A scalp oil control composition for preventing seborrheic alopecia, and a preparation method and use thereof

Abstract

The present application relates to the technical field of daily chemicals, and particularly discloses a scalp oil control composition for preventing seborrheic alopecia, a preparation method and application thereof. The scalp oil control composition takes nicotinamide, capryloyl glycine, pyrithione ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract and rice fermentation filtrate as main components. The components synergistically achieve the effects of oil control, hair care and prevention of seborrheic alopecia. The preparation method is simple, the obtained product has high bioavailability of active ingredients, good hair care effect and low irritation, has the effects of caring for hair, strengthening hair roots, regulating scalp microecology and preventing seborrheic alopecia, and can be widely applied to related washing and caring products for preventing seborrheic alopecia.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of daily chemicals, and particularly relates to a scalp oil control composition for preventing seborrheic alopecia as well as a preparation method and application thereof. BACKGROUND

[0002] Seborrheic alopecia is a high-incidence type of alopecia, and its main feature is excessive secretion of scalp oil, which is caused by androgen imbalance, enhanced sensitivity of sebaceous glands, scalp microecological disorder and genetic factors. Excessive oil clogs hair follicles and triggers inflammation, ultimately causing hair to become thin and fall out, which seriously affects the appearance and mental health of patients. The current market products such as external lotions, hair growth sprays and oral drugs have obvious limitations: the external lotions have a small residence ratio, the hair growth effect of the products is not obvious, there is a large individual difference and long-term maintenance is required; the oral drugs are not included in the field of cosmetics, and need to be taken under the guidance of a doctor, which has the risk of causing side effects, and most of the products only target a single link and cannot fundamentally solve the problem.

[0003] CN202510503053.3 discloses a Chinese medicine composition for preventing hair loss for scalp care as well as a preparation method and application thereof, which comprises the following raw materials: 8-15 parts of ginseng, 20-30 parts of Chinese arborvitae leaves, 12-20 parts of prepared radix polygoni multiflori, 15-25 parts of radix salviae miltiorrhizae, 18-28 parts of eclipta prostrata and 10-16 parts of chuanxiong. The Chinese medicine extract prepared from the above-mentioned raw materials is used as an effective component of a shampoo. Although the composition has a certain theoretical basis and has a certain oil control and hair loss prevention effect, the effective components are all Chinese medicine extracts, which are relatively large due to the influence of the production place and season of medicinal plants, and the preparation process of the extract is complex, which has a certain influence on the extraction efficiency. The composition focuses on the aspect of preventing hair loss, but fails to help solve the key breakthrough of the modern social problem of hair loss from the dimension of oil control mechanism, so there are cases of insufficient lasting effect or unsatisfactory hair loss prevention effect.

[0004] CN202111465869.X discloses a scalp care composition with multiple effects as well as a preparation method and application thereof. The composition mainly comprises polyhydric alcohols, sophora flavescens extract, myine plagiobryum root extract, keratin, sugar alcohol, hydroxyphenylpropionamide benzoic acid, creatine, panthenol and nicotinamide. Although the scalp care composition contains a variety of active ingredients, the active ingredients mainly have the effects of moisturizing and hair care, but fail to comprehensively plan from the mechanism of hair loss and make a technical breakthrough in promoting absorption, resulting in certain limitations of the product efficacy.

[0005] CN201710843581.9 discloses a nourishing shampoo, the component weight ratio is: edible white vinegar: 10-20 parts; tea oil: 15-30 parts; beeswax: 16-20 parts; water: 40-60 parts; soybean saponin: 5-9 parts; salicylic acid: 10-20 parts; benzyl alcohol: 10-20 parts; extract of husked milkwort: 10-12 parts. The use amount of salicylic acid in the formula combination is relatively high, and the use limit of salicylic acid in cosmetics is 3.0%, at the same time, there are some technical difficulties to be discussed in the dissolution or dispersion of 16-20 parts of beeswax in the component ratio, and the hair cleaning and scalp oil control in the washing process cannot be effectively solved due to 15-30 parts of tea oil, and the use amount of salicylic acid in the composition is large, and the product stability risk and irritation risk are high.

