Preparation method of essence and fragrance oil microcapsule process and application thereof

Abstract

The application provides a preparation method of a flavoring oil microcapsule process and application thereof, and belongs to the field of medical, dental or cosmetic preparations.The core material and the package material; the core material comprises basil oil, melaleuca alternifolia oil, myrrh oil, natural copaiba oil and kaempferia galanga oil; the package material comprises a main package material and cholesterol; and the main package material is lecithin or hydrogenated lecithin.The application uses natural essential oil as the core material, lecithin or sodium alginate as the wall material, and a special preparation process to prepare a microcapsule composition which has a natural antibacterial effect in addition to a long-lasting fragrance, and can be added to various washing and protecting products, so as to increase the pleasure of consumers and balance the skin microecology.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of medical, dental or cosmetic formulations, and in particular to a process for the preparation of microcapsules of essential oils and its application. BACKGROUND

[0002] With the popularization of health concepts, the personal care market is undergoing a transformation from "basic functions" to "multi-functional integration". Consumers' demand for skincare products has gone beyond basic functions such as cleansing and moisturizing, and they now seek sensory experience, safety attributes, and added value. In this context, washing and caring products with long-lasting fragrance and natural antibacterial function have become the new favorite of the market, and the introduction of microcapsule technology has provided a key solution to this demand.

[0003] Natural essential oils, as volatile aromatic substances produced by plant metabolism, are ideal core materials for achieving "fragrance-antibacterial" dual functions. They are rich in variety and function, and can be divided into the following categories according to the main active ingredients and application scenarios:

[0004] Antibacterial essential oils: represented by tea tree oil, thyme oil, and cinnamon oil. Tea tree oil is derived from Australian tea tree leaves and rich in terpene-4-ol (content up to 30%-40%), which has strong inhibitory effect on Staphylococcus aureus, Escherichia coli and other Gram-positive and negative bacteria, and also has significant activity against fungi (such as Malassezia). It is a commonly used ingredient in scalp care products to reduce dandruff. Thyme oil contains thymol (50%-60%), which has broad-spectrum antibacterial ability, especially for rapid killing of skin pathogenic bacteria. Cinnamon oil contains cinnamaldehyde, which can destroy the integrity of bacterial cell membranes, with an inhibition rate of more than 95%, and has lower irritation than chemical synthetic antibacterial agents.

[0005] Relaxing fragrance essential oils: including lavender oil, rose oil, and chamomile oil. Lavender oil contains linalool and linalyl acetate, which not only has a soothing smell, but also can relieve anxiety by regulating neurotransmitters. The linalyl alcohol contained in it has a mild anti-inflammatory effect on the skin. Rose oil contains mainly geraniol and citronellol, with a long-lasting and sweet fragrance, and has the functions of moisturizing and repairing the skin barrier. The blue camphene in chamomile oil has a calming effect and can reduce the discomfort caused by skin sensitivity.

[0006] Fresh conditioning essential oils: such as lemon oil, sweet orange oil, and peppermint oil. Lemon oil is rich in limonene (more than 80%), with a refreshing and invigorating smell, and has certain antioxidant and antibacterial activity. Sweet orange oil contains a large amount of decanal and octanal, with a sweet and mild fragrance, suitable for mass consumption scenarios. Peppermint oil contains menthol, which can bring a cooling sensation and inhibit microorganisms on the skin surface, commonly used in summer washing and caring products.

[0007] However, the application of natural essential oils has significant bottlenecks: on the one hand, they are highly volatile, have poor chemical stability, and are easily degraded in the presence of light, high temperature, or oxygen, resulting in a short fragrance retention time (usually only a few hours in personal care products); on the other hand, direct contact with the skin at high concentrations can cause irritation, and they have poor compatibility with surfactants, preservatives, and other ingredients in personal care products, leading to unstable systems. These problems greatly limit the efficient application of essential oils in the personal care field.

