Antiperspirant personal care compositions

Abstract

Described herein is a personal care composition comprising: a cosmetically acceptable carrier; an antiperspirant component, the antiperspirant component comprising a gluconolactone or an acid thereof; and optionally, a thickening agent. Also described herein are methods of making and using these compositions.

Description

[0001] Cross-reference to related applications

[0002] This application claims the benefit of priority to U.S. Patent Application No. 63 / 493,448, filed March 31, 2023, entitled “Personal Care Compositions,” the contents of which are incorporated herein in their entirety for all purposes. Background Technology

[0003] Personal care compositions, such as antiperspirant or deodorant compositions, can be used to reduce body odor. Antiperspirant or deodorant compositions can be applied to the armpit (underarm) area to stop or treat sweating, limit the growth of odor-causing bacteria, or apply fragrance. Antiperspirant or deodorant compositions can be delivered topically as roll-on, gel, cream, stick, or aerosol formulations.

[0004] Underarm deodorants and antiperspirants typically control odor by eliminating odor-causing bacteria. Conventional antiperspirant salts, such as aluminum and / or zirconium salts, tend to be acidic in aqueous solutions, a property that makes them effective bactericides, thus providing deodorizing benefits. Furthermore, long-lasting antiperspirant compositions often contain increased amounts of active ingredients as a means of achieving sustained effectiveness. However, skin sensitivity and vulnerability to various compounds may limit the practically maximum concentration in personal care compositions.

[0005] Aluminum salts are typically the active ingredient in antiperspirant products. In recent years, there has been increasing consumer pressure to reduce or remove aluminum salts from antiperspirant or deodorant products. However, replacing aluminum salts in antiperspirant and deodorant products while maintaining the same sweat-blocking properties that consumers value is a challenge in the personal care compositions industry. Summary of the Invention

[0006] This summary is intended only to provide a brief overview of some aspects of one or more embodiments of the present disclosure. Further areas of application of the present disclosure will become apparent from the detailed description provided below. This summary is not an exhaustive overview, nor is it intended to identify key or essential elements of the teachings, nor to define the scope of the disclosure. Rather, its purpose is solely to present one or more concepts in a simplified form as an introduction to the following detailed description.

[0007] Aspects of the present invention relate to personal care compositions, which can be in the form of deodorants and / or antiperspirants. According to one aspect of the present invention, there is provided a personal care composition comprising: a cosmetically acceptable carrier; an antiperspirant component comprising gluconolactone and / or an acid thereof; and, optionally, a thickening agent. In some embodiments, the antiperspirant component further comprises an ingredient selected from the group consisting of lactobionic acid, maltobionic acid, galacturonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, acids thereof, salts thereof, or combinations of two or more thereof. According to another aspect, there is provided a personal care composition comprising: an antiperspirant component comprising gluconolactone and / or an acid thereof; from about 0.1 wt% to about 7 wt% of a thickening agent; from about 0.1 wt% to about 25 wt% of a polyol; and, water, wherein all weight percentages are based on the total weight of the personal care composition. According to another aspect of the present invention, there is provided a personal care composition comprising an antiperspirant component consisting essentially of gluconolactone and / or an acid thereof.

[0008] Further embodiments of the present invention provide personal care compositions, wherein the antiperspirant component comprises gluconolactone, or an acid thereof; and, a metal oxalate salt. In some embodiments, the metal oxalate salt is selected from the group consisting of potassium oxalate, potassium titanium oxalate, and combinations thereof.

[0009] A list of non-limiting exemplary embodiments is provided below:

[0010] According to embodiment 1, there is provided a personal care composition comprising:

[0011] a cosmetically acceptable carrier;

[0012] an antiperspirant component comprising gluconolactone; and

[0013] optionally, a thickening agent.

[0014] According to embodiment 2, there is provided a personal care composition according to embodiment 1, wherein the antiperspirant component further comprises an ingredient selected from the group consisting of maltobionic acid, lactobionic acid, galacturonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannonolactone, galactoheptonolactone; and combinations of two or more thereof.

[0015] According to embodiment 3, there is provided a personal care composition according to embodiment 1 or embodiment 2, further comprising an additional polyhydroxy acid and / or a salt thereof.

[0016] According to embodiment 4, there is provided the personal care composition according to embodiment 3, wherein the additional polyhydroxy acid and / or salt thereof comprises galactose, lactobionic acid, or a combination thereof.

[0017] According to embodiment 5, there is provided the personal care composition according to embodiment 3 or embodiment 4, wherein the additional polyhydroxy acid and / or salt thereof is present in an amount of about 0.1 wt% to about 7 wt%, based on the total weight of the personal care composition.

[0018] According to embodiment 6, there is provided the personal care composition according to any preceding embodiment, further comprising an alpha hydroxy acid and / or salt thereof.

[0019] According to embodiment 7, there is provided the personal care composition according to embodiment 6, wherein the alpha hydroxy acid comprises glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxyl octanoic acid, hydroxyl decanoic acid, a salt thereof, or a combination of two or more thereof.

[0020] According to embodiment 8, there is provided the personal care composition according to embodiment 6 or embodiment 7, wherein the alpha hydroxy acid and / or salt thereof is present in an amount of about 0.1 wt% to about 7 wt%, based on the total weight of the personal care composition.

[0021] According to embodiment 9, there is provided the personal care composition according to any preceding embodiment, further comprising a emollient in an amount of about 0.1 wt% to about 15 wt%, based on the total weight of the personal care composition.

[0022] According to embodiment 10, there is provided the personal care composition according to embodiment 9, wherein the emollient is selected from the group consisting of: isododecane, sodium starch octenyl succinate, benzoic acid C 12-15alkyl esters, mineral oil, caprylyl glycol, dimethicone, dicaprylyl ether, ethyl trisiloxane, PPG-14 butyl ether, PPG-3 myristyl ether, stearyl alcohol, stearic acid and its salts, glyceryl monoricinoleate, isobutyl palmitate, isocetyl stearate, isocetyl stearate, sulfated tallow oil, oleyl alcohol, propylene glycol, isopropyl laurate, mink oil, sorbitan stearate, cetyl alcohol, hydrogenated castor oil, stearyl stearate, hydrogenated soy glycerides, isopropyl isostearate, hexyl laurate, dimethyl baratolic acid, decyl oleate, diisopropyl adipate, n-dibutyl sebacate, diisopropyl sebacate, 2-ethylhexyl palmitate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl stearate, di-(2-ethylhexyl) adipate, di-(2-ethylhexyl) succinate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, octacosanol, butyl stearate, polyethylene glycol, oleic acid, triethylene glycol, lanolin, castor oil, acetylated lanolin alcohols, acetylated lanolin, petrolatum, isopropyl esters of lanolin, fatty acids, mineral oil, butyl myristate, isostearic acid, palmitic acid, PEG-8 distearate, PEG-23 oleyl ether, oleyl oleate, isopropyl linoleate, cetyl lactate, lauryl lactate, myristyl lactate, quaternized hydroxyalkyl, aminoglycolate, vegetable oil, isodecyl oleate, isostearyl neopentanoate, myristyl myristate, oleyl ethoxymyristate, diethylene glycol stearate, ethylene glycol monostearate, myristyl stearate, isopropyl lanolate, paraffin, glycyrrhizic acid, hydroxyethyl stearamide, and combinations of two or more thereof.

[0023] According to embodiment 11, there is provided the personal care composition of any preceding embodiment, further comprising from about 0.1 wt% to about 25 wt% of a polyol, based on the total weight of the personal care composition.

[0024] According to embodiment 12, there is provided the personal care composition according to embodiment 11, wherein the polyol comprises ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol, or combinations of two or more thereof.

[0025] According to embodiment 13, there is provided the personal care composition according to any preceding embodiment, further comprising from about 0.5 wt% to about 9 wt% of a structurant, based on the total weight of the personal care composition.

[0026] According to embodiment 14, there is provided the personal care composition according to any preceding embodiment, wherein the thickening agent is selected from the group consisting of xanthan gum, guar gum, biosaccharide gum, cellulose, acacia seneca gum, sclerotium gum, agarose, pectin, gellan gum, hyaluronic acid, and combinations of two or more thereof.

[0027] According to embodiment 15, there is provided a personal care composition according to any preceding embodiment, further comprising from about 0.1 wt% to about 7 wt% of a preservative, based on the total weight of the personal care composition.

[0028] According to embodiment 16, there is provided a personal care composition according to embodiment 15, wherein the preservative comprises caprylyl glycol, phenoxyethanol, butylated hydroxytoluene, ethylenediaminetetraacetic acid, ethylhexylglycerin, citric acid, benzoic acid, or a combination of two or more thereof.

