Traditional Chinese medicine composition for treating cervical insomnia

Abstract

The embodiment of the invention provides a traditional Chinese medicine composition for treating cervical insomnia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 g of raw astragalus membranaceus, 15 g of peach kernels, 12 g of ligusticum wallichii, 15 g of rhizoma sparganii, 9 g of earthworms, 12 g of radix puerariae, 9 g of rhizoma drynariae, 15 g of acorus calamus, 15 g of polygala tenuifolia and 15 g of poria cocos. The prescription medicine can effectively improve secondary insomnia caused by cervical degenerative change, and is good in safety.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition based on the theory of dredging the governor vessel, removing blood stasis and tonifying qi and tranquilizing the mind, which is suitable for treating secondary insomnia caused by cervical spondylosis, and has a synergistic improvement effect on dizziness, blurred vision, chest tightness, palpitation, stiff neck, and low back pain caused by cervical spondylosis. BACKGROUND

[0002] In the theory of traditional Chinese medicine, insomnia belongs to the category of "not sleeping"; the pathogenesis of secondary insomnia caused by cervical spondylosis is mainly attributed to "disorder of the governor vessel". In the current clinical practice of Western medicine and traditional Chinese medicine, there is a tendency of "emphasizing sleep and ignoring cervical spondylosis". Although existing traditional Chinese medicine solutions such as Anshen Buxin Pills and Suanzaoren Decoction can improve sleep, they lack specificity in addressing symptoms such as dizziness, blurred vision, chest tightness, palpitation, stiff neck, and low back pain caused by cervical spondylosis, and have few blood-activating and meridian-unblocking ingredients, making it difficult to treat both the symptoms and the root cause. Western medicine often uses benzodiazepine drugs such as alprazolam to relieve insomnia symptoms, but these drugs cannot address the root cause of the disease, i.e., cervical spondylosis, and have side effects such as dependence, next-day drowsiness, and rebound effects after drug withdrawal. BACKGROUND SUMMARY

[0003] The present application provides a traditional Chinese medicine composition for treating cervical insomnia, which is composed of 30 parts of raw astragalus, 15 parts of peach kernel, 12 parts of Szechuan lovage root, 15 parts of rhizoma polygonati, 9 parts of bone glue, 12 parts of kudzu root, 9 parts of drynaria, 15 parts of pinellia, 15 parts of milkwort root, and 15 parts of poria.

[0004] In one possible solution, the traditional Chinese medicine composition further includes 10 parts of cassia twig and 12 parts of angelica to enhance the effect of warming the meridians and unblocking yang.

[0005] In one possible solution, the traditional Chinese medicine composition further includes 15 parts of Suanzaoren and 13 parts of white atractylodes to strengthen the effect of tranquilizing the mind and tonifying the spleen.

[0006] In one possible solution, the traditional Chinese medicine composition further includes 6 parts of licorice to harmonize the various drugs and relieve gastrointestinal irritation.

[0007] In one possible solution, the dosage form of the traditional Chinese medicine composition is granules, capsules, or plaster.

[0008] The composition uses the principle of "dredging the governor vessel, removing blood stasis, tonifying qi, and tranquilizing the mind": raw astragalus is the main drug, which tonifies qi and raises yang to improve the circulation of qi and blood in the governor vessel; peach kernel, Szechuan lovage root, and earthworms activate blood and remove blood stasis to address meridian obstruction caused by cervical spondylosis; kudzu root and drynaria lead the drug upward to repair damage to the governor vessel; pinellia and milkwort root open the orifices, calm the mind, regulate central nervous system neurotransmitters (such as 5-HT and GABA), and reduce the ISI score.​ DETAILED DESCRIPTION

[0009] In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0010] The technical solutions of the present application will be described in detail below with specific embodiments. The following specific embodiments can be combined with each other, and some embodiments can not be described again for the same or similar concepts or processes.

[0011] In order to better illustrate the technical solutions, the traditional Chinese medicinal ingredients are explained as follows:

[0012] Core prescription traditional Chinese medicinal ingredients

[0013] 1. Radix Astragali seu Hedysel

[0014] Source: Dried roots of Astragalus membranaceus (Fisch.) Bunge or Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Regel) Hsiao, preferably with long and thick strips and yellowish white cross section.

[0015] Nature, taste and meridian entry: sweet, slightly warm; enters the spleen and lung meridians.

[0016] Function: Tonifying Qi and raising Yang, consolidating the exterior and stopping sweating, promoting water and eliminating swelling, and promoting toxin discharge and tissue regeneration.