[0008] Microcapsule technology, as a new encapsulation technology, effectively solves the above problems by encapsulating core materials (such as essential oils) in microcontainers formed by wall materials. The type and performance of the microcapsule wall material, as the core carrier, directly determine the encapsulation rate, slow-release effect, stability, and biocompatibility of the microcapsule. Currently, commonly used microcapsule wall materials can be divided into the following categories:

[0009] Natural polymer wall materials: These wall materials are derived from natural substances and have the advantages of good biocompatibility, biodegradability, and high safety, making them the first choice in the skin care field; for example:

[0010] Sodium alginate: a natural polysaccharide extracted from brown algae, containing a large number of carboxyl groups that can cross-link with metal ions such as calcium ions to form a gel network, with excellent film-forming properties and good biodegradability, making it suitable as a slow-release wall material that can control the release rate of the core material by adjusting the cross-linking degree.

[0011] Lecithin: a phospholipid substance extracted from soybeans or egg yolks, with an amphiphilic structure, making it an excellent emulsifier and able to form a liposome membrane structure, enhancing the affinity of the microcapsule with the skin, and often used to improve the skin permeability of the core material.

[0012] Chitosan: a natural cationic polysaccharide from animal shells, with broad-spectrum antibacterial properties (it can inhibit bacterial growth) and biological adhesion, and when combined with sodium alginate, it can form a polyelectrolyte complex, further enhancing the stability and functionality of the microcapsule.

[0013] Gelatin and gum arabic: gelatin is derived from animal collagen and has good film-forming properties; gum arabic is secreted from acacia trees and has excellent emulsifying properties. Both are often prepared into microcapsules through complex coacervation and are suitable for scenarios with high encapsulation rate requirements.

[0014] Synthetic polymer wall materials: These wall materials are obtained through chemical synthesis and have the characteristics of strong controllability and high mechanical strength, making them suitable for scenarios with strict stability requirements.

[0015] Polyethylene glycol (PEG): a water-soluble polymer with good biocompatibility, which can control the hydrophilicity and degradation rate of the wall material by adjusting the molecular weight, and is often used to improve the dispersibility of microcapsules in water-based systems (such as shampoo).

[0016] Polylactic acid (PLA): biodegradable synthetic polyester, high mechanical strength, good temperature resistance, suitable for long-term sustained release scenarios, but relatively high cost.

[0017] Polymethyl methacrylate (PMMA): strong film-forming property, excellent chemical stability, but poor biodegradability, mostly used in industrial fields, less used in skincare products.

[0018] Inorganic wall material: such as silicon dioxide, calcium carbonate, etc., with good thermal stability and mechanical strength, but limited biocompatibility, usually used as auxiliary wall material in personal care products to improve the structural stability of microcapsules. SUMMARY

[0019] The purpose of the present application is to provide a fragrance and essential oil microcapsule process preparation method and its application, which achieves good antibacterial effect by different essential oil combinations. A fragrance microcapsule, comprising a core material and a coating material;

[0020] The mass ratio of the core material and the coating material is 3-4:6-7;

[0021] The core material comprises the following ingredients by mass fraction:

[0022]

[0023] The basil oil is at least one of sweet basil oil, clove basil oil, and sacred basil oil.

[0024] Preferably, the coating material comprises a main coating material and cholesterol; the main coating material is lecithin or hydrogenated lecithin.

[0025] Preferably, the mass ratio of the main coating material and cholesterol is 6-7:3-4; the main coating material is hydrogenated lecithin.

[0026] Preferably, the core material further comprises a fat-soluble antioxidant; the mass fraction is 0.2-0.5 parts. The fat-soluble antioxidant comprises at least one of vitamin E and its derivatives, carotenoids, and vitamin C palmitate.

[0027] Preferably, the natural green kainite oil is natural green kainite oil.

[0028] Another purpose of the present application is to provide a preparation method of the aforementioned fragrance microcapsule, comprising the following steps:

[0029] S1: Dissolve the coating material and the core material in anhydrous ethanol and rotary evaporate to obtain a lipid film;

[0030] S2: Prepare PBS buffer, preheat, then pour into the lipid film, constant temperature stirring to obtain liposomes;

[0031] S3: the liposome is broken and then purified; and a fragrance microcapsule is obtained.

