Raman image probe molecule with photothermal conversion capability and preparation and preparation method thereof

By designing a small-molecule Raman imaging probe with thiophene-coupled benzobisthiadiazole as the parent nucleus, the problem of requiring a metal substrate material in existing Raman imaging probes has been solved, realizing Raman scattering and photothermal conversion without substrate enhancement, thus improving the precision and safety of tumor treatment.

CN120887904APending Publication Date: 2025-11-04QUZHOU FUDA BIOMEDICAL INNOVATION RESEARCH INSTITUTE
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Patent Information

Application Number
CN202511004602.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-21
Publication Date
2025-11-04

AI Technical Summary

Technical Problem

Existing Raman imaging probes require the preparation of metal substrate materials, which raises concerns about biosafety and difficulty in in vivo metabolism. Furthermore, it is difficult to achieve Raman scattering signals and photothermal conversion performance without substrate enhancement.

Method used

A class of small molecule organic compound Raman imaging probes was designed, using thiophene-coupled benzobisthiadiazole as the parent core, and synthesized through Stille and Suzuki reactions. It has characteristic peaks of Raman shifts of 894 cm-1 and 1264 cm-1, and can generate strong Raman scattering signals and perform photothermal conversion in the aggregated state.

Benefits of technology

It enables in vivo Raman spectroscopy imaging and photothermal therapy without the need for surface enhancement on a metal substrate, improving the precision and safety of treatment and possessing highly efficient photothermal conversion capabilities.

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Abstract

The invention relates to a Raman image probe molecule with photothermal conversion capability and a preparation and a preparation method thereof. The Raman image probe takes thiophene coupled benzo-bis-thiadiazole as a parent nucleus, and has specific Raman shift and good photothermal conversion efficiency. In a gathering state, after being irradiated by near-infrared light (700-900 nm), the material can generate a characteristic Raman scattering signal, can convert light energy into heat energy, and has a good photothermal conversion property. The nano preparation is prepared from distearoyl phosphatidyl ethanolamine-polyethylene glycol and a derivative thereof or albumin or a polyethylene glycol block copolymer and the Raman image probe, and has Raman scattering signal and photothermal conversion performance. The prepared nano preparation can generate strong characteristic Raman scattering signals under the irradiation of near-infrared light and can convert light energy into heat energy. The nano preparation can be applied to tumor living body Raman spectrum imaging and photothermal therapy, and realizes tumor diagnosis and treatment integrated precise therapy.
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