and sweet in flavor, neutral in nature. Enters the liver and kidney meridians. It nourishes the liver and kidneys, strengthens the bones and tendons, and dispels rheumatism. It is used to treat rheumatic pain, soreness of the waist and knees, and weakness in the bones and tendons. It has a significant inhibitory effect on poliovirus and other enteroviruses, and inhibits the growth of Salmonella typhi and Staphylococcus aureus.

[0010] Schisandra chinensis: Sour and warm in nature. It enters the Lung, Kidney, and Heart meridians. It has astringent and firming properties, replenishes Qi and promotes fluid production, and nourishes the kidneys and calms the mind. It is used for lung deficiency, cough and asthma, thirst due to fluid deficiency, neurasthenia, chronic diarrhea, spontaneous sweating, night sweats, thirst due to fluid loss, restlessness, and insomnia. It has a stimulating effect on all levels of the nervous system; it has a stimulating effect on the respiratory system, and has antitussive and expectorant properties. It can promote bile secretion, lower serum transaminases, and protect liver cells. It also has immune-enhancing, antioxidant, anti-aging, and antibacterial properties.

[0011] Gastrodia elata: Sweet in flavor, slightly warm in nature. It enters the Liver Meridian. It calms the liver, calms wind, relieves spasms, and relieves pain. It can be used for dizziness and vertigo. Gastrodia elata also has analgesic and anti-inflammatory properties, and its polysaccharides have immunomodulatory properties.

[0012] Prepared Evodia rutaecarpa: Pungent and bitter in flavor, with a warming nature. It enters the Liver, Spleen, and Stomach meridians. It warms the middle and dispels cold, soothes the liver, and relieves pain. It is used to treat cold pain in the abdomen, hiccups, acid reflux, headaches in the Jueyin meridians, vomiting, and diarrhea. Prepared Evodia rutaecarpa also has analgesic and antiemetic properties, and has antiplatelet and antithrombotic properties.

[0013] Cinnamon twig: Pungent and sweet in flavor, warm in nature. It enters the Heart, Lung, and Bladder meridians. It promotes diaphoresis, warms the meridians and dredges the collaterals, and promotes Yang and Qi. It is used to treat the symptoms of colds and flu, cold pain in the abdomen and stomach, soreness in the shoulders, back, and joints, chest pain, phlegm, edema, and palpitations. Its decoction and cinnamaldehyde have cooling and antipyretic effects. The decoction and ethanol extract have antibacterial and antiviral properties. Cinnamon oil has stomachic and relieving gastrointestinal spasms, as well as diuretic and cardiotonic effects. The volatile oil has antitussive and expectorant properties.

[0014] Saposhnikovia root: Sweet, pungent, and warm in nature. It enters the bladder, liver, and spleen meridians. It has the functions of dispelling wind, removing dampness, and dispelling wind. It is used for colds, headaches, fever, analgesia, and rheumatic pain. It has antipyretic, anti-inflammatory, analgesic, sedative, anticonvulsant, anti-allergic, and anti-pathogenic effects, and can enhance the phagocytic function of macrophages.

[0015] Salvia miltiorrhiza: Bitter in flavor and cold in nature. It enters the Heart, Pericardium, and Liver meridians. It promotes blood circulation, dissipates stasis, reduces swelling and relieves pain, nourishes blood, and calms the mind. It is used to treat pain from blood stasis in the chest, abdomen, or limbs, carbuncles, sores, restlessness, and insomnia. It improves microcirculation and blood flow, and also has sedative, analgesic, anti-inflammatory, antibacterial, and anti-allergic properties. It also improves renal function and protects against ischemic renal damage.

[0016] Angelica sinensis: Sweet and pungent in flavor, warm in nature. It enters the liver, heart, and spleen meridians. It nourishes and invigorates blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. It is used for sallow complexion due to blood deficiency, dizziness, and palpitations.

[0017] Chuanxiong: Spicy, slightly bitter, and warm in nature. It enters the Liver, Gallbladder, and Pericardium meridians. It promotes blood circulation and qi, dispels wind and relieves pain. It is used to treat headaches, chest and flank pain, colds, dizziness, sores, swelling, rheumatic pain, and other symptoms. Its extract reduces vascular resistance, improves microcirculation, and has sedative, antihypertensive, antibacterial, and antihistamine properties.