[0006] Based on the existing technology, the oil control and hair loss prevention effect is not ideal, the utilization rate of active ingredients is low, some formulas use salicylic acid for synergistic softening of keratin and promoting absorption of active substances, but there are many pain points of irritation risk, and the effect of preventing hair loss is not prevented or solved from the perspective of seborrheic alopecia which exists in modern society. The present application proposes a new scalp oil control composition for preventing seborrheic alopecia. SUMMARY

[0007] Based on this, the purpose of the present application is to overcome the shortcomings of the prior art, and to provide a scalp oil control composition for preventing seborrheic alopecia and a preparation method and application thereof. The purpose is to solve the key technical problems of the existing scalp care composition, such as unsatisfactory oil control and hair loss prevention effect, low utilization rate of active ingredients, and irritation risk of salicylic acid.

[0008] To achieve the above-mentioned purpose, the technical scheme adopted by the present application is:

[0009] In a first aspect, the present application provides a scalp oil control composition for preventing seborrheic alopecia, characterized in that it comprises the following components by weight: nicotinamide 3.0-10.0 parts, capryloyl glycine 0.5-5.0 parts, pyrithione ethanolamine salt 0.3-1.0 parts, betaine salicylic acid 0.5-3.0 parts, lemon peel extract 1.0-8.0 parts, white willow bark extract 1.0-5.0 parts, and rice fermentation filtrate 5.0-50.0 parts.

[0010] Preferably, the scalp oil control composition comprises the following components by weight: nicotinamide 5.0-10.0 parts, capryloyl glycine 3.0-5.0 parts, pyrithione ethanolamine salt 0.5-1.0 parts, betaine salicylate 1.5-3.0 parts, lemon peel extract 4.0-8.0 parts, white willow bark extract 3.0-5.0 parts, rice fermentation filtrate 25.0-50.0 parts. Preferably, the scalp oil control composition further comprises appropriate adjuvants, which include one or more of humectants, penetration enhancers, thickening agents, preservatives, pH adjustors.

[0011] Preferably, the humectant is at least one of betaine, small molecule sodium hyaluronate, and ceramide. Betaine has a synergistic effect on the dissolution and absorption of betaine salicylate; small molecule sodium hyaluronate is obtained from Nanoha® enzyme-cut oligomeric sodium hyaluronate from Huaxi Biotechnology Co., Ltd., with a molecular weight of less than 10 kDa, high safety and biological activity, and can be absorbed into the epidermis and dermis, providing deep moisturizing, repairing damaged cells, scavenging free radicals, improving skin elasticity, reducing wrinkles, and playing an anti-aging role; ceramide has the effect of protecting the scalp barrier. The thickening agent is at least one of carbomer, xanthan gum, guar gum, or polyquaternium-10.

[0012] Preferably, the penetration enhancer is at least one of menthol, PEG-60 hydrogenated castor oil, or laurocapram, which changes the structure or physical and chemical environment of the stratum corneum in the formula, thereby improving the transdermal absorption efficiency of active ingredients. Menthol increases lipid fluidity and relaxes intercellular connections between keratinocytes, forming a more relaxed penetration channel. PEG-60 hydrogenated castor oil, as a non-ionic surfactant, enhances the dissolution and diffusion of active substances in the stratum corneum by solubilizing lipid components and reducing interfacial tension to form a microemulsion system. Laurocapram reduces the diffusion resistance of active ingredients by interfering with the arrangement of stratum corneum lipids and reducing the lipid phase transition temperature to increase fluidity.

[0013] Preferably, the preservative is at least one of phenoxyethanol, caprylyl glycol, sodium benzoate, ethylhexylglycerin, or a commonly used cosmetic preservative.

[0014] Nicotinamide can promote blood circulation on the scalp, supply energy to the scalp, and deliver sufficient nutrients to hair follicles; at the same time, it can regulate sebum secretion and maintain normal function of hair follicles, thereby reducing the problem of hair loss caused by malnutrition. In addition, nicotinamide can improve scalp microcirculation, enhance the vitality and repair capacity of scalp cells, and indirectly reduce the irritability of salicylic acid to the scalp.