[0029] According to embodiment 17, there is provided a personal care composition comprising:

[0030] a antiperspirant component comprising gluconolactone and / or an acid thereof; and

[0031] from about 0.1 wt% to about 7 wt% of a thickening agent; and

[0032] from about 0.1 wt% to about 25 wt% of a polyol;

[0033] wherein all weight percentages are based on the total weight of the personal care composition.

[0034] According to embodiment 18, there is provided a personal care composition according to embodiment 17, further comprising an additional polyhydroxy acid and / or a salt thereof.

[0035] According to embodiment 19, there is provided a personal care composition according to any preceding embodiment, further comprising an alpha hydroxy acid and / or a salt thereof selected from the group consisting of glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxyl octanoic acid, hydroxyl decanoic acid, salts thereof, and combinations of two or more thereof.

[0036] According to embodiment 20, there is provided a personal care composition comprising:

[0037] a antiperspirant component consisting essentially of gluconolactone and / or an acid thereof.

[0038] According to embodiment 21, there is provided a personal care composition according to any preceding embodiment, wherein the antiperspirant component consists of gluconolactone and / or an acid thereof.

[0039] According to embodiment 22, there is provided a personal care composition according to any preceding embodiment, wherein the personal care composition is substantially free of an aluminum salt.

[0040] According to embodiment 23, there is provided a personal care composition according to any preceding embodiment, wherein the personal care composition is substantially free of a zinc-based antiperspirant active.

[0041] According to embodiment 124, there is provided a personal care composition according to any preceding embodiment, wherein the personal care composition is substantially free of an iron-based antiperspirant active.

[0042] According to embodiment 25, there is provided a personal care composition according to any preceding embodiment, wherein the personal care composition is substantially free of a zirconium-based antiperspirant active.

[0043] According to embodiment 26, there is provided a personal care composition according to any preceding embodiment, wherein the personal care composition is substantially free of a titanium-based antiperspirant active.

[0044] According to embodiment 27, there is provided a personal care composition according to any preceding embodiment, wherein the personal care composition is substantially free of a magnesium-based antiperspirant active.

[0045] According to embodiment 28, there is provided a personal care composition according to any of embodiments 1 to 19 and 23 to 27, wherein the antiperspirant component consists essentially of gluconolactone, lactobionic acid, maltobionic acid, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, an acid thereof, a salt thereof, or a combination of two or more thereof.

[0046] According to embodiment 29, there is provided a personal care composition according to any of embodiments 1 to 19 and 23 to 27, wherein the antiperspirant component consists of gluconolactone, lactobionic acid, maltobionic acid, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, an acid thereof, a salt thereof, or a combination of two or more thereof.

[0047] According to embodiment 30, there is provided a method for treating hyperhidrosis in a mammalian subject, comprising: applying to the skin surface of a mammalian subject in need thereof a personal care composition according to any preceding embodiment.

[0048] According to embodiment 31, there is provided a method for reducing or preventing sweat production in a mammalian subject, comprising: applying to the skin surface of a mammalian subject in need thereof a personal care composition according to any of embodiments 1 to 29. BRIEF DESCRIPTION OF DRAWINGS

[0049] Figure 1is a histogram depicting sweat reduction achieved by the non-limiting exemplary personal care composition according to one aspect of the present application. DETAILED DESCRIPTION

[0050] The principles of the application are described by reference to various exemplary embodiments of the application for purposes of illustration only. While certain embodiments of the application are specifically adapted to other compositions and methods, and can be used therein, as will be apparent to one of ordinary skill in the art, having the benefit of this disclosure. Before the present compositions and methods are disclosed and described, it is to be understood that the application is not limited to the specific embodiments

[0051] As used herein and in the appended claims, the singular forms "a," "an," and "the" include plural reference unless the context dictates otherwise. The singular form of any of the ingredients of any class refers not only to one chemical substance in that class, but also to mixtures of these chemical substances. The terms "a," "an," "one or more," and "at least one" are used interchangeably herein. The terms "comprising," "including," and "having" can be used interchangeably. The term "comprising" is to be construed as "including, but not limited to." The term "comprising" is to be construed as "including, but not limited to."

[0052] As used throughout, ranges are used as shorthand for describing each and every value and sub-range within the range. Any value within the range can be selected as the terminus of the range. Thus, 1 to 5 specifically includes 1, 2, 3, 4, and 5, as well as sub-ranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.

[0053] The term "about" when referring to a number means any number that is within 10% of that number. For example, the phrase "about 2% by weight" means a number that is between 1.8% and 2.2% by weight and includes 1.8% and 2.2% by weight.

[0054] All references cited herein are hereby incorporated by reference in their entirety. In the event of a conflict in terminology between definitions in the present disclosure and those set forth in the cited references, the definitions set forth in the present disclosure control.

[0055] Abbreviations and symbols as used herein take their ordinary meaning unless otherwise stated. The abbreviation "wt%" means weight percent relative to the weight of the personal care composition. The symbol "°" means degrees, for example, degrees of temperature or degrees of an angle. The symbols "h", "min", "mL", "nm", and "pm" mean hours, minutes, milliliters, nanometers, and micrometers, respectively. The abbreviation "UV-VIS" in reference to a spectrometer or spectroscopy means ultraviolet-visible. The abbreviation "rpm" means revolutions per minute.

[0056] In reference to chemical structures and names, the symbols "C", "H", and "O" mean carbon, hydrogen, and oxygen, respectively. The symbols "-", "=", and "≡" mean single, double, and triple bonds, respectively.

[0057] "Volatile" as used herein means a flash point below about 100 °C. "Non-volatile" as used herein means a flash point above about 100 °C.

[0058] Any member of a list of species used to exemplify or define a genus can be mutually exclusive from, overlapping with, a subset of, identical to, nearly identical to, or the same as any other member of the list of species. Furthermore, unless explicitly stated, a list of species defining or exemplifying a genus is open, and gives rise to the possibility that other species defining or exemplifying the genus as good as or better than any other species listed can exist, for example when a Markush group is recited.

[0059] The phrase "mixtures thereof", "combinations thereof", or "combinations of two or more thereof" does not require that the mixture contain all of A, B, C, D, E, and F (although it can contain all of A, B, C, D, E, and F). Rather, it indicates that a mixture can contain any two or more of A, B, C, D, E, and F. In other words, it is equivalent to the phrase "one or more members selected from the group consisting of A, B, C, D, E, F, and mixtures of any two or more of A, B, C, D, E, and F". Likewise, the term "salts thereof" also refers to "salts of the same". Thus, where the disclosure refers to "a member selected from the group consisting of A, B, C, D, E, F, salts thereof, and mixtures thereof", it indicates that it can include one or more of A, B, C, D, and F, it can include one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F, or it can include a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F.

[0060] All components and elements set forth affirmatively in the disclosure can be excluded negatively from the claims. In other words, the personal care compositions of the present disclosure can be free or substantially free of all components and elements recited affirmatively throughout the disclosure. In some cases, the personal care compositions of the present disclosure can be substantially free of non-incidental amounts of the ingredients or compounds described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound added individually to the personal care composition. For example, a personal care composition can be substantially free of non-incidental amounts of an ingredient or compound, although such ingredient or compound can be present as part of a raw material included as a blend of two or more compounds.

[0061] Some of the various classes of components identified can overlap. In such cases where overlap can exist and the personal care composition includes two components (or the composition includes more than two overlapping components), the overlapping compound does not represent more than one component. For example, certain compounds can be referred to as both emulsifiers and surfactants. If a particular personal care includes both emulsifiers and surfactants, the compound that can be referred to as both an emulsifier and a surfactant would only act as one or the other - not both.

[0062] For purposes of readability, chemical functional groups are in their adjective form; for each adjective, the word "group" is assumed. For example, the adjective "alkyl" without a noun following it should be interpreted as "alkyl group."

[0063] As used herein, the term "antiperspirant" refers to a product that is applied topically to reduce the production of sweat (perspiration) at the site. As used herein, "reduce" in the context of the term "reduce perspiration" means to lower or lessen the moisture, sweat, or perspiration of the area to which it is applied. As used herein, the term "deodorant" refers to an agent that inhibits odor-causing bacteria that make perspiration odor.