[0018] Red Peony Root: Bitter in taste, slightly cold in nature. It enters the Liver Meridian. It promotes blood circulation, dissipates blood stasis, clears heat, and cools the blood. It is used for chest and flank pain, abdominal pain, heat invading the bloodstream, hematemesis, epistaxis, conjunctivitis, and carbuncles. Red Peony Root can dilate coronary arteries, resist myocardial ischemia, increase myocardial tolerance to hypoxia, improve blood rheology and microcirculation, and inhibit platelet aggregation. It has analgesic and anticonvulsant effects, and can protect against liver damage. It also has antibacterial properties.

[0019] Moutan Bark: Bitter and pungent in flavor, slightly cold in nature. It enters the Heart, Liver, and Kidney meridians. It clears heat and cools blood, promotes blood circulation and dissipates blood stasis, and relieves pain. It is used for fever-induced rash, headaches, feverish irritability, and stagnant Qi and blood. It has central nervous system inhibitory effects, including anti-inflammatory, analgesic, sedative, anticonvulsant, and antipyretic. It also protects the liver, acts as a diuretic, lowers blood sugar, has anti-allergic effects, inhibits platelet aggregation, scavenges free radicals, and has immunomodulatory properties.

[0020] Tangerine peel: Bitter, pungent, and warm in nature. It enters the spleen and lung meridians. It regulates qi, strengthens the spleen, expels dampness, and resolves phlegm. It is used to treat chest and abdominal distension, belching and vomiting, loss of appetite, and cough with sputum. Tangerine peel's volatile oil has a mild stimulating effect on the gastrointestinal tract, promoting the secretion of digestive juices and eliminating intestinal gas. It also has a stimulating expectorant effect, facilitating expectoration of phlegm. It also has a certain inhibitory effect on bacteria such as Staphylococcus aureus and Proteus.

[0021] Pinellia ternata (French Pinellia): Pungent in flavor and warm in nature. It enters the spleen, stomach, and lung meridians. It has the functions of drying dampness and resolving phlegm, relieving nausea and vomiting, and dissolving lumps and masses. It is used for coughs and wheezing caused by phlegm and fluid retention, cough and shortness of breath, chest and abdominal distension, nausea, vomiting, and dizziness. It has antiemetic, antitussive, expectorant, and antibacterial properties.

[0022] Roasted Licorice: Sweet and neutral in nature. It enters the Heart, Lung, Spleen, and Stomach meridians. It tonifies the spleen and replenishes Qi, relieves coughs, resolves phlegm, clears heat and detoxifies, relieves acute pain, and harmonizes the properties of drugs. It is used for spleen and stomach deficiency, insufficient Qi, cough and shortness of breath, and to mitigate the effects of potent drugs and detoxify. It relieves smooth muscle spasms and relieves pain; it promotes pancreatic secretion; has significant antitussive, expectorant, and antiasthmatic properties; has antibacterial, antiviral, anti-inflammatory, and anti-allergic effects; protects inflamed throats and tracheal mucosa; and has effects similar to adrenocortical hormones. It also has antidiuretic, lipid-lowering, hepatoprotective, and detoxifying properties.

[0023] The beneficial effects of the present invention are: The Chinese medicine preparation of the present invention has a good therapeutic effect on viral pneumonia caused by various viruses such as coronavirus, respiratory syncytial virus, and parainfluenza virus, with a high efficacy rate, can quickly alleviate the inflammatory response and significantly reduce the release of inflammatory mediators, and can quickly reduce the patient's fever, with an average duration of about 29 hours. It can also quickly improve symptoms such as cough and chest tightness, and quickly improve the patient's imaging changes. This composition has no obvious toxic and side effects at the clinically recommended dose, is highly effective, safe, and non-toxic, and has a stable therapeutic effect. This product can effectively treat patients with viral pneumonia and has good application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a comparison chart before and after 2 weeks of treatment for case 1 in the observation group.

[0025] Figure 2 This is a comparison chart before and after one week of treatment for case 2 in the observation group.

[0026] Figure 3 This is a comparison chart before and after one week of treatment for case 3 in the observation group.

[0027] Figure 4 This is a comparison chart before and after one week of treatment for case 4 in the observation group.

[0028] Figure 5 This is a comparison chart before and after 2 weeks of treatment for case 5 in the observation group.

[0029] Figure 6 This is a comparison chart before and after 2 weeks of treatment for case 6 in the observation group.

[0030] Figure 7 This is a comparison chart before and after one week of treatment for case 7 in the observation group.

[0031] Figure 8 This is a comparison chart before and after one week of treatment for case 8 in the observation group.