[0032] Preferably, in the step S1, the water bath temperature of the rotary evaporation is ≤40℃, and the vacuum degree is ≤-0.09Mpa;

[0033] In the step S2, the PBS buffer is preheated to 50±0.5℃,

[0034] In the step S3, the liposome is broken by ultrasonic waves, and an ice water bath is used to keep the temperature of the liposome ≤25℃ during the breaking; and the purification is centrifugation or chromatography separation of the liposome after the ultrasonic treatment, taking the liposome component, sterilizing the liposome, and obtaining the fragrance microcapsule.

[0035] A third object of the present application is to provide the use of the aforementioned fragrance microcapsule in the preparation of cosmetics, including but not limited to serum, cream, emulsion, lyophilized powder and other dosage forms.

[0036] The core material of the present application is selected from various essential oils, which have been confirmed in existing research to have antibacterial or anti-inflammatory activity, providing a theoretical basis for functional realization.

[0037] Basil oil (sweet basil, clove basil, etc.) contains eugenol, linalool, etc. Although the components and effects of basil oil vary slightly depending on the variety, they are mainly composed of terpenes and phenols. Basil oil has inhibitory effects on both gram-positive and gram-negative bacteria. However, the present application found that the anti-inflammatory effect of tropical basil is not obvious, so this variety is not used in the present application.

[0038] Murraya alternifolia oil (tea tree oil) is an internationally recognized natural antibacterial agent, and its components and effects have clear research support. It contains terpinen-4-ol as the core active ingredient, as well as γ-terpinene, 1,8-cineole, and eucalyptol. Terpinen-4-ol is the main antibacterial component, which targets bacterial cell membranes (changes membrane fluidity and permeability), inhibits bacterial DNA synthesis, and has strong inhibitory effects on various pathogenic bacteria and fungi. It is still active against drug-resistant bacteria and does not easily induce bacterial drug resistance. In addition, it can reduce neutrophil infiltration at the inflammation site and inhibit the release of inflammatory mediators (such as leukotriene B4), thereby relieving the redness and itching of skin inflammation (such as acne and eczema).

[0039] Guggul oil is derived from guggul resin and is mainly composed of sesquiterpenes and phenols. It is traditionally used for anti-inflammatory and wound healing. It is mainly composed of guggulene, elemene, eugenol, guggulol, and oleanolic acid. Guggulene exerts an antifungal effect by damaging fungal cell membranes. Eugenol helps to inhibit bacterial growth, and oleanolic acid can inhibit the excessive activation of macrophages and reduce the release of inflammatory factors (IL-1, TNF-α). Guggulol can inhibit the activity of lipoxygenase, block the inflammation pathway, and relieve chronic inflammation.

[0040] Grape kernel oil is a by-product of wine distillation or obtained by steam distillation of grape tissue and microbial residues (commonly known as wine mud) in grape fermentation liquor; and since it presents yellow-green color, it is called green grape kernel oil; after distillation and refining, the green grape kernel oil is a yellow liquid, which is called white grape kernel oil. The green grape kernel oil mainly contains esters, isoamyl esters, and dill aldehyde, etc. The present application finds that single grape kernel oil does not have obvious antibacterial or anti-inflammatory effect; but when it is combined with other components of the present application, the antibacterial and anti-inflammatory effects of the combination can be obviously improved; and the synergistic effect of the green grape kernel oil is obviously greater than that of the white grape kernel oil.

[0041] The zedoary oil is derived from the rhizome of zedoary (also known as shaji), and the main components include pentadecane, ethyl cinnamate, ethyl p-methoxycinnamate, δ-cadinene, etc.; and it has both antibacterial and mild anti-inflammatory activity.