[0064] Aspects of the present application relate to personal care compositions, which can be in the form of deodorants and / or antiperspirants. According to one aspect of the present application, there is provided a personal care composition comprising: a cosmetically acceptable carrier; an antiperspirant component comprising gluconolactone and / or an acid thereof; and, optionally, a thickening agent. In some embodiments, the antiperspirant component further comprises an ingredient selected from the group consisting of lactobionic acid, maltobionic acid, galacturonolactone, glucuronolactone, galacturonolactone, gulonicolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannuronolactone, galactoheptonolactone, an acid thereof, a salt thereof, or a combination of two or more thereof. According to another aspect of the present application, there is provided a personal care composition comprising: an antiperspirant component comprising gluconolactone and / or an acid thereof; a thickening agent; from about 0.1 wt% to about 25 wt% of a polyol based on the total weight of the personal care composition; and water. According to another aspect of the present application, there is provided a personal care composition comprising an antiperspirant component consisting essentially of gluconolactone and / or an acid thereof.

[0065] The personal care composition can provide a reduction in perspiration of about 40% or more. For example, the personal care composition can provide a reduction in perspiration of about 40% or more as compared to a personal care composition having the same formulation except that it comprises an additional carrier (e.g., water) in place of the gluconolactone, lactobionic acid, maltobionic acid, galacturonolactone, glucuronolactone, galacturonolactone, gulonicolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannuronolactone, galactoheptonolactone, an acid thereof, a salt thereof, or a combination of two or more thereof. In certain embodiments, the personal care composition provides a reduction in perspiration of about 45% or more, about 50% or more, about 53% or more, about 59% or more, about 62% or more, about 64% or more, about 66% or more, or about 68% or more. For example, the personal care composition can provide a reduction in perspiration of about 50% to about 68%, about 53% to about 68%, about 56% to about 68%, about 59% to about 68%, about 62% to about 68%; about 50% to about 65%, about 53% to about 65%, about 56% to about 65%, about 59% to about 65%, about 62% to about 65%; about 50% to about 62%, about 53% to about 62%, about 56% to about 62%, about 59% to about 62%, or any range or sub-range thereof. The reduction in perspiration disclosed above can be achieved over a 24 hour period of application.

[0066] The personal care composition can achieve reduction in perspiration while being substantially free or free of certain conventional antiperspirant compositions, such as aluminum-based antiperspirant actives, zirconium-based antiperspirant actives, zinc-based antiperspirant actives, titanium-based antiperspirant actives, iron-based antiperspirant actives, and / or magnesium-based antiperspirant actives. For example, the personal care composition can have about 3% or less, about 2% or less, about 1% or less, about 0.5% or less, about 0.1% or less, about 0.05% or less, or about 0.01% or less, by weight, based on the total weight of the personal care composition, of aluminum-based antiperspirant actives, magnesium-based antiperspirant actives, titanium-based antiperspirant actives, free of zirconium-based antiperspirant actives, iron-based antiperspirant actives, and / or zinc-based antiperspirant actives, individually or cumulatively. In some embodiments, the personal care composition has about 0% or 0%, by weight, based on the total weight of the personal care composition, of aluminum-based antiperspirant actives, magnesium-based antiperspirant actives, titanium-based antiperspirant actives, zirconium-based antiperspirant actives, and / or zinc-based antiperspirant actives, individually or cumulatively.

[0067] As used herein, the term "free of aluminum-based antiperspirant actives" means that the personal care composition of the present disclosure does not include aluminum-based antiperspirant actives. For example, aluminum-based antiperspirant actives are not added to the personal care composition of the present disclosure to exhibit some personal care effect.

[0068] As used herein, the term "aluminum-free" or "free of aluminum" means that the personal care composition does not include any aluminum-based antiperspirant. Non-limiting examples of aluminum-based antiperspirant actives can include those listed in the U.S. Antiperspirant Monograph, such as aluminum chlorohydrate, aluminum chloride, aluminum dichlorohydrate, aluminum dichlorohydrate polyethylene glycol, aluminum dichlorohydrate propylene glycol, aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium trichlorohydrate, aluminum zirconium dichlorohydrate, aluminum-zirconium glycine complex (e.g., aluminum zirconium trichlorohydrate glycine, aluminum zirconium pentachlorohydrate glycine, aluminum zirconium tetrachlorohydrate glycine, and aluminum zirconium octachlorohydrate glycine), aluminum chlorohydrate propylene glycol (aluminum chlorohydrate PG), aluminum chlorohydrate polyethylene glycol (aluminum chlorohydrate PEG), aluminum dichlorohydrate propylene glycol (aluminum dichlorohydrate PG), and aluminum dichlorohydrate polyethylene glycol (aluminum dichlorohydrate PEG). In some embodiments, the personal care composition can be free of one or more of the foregoing examples of aluminum-based antiperspirant actives.

[0069] As used herein, the term "zirconium-free" or "does not contain a zirconium-based antiperspirant active" means that the personal care composition does not include a zirconium-based antiperspirant. Non-limiting examples of zirconium-based antiperspirant actives include aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium trichlorohydrate, and aluminum-zirconium glycine complexes (e.g., aluminum zirconium trichlorohydrate glycine, aluminum zirconium pentachlorohydrate glycine, aluminum zirconium tetrachlorohydrate glycine, and aluminum zirconium octachlorohydrate glycine). In some embodiments, the personal care composition can be free of one or more of the foregoing examples of zirconium-based antiperspirant actives.

[0070] As used herein, the term "does not contain a zinc-based antiperspirant active" means that the personal care composition does not include a zinc-based antiperspirant active. Non-limiting examples of zinc-based antiperspirant actives can include one or more of zinc oxide, zinc hydroxide, zinc hydroxide ions with a counterion, and zinc ions with a counterion. In some embodiments, the personal care composition can be free of one or more of the foregoing examples of zinc-based antiperspirant actives.

[0071] As used herein, the term "does not contain an iron-based antiperspirant active" means that the personal care composition does not include an iron-based antiperspirant active.

[0072] As used herein, the term "does not contain a titanium-based antiperspirant active" means that the personal care composition does not include a titanium-based antiperspirant active. For example, the personal care composition can include a reduced amount of a titanium-based antiperspirant active such as ammonium titanium lactate, etc., be substantially free of a titanium-based antiperspirant active such as ammonium titanium lactate, etc., or be free of a titanium-based antiperspirant active such as ammonium titanium lactate, etc. In some embodiments, the personal care composition can be free of one or more of the foregoing examples of titanium-based antiperspirant actives.

[0073] As used herein, the term "does not contain a magnesium-based antiperspirant active" means that the personal care composition does not include a magnesium-based antiperspirant active. Non-limiting examples of magnesium-based actives include, but are not limited to, magnesium chloride, magnesium bromide, magnesium fluoride, and organic salts such as carboxylic acids substituted with various alkyl chain lengths, magnesium oxide, and magnesium hydroxide. As used herein, the term "axillary" or "axillary region" refers to the armpit or underarm of the body. In some embodiments, the personal care composition can be free of one or more of the foregoing examples of magnesium-based antiperspirant actives.

[0074] Additionally or alternatively, the personal care composition can inhibit and / or reduce the growth of malodorous bacteria that cause underarm odor. Without being limited by any particular theory, it is believed that by reducing underarm perspiration, the personal care composition can reduce the formation of malodorous bacteria.

[0075] Depending on the particular combination of other components, the form of the personal care composition, and / or the use of the formulation (e.g., roll-on, stick, spray, etc.), suitable components such as those listed below can be included in or excluded from the formulation of the personal care composition. For example, the personal care composition can be an antiperspirant or deodorant in the form of a roll-on, gel, cream, stick, or aerosol formulation. The personal care composition can also be in the form of a solid, semi-solid, or liquid composition.

[0076] The personal care composition comprises, preferably in an effective amount, an antiperspirant component comprising gluconolactone, lactobionic acid, maltobionic acid, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, an acid thereof; a salt thereof, or a combination of two or more thereof. The antiperspirant component can comprise gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, an acid thereof, or a combination of two or more thereof. Additionally or alternatively, the antiperspirant component can comprise lactobionic acid, maltobionic acid, gluconic acid, a salt thereof, or a combination of two or more thereof. In some preferred embodiments, the personal care composition comprises gluconolactone and / or a salt thereof. The personal care composition can comprise gluconolactone in acid form (e.g., gluconic acid). The gluconolactone can be gluconic delta lactone. In some preferred embodiments, the personal care composition comprises an antiperspirant component consisting of one or more compounds selected from the group consisting of gluconolactone, lactobionic acid, maltobionic acid, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, an acid thereof, a salt thereof.