[0032] The left picture is before treatment; the right picture is after treatment. DETAILED DESCRIPTION

[0033] In the past, most of the traditional Chinese medical science thought that the main cause of viral pneumonia was to feel the pathogenic factors of warm and hot nature, and thought that the pathogenic factors of warm and hot nature were the easiest to attack the lung, and clinically, the heat-clearing and cold-cooling medicine addition and subtraction treatments such as Yinqiao Powder, Maxing Shigan Decoction were used more. The present invention has found that the congenital vital energy deficiency of the overwhelming majority of patients of viral pneumonia or because of the acquired greed for coolness and the coldness and taking bitter cold medicine over a long period of time makes vital energy impaired, and again meet the mixed extremes of wind, cold, and dampness and become numbness, invade and form the lung paralysis of cold coagulation, stagnation of qi, blood stasis, thereby affect other viscera functions such as heart, kidney, liver, spleen, cause the water liquid transportation and distribution disorder, form cold drink.Cold drink numbness is blocked in the lung, causes the lung qi not to be announced, and water drink is not transformed, and clinically shows as cough, chest tightness and breath-holding, much thin sputum etc., because patient's vital energy is not enough so also can there be mental fatigue, shortness of breath, severe patient's dyspnea. Exogenous pathogens block lung qi, obstructing the qi flow and obstructing the lung collaterals, leading to poor blood circulation and internal blood stasis. Patients may experience symptoms such as cyanosis of the lips and a dark purple tongue. The Chinese medicine preparation of the present invention uses ginseng, mistletoe, and Gastrodia elata as main ingredients to strengthen the body's foundation, nourish the spleen and lungs, and strengthen the body's resistance and eliminate pathogenic factors. Ginseng can significantly replenish vital energy and has the effects of replenishing qi and strengthening deficiency. The "Ben Jing" records that "long-term use of Gastrodia elata can improve qi and strength, increase yin, promote weight gain, reduce weight, and increase longevity." Mistletoe can nourish the liver and kidneys and strengthen the tendons and bones. The auxiliary ingredients include cinnamon twig, processed evodia rutaecarpa, and saposhnikovia divaricata to promote lung defense, warm the lungs, eliminate phlegm, dispel cold, and relieve cough. They are used for coughs and expectoration caused by cold phlegm in the lungs. Schisandra chinensis is also used to nourish the lungs and kidneys, and is used for cough and asthma caused by lung and kidney deficiency. The adjuvant ingredients in this prescription include angelica sinensis, Chuanxiong rhizome, salvia miltiorrhiza, moutan bark, and red peony root to promote blood circulation, promote qi circulation, and dispel stasis and dredge the collaterals. Tangerine peel and Pinellia ternata are used to regulate qi and balance the middle qi, relieve coughs, and resolve phlegm. Pinellia ternata, in particular, is a key herb for treating damp phlegm. Roasted licorice root, as a guiding herb in the formula, not only tonifies the spleen and replenishes qi, moistens the lungs and relieves coughs, but also harmonizes the other herbs. Together, these herbs achieve the effects of strengthening the body's vital energy, dispelling pathogenic factors, promoting lung defense, warming the lungs and eliminating fluid, activating blood circulation and qi, removing blood stasis and unblocking meridians, and relieving coughs and phlegm, all while relieving numbness.

[0034] The Chinese herbal preparations of the present invention are often taken as decoctions. They can also be prepared into any pharmaceutically acceptable preparation by adding conventional pharmaceutical excipients. For example, the raw materials described above can be ground into powders for oral administration, or manufactured into tablets or capsules for oral administration, or prepared into injectable preparations. The Chinese herbal preparations of the present invention can be prepared into any commonly used oral or injectable preparations using conventional methods using various conventional pharmaceutical excipients required for preparing different dosage forms, such as disintegrants, lubricants, and binders, and can also include optional coating materials.