[0042] In terms of process, the present application uses liposomes (the main packaging material is lecithin or hydrogenated lecithin; cholesterol is used as an auxiliary) as the packaging material, which has multiple gains for the “antibacterial and anti-inflammatory” function:

[0043] Improve stability: essential oils (lipid-soluble) are easy to volatilize and oxidize, the bilayer structure of liposomes can wrap them inside, reducing contact with external oxygen and light; at the same time, the addition of lipid-soluble antioxidants (vitamin E, etc.) in the core material further delays oxidation and prolongs the shelf life of active ingredients.

[0044] Enhance controlled release: liposomes can slowly release essential oils through the skin, avoiding rapid loss of active ingredients and prolonging the antibacterial and anti-inflammatory effect time; and hydrogenated lecithin has higher stability than ordinary lecithin, and is more suitable for long-term controlled release scenarios.

[0045] Reduce irritation: some essential oils (such as clove basil oil) have potential skin irritation, and liposome wrapping can reduce direct contact between essential oils and the skin, reducing the risk of adverse reactions, and are more suitable for skin contact scenarios in wash and care products and skin care products. DETAILED DESCRIPTION

[0046] In order to better understand the present application, the present application will be further described below in combination with specific serial numbers, wherein the terms used in the serial numbers are used to describe specific specific embodiments, and do not constitute a limitation on the protection scope of the present application.

[0047] In the specific embodiments, the experimental methods used are conventional methods, and the materials, reagents, etc. used are commercially available unless otherwise specified.

[0048] Unless otherwise specified, the percentages, %s, etc. in the specific embodiments are mass percentages.

[0049] Some of the raw materials used in the present application are as follows:

[0050] Sweet basil oil: scientific name Ocimun basilicum CT linalol.

[0051] Cloves basil oil: scientific name Ocimun Gratissimunl L.

[0052] Holy basil oil: scientific name Ocimun sanctum.

[0053] Tropical basil oil: scientific name Ocimun basilicum CT methylchavicol.

[0054] Alternifolia oil: scientific name Melaleuca alternifolia.

[0055] Myrrh oil: scientific name Commiphora erythraea.

[0056] Natural green cognac oil: mixture of grape pomace oil and grape (Vitis Vinifera L.) leaf oil.

[0057] Natural white cognac oil: natural green cognac oil after water vapor distillation treatment.

[0058] Artificial white cognac oil: cas: 8016-21-5; Cognac Oil Artificial.

[0059] Galangal oil: scientific name Keampferia Galanga; INCI name Keampferia Galanga root extract.

[0060] German chamomile oil: scientific name Matricaria chamomilla.

[0061] Blue gum eucalyptus oil: scientific name Eucalytus globulus.

[0062] Juniper berry oil: scientific name Juniperus communis L.

[0063] Example one

[0064] Preparation of fragrance microcapsules, including the following steps:

[0065] S1: weigh each raw material core material according to Table 1 and Table 2, and reserve;

[0066] S2: weigh the coating material and the core material, and dissolve in anhydrous ethanol; the ratio of coating material, core material and anhydrous ethanol is 156-182 mg: 78-104 mg: 10 ml; specific as shown in Table 1 and Table 2;

[0067] Total lipid concentration is 20 mg / mL; lipid film liquid is obtained;

[0068] S3: The lipid film liquid is poured into a rotary evaporation flask, the water bath temperature is set to 40℃, and the rotary evaporator is started according to the following technical parameters:

[0069] Rotating speed: 120 rpm

[0070] Vacuum degree: -0.09 MPa

[0071] Time: at least 30 minutes, until a uniform lipid film is formed on the wall of the flask, and then stop.