[0017] Modern research: Contains astragalus polysaccharides, saponins, etc., which can enhance immunity, anti-fatigue and improve myocardial blood supply.

[0018] Function in the prescription: As the monarch herb, it tonifies Qi to unblock the meridians and blood vessels, and improves the cervical spondylosis.

[0019] 2. Semen Persicae

[0020] Source: Dried mature seeds of Prunus persica (L.) Batsch or Prunus davidiana (Carie) Franch.

[0021] Nature, taste and meridian entry: bitter and sweet, neutral; enters the heart, liver and large intestine meridians.

[0022] Function: Activating blood and removing stasis, moistening the intestines and promoting defecation, relieving cough and asthma.

[0023] Modern research: Contains amygdalin and flavonoids, which have anti-coagulation and anti-inflammatory effects, and can improve blood stasis type insomnia.

[0024] 3. Rhizoma Chuanxiong

[0025] Source: Dried rhizomes of Chuanxiong Rhizoma.

[0026] Flavor-meridians: pungent, warm; liver, gallbladder, pericardium.

[0027] Function: Activating blood and qi, dispelling wind and relieving pain.

[0028] Modern research: Contains ligustrazine, can dilate blood vessels, improve cerebral circulation, relieve neck straight and headache.

[0029] 4. Three needles

[0030] Source: Dry tuber of black three collenchyma plant.

[0031] Flavor-meridians: bitter, bitter, flat; liver, spleen.

[0032] Function: Breaking blood and qi, eliminating accumulation and relieving pain.

[0033] Modern research: Inhibit platelet aggregation, for qi stagnation and blood stasis type of cervical spondylosis and insomnia.

[0034] 5. Earthworm

[0035] Source: Dry body of giant earthworm animal ring hairworm.

[0036] Flavor-meridians: salty, cold; liver, spleen, bladder.

[0037] Function: Clearing heat and calming, dredging collaterals and relieving asthma, diuresis.

[0038] Modern research: Contains eel kinase, can dissolve thrombus, improve cerebral ischemia caused by insomnia.

[0039] Auxiliary components of traditional Chinese medicine

[0040] 6. Kudzu root

[0041] Source: Dry root of wild kudzu of legume.

[0042] Flavor-meridians: sweet, pungent, cool; spleen, stomach.

[0043] Function: Resolving muscle fever, relieving thirst, ascending yang and stopping diarrhea.

[0044] Modern research: Puerarin can dilate coronary artery and relieve neck pain.

[0045] 7. Bone broken

[0046] Source: Dry rhizome of Drynaria fortunei of Drynaria fortunei.

[0047] Flavor-meridians: bitter, warm; liver, kidney.

[0048] Function: Tonifying kidney and strengthening bone, continuing injury and relieving pain.

[0049] Modern research: Promote bone repair, improve back pain and osteoporosis.

[0050] 8. Calamus

[0051] Source: Dried rhizome of Acorus calamus, a plant of the Araceae family.

[0052] Nature and flavor: pungent, bitter, warm; enters the heart and stomach meridians.

[0053] Function: Opens the orifices and eliminates phlegm, calms the mind and improves intelligence, eliminates dampness and harmonizes the stomach.

[0054] Modern research: Regulates central neurotransmitters (such as 5-HT) and relieves anxiety-related insomnia.

[0055] 9. Polygala tenuifolia

[0056] Source: Dried roots of Polygala tenuifolia, a plant of the Polygalaceae family.

[0057] Nature and flavor: bitter, pungent, warm; enters the heart, kidney and lung meridians.

[0058] Function: Soothes the mind and improves intelligence, eliminates phlegm and reduces swelling, and connects the heart and kidneys.

[0059] Modern research: Contains Polygala tenuifolia saponins, which enhance memory and sleep quality.

[0060] 10. Poria cocos

[0061] Source: Dried sclerotia of the Polyporaceae fungus Poria cocos.

[0062] Nature and flavor: sweet, light, neutral; enters the heart, lung, spleen and kidney meridians.

[0063] Function: Diuresis and dampness removal, spleen strengthening and mind calming.

[0064] Modern research: Poria polysaccharide regulates immunity and improves spleen deficiency-type indigestion and insomnia.

[0065] Complementary medicine

[0066] 11. Cassia twig

[0067] Source: Young branches of cinnamon bark, a plant of the Lauraceae family.

[0068] Nature and flavor: Pungent, sweet, warming; enters the Heart, Lung, and Bladder meridians. Function: Warms the meridians and promotes Yang, induces sweating and relaxes muscles, and calms and relieves adverse reactions.

[0069] Modern research: Improves microcirculation and relieves cold hands and feet.