[0035] The present invention will be further described below with reference to the embodiments. Example 1

[0036] Respectively weigh 10g of Radix Ginseng, 9g of Herba Mori Parasitici, 4g of Fructus Schisandrae Chinensis, 6g of Rhizoma Gastrodiae, 4g of Fructus Evodiae (Processed), 7g each of Cinnamon Twig and Radix Saposhnikoviae, 20g of Radix Salviae Miltiorrhizae, 9g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, and Radix Paeoniae Rubra, 12g of Cortex Moutan, 9g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizoma, and Radix Glycyrrhizae Preparata. Add water to the Chinese medicinal materials in the formula so that they are submerged by 2-3 cm, soak for 30 minutes, boil over high heat, and then simmer for 20 minutes over low heat. Pour out the filtrate, add water and simmer for 20 minutes. After mixing the two filtrates, concentrate to 200ml to obtain Chinese medicine decoction 1 of the present invention. Example 2

[0037] Respectively weigh 20g of Radix Ginseng, 15g of Herba Mori Parasitici, 6g of Fructus Schisandrae Chinensis, 9g of Rhizoma Gastrodiae, 3g of Fructus Evodiae (Processed), 6g each of Ramulus Cinnamomi and Radix Saposhnikoviae, 10g of Radix Salviae Miltiorrhizae, 6g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, and Radix Paeoniae Rubra, 8g of Cortex Moutan, 6g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizoma, and Radix Glycyrrhizae Preparata. Add water to the Chinese medicinal materials of the formula quantity so as to cover 2-3 centimeters of the Chinese medicinal materials, soak for 30 minutes, boil over high heat, and then simmer for 20 minutes with slow fire. Pour out the filtrate, add water and simmer for 20 minutes. After mixing the two filtrates, concentrate to 200ml to obtain Chinese medicine decoction 2 of the present invention. Example 3

[0038] Respectively weigh 15g of Radix Ginseng, 12g of Herba Mori Parasitici, 5g of Fructus Schisandrae Chinensis, 8g of Rhizoma Gastrodiae, 3g of Fructus Evodiae (Processed), 6g each of Cinnamon Twig and Radix Saposhnikoviae, 20g of Radix Salviae Miltiorrhizae, 9g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, and Radix Paeoniae Rubra, 12g of Cortex Moutan, 8g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizoma, and Radix Glycyrrhizae Preparata. The Chinese medicinal materials of the formula amount are added with water so as to cover 2-3 centimeters of the Chinese medicinal materials, soaked for 30 minutes, boiled over high heat, and then decocted over low heat for 20 minutes. The filtrate is poured out, and then decocted with water for 20 minutes. The two filtrates are mixed and concentrated to 200ml to obtain Chinese medicine decoction 3 of the present invention. Example 4

[0039] Weigh 10g of Radix Ginseng, 9g of Herba Mori Parasitici, 4g of Fructus Schisandrae Chinensis, 6g of Rhizoma Gastrodiae, 4.5g of Fructus Evodiae (Processed), 9g each of Ramulus Cinnamomi and Radix Saposhnikoviae, 20g of Radix Salviae Miltiorrhizae, 9g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, and Radix Paeoniae Rubra, 12g of Cortex Moutan, 6g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizoma, and Radix Glycyrrhizae Preparata. Add water to the Chinese medicinal materials of the formula so that they are submerged by 2-3 cm, soak for 30 minutes, boil over high heat, and then simmer for 20 minutes over low heat. Pour out the filtrate, add water and simmer for 20 minutes. After the two filtrates are mixed, concentrate to 200ml to obtain Chinese medicine decoction 4 of the present invention. Example 5

[0040] Weigh respectively 15g of Radix Ginseng, 12g of Herba Mori Parasitici, 5g of Fructus Schisandrae Chinensis, 8g of Rhizoma Gastrodiae, 4g of Fructus Evodiae (Processed), 8g each of Ramulus Cinnamomi and Radix Saposhnikoviae, 15g of Radix Salviae Miltiorrhizae, 8g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, and Radix Paeoniae Rubra, 10g of Cortex Moutan, 8g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizomae Preparata, and Radix Glycyrrhizae Preparata. Add water to the Chinese medicinal materials of the formula quantity so as not to exceed 2-3 centimeters of the Chinese medicinal materials, soak for 30 minutes, boil over high heat, then simmer for 20 minutes with slow fire, pour out the filtrate, add water and simmer for 20 minutes, and concentrate to 200ml after mixing the two filtrates to obtain Chinese medicine preparation decoction 5 of the present invention.

[0041] Clinical study on the treatment of viral pneumonia with the traditional Chinese medicine preparation of the present invention 1. Materials and Methods (1) General Data A total of 120 patients with viral pneumonia admitted to the Hebei University of Economics and Trade Hospital between November 1, 2022, and May 1, 2025, were randomly assigned to two groups, with 60 patients in each group. There were 66 males and 54 females. There was no statistically significant difference in age, onset time, and other aspects between the two groups, indicating that they were comparable. See Table 1 for details.