[0072] S4: Prepare 10 ml of PBS buffer containing 0.05% ascorbic acid, and preheat to 50℃; after preheating, pour the PBS buffer into the rotary evaporation flask; manually rotate the rotary evaporation flask to remove the lipid film; then keep the temperature at 50℃ and stir at a speed of 300 rpm for 1 h;

[0073] S5: Insert the probe-type ultrasonic disruptor into the rotary evaporation flask, and perform intermittent mode ultrasonic disruption at a power of 200 W for 8 min; use an ice water bath to control the temperature ≤25℃ during disruption; obtain a liposome suspension;

[0074] S6: Transfer the liposome suspension to a centrifuge, centrifuge at 12,000 rpm and 4℃ for 30 min; discard the supernatant, and resuspend the precipitate with 5 mL of PBS; repeat twice; obtain primary microcapsules.

[0075] S7: The primary microcapsules are passed through a 0.22 μm sterile filter membrane, and then sealed and stored; obtain fragrance microcapsules.

[0076] Table 1: Ingredient ratio of fragrance microcapsule core material

[0077] Raw material (mass parts) / No. 1 2 3 4 5 Sweet basil oil 5 0 0 6 8 Cloves basil oil 0 5 0 0 0 Sacred basil oil 0 0 5 0 0 Murraya oil 3 3 3 4 4 Myrrh oil 1.0 1.0 1.0 1.5 2.0 Natural green kankan oil 2.0 2.0 2.0 2.5 3.0 Kaempferia oil 2.0 2.0 2.0 2.5 3.0 Tocopherol 0 0 0 0.1 0 Vitamin C palmitate 0 0 0 0.1 0 β-carotene 0 0 0 0 0.5 Total amount of core material (mg) 78 78 78 91 104

[0078] Table 1 (continued): Ingredient ratio of fragrance microcapsule core material

[0079] Raw material (mass parts) / No. 6 7 8 9 10 Sweet basil oil 0 5 5 5 5 Tropical basil oil 5 0 0 0 0 Murraya oil 3 3 3 3 0 Myrrh oil 1.0 1.0 1.0 0 1.0 Natural green kankan oil 2.0 0 0 2.0 2.0 Natural white kankan oil 0 2.0 0 0 0 Artificial white kankan oil 0 0 2.0 0 0 Kaempferia oil 2.0 2.0 2.0 2.0 2.0 German chamomile oil 0 0 0 1.0 0 Blue gum eucalyptus oil 0 0 0 0 3 Total amount of core material (mg) 78 78 78 78 78

[0080] Table 1 (continued 2): Ingredient ratio of fragrance microcapsule core material

[0081] Raw material (mass parts) / No. 11 12 13 14 15 Sweet basil oil 5 5 5 0 5 Murraya oil 3 0 0 3 0 Myrrh oil 1.0 0 1.0 0 1.0 Natural green kankan oil 2.0 0 0 2.0 0 Kaempferia oil 0 2.0 0 0 2.0 Juniper oil 2.0 0 0 0 0 Total amount of core material (mg) 78 78 78 78 78

[0082] The components in Table 1 are weighed according to the mass fraction, and then the specific value of the total amount of core material is taken.

[0083] Table 2: Ingredient ratio of fragrance microcapsule coating material

[0084]

[0085]

[0086] The components in Table 2 are weighed according to the mass parts, and then the specific values of the total amount of the packaging material are taken.

[0087] The performance of each fragrance microcapsule prepared in Example 1 was tested, including the following: in-vitro antibacterial test, DPPH free radical scavenging experiment, COX-2 / 5-LOX enzyme activity inhibition experiment, and sustained-release performance experiment.

[0088] In-vitro antibacterial test: The antibacterial performance was tested according to the Disinfection Technical Specification (2002 edition) item 2.2.3.2.1, and the results are shown in Table 3 below.

[0089] Since the fragrance microcapsules are solids, a 4% concentration solution was prepared with deionized water before testing.