[0015] Capryloyl glycine has a significant oil control effect, can regulate the function of sebaceous glands on the scalp, reduce sebum secretion, and at the same time reduce the generation of dandruff, maintaining a clean state of the scalp.

[0016] Pyrocatechin ketone ethanolamine salt can synergistically enhance the oil control effect when used in combination with other ingredients, further inhibit the secretion of sebum on the scalp, and improve the anti-dandruff ability, so that the scalp can keep clean and fresh for a long time.

[0017] Betaine salicylic acid has the functions of softening keratin, helping and removing the excess keratin layer on the scalp, facilitating the penetration and absorption of other active ingredients, improving the utilization rate, deeply cleaning the dirt and oil in the hair follicle, and having the effects of anti-inflammatory and antibacterial, so as to achieve the synergistic effects of anti-dandruff, softening keratin, moisturizing, promoting the penetration and absorption of active substances. Betaine salicylic acid has the effects of mildness, moisturizing of betaine and oil control, skin tendering, anti-inflammatory and antibacterial of salicylic acid, and helps to maintain the skin barrier, and solves the problems of strong exfoliation, strong irritation and poor solubility of salicylic acid.

[0018] The flavonoids and vitamins contained in lemon peel extract can regulate the secretion function of sebaceous glands, inhibit the growth of bacteria and fungi, and reduce inflammatory reactions. Its antioxidant effect can also protect scalp cells from free radical damage, thereby reducing dandruff. At the same time, its good soothing and anti-inflammatory effects can reduce the irritation of betaine salicylic acid to the scalp, and have the synergistic effect of the combination itself.

[0019] White willow bark extract plays a role through multiple mechanisms. The components such as salicin contained in the white willow bark extract have anti-inflammatory, analgesic and soothing effects. When used in combination with betaine salicylic acid, it can not only bring the exfoliation effect of salicylic acid, promote scalp metabolism and promote the absorption of functional substances, but also help to regulate sebum secretion, reduce inflammatory reactions, help to remove aged keratin, soothe and moisturize the scalp, and improve the scalp discomfort.

[0020] Rice fermentation filtrate contains natural rice grain trace components and can synergistically enhance other ingredients through multiple mechanisms, help to regulate sebum secretion, deeply clean the scalp, supplement nutrients and moisture to the scalp, enhance the barrier function, and also have antibacterial and anti-inflammatory effects, thereby effectively promoting scalp health and further improving the overall oil control, hair loss prevention and hair care effects. The rich nutritional components such as amino acids and polysaccharides in rice fermentation filtrate can supplement moisture and nutrients to the scalp, enhance the barrier function of the scalp, improve the resistance of the scalp, and reduce the irritation of the external environment to the scalp. Moreover, the Schizosaccharomyces pombe in the natural fermentation filtrate and its fermentation active components also have the function of regulating the scalp microecology.

[0021] In a second aspect, the application provides a preparation method of a scalp oil control composition for preventing seborrheic alopecia, comprising the following steps:

[0022] (1) weighing nicotinamide, capryloyl glycine, pyrocatechol ketone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract, rice fermentation filtrate and auxiliary materials according to the proportion;

[0023] (2) Mix the required deionized water and thickening agent, heat, stir, and dissolve completely to obtain a mixed solution A;

[0024] (3) Add nicotinamide, octanoyl glycine, and pyrithione ethanolamine salt to the mixed solution A, and stir until completely dissolved to obtain a mixed solution B;

[0025] (4) Add an appropriate amount of moisturizer, penetration enhancer, and betaine salicylic acid to the mixed solution B, and stir until completely dissolved to obtain a solution C;

[0026] (5) Add lemon peel extract, white willow bark extract, and rice fermentation filtrate to the mixed solution C, and stir until mixed evenly to obtain a solution D;

[0027] (6) Add a preservative and a pH adjuster, and stir until mixed evenly to obtain the scalp oil control composition.

[0028] Preferably, in step (2), the deionized water should be sterile production water, and the amount of deionized water added should be 10-20 times the amount of thickening agent, the stirring temperature should be 30-60°C, and the stirring rate should be 35-60 r / min.