[0042] Table 1 Comparison of age and onset time before treatment between the two groups of patients (x±s) Note: There was no statistically significant difference in age and onset time before treatment between the two groups of patients ( P >0.05) (2) Inclusion criteria ① Refer to the diagnostic criteria for viral pneumonia in Practical Internal Medicine, with onset less than 72 hours, age greater than 18 years, and regardless of gender; ② Lung CT shows bilateral, multilobar interstitial infiltration, ground-glass opacity, and possibly consolidation; ③ I am aware of the specific diagnosis and treatment plan and sign an informed consent form; ④ Assess the specific circumstances of the enrolled patients, and ensure they have a certain level of reading comprehension and appropriate verbal communication skills, good compliance, taking medication or examinations as required, and being able to cooperate with this treatment plan.

[0043] (3) Exclusion criteria ① Patients with other lung diseases such as tuberculosis, pleural effusion, malignant tumors and other organic diseases; ② Patients with chronic respiratory diseases; ③ Patients with dysfunction of important organs such as heart, brain, liver, and kidney, as well as serious chronic diseases such as autoimmune diseases; ④ Patients with a history of allergy to the above-mentioned drugs; ⑤ Patients with senile dementia, mental disorders, cognitive or communication disorders; ⑥ Patients who have used antiviral Western medicine or glucocorticoids, immunosuppressants in the past month, etc.

[0044] (4) Treatment methods Patients in the control group received oral oseltamivir phosphate capsules (National Medicine Approval No. H20044397, ** Pharmaceutical Co., Ltd.), 75 mg twice daily for 7 consecutive days, in addition to conventional treatments for fever reduction, cough and phlegm relief, and complication prevention. The observation group received the Fuzheng Tongluo Qudu prescription of the present invention (with antipyretics administered as needed). The ingredients include: 15g ginseng, 12g parasitic loquat, 5g schisandra chinensis, 8g gastrodia elata, 4g processed evodia rutaecarpa, 8g each of cinnamon twig and saposhnikovia root, 15g salvia miltiorrhiza, 8g each of angelica root, ligusticum chuanxiong, and red peony root, 10g moutan bark, 8g tangerine peel, 8g pinellia tuber, and 8g roasted liquorice root. One dose of the decoction was taken daily, divided into two doses, for a course of 7 days.

[0045] (5) Observation indicators ① Time required for clinical symptom relief: Mainly observe the time required for fever and cough symptoms to be relieved.

[0046] ② Inflammatory indicators: After one week of treatment, 5 mL of venous blood samples were collected from both groups of patients, and C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), serum amyloid protein (SAA), and interleukin-6 (IL-6) were measured by chemiluminescence method using kits (Shenzhen New Industry Biomedical Engineering Co., Ltd.).

[0047] ③ Clinical efficacy criteria: After one week of treatment, if the patient's body temperature returns to normal, symptoms such as cough, chest tightness and shortness of breath disappear, and lung CT shows complete absorption of lung lesions, it is clinically cured; if the patient's body temperature is basically normal, symptoms such as cough, chest tightness and shortness of breath are significantly improved, and lung CT shows that most of the lung lesions are absorbed, it is considered a marked effect. If the patient's fever is reduced, symptoms such as cough, chest tightness and shortness of breath improve, and lung CT shows that the lung lesions are partially absorbed, it is considered an improvement; if the patient's fever, cough, chest tightness and shortness of breath do not improve, and lung CT shows that the lung lesions do not change or worsen, it is considered an ineffective treatment.

[0048] (6) Statistical methods Data were collated and statistically analyzed using R (version 4.5.0). Continuous data were first subjected to the Shapiro-Wilk normality test. If normal distribution was satisfied, the t-test was used; if not, the Wilcoxon rank-sum test was used. Enumeration data were analyzed using the chi-square test based on theoretical frequency and sample size. Two-sided or one-sided tests were used depending on the study objectives. P < 0.05 was considered statistically significant.

[0049] 2. Treatment Results (1) Comparison of fever and cough symptom relief time The average time for symptoms such as fever and cough to be relieved in the observation group was shorter than that in the control group, and the difference was statistically significant ( P <0.05), see Table 2 for details.