[0077] The total amount of gluconolactone, lactobionic acid, maltobionic acid, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, acids thereof, salts thereof, or combinations of two or more thereof present in the personal care composition can be from about 0.2 wt% to about 11 wt%, based on the total weight of the personal care composition. For example, the personal care composition can include a total amount of gluconolactone, lactobionic acid, maltobionic acid, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, glucarolactone, panduratinolactone, glucoheptonolactone, mannoheptonolactone, galactoheptonolactone, acids thereof, salts thereof, or combinations of two or more thereof from about 0.2 wt% to about 9 wt%, about 0.2 wt% to about 7 wt%, about 0.2 wt% to about 5 wt%, about 0.2 wt% to about 4 wt%, about 0.2 wt% to about 3 wt%, about 0.2 wt% to about 2 wt%, about 0.2 wt% to about 1 wt%; about 0.5 wt% to about 11 wt%, about 0.5 wt% to about 9 wt%, about 0.5 wt% to about 7 wt%, about 0.5 wt% to about 5 wt%, about 0.5 wt% to about 4 wt%, about 0.5 wt% to about 3 wt%, about 0.5 wt% to about 2 wt%, about 0.5 wt% to about 1 wt%; about 1 wt% to about 11 wt%, about 1 wt% to about 9 wt%, about 1 wt% to about 7 wt%, about 1 wt% to about 5 wt%, about 1 wt% to about 4 wt%, about 1 wt% to about 3 wt%, about 1 wt% to about 2 wt%; about 2 wt% to about 11 wt%, about 2 wt% to about 9 wt%, about 2 wt% to about 7 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 4 wt%, about 2 wt% to about 3 wt%; about 3 wt% to about 11 wt%, about 3 wt% to about 9 wt%, about 3 wt% to about 7 wt%, about 3 wt% to about 5 wt%; about 5 wt% to about 11 wt%, about 5 wt% to about 9 wt%, about 5 wt% to about 7 wt%; about 7 wt% to about 11 wt%, about 7 wt% to about 9 wt%, about 9 wt% to about 11 wt%, or any range or sub-range therein, based on the total weight of the personal care composition.

[0078] The personal care composition can include an additional polyhydroxy acid and / or salt thereof in addition to gluconic acid. The amount of additional polyhydroxy acid and / or salt thereof can be present in an amount of about 0.1 wt% to about 10 wt%, based on the total weight of the personal care composition. For example, the amount of additional polyhydroxy acid and / or salt thereof present in the personal care composition can be about 0.1 wt% to about 8 wt%, about 0.1 wt% to about 6 wt%, about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 4 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%; about 0.5 wt% to about 8 wt%, about 0.5 wt% to about 6 wt%, about 0.5 wt% to about 5 wt%, about 0.5 wt% to about 4 wt%, about 0.5 wt% to about 3 wt%, about 0.5 wt% to about 2 wt%, about 0.5 wt% to about 1 wt%; about 1 wt% to about 10 wt%, about 1 wt% to about 8 wt%, about 1 wt% to about 6 wt%, about 1 wt% to about 5 wt%, about 1 wt% to about 4 wt%, about 1 wt% to about 3 wt%, about 1 wt% to about 2 wt%; about 2 wt% to about 10 wt%, about 2 wt% to about 8 wt%, about 2 wt% to about 6 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 4 wt%, about 2 wt% to about 3 wt%; about 3 wt% to about 10 wt%, about 3 wt% to about 8 wt%, about 3 wt% to about 6 wt%, about 3 wt% to about 5 wt%, about 3 wt% to about 4 wt%, including ranges and subranges thereof. The polyhydroxy acid can include, but is not limited to, gluconolactone, galactose, lactobionic acid, or combinations thereof. In some embodiments, the polyhydroxy acid is lactobionic acid or combinations thereof.

[0079] The personal care composition can include one or more alpha hydroxy acids and / or salts thereof. For example, the personal care composition can include one or more alpha hydroxy acids, such as those selected from C3to C7alpha hydroxy acids or C4to C6alpha hydroxy acids. In some embodiments, the personal care composition includes a salt of an alpha-hydroxy acid. The salt of the alpha-hydroxy acid is preferably a sodium or potassium salt. In at least one embodiment, the salt is a sodium salt (i.e., the cation bound to the salt is sodium). Non-limiting examples of alpha hydroxy acids include, but are not limited to, mandelic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxyl octanoic acid, hydroxyl decanoic acid, glutaric acid, gluconic acid, salts thereof, or combinations of two or more thereof. In some embodiments, the alpha hydroxy acid is citric acid, mandelic acid, glycolic acid, lactic acid, salts thereof, or combinations of two or more thereof. In certain instances, the alpha-hydroxy acid is selected from the group consisting of malic acid, tartaric acid, alpha-hydroxy glutaric acid, gluconic acid, salts thereof, and combinations of two or more thereof. In yet other instances, the alpha-hydroxy acid and / or salt thereof is selected from the group consisting of lactic acid, malic acid, and combinations thereof. In at least one embodiment, the alpha hydroxy acid is lactic acid.

[0080] The personal care composition of the present application can include alpha hydroxy acids and / or salts thereof in a total amount of from about 0.1 wt% to about 7 wt%, based on the total weight of the personal care composition. In some instances, one or alpha hydroxy acids and / or salts thereof are present in the personal care composition in an amount of from about 0.1 wt% to about 6 wt%, from about 0.1 wt% to about 5 wt%, from about 0.1 wt% to about 4 wt%, from about 0.1 wt% to about 3 wt%, from about 0.1 wt% to about 2 wt%, from about 0.1 wt% to about 1 wt%; from about 0.4 wt% to about 7 wt%, from about 0.4 wt% to about 6 wt%, from about 0.4 wt% to about 5 wt%, from about 0.4 wt% to about 4 wt%, from about 0.4 wt% to about 3 wt%, from about 0.4 wt% to about 2 wt%, from about 0.4 wt% to about 1 wt%; from about 0.8 wt% to about 7 wt%, from about 0.8 wt% to about 6 wt%, from about 0.8 wt% to about 5 wt%, from about 0.8 wt% to about 4 wt%, from about 0.8 wt% to about 3 wt%, from about 0.8 wt% to about 2 wt%; from about 1.4 wt% to about 7 wt%, from about 1.4 wt% to about 6 wt%, from about 1.4 wt% to about 5 wt%, from about 1.4 wt% to about 4 wt%, from about 1.4 wt% to about 3 wt%; from about 2 wt% to about 7 wt%, from about 2 wt% to about 6 wt%, from about 2 wt% to about 5 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 3 wt% to about 7 wt%, from about 3 wt% to about 6 wt%, from about 3 wt% to about 5 wt%; from about 4 wt% to about 7 wt%, from about 4 wt% to about 6 wt%, from about 5 wt% to about 7 wt%, or any range or sub-range thereof, based on the total weight of the personal care composition.

[0081] The personal care composition can comprise one or more emollients. The amount of emollient in the personal care composition can be from about 0.1 wt% to about 15 wt%, based on the total weight of the personal care composition. For example, the total amount of emollient in the personal care composition can be from about 0.1 wt% to about 15 wt%, from about 0.1 wt% to about 12 wt%, from about 0.1 wt% to about 9 wt%, from about 0.1 wt% to about 6 wt%, from about 0.1 wt% to about 4 wt%, from about 0.1 wt% to about 2 wt%; from about 0.5 wt% to about 15 wt%, from about 0.5 wt% to about 12 wt%, from about 0.5 wt% to about 9 wt%, from about 0.5 wt% to about 6 wt%, from about 0.5 wt% to about 4 wt%, from about 0.5 wt% to about 2 wt%; from about 1 wt% to about 15 wt%, from about 1 wt% to about 12 wt%, from about 1 wt% to about 9 wt%, from about 1 wt% to about 6 wt%, from about 1 wt% to about 4 wt%, from about 1 wt% to about 2 wt%; from about 2 wt% to about 15 wt%, from about 2 wt% to about 12 wt%, from about 2 wt% to about 9 wt%, from about 2 wt% to about 6 wt%, from about 2 wt% to about 4 wt%; from about 4 wt% to about 15 wt%, from about 4 wt% to about 12 wt%, from about 4 wt% to about 9 wt%, from about 4 wt% to about 6 wt%; from about 7 wt% to about 15 wt%, from about 7 wt% to about 12 wt%, from about 7 wt% to about 9 wt%; from about 10 wt% to about 15 wt%, from about 10 wt% to about 12 wt%, or from about 12 wt% to about 15 wt%, including any range or sub-range therein.