[0029] Preferably, in step (4), the amount of penetration enhancer added should be 0.5-2.0 parts, and the stirring temperature should be 55-60°C.

[0030] Preferably, in step (5), the stirring temperature should be 45-48°C, and the stirring rate should be 35-60 r / min. In a third aspect, the scalp oil control composition of the present application can be used to prepare a washing and conditioning product for preventing seborrheic alopecia, such as a shampoo, a hair conditioner, a scalp nutrient solution, etc.

[0031] Compared with the prior art, the present application has the following advantages:

[0032] (1) Nicotinamide, octanoyl glycine, pyrithione ethanolamine salt, and other ingredients synergistically act on multiple links such as regulating sebum secretion, antibacterial and anti-inflammatory, and improving the nutrient supply of hair follicles, which can not only quickly reduce the accumulation of scalp oil, but also create a healthy growth environment for hair follicles, achieving the dual effects of oil control and hair loss prevention, and the effects are long-lasting and stable.

[0033] (2) The salicylic acid is adjusted to betaine salicylic acid, which reduces the risk of poor solubility and easy precipitation of salicylic acid and the risk of irritation of pure salicylic acid compared with directly using salicylic acid in the prior art. Betaine salicylic acid can soften the stratum corneum of the scalp and promote the penetration and absorption of active ingredients such as nicotinamide and octanoyl glycine; at the same time, the moisturizer, penetration enhancer, and betaine salicylic acid form a synergistic system, further improving the solubility of betaine salicylic acid or the bioavailability of each active ingredient, and ensuring that the active ingredients fully play their roles.

[0034] (3) Utilize the soothing anti-inflammatory effect of lemon peel extract and white willow bark extract, and the enhanced repair effect of rice fermentation filtrate and nicotinamide on the scalp barrier to form a multiple irritant protection mechanism, significantly reducing the risk of product irritation to the scalp, even for sensitive skin.

[0035] (4) The composition has comprehensive efficacy and can be widely applied to various hair care products for preventing seborrheic alopecia, such as shampoos, hair conditioners, and scalp nutrient liquids. The preparation method has simple steps, does not require special equipment, is easy to industrialize, and has good industrialization prospects. DETAILED DESCRIPTION

[0036] For the purpose, technical solution and beneficial effects of the present application, the technical solution of the present application will be described in detail below in conjunction with specific examples. It should be noted that the examples described herein are only part of the examples of the present application, not all. Based on these examples in the present application, all other examples obtained by those of ordinary skill in the art without creative labor fall within the scope of the present application. In addition, in specific examples, if the experimental method is not specifically stated, it is a conventional experimental method; if the materials, reagents, etc. are not specifically stated, they can be obtained through commercial channels.

[0037] Example 2

[0038] A scalp oil control composition for preventing seborrheic alopecia comprises, by weight, the following components: nicotinamide 5.0 parts, octanoyl glycine 3.0 parts, pyrithione ethanolamine salt 0.5 parts, betaine salicylic acid 1.5 parts, lemon peel extract 4.0 parts, white willow bark extract 3.0 parts, rice fermentation filtrate 25.0 parts, and moisturizing agent sodium hyaluronate 2.0 parts, thickening agent xanthan gum 1.0 parts, penetration enhancer PEG-60 hydrogenated castor oil 1.0 parts, preservative phenoxyethanol 0.6 parts, sodium benzoate 0.3 parts, pH adjuster 0.3 parts, and deionized water 15.0 parts.

[0039] Preparation method:

[0040] (1) Weigh each component according to the above weight parts;

[0041] (2) Mix, heat, stir and completely dissolve the deionized water and xanthan gum to obtain a mixed solution A;

[0042] (3) Add nicotinamide, octanoyl glycine and pyrithione ethanolamine salt to the mixed solution A, stir until completely dissolved to obtain a mixed solution B;

[0043] (4) Add the moisturizing agent sodium hyaluronate, the penetration enhancer PEG-60 hydrogenated castor oil, and the betaine salicylic acid into the mixed solution B, stir until completely dissolved, to obtain solution C;

[0044] (5) Add the lemon peel extract, the white willow bark extract, and the rice fermentation filtrate into the mixed solution C, stir until mixed evenly, to obtain solution D;

[0045] (6) Add the phenoxyethanol, the sodium benzoate, and the pH adjuster, stir until mixed evenly, to obtain the scalp oil control composition.