[0050] Table 2 Comparison of clinical symptom relief time between the two groups

[0051]

[0052] Note: Compared with the control group, △ P <0.05. (2) Comparison of clinical efficacy between the two groups of patients Comparing the clinical efficacy of the two groups of patients, the total effective rate of the observation group was 96.67% (58 / 60), which was higher than 83.33% (50 / 60) of the control group, with statistical significance ( P <0.05), see Table 3 for details. Figures 1 to 8 These are any 8 cases out of 60 cases in the observation group. Lung CT of these cases shows that the lung lesions of these cases were significantly absorbed after taking the Chinese medicinal preparation of the present invention.

[0053] Table 3 Comparison of clinical treatment effects between the two groups of patients [cases (%)]

[0054] Note: Compared with the control group, △P<0.05.

[0055] (3) Comparison of inflammatory factor indicators There was no statistically significant difference in serum CRP, TNF-α, SAA and IL-6 between the two groups before treatment ( P >0.05). Compared with before treatment, serum CRP, TNF-α, SAA and IL-6 in both groups decreased after 7 days of treatment. After treatment, serum CRP, TNF-α, SAA and IL-6 in the observation group were lower than those in the control group, and the difference was statistically significant ( P <0.05). See Table 4 and Table 5 for details. Table 4 Comparison of inflammatory factor indicators between the two groups of patients before and after treatment

[0056]

[0057] Table 5 Comparison of inflammatory factor indicators between the two groups of patients before and after treatment

[0058]

[0059] Note: Compared with the group before treatment, *P < 0.05; compared with the control group after treatment, △P < 0.05.

[0060] The results of this study showed that the clinical efficacy of this Chinese medicine preparation in treating patients with viral pneumonia was superior to that of the control group, and no significant adverse reactions were found during the treatment process. After taking the Chinese medicine of this invention, the inflammatory response of patients with viral pneumonia was rapidly reduced, fever was quickly reduced, and symptoms such as cough and chest tightness were quickly improved.

Claims

1. A Chinese medicine preparation for treating viral pneumonia, characterized in that: The Chinese medicine preparation is calculated by weight as follows: 10-20 parts of ginseng, 9-15 parts of mistletoe, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cinnamon twig, 6-9 parts of siler, 3-4.5 parts of processed evodia rutaecarpa, 10-20 parts of salvia miltiorrhiza, 8-12 parts of moutan bark, 6-9 parts of red peony root, 6-9 parts of dried tangerine peel, 6-9 parts of pinellia ternata, and 6-9 parts of roasted liquorice.

2. The Chinese medicine preparation for treating viral pneumonia according to claim 1, wherein: The traditional Chinese medicine preparation further comprises the following components in parts by weight: 6 to 9 parts of angelica sinensis and 6 to 9 parts of ligusticum chuanxiong.

3. The Chinese medicine preparation for treating viral pneumonia according to claim 2, wherein: The Chinese medicine preparation is calculated by weight as follows: 12-18 parts of ginseng, 10-14 parts of mistletoe, 4-6 parts of schisandra chinensis, 7-9 parts of gastrodia elata, 7-9 parts of cinnamon twig, 7-9 parts of siler, 3.5-4.5 parts of processed evodia rutaecarpa, 12-18 parts of salvia miltiorrhiza, 7-9 parts of angelica sinensis, 7-9 parts of ligusticum chuanxiong, 9-11 parts of moutan bark, 7-9 parts of red peony root, 7-9 parts of dried tangerine peel, 7-9 parts of pinellia ternata, and 7-9 parts of roasted liquorice.

4. The Chinese medicine preparation for treating viral pneumonia according to claim 2, characterized in that: The Chinese medicine preparation is calculated by weight as follows: 15 parts of ginseng, 12 parts of mistletoe, 5 parts of schisandra chinensis, 8 parts of gastrodia elata, 8 parts of cinnamon twigs, 8 parts of siler, 4 parts of processed evodia rutaecarpa, 15 parts of salvia miltiorrhiza, 10 parts of moutan bark, 8 parts of red peony root, 8 parts of angelica sinensis, 8 parts of ligusticum chuanxiong, 8 parts of dried tangerine peel, 8 parts of pinellia tuber, and 8 parts of prepared liquorice.

5. A decoction of a traditional Chinese medicine preparation for treating viral pneumonia according to any one of claims 1 to 4, characterized in that: Add water to the formulated amount of Chinese medicinal materials to cover them by 2-3 cm, soak for 30 minutes, boil over high heat, then simmer for 20 minutes over low heat, pour out the filtrate, add water and simmer for another 20 minutes, mix the two filtrates and concentrate to 200 ml to obtain a decoction of the Chinese medicinal preparation.

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