[0090] Table 3 In-vitro antibacterial test

[0091] No. / Bacteriostatic rate (%) Escherichia coli Staphylococcus aureus Candida albicans 1 ＞99 ＞99 ＞99 2 ＞99 ＞99 ＞99 3 ＞99 ＞99 ＞99 4 ＞99 ＞99 ＞99 5 ＞99 ＞99 ＞99 6 ＞99 ＞99 ＞99 7 ＞99 ＞99 ＞99 8 ＞99 ＞99 ＞99 9 ＞99 ＞99 ＞99 10 ＞99 ＞99 ＞99 11 ＞99 ＞99 ＞99 12 ＞99 ＞99 ＞99 13 ＞99 ＞99 ＞99 14 ＞99 ＞99 ＞99 15 ＞99 ＞99 ＞99

[0092] All the fragrance microcapsules contain Melaleuca alternifolia oil, Myrrha oil, Basil oil, and Kaempferia oil, which are all natural and strong antibacterial ingredients that can significantly inhibit bacteria and fungi. Specifically, terpinen-4-ol in Melaleuca alternifolia oil can destroy microbial cell membranes; furanoeudesmane compounds in Myrrha oil inhibit the formation of Gram-positive bacterial biofilms; methyl chavicol and eugenol in Basil oil interfere with bacterial energy metabolism (except for Ocimum tenuiflorum); and methoxy flavones in Kaempferia oil target fungal cell walls. Moreover, any fragrance microcapsule with a serial number contains at least one or more essential oils with strong antibacterial activity, and the total amount of the core material in serial numbers 6-15 is consistent with serial numbers 1-3, and the concentration of the core antibacterial ingredients is not reduced. Therefore, they all exhibit the same strong antibacterial effect.

[0093] DPPH free radical scavenging experiment:

[0094] DPPH methanol solution is purple and has a strong absorbance value at 517 nm. If combined with the sample, the absorbance value at 517 nm will decrease, thereby determining the sample's ability to scavenge DPPH free radicals.

[0095] The specific method is as follows:

[0096] (1) Take the sample of Example 1, mix it with sterile water to prepare a 2% concentration of the test solution with an equal volume (2 mL) of 2×10 -4 mol / L DPPH solution (A1);

[0097] (2) Take an equal volume of anhydrous ethanol (solvent for the test substance) and 2×10 -4 mol / L DPPH solution (A2);

[0098] (3) Take equal volume of anhydrous ethanol and mix with the test liquid (A3);

[0099] (4) After 40 minutes of reaction, measure the absorbance values of A1, A2 and A3 at 517 nm.

[0100] The clearance rate calculation formula is: clearance rate (%) = [1 - (A1 - A3) / A2] x 100%

[0101] The test results are shown in Table 4.

[0102] Table 4 Antioxidant test results

[0103] No. DPPH radical scavenging rate (%) 1 86.27 2 86.33 3 87.01 4 90.34 5 92.02 6 82.13 7 84.48 8 78.16 9 83.70 10 82.98 11 82.78 12 81.23 13 80.50 14 78.37 15 77.67

[0104] As can be seen from Table 4, the antioxidant capacity of No. 6 is greatly reduced by replacing the sweet basil oil with the tropical basil oil; it is proved that the tropical basil oil has obvious difference in antioxidant capacity compared with the other three kinds of basil oils and cannot be replaced; the antioxidant capacity of No. 7 is weak by replacing the green kainite oil with the natural white kainite oil; it is proved that the antioxidant substances are reduced after distillation; the antioxidant capacity of No. 8 is not present by replacing the green kainite oil with the artificial white kainite oil. The antioxidant capacities of No. 9, No. 10 and No. 11 are different by replacing the myrrh oil with the German chamomile oil, the alternating leaf callistemon oil with the blue gum eucalyptus oil and the shanzhai oil with the montana oil, respectively; and the antioxidant capacities of No. 12, No. 13, No. 14 and No. 15 are different under the premise of equal amount compared with No. 1; it is proved that there is obvious synergistic effect between the essential oils selected in the application.

[0105] COX-2 enzyme activity inhibition experiment:

[0106] COX-2 is an inducible enzyme which is activated in the pathological process of inflammation, pain, etc., can catalyze arachidonic acid to convert into inflammatory mediators such as prostaglandin (such as PGE2), and then cause inflammation such as redness and pain. Therefore, the results of the COX-2 enzyme activity inhibition experiment can indirectly reflect the anti-inflammatory potential and analgesic potential.