[0046] Example 3

[0047] A scalp oil control composition for preventing seborrheic alopecia, comprising the following components in parts by weight: nicotinamide 10.0 parts, octanoyl glycine 5.0 parts, pyrithione ethanolamine salt 1.0 part, betaine salicylic acid 3.0 parts, lemon peel extract 8.0 parts, white willow bark extract 5.0 parts, rice fermentation filtrate 50.0 parts, and the moisturizing agent ceramide 3.0 parts, the thickening agent guar gum 1.8 parts, the penetration enhancer laurocapram 2.0 parts, the preservative ethylhexylglycerin 0.7 parts, the pH adjuster 0.4 parts, and deionized water 18.0 parts.

[0048] Preparation method:

[0049] (1) Weigh each component according to the above weight parts;

[0050] (2) Mix and heat, stir, and completely dissolve the deionized water and the guar gum, to obtain mixed solution A;

[0051] (3) Add the nicotinamide, the octanoyl glycine, and the pyrithione ethanolamine salt into the mixed solution A, stir until completely dissolved, to obtain mixed solution B;

[0052] (4) Add the moisturizing agent ceramide, the penetration enhancer laurocapram, and the betaine salicylic acid into the mixed solution B, stir until completely dissolved, to obtain solution C;

[0053] (5) Add the lemon peel extract, the white willow bark extract, and the rice fermentation filtrate into the mixed solution C, stir until mixed evenly, to obtain solution D;

[0054] (6) Add the ethylhexylglycerin and the pH adjuster, stir until mixed evenly, to obtain the scalp oil control composition.

[0055] Comparative Example 1

[0056] A composition, compared with Example 2, lacks nicotinamide, and is replaced with an equal amount of deionized water.

[0057] Comparative Example 2

[0058] A composition, compared with Example 2, lacks capryloyl glycine, and is replaced by an equal amount of deionized water.

[0059] Comparative Example 3

[0060] A composition, compared with Example 2, lacks pyrithione ethanolamine salt, and is replaced by an equal amount of deionized water.

[0061] Comparative Example 4

[0062] A composition, compared with Example 2, lacks betaine salicylic acid, and is replaced by an equal amount of deionized water.

[0063] Comparative Example 5

[0064] A composition, compared with Example 2, lacks lemon peel extract, and is replaced by an equal amount of deionized water.

[0065] Comparative Example 6

[0066] A composition, compared with Example 2, lacks white willow bark extract, and is replaced by an equal amount of deionized water.

[0067] Comparative Example 7

[0068] A composition, compared with Example 2, lacks lemon peel extract and white willow bark extract, and is replaced by an equal amount of deionized water.

[0069] Comparative Example 8

[0070] A composition, compared with Example 2, lacks rice fermentation filtrate, and is replaced by an equal amount of deionized water.

[0071] Oil control effect test

[0072] A skin oil detector was used for the test. Volunteers with a tendency of seborrheic alopecia and a vigorous secretion of scalp oil were selected and randomly divided into 11 groups, 10 people in each group, and the scalp oil control compositions prepared by using the scalp oil control compositions of Examples 2-3 and Comparative Examples 1-8 of the present application (in the form of shampoo) were used. Before use and after 2 weeks and 4 weeks of use, the oil content of the scalp of each group of volunteers was detected, and the average value was taken, and the results are shown in Table 1.

[0073] Anti-shedding effect test

[0074] Hair loss counting method was adopted. Volunteers with dandruff tendency were selected and randomly divided into 11 groups, 10 people in each group, and the scalp oil control compositions prepared by the application examples 2-3 and the comparative examples 1-8 (used in the form of shampoo) were used respectively. The volunteers collected the fallen hair with a fixed container when washing hair 3 days before using the product, 2 weeks and 4 weeks after using the product, and after drying, the broken hair with length <5 cm was removed, and the number of remaining long hair was counted; the number of hair loss of each group of volunteers was detected respectively, and the average value was taken, and the results are shown in Table 2.