[0070] 12. Angelica

[0071] Source: Dried root of Angelica sinensis, a plant of the Umbelliferae family.

[0072] Nature and flavor: sweet, pungent, warm; enters the liver, heart and spleen meridians.

[0073] Function: Nourishes blood and promotes blood circulation, regulates menstruation and relieves pain, moistens the intestines and promotes bowel movements.

[0074] Modern research: Anti-platelet aggregation, promotes the circulation of Qi and blood in the Du channel.

[0075] 13. Source of sour jujube kernels: dried seeds of the sour jujube plant of the Rhamnaceae family.

[0076] Nature and flavor: sweet, sour, neutral; enters the liver, gallbladder and heart meridians.

[0077] Function: Nourishes the heart and liver, calms the mind and soothes the nerves, reduces sweat and promotes salivation.

[0078] Modern research: Contains saponins and flavonoids, which prolong slow-wave sleep time.

[0079] 14. Atractylodes macrocephala

[0080] Source: Dried rhizome of Atractylodes macrocephala, a plant of the Asteraceae family.

[0081] Nature and flavor: bitter, sweet, warm; enters the spleen and stomach meridians.

[0082] Function: Strengthens the spleen and replenishes Qi, dries dampness and promotes diuresis, stops sweating and stabilizes pregnancy.

[0083] Modern research: Enhances intestinal absorption function and improves spleen deficiency type diarrhea.

[0084] 15. Licorice

[0085] Source: Dried root of licorice, a plant of the legume family.

[0086] Nature and flavor: sweet, neutral; enters the heart, lung, spleen and stomach meridians.

[0087] Function: Nourishes the spleen and replenishes Qi, clears away heat and detoxifies, and harmonizes various medicines.

[0088] Modern research: Glycyrrhizic acid is anti-inflammatory and anti-allergic, and reduces drug toxicity.

[0089] Example 1 (basic prescription):

[0090] Weigh 30 parts of raw astragalus, 15 parts of peach kernel, 12 parts of Chuanxiong, 15 parts of Trigonosciadium japonicum, 9 parts of earthworm, 12 parts of Pueraria root, 9 parts of Drynaria rhizome, 15 parts of Acorus calamus, 15 parts of Polygala tenuifolia, and 15 parts of Poria by weight, add water and decoct for 3 times, combine the filtrates and concentrate them into an extract to prepare granules.

[0091] Example 2 (supplementary medicine):

[0092] On the basis of Example 1, 10 parts of cinnamon twigs and 12 parts of angelica sinensis were added, and ultrafine grinding technology was used to prepare capsules to improve bioavailability.

[0093] Example 3 (supplementary medicine):

[0094] On the basis of embodiment 2, add 15 parts of jujube kernel and 13 parts of white atractylodes, and after decocting with water, combine the filtrates and concentrate to extract to make a plaster.

[0095] Clinical trial data:

[0096] Patients with cervical insomnia (insomnia of the Du meridian) were randomly divided into treatment and control groups, 48 cases in each. The treatment group was given Tongdu Decoction, 1 dose per day; the control group was given alprazolam tablets, 0.4 mg each time, taken once before sleep. Both groups were treated for 4 weeks. The insomnia severity index (ISI) score, Pittsburgh Sleep Quality Index (PSQI) score, sleep state rating scale (SRSS) score, and TCM symptom scores of the two groups before and after treatment were compared. Results The ISI, PSQI, SRSS scores and symptom scores of the two groups after treatment were significantly lower than those before treatment (P<0.01), and the ISI, PSQI, SRSS scores and symptom scores of the treatment group after treatment were significantly lower than those of the control group (P<0.01).

[0097] In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "example", "specific example" or "some examples" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, the skilled in the art can combine and combine the different embodiments or examples described in the present specification and the features of the different embodiments or examples without contradiction.

[0098] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement to part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A Chinese medicine composition for treating cervicogenic insomnia, characterized in that: The medicine consists of 30 parts of raw astragalus, 15 parts of peach kernel, 12 parts of chuanxiong, 15 parts of trigonosciadium japonicum, 9 parts of earthworm, 12 parts of kudzu root, 9 parts of drynaria, 15 parts of calamus, 15 parts of polygala tenuifolia and 15 parts of poria.

2. The Chinese medicine composition according to claim 1, characterized in that It also includes 10 parts of cassia twigs and 12 parts of angelica sinensis.

3. The Chinese medicine composition according to claim 2, characterized in that It also includes 15 parts of Chinese date seeds and 13 parts of white atractylodes.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that Its dosage form is granules, capsules or plasters.