[0107] The prostaglandin E2 (PGE2) ELISA indirect detection method is adopted, the inhibition rate of enzyme activity is evaluated by measuring the PGE2 produced by COX-2 catalysis; and celecoxib is used as a control; the sample concentration of No. 1-15 is 2 mg / ml; which is equal to about 0.2% w / v.

[0108] The results are shown in Table 5.

[0109] Table 5 COX-2 enzyme activity inhibition experiment results

[0110] No. [PGE2 concentration (pg / mL)] 1 478±33 2 468±31 3 454±28 4 401±29 5 366±21 6 667±35 7 543±33 8 523±36 9 501±24 10 550±34 11 503±30 12 732±45 13 628±41 14 884±52 15 523±38 Blank control 1046±42 Celecoxib 152±12

[0111] Sustained release performance test: Franz diffusion cell method was used to simulate skin release to test the sustained release performance, the cumulative release rate in 24h and the burst effect (0.5h release rate <15%); the samples of serial numbers 1-5 were measured.

[0112] Some parameters are as follows:

[0113] Diffusion area: 1.77 cm 2 (standard cell)

[0114] Receptor cell volume: 7 mL

[0115] Artificial membrane: cellulose acetate membrane (0.45 μm)

[0116] Receptor medium: pH 7.4 PBS buffer and 30% ethanol;

[0117] The results are shown in Table 6.

[0118] Table 6: Results of sustained release performance test

[0119]

[0120]

[0121] The above detailed description is a specific description of one of the possible embodiments of the present application, which is not intended to limit the patent scope of the present application, and any equivalent implementation or change without departing from the present application shall be included in the scope of the technical solutions of the present application.

Claims

1. A flavor microcapsule, characterized in that, It consists of a core material and a packaging material; The mass ratio of the core material to the packaging material is 3-4:6-7; The core material consists of the following components by weight: 5-8 parts basil oil 3-4 parts of Melaleuca alternifolia oil 1-2 parts myrrh oil 2-3 parts natural Cognac oil 2-3 parts galangal oil; The basil oil is at least one of sweet basil oil, clove basil oil, and holy basil oil; The natural Kornia oil is natural green Kornia oil; The packaging material consists of a main packaging material and cholesterol; the main packaging material is lecithin or hydrogenated lecithin. The mass ratio of the main packaging material to cholesterol is 6-7:3-4.

2. The flavor microcapsule according to claim 1, characterized in that, The main packaging material is hydrogenated lecithin.

3. The flavor microcapsule according to claim 1, characterized in that, The core material also includes a fat-soluble antioxidant, which is 0.2-0.5 parts by weight.

4. The flavor microcapsule according to claim 3, characterized in that, The fat-soluble antioxidants include at least one of vitamin E and its derivatives, carotenoids, and vitamin C palmitate.

5. The method for preparing flavor microcapsules according to any one of claims 1-4, characterized in that, Includes the following steps: S1: Dissolve the packaging material and core material in anhydrous ethanol and then rotary evaporate to obtain a lipid membrane; S2: Prepare PBS buffer, preheat it, then pour it into the lipid membrane, stir at a constant temperature to obtain liposomes; S3: The liposomes are broken down and then purified to obtain flavor microcapsules.

6. The method for preparing flavor microcapsules according to claim 5, characterized in that: In step S1, the water bath temperature for rotary evaporation is ≤40℃ and the vacuum degree is ≤-0.09Mpa; In step S2, the PBS buffer is preheated to 50±0.5℃. In step S3, the liposomes are broken down by ultrasound, and the temperature of the liposomes is kept ≤25℃ in an ice-water bath during the breaking down process; the purification involves centrifuging or separating the ultrasound-treated liposomes by chromatography, taking the liposome components, sterilizing the liposomes, and obtaining flavor microcapsules.

7. The use of the fragrance microcapsules according to any one of claims 1-4 in the preparation of cosmetics.

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