[0082] Classes of non-volatile emollients include non-silicone emollients and silicone emollients. Non-volatile non-silicone emollients include benzoic acid C 12-15 alkyl esters. The one or more emollients can be selected from: isododecane, sodium starch octenyl succinate, benzoic acid C 12-15alkyl esters, mineral oil, caprylyl glycol, dimethicone, dicaprylyl ether, ethyl trisiloxane, PPG-14 butyl ether, PPG-3 myristyl ether, stearyl alcohol, stearic acid and its salts, glyceryl monoricinoleate, isobutyl palmitate, isocetyl stearate, isocetyl stearate, sulfated tallow, oleyl alcohol, propylene glycol, isopropyl laurate, mink oil, sorbitan stearate, cetyl alcohol, hydrogenated castor oil, stearyl stearate, hydrogenated soy glycerides, isopropyl isostearate, hexyl laurate, dimethyl baratolic acid, decyl oleate, diisopropyl adipate, n-dibutyl sebacate, diisopropyl sebacate, 2-ethylhexyl palmitate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl stearate, di-(2-ethylhexyl) adipate, di-(2-ethylhexyl) succinate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, octacosanol, butyl stearate, polyethylene glycol, oleic acid, triethylene glycol, lanolin, castor oil, acetylated lanolin alcohols, acetylated lanolin, petrolatum, isopropyl esters of lanolin, fatty acids, mineral oil, butyl myristate, isostearic acid, palmitic acid, PEG-8 distearate, PEG-23 oleyl ether, oleyl oleate, isopropyl linoleate, cetyl lactate, lauryl lactate, myristyl lactate, quaternized hydroxyalkyl, aminoglycolate, vegetable oil, isodecyl oleate, isostearyl neopentanoate, myristyl myristate, oleyl ethoxymyristate, diethylene glycol stearate, ethylene glycol monostearate, myristyl stearate, isopropyl lanolate, paraffin, glycyrrhizic acid, hydroxyethyl stearamide, and combinations of two or more thereof.

[0083] The personal care composition can comprise one or more polyols. Preferably, the personal care composition comprises one or more polyols in an amount of from about 0.1 wt% to about 25 wt%, based on the total weight of the personal care composition.For example, the total amount of the polyol in the personal care composition can be from about 0.1 wt% to about 22 wt%, from about 0.1 wt% to about 18 wt%, from about 0.1 wt% to about 12 wt%, from about 0.1 wt% to about 8 wt%, from about 0.1 wt% to about 6 wt%, from about 0.1 wt% to about 4 wt%, from about 0.1 wt% to about 3 wt%, from about 0.1 wt% to about 2 wt%; from about 0.1 wt% to about 1 wt%; from about 0.5 wt% to about 22 wt%, from about 0.5 wt% to about 18 wt%, from about 0.5 wt% to about 12 wt%, from about 0.5 wt% to about 8 wt%, from about 0.5 wt% to about 6 wt%, from about 0.5 wt% to about 4 wt%, from about 0.5 wt% to about 3 wt%, from about 0.5 wt% to about 2 wt%; from about 0.5 wt% to about 1 wt%; from about 1 wt% to about 22 wt%, from about 1 wt% to about 18 wt%, from about 1 wt% to about 12 wt%, from about 1 wt% to about 8 wt%, from about 1 wt% to about 6 wt%, from about 1 wt% to about 4 wt%, from about 1 wt% to about 3 wt%, from about 1 wt% to about 2 wt%; from about 2 wt% to about 22 wt%, from about 2 wt% to about 18 wt%, from about 2 wt% to about 12 wt%, from about 2 wt% to about 8 wt%, from about 2 wt% to about 6 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 3 wt% to about 22 wt%, from about 3 wt% to about 18 wt%, from about 3 wt% to about 12 wt%, from about 3 wt% to about 8 wt%, from about 3 wt% to about 6 wt%; from about 5 wt% to about 25 wt%, from about 5 wt% to about 22 wt%, from about 5 wt% to about 20 wt%, from about 5 wt% to about 18 wt%, from about 5 wt% to about 16 wt%, from about 5 wt% to about 12 wt%, from about 5 wt% to about 10 wt%, from about 5 wt% to about 8 wt%; from about 7 wt% to about 25 wt%, from about 7 wt% to about 22 wt%, from about 7 wt% to about 20 wt%, from about 7 wt% to about 18 wt%, from about 7 wt% to about 16 wt%; from about 9 wt% to about 25 wt%, from about 9 wt% to about 22 wt%, from about 9 wt% to about 20 wt%, from about 9 wt% to about 18 wt%, from about 9 wt% to about 16 wt%; from about 12 wt% to about 25 wt%, from about 12 wt% to about 22 wt%, from about 12 wt% to about 20 wt%, from about 12 wt% to about 18 wt%, from about 12 wt% to about 16 wt%; from about 14 wt% to about 25 wt%, from about 14 wt% to about 22 wt%, from about 14 wt% to about 20 wt%, from about 14 wt% to about 18 wt%; from about 16 wt% to about 25 wt%, from about 16 wt% to about 22 wt%, from about 16 wt% to about 20 wt%; from about 18 wt% to about 25 wt%, from about 21 wt% to about 25 wt%, or any range or sub-range thereof, based on the total weight of the personal care composition.

[0084] The polyol can be selected from a diol or a compound having multiple hydroxyl groups. In some cases, the one or more polyols are selected from C2-C 32 Polyol. The one or more polyols can be liquid at ambient temperature (25 °C). The one or more polyols can have 2 to 32 carbon atoms, 3 to 16 carbon atoms, or 3 to 12 carbon atoms.

[0085] In certain cases, polyols that can be included in the personal care composition include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, dipropylene glycol, and mixtures thereof. In some cases, the personal care composition includes glycerin and, optionally, one or more polyols other than glycerin. Non-limiting examples of polyols that can optionally be included in the personal care include and / or can be selected from: alkanediols, such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-buten-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, octylene glycol, 1,2-hexanediol, 1,2-pentanediol, and 4-methyl-1,2-pentanediol; glycol ethers, such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylene glycol mono-iso-propyl ether, sorbitol, sorbitan, glycerol triacetate, and mixtures thereof.

[0086] The one or more polyols can optionally be a diol or a glycol ether, such as ethylene glycol, propylene glycol, or the mono-methyl, mono-ethyl, and mono-butyl ethers of the ethers thereof, such as the mono-methyl ether of propylene glycol; butylene glycol; hexylene glycol; dipropylene glycol; and the alkyl ethers of diethylene glycol, such as the mono-ethyl or mono-butyl ether of diethylene glycol. In some cases, the one or more polyols can include or be selected from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, 1,3-propanediol, diethylene glycol, dipropylene glycol, 1,4-butanediol, 1,5-pentanediol, hexane-1,6-diol, glycerin, diglycerin, octylene glycol, and / or mixtures of two or more thereof. In certain embodiments, the personal care composition can include a polyol selected from glycerin (preferably, vegetable refined glycerin), butylene glycol, and 1,3-propanediol, polyglutamic acid, sugar isomer, and combinations thereof. In some embodiments, the polyol is polyethylene glycol, such as polyethylene glycol 600.

[0087] Additionally or alternatively, the personal care composition can include a polyol having a molecular weight of from about 100 g / mol to 5000 g / mol. For example, the polyol can include polyethylene glycol, polypropylene glycol, block polymers of polyethylene glycol and polypropylene glycol, or a combination of two or more thereof. In some embodiments, the polyol includes polypropylene glycol, polypropylene glycol, and / or block polymers of polyethylene glycol and polypropylene glycol having a molecular weight of from about 100 to about 900, from about 200 to about 800, about 400, from about 1500 to about 2500, from about 2000 to about 4500, or any range or sub-range thereof.

[0088] The personal care composition can optionally include one or more thickening agents. The total amount of thickening agent, if present, in the personal care composition can be from about 0.1 wt% to about 7 wt%, from about 0.1 wt% to about 5 wt%, from about 0.1 wt% to about 4 wt%, from about 0.1 wt% to about 3 wt%, from about 0.1 wt% to about 2 wt%, from about 0.1 wt% to about 1 wt%; from about 0.5 wt% to about 7 wt%, from about 0.5 wt% to about 5 wt%, from about 0.5 wt% to about 4 wt%, from about 0.5 wt% to about 3 wt%, from about 0.5 wt% to about 2 wt%, from about 0.5 wt% to about 1 wt%; from about 1 wt% to about 7 wt%, from about 1 wt% to about 5 wt%, from about 1 wt% to about 4 wt%, from about 1 wt% to about 3 wt%, from about 1 wt% to about 2 wt%; from about 2 wt% to about 7 wt%, from about 2 wt% to about 5 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 3 wt% to about 7 wt%, from about 3 wt% to about 5 wt%, from about 3 wt% to about 4 wt%, or any range or sub-range thereof, based on the total weight of the personal care composition.

[0089] A thickening agent can be referred to as a "thickener." Thickening agents are generally included to increase the viscosity of the personal care composition. Non-limiting examples of thickening agents that can be incorporated into or excluded from the personal care composition include natural gums, polyacrylate crosspolymers or crosslinked polyacrylate polymers, cationic acrylate copolymers, anionic acrylate or carboxylic acid polymers, polyacrylamide polymers, polysaccharides (e.g., cellulose derivatives), cationic gums, polyquatemary ammonium salts, vinylpyrrolidone homopolymers / copolymers, C 8-24 hydroxy-substituted aliphatic acids, C 8-24 conjugated aliphatic acids, sugar fatty esters, polyglycerol esters, and mixtures thereof. Particular types of thickening agents that can be mentioned include: gums (e.g., natural gums), sucrose esters, polyvinylpyrrolidone (PVP) and copolymers, celluloses, polyquatemary ammonium compounds, and homopolymers or copolymers based on carboxylic acids or carboxylic esters, which can be linear or crosslinked.

[0090] Additionally or alternatively, the thickening agent can be selected from xanthan gum, guar gum, biosaccharide gum, cellulose, farnaran gum, kollaren gum, agarose, pectin, gellan gum, hyaluronic acid. In some cases, the thickening agent can be a gum, for example selected from one or more of xanthan gum, sodium starch octenyl succinate, hydroxypropyl starch phosphate, diutan gum, carrageenan gum, carboxymethyl cellulose, cellulose gum, kollaren gum, hydroxypropyl methylcellulose, and combinations thereof. Additionally, the thickening agent can include a polymeric thickening agent selected from polyacryloyldimethyltaurate, acryloyldimethyltaurate NP copolymer, acrylates copolymer, polyacrylamide, carbomer, acrylates / acrylamide copolymer, and mixtures thereof. 10-30 alkyl acrylate crosspolymer, acrylates / beheneth-25 methacrylate copolymer, and mixtures thereof.

[0091] In certain cases, the personal care composition can include a thickening agent selected from thickening polymers such as polyvinyl alcohol, sodium polyacrylate, sodium polymethacrylate, polyacrylate glyceryl ester, carboxyvinyl polymer, polyacrylamide, polyvinylpyrrolidone, polyvinylmethylether, polyvinylsulfone, maleic acid copolymer, polyethylene oxide, polydiallylamine, polyethyleneimine, water-soluble cellulose derivatives (e.g., carboxymethyl cellulose, methyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium cellulose sulfate) and / or starch derivatives (e.g., starch oxidate, dialdehyde starch, dextrin, gellan gum, acetyl starch, starch phosphate, carboxymethyl starch, hydroxyethyl starch, hydroxypropyl starch). In some embodiments, the thickening agent is selected from hydroxypropyl methylcellulose, polyethylene glycol (PEG), polyacrylic acid (sold under the name Carbopol), cross-linked homopolymer of acrylic acid (sold under the name Carbopol® Ultrez 30 polymer), and Carbopol® Ultrez 20 polymer. 10-30 acrylate crosspolymer of alkyl acrylate (sold under the name Carbopol® Ultrez 20 polymer).

[0092] Additionally or alternatively, the personal care composition can include one or more structurants. The amount of the one or more structurants, if present, can be from about 0.5 wt% to about 9 wt%, based on the total weight of the personal care composition. For example, the personal care composition can include one or more structurants in an amount of from about 0.5 wt% to about 9 wt%, from about 0.5 wt% to about 7 wt%, from about 0.5 wt% to about 6 wt%, from about 0.5 wt% to about 5 wt%, from about 0.5 wt% to about 4 wt%, from about 0.5 wt% to about 3 wt%, from about 0.5 wt% to about 2 wt%, from about 0.5 wt% to about 1.5 wt%, from about 0.5 wt% to about 1 wt%; from about 1 wt% to about 9 wt%, from about 1 wt% to about 7 wt%, from about 1 wt% to about 6 wt%, from about 1 wt% to about 5 wt%, from about 1 wt% to about 4 wt%, from about 1 wt% to about 3 wt%, from about 1 wt% to about 2 wt%; from about 1.5 wt% to about 9 wt%, from about 1.5 wt% to about 7 wt%, from about 1.5 wt% to about 6 wt%, from about 1.5 wt% to about 5 wt%, from about 1.5 wt% to about 4 wt%, from about 1.5 wt% to about 3 wt%, from about 1.5 wt% to about 2 wt%; from about 2 wt% to about 9 wt%, from about 2 wt% to about 7 wt%, from about 2 wt% to about 6 wt%, from about 2 wt% to about 5 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 3 wt% to about 9 wt%, from about 3 wt% to about 7 wt%, from about 3 wt% to about 6 wt%, from about 3 wt% to about 5 wt%, from about 3 wt% to about 4 wt%; from about 4 wt% to about 9 wt%, from about 4 wt% to about 7 wt%, from about 4 wt% to about 6 wt%, from about 4 wt% to about 5 wt%, or any range or sub-range thereof, based on the total weight of the personal care composition.

[0093] Examples of structurants include waxes and / or gellants. The structurant can be a solid at ambient conditions, such as a wax (waxy material), an organic solid, a modified silicone solid, a crystal or other gellant, or combinations thereof. In certain embodiments, the structurant can be a gellant. Examples of structurants include waxes, esters of fatty acids and fatty alcohols, triglycerides, or other cosmetically acceptable materials (e.g., which are solid or semi-solid at room temperature and provide a consistency suitable for application to the skin), and combinations thereof. In some embodiments, the structurant can be selected from the group consisting of steareth-21, steareth-10, steareth-11, steareth-13, steareth-15, steareth-20, ceteareth-6, ceteareth-7, ceteareth-8, ceteareth-9, ceteareth-10, ceteareth-11, and ceteareth-12, polyglyceryl-6 palmitate / succinate mixture, glyceryl stearate, cetearyl alcohol (e.g., 70 / 30 stearyl / cetyl alcohol blend), and combinations of two or more thereof.

[0094] In certain embodiments, the personal care composition can include one or more preservatives. The preservative can be selected from the group consisting of caprylyl glycol, phenoxyethanol, butylated hydroxytoluene, ethylenediaminetetraacetic acid, ethylhexylglycerin, citric acid, benzoic acid, salts thereof, and combinations thereof. Additional examples of preservatives include lactic acid, sodium benzoate, sodium lactate, triethyl citrate, butylated hydroxytoluene, and pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, salts thereof, or combinations thereof.

[0095] The personal care composition can comprise the preservative in an amount of from about 0.1 wt% to about 7 wt%, based on the total weight of the personal care composition. In some cases, the one or more preservatives are present in the personal care composition in a total amount of from about 0.1 wt% to about 6 wt%, from about 0.1 wt% to about 5 wt%, from about 0.1 wt% to about 4 wt%, from about 0.1 wt% to about 3 wt%, from about 0.1 wt% to about 2 wt%, from about 0.1 wt% to about 1 wt%; from about 0.4 wt% to about 7 wt%, from about 0.4 wt% to about 6 wt%, from about 0.4 wt% to about 5 wt%, from about 0.4 wt% to about 4 wt%, from about 0.4 wt% to about 3 wt%, from about 0.4 wt% to about 2 wt%, from about 0.4 wt% to about 1 wt%; from about 0.8 wt% to about 7 wt%, from about 0.8 wt% to about 6 wt%, from about 0.8 wt% to about 5 wt%, from about 0.8 wt% to about 4 wt%, from about 0.8 wt% to about 3 wt%, from about 0.8 wt% to about 2 wt%; from about 1.4 wt% to about 7 wt%, from about 1.4 wt% to about 6 wt%, from about 1.4 wt% to about 5 wt%, from about 1.4 wt% to about 4 wt%, from about 1.4 wt% to about 3 wt%; from about 2 wt% to about 7 wt%, from about 2 wt% to about 6 wt%, from about 2 wt% to about 5 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 3 wt% to about 7 wt%, from about 3 wt% to about 6 wt%, from about 3 wt% to about 5 wt%; from about 4 wt% to about 7 wt%, from about 4 wt% to about 6 wt%, from about 5 wt% to about 7 wt%, or any range or sub-range thereof, based on the total weight of the personal care composition.

[0096] The personal care composition can comprise water. Water can be present in the personal care composition in an amount ranging from about 45 wt% to about 94 wt%, based on the total weight of the personal care composition. For example, the personal care composition can comprise water in an amount of from about 55 wt% to about 94 wt%, from about 65 wt% to about 94 wt%, from about 68 wt% to about 94 wt%, from about 71 wt% to about 94 wt%, from about 75 wt% to about 94 wt%, from about 78 wt% to about 94 wt%, from about 81 wt% to about 94 wt%, from about 84 wt% to about 94 wt%; from about 45 wt% to about 91 wt%, from about 55 wt% to about 91 wt%, from about 65 wt% to about 91 wt%, from about 68 wt% to about 91 wt%, from about 71 wt% to about 91 wt%, from about 75 wt% to about 91 wt%, from about 78 wt% to about 91 wt%, from about 81 wt% to about 91 wt%; from about 45 wt% to about 88 wt%, from about 55 wt% to about 88 wt%, from about 65 wt% to about 88 wt%, from about 68 wt% to about 88 wt%, from about 71 wt% to about 88 wt%, from about 75 wt% to about 88 wt%, from about 78 wt% to about 88 wt%; from about 45 wt% to about 85 wt%, from about 55 wt% to about 85 wt%, from about 65 wt% to about 85 wt%, from about 68 wt% to about 85 wt%, from about 71 wt% to about 85 wt%, from about 75 wt% to about 85 wt%, from about 78 wt% to about 85 wt%; from about 45 wt% to about 82 wt%, from about 55 wt% to about 82 wt%, from about 65 wt% to about 82 wt%, from about 68 wt% to about 82 wt%, from about 71 wt% to about 82 wt%, from about 75 wt% to about 82 wt%; from about 45 wt% to about 79 wt%, from about 55 wt% to about 79 wt%, from about 65 wt% to about 79 wt%, from about 68 wt% to about 79 wt%; from about 45 wt% to about 76 wt%, from about 55 wt% to about 76 wt%, from about 65 wt% to about 76 wt%, from about 68 wt% to about 76 wt%, or any range or sub-range thereof.

[0097] The personal care composition can comprise one or more pH adjusting agents to increase or decrease the overall pH of the personal care composition. For example, one or more acids can be included to decrease the pH of the personal care composition. Examples of suitable acids for lowering the pH of the personal care composition include, but are not limited to, citric acid, acetic acid, and the like. The personal care composition can comprise one or more bases such as sodium hydroxide, potassium hydroxide, and the like to increase the pH of the personal care composition. Additional or alternative acids and bases suitable for adjusting the pH of the personal care composition are readily known to one of ordinary skill in the art.

[0098] The amount of pH adjusting agent in the personal care composition can be based on the desired pH of the personal care composition and / or the final form of the product. For example, the total amount of pH adjusting agent can range from about 0.05 wt% to about 20 wt%, based on the total weight of the personal care composition. In some cases, the total amount of pH adjusting agent is from about 0.05 wt% to about 15 wt%, from about 0.1 wt% to about 10 wt%, or from about 0.12 wt% to about 5 wt%, based on the total weight of the personal care composition, including ranges and subranges therebetween.

[0099] The pH of the personal care composition can be from 4.5 to about 10, from 4.5 to about 9, from 4.5 to about 8, from 4.5 to about 7, from 4.5 to about 6; from about 5 to about 10, from about 5 to about 9, from about 5 to about 8, from about 5 to about 7, from about 5 to about 6; from about 6 to about 10, from about 6 to about 9, from about 6 to about 8, or from about 6 to about 7; from about 7 to about 10, from about 7 to about 9, or from about 7 to about 8, including any ranges and subranges therebetween. In some embodiments, the pH of the personal care composition is from about 3.5 to about 7.5. In other embodiments, the pH of the personal care composition is from about 4 to about 7. In further embodiments, the pH of the personal care composition is from about 4.5 to about 6.5. Yet other embodiments provide a personal care composition having a pH of from about 5 to about 6.5.

[0100] Additional ingredients can be present in the personal care composition. These include water and ingredients to thicken, preserve, emulsify, add fragrance, add pigments and / or color. The personal care composition can include any of the following additional ingredients in an amount of about 0.01 wt% to about 5 wt%. In some cases, the amount of additional ingredients present in the personal care composition is about 0.01 wt% to about 4 wt%, about 0.01 wt% to about 3 wt%, about 0.01 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%, about 0.01 wt% to about 0.5 wt%, about 0.01 wt% to about 0.1 wt%; about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 4 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.5 wt%, about 0.1 wt% to about 0.1 wt%; about 0.5 wt% to about 5 wt%, about 0.5 wt% to about 4 wt%, about 0.5 wt% to about 3 wt%, about 0.5 wt% to about 2 wt%, about 0.5 wt% to about 1 wt%; about 0.75 wt% to about 5 wt%, about 0.75 wt% to about 4 wt%, about 0.75 wt% to about 3 wt%, about 0.75 wt% to about 2 wt%, about 0.75 wt% to about 1 wt%; about 1 wt% to about 5 wt%, about 1 wt% to about 4 wt%, about 1 wt% to about 3 wt%, about 1 wt% to about 2 wt%; about 2 wt% to about 5 wt%, about 2 wt% to about 4 wt%, about 2 wt% to about 3 wt%; about 3 wt% to about 5 wt%, about 3 wt% to about 4 wt%, including any ranges or sub-ranges therebetween, based on the total weight of the personal care composition.

[0101] Non-limiting examples of fragrances and perfumes include odoriferous compounds selected from the group consisting of 7-acetyl-l,2,3,4,5,6,7,8-octahydro-l,l,6,7-tetramethyl-naphthalene, alpha-ionone, beta-ionone, gamma-ionone, alpha-isomethyl ionone, methyl cedrylone, methyl dihydrojasmonate, methyl 1,6,10-trimethyl-2,5,9-cyclododecatrien-l-yl ketone, 7-acetyl-l,l,3,4,4,6-hexamethyl tetrahydronaphthalene, 4-acetyl-6-tert-butyl-l,l-dimethyl indan, hydroxyphenyl butanone, benzophenone, methyl beta-naphtyl ketone, 6-acetyl-l,l,2,3,3,5-hexamethyl indane, 5-acetyl-3-isopropyl-l,l,2,6-tetramethyl indane, 1-dodecanal, 4-(4-hydroxy-4-methyl pentyl)-3-cyclohexen-l- carboxaldehyde, 7-hydroxy-3,7-dimethyloctanal, 10-undecen-l-al, isohexenyl cyclohexyl methanol, formyl tricyclodecane, condensation product of hydroxy-citronellal with methyl anthranilate, condensation product of hydroxy-citronellal with indole, condensation product of phenyl acetaldehyde with indole, 2-methyl-3-(p-tert-butylphenyl)propanal, ethyl vanillin, heliotropin, hexyl cinnamic aldehyde, amyl cinnamic aldehyde, 2-methyl-2-(isopropylphenyl)propanal, coumarin, gamma-decalactone, pentadecalactone, 16-hydroxy-9-hexadecenoic acid lactone, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran, beta-naphtyl methyl ether, ambroxan, dodecahydro-3a,6,6,9a-tetramethyl naphtho[2,l-b]furan, cedrol, 5-(2,2,3-trimethylcyclopent-3-enyl)-3-methylpentan-2-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-l-yl)-2-buten-l-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedryl acetate, and t-butylcyclohexyl acetate.

[0102] Additional fragrances can include odoriferous compounds selected from the group consisting of essential oils, balsams and resins from a large number of sources, such as Peruvian balsam, olibanum resin, stacte, labdanum resin, mace, cinnamon oil, benzoin resin, coriander, and bright lavender.

[0103] The personal care composition can also include one or more color agents. The color agents can be pigments, dyes, or mixtures thereof. Non-limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, mica, and the like. Non-limiting examples of dyes include food dyes suitable for use in food, drug, and cosmetic applications, and mixtures thereof. Some color agents are referred to as FD&C dyes.

[0104] The colorant can be present in an amount ranging from about 0.0001 wt.% to about 0.4 wt.% (including all percents and subranges therebetween), based on the total weight of the personal care composition. In some embodiments, the colorant can be present in an amount ranging from about 0.0001 wt.% to about 4 wt.% (including all percents and subranges therebetween), based on the total weight of the personal care composition.

[0105] Further embodiments of the present application provide personal care compositions, wherein the antiperspirant component comprises gluconolactone, or an acid thereof; and a metal oxalate salt. In some embodiments, the metal oxalate salt is selected from the group consisting of potassium oxalate, potassium titanyl oxalate, and combinations thereof. In some embodiments, the metal in the metal oxalate salt is selected from the group consisting of Ba, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Re, Os, Ir, and combinations of two or more thereof.

[0106] As used herein, "potassium titanyl oxalate" refers to a composition / compound having the following molecular formula: C4K2O9Ti (or C4K2O9Ti 2H2O if in dihydrate form). As used herein, "potassium titanyl oxalate" can be abbreviated using the name "KTO".

[0107] In some embodiments, the present application provides a method for treating hyperhidrosis in a mammalian subject, comprising applying to the skin surface of a mammalian subject in need thereof a personal care composition as described herein. In other embodiments, the present application provides a method for reducing or preventing perspiration in a mammalian subject, comprising: applying to the skin surface of a mammalian subject in need thereof a personal care composition as described herein.

[0108] Some embodiments of the present application provide a method of controlling perspiration and / or odor. In some embodiments, the method generally comprises applying to the skin of a user an antiperspirant effective amount of a personal care composition disclosed herein.

[0109] Examples

[0110] Example 1

[0111] An exemplary personal care composition of the present application (Composition A) can have the formulation shown in Table 1.

[0112]

[0113] Example 2

[0114] A personal care composition having a gum base backbone (Composition B) was prepared according to aspects of the present application. Composition B contained 2 wt% gluconolactone. A comparative composition (Comparative Composition 1) was prepared that had the same formulation as Composition B except that Comparative Composition 1 had an additional 2 wt% water in place of the gluconolactone. The formulation of Composition B and Comparative Composition 1 is shown in Table 2 (below).

[0115]

[0116] Composition B and Comparative Composition 1 were evaluated to assess sweat reduction. Specifically, a thermal imaging study was conducted to evaluate the performance and efficacy of Composition B. The thermal imaging study simulated the performance of Composition B and Comparative Composition 1 under real life conditions. Baseline was collected by having a human subject wear a 100% cotton T-shirt while performing an aerobic exercise. Immediately thereafter, the T-shirt was collected and the retained sweat was recorded using a thermal imager. On the following day, at least 2 hours prior to exercise, Composition B was applied to one of the subject's underarms while Comparative Composition 1 was applied to the other of the subject's underarms. Thermal imaging was then performed.

[0117] The thermal imaging results indicated that Composition B provided about a 62% reduction in sweat relative to Comparative Composition 1.

Claims

1. A personal care composition comprising: a cosmetically acceptable carrier; an antiperspirant component comprising gluconolactone; and optionally, a thickening agent.

2. The personal care composition of claim 1, wherein the antiperspirant component further comprises an ingredient selected from the group consisting of maltobionic acid, lactobionic acid, galacturonolactone, glucuronolactone, galacturonolactone, gulonicolactone, ribonolactone, glucaric acid lactone, panduronic acid, glucoheptonic acid lactone, mannuronic acid lactone, galactoheptonic acid lactone; and combinations of two or more thereof.

3. The personal care composition of claim 1 or claim 2, further comprising from about 0.1 wt% to about 7 wt% of an additional polyhydroxy acid and / or salt thereof.

4. The personal care composition of claim 3, wherein the additional polyhydroxy acid and / or salt thereof comprises galactose, lactobionic acid, or combinations thereof.

5. The personal care composition of any preceding claim, further comprising from about 0.1 wt% to about 7 wt% of an alpha hydroxy acid and / or salt thereof, wherein the alpha hydroxy acid comprises glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxyl octanoic acid, hydroxyl decanoic acid, salts thereof, or combinations of two or more thereof.

6. The personal care composition of any preceding claim, further comprising from about 0.1 wt% to about 15 wt% emollient, based on the total weight of the personal care composition, wherein the emollient is selected from: isododecane, sodium starch octenyl succinate, benzoic acid C 12-15 alkyl esters, mineral oil, caprylyl glycol, dimethicone, dicaprylyl ether, ethyl trisiloxane, PPG-14 butyl ether, PPG-3 myristyl ether, stearyl alcohol, stearic acid and salts thereof, glyceryl monoricinoleate, isobutyl palmitate, isocetyl stearate, isocetyl stearate, sulfated tallow, oleyl alcohol, propylene glycol, isopropyl laurate, mink oil, sorbitan stearate, cetyl alcohol, hydrogenated castor oil, stearyl stearate, hydrogenated soybean glycerides, isopropyl isostearate, hexyl laurate, dimethyl baratolic acid, decyl oleate, diisopropyl adipate, n-dibutyl sebacate, diisopropyl sebacate, 2-ethylhexyl palmitate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl stearate, di-(2-ethylhexyl) adipate, di-(2-ethylhexyl) succinate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, octacosanol, butyl stearate, polyethylene glycol, oleic acid, triethylene glycol, lanolin, castor oil, acetylated lanolin alcohols, acetylated lanolin, petrolatum, isopropyl esters of lanolin, fatty acids, mineral oil, butyl myristate, isostearic acid, palmitic acid, PEG-8 distearate, PEG-23 oleyl ether, oleyl oleate, isopropyl linoleate, cetyl lactate, lauryl lactate, myristyl lactate, quaternized hydroxyalkyl, aminoglycolate, vegetable oil, isodecyl oleate, isostearyl neopentanoate, myristyl myristate, oleyl ethoxymyristate, diethylene glycol stearate, ethylene glycol monostearate, myristyl stearate, isopropyl lanolate, paraffin, glycyrrhizic acid, hydroxyethyl stearamide, and combinations of two or more thereof.

7. The personal care composition of any preceding claim, further comprising from about 0.1 wt% to about 25 wt% of a polyol based on the total weight of the personal care composition, wherein the polyol comprises ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerol, diethylene glycol, and dipropylene glycol, or combinations of two or more thereof.

8. The personal care composition of any preceding claim, further comprising from about 0.5 wt% to about 9 wt% of a structurant based on the total weight of the personal care composition.

9. The personal care composition of any preceding claim, wherein the personal care composition comprises a thickening agent selected from the group consisting of xanthan gum, guar gum, biosaccharide gum, cellulose, acacia gum, gum tragacanth, agarose, pectin, gellan gum, hyaluronic acid, and combinations of two or more thereof.

10. The personal care composition of any preceding claim, further comprising from about 0.1 wt% to about 7 wt% of a preservative based on the total weight of the personal care composition.

11. The personal care composition of claim 10, wherein the preservative comprises caprylyl glycol, phenoxyethanol, butylated hydroxytoluene, ethylenediaminetetraacetic acid, ethylhexylglycerin, citric acid, benzoic acid, or combinations of two or more thereof.

12. A personal care composition comprising: an antiperspirant component comprising gluconolactone and / or its acid; and from about 0.1 wt% to about 7 wt% of a thickening agent; and from about 0.1 wt% to about 25 wt% of a polyol, wherein all weight percentages are based on the total weight of the personal care composition.

13. A personal care composition comprising: an antiperspirant component consisting essentially of gluconolactone and / or its acid.

14. The personal care composition of any preceding claim, wherein the antiperspirant component consists of gluconolactone and / or an acid thereof.

15. The personal care composition of any preceding claim, wherein the personal care composition is substantially free of an aluminum salt.

16. The personal care composition of any preceding claim, wherein the personal care composition is substantially free of a zinc-based antiperspirant active, an iron-based antiperspirant active, a zirconium-based antiperspirant active, a titanium-based antiperspirant active, and a magnesium-based antiperspirant active.

17. The personal care composition of any of claims 1 to 12, wherein the antiperspirant component consists essentially of: gluconolactone, lactobionic acid, maltobionic acid, galactobionic acid lactone, glucuronic acid lactone, galacturonic acid lactone, gulonic acid lactone, ribonic acid lactone, glucaric acid lactone, panduronic acid, glucoheptonic acid lactone, mannobionic acid lactone, galactoheptonic acid lactone, an acid thereof, a salt thereof, or a combination of two or more thereof.

18. The personal care composition of any of claims 1 to 12, wherein the antiperspirant component consists of: gluconolactone, lactobionic acid, maltobionic acid, galactobionic acid lactone, glucuronic acid lactone, galacturonic acid lactone, gulonic acid lactone, ribonic acid lactone, glucaric acid lactone, panduronic acid, glucoheptonic acid lactone, mannobionic acid lactone, galactoheptonic acid lactone, an acid thereof, a salt thereof, or a combination of two or more thereof.

19. A method for treating hyperhidrosis in a mammalian subject, the method comprising: applying the personal care composition of any preceding claim to the skin surface of a mammalian subject in need thereof.

20. A method for reducing or preventing perspiration production in a mammalian subject, the method comprising: applying the personal care composition of any one of claims 1 to 18 to the skin surface of a mammalian subject in need thereof.

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