[0075] Active ingredient utilization rate effect test

[0076] Franz diffusion cell method was adopted. Pig ear skin was used as a penetration barrier, which was fixed between the supply chamber and the receiving chamber of the Franz diffusion cell, and phosphate buffer was added to the receiving chamber as the receiving medium. The compositions of the application examples 2-3 and the comparative examples 1-8 were taken in an appropriate amount and added to the supply chamber, and the experiment was carried out under the condition of 32℃ and stirring rate of 300r / min. Samples were taken from the receiving chamber at 2h, 4h and 6h, and the contents of nicotinamide and capryloyl glycine in the samples were detected by high performance liquid chromatography (HPLC), each sample was detected 3 times, and the average value was taken; the cumulative penetration amount was calculated, the higher the cumulative penetration amount, the higher the active ingredient utilization rate, and the results are shown in Table 3.

[0077] Irritation effect test

[0078] Human skin patch test was adopted, and the relevant method in the “Cosmetic Safety Technology Specification” (2015 edition) was referred. Volunteers meeting the conditions were selected and randomly divided into 11 groups, 10 people in each group, and the scalp oil control compositions prepared by the application examples 2-3 and the comparative examples 1-8 were used respectively. The composition (in the form of 10% aqueous solution) was added to the medicine chamber of the patch tester, and the amount was 0.020-0.025mL. The patch tester was attached to the flexor of the volunteer's forearm, and the attachment time was 24h. After removing the patch tester, the skin reaction was observed at 30min, 24h and 48h respectively, and the score (0-4 points) was given according to the skin reaction grading standard in the specification (0-4 points), and each volunteer was scored at each time point once; the average reaction score of each group was taken. In addition, the trans-epidermal water loss of the scalp of each group of volunteers was detected after using the product for 4 weeks, and the average value was taken; the lower the trans-epidermal water loss, the better the scalp barrier function, and the smaller the irritation degree, and the results are shown in Table 4.

[0079] Hair care effect test

[0080] The verification is carried out through hair tension test and hair gloss test. Volunteers with dandruff tendency are selected and randomly divided into 11 groups, 10 people in each group, and the scalp oil control compositions prepared by the scalp oil control compositions of the application examples 2-3 and the comparative examples 1-8 (in the form of shampoo) are used respectively. The hair tension test uses a hair strength tester to detect the breaking strength of the hair; the hair gloss test uses gloss to detect the gloss of the hair surface. The test is carried out before and after 4 weeks of use for each group of volunteers, and the average value is taken, and the results are shown in Table 5.

[0081] Test results

[0082] Table 1 Oil control effect test results

[0083] Group Sebum content before use (μg / cm²) Sebum content after 2 weeks of use (μg / cm²) Sebum content after 4 weeks of use (μg / cm²) Example 2 58.9 38.4 26.6 Example 3 56.2 39.8 28.3 Comparative Example 1 57.5 48.9 40.3 Comparative Example 2 59.3 49.2 42.5 Comparative Example 3 58.7 47.5 41.9 Comparative Example 4 57.9 49.3 43.8 Comparative Example 5 58.4 44.7 35.5 Comparative Example 6 58.1 45.9 36.4 Comparative Example 7 58.2 47.3 38.9 Comparative Example 8 58.6 43.3 37.3

[0084] The core of the application is that the oil secretion is regulated by nicotinamide, the sebum production is inhibited by capryloyl glycine, the oil control effect is enhanced by pyrithione ethyl alcohol amine salt, and the penetration and absorption are promoted by betaine salicylic acid, forming a four-dimensional oil control system. The oil control effect of the application examples 2-3 is obviously better than that of each comparative example. The comparative example 1 is relatively poor in promoting circulation and nutrient supply due to the reduction of nicotinamide, and the oil content reaches 40.3 μg / cm after 4 weeks. The comparative example 2 is relatively insufficient in sebum secretion inhibition due to the reduction of capryloyl glycine, and the oil content reaches 42.5 μg / cm after 4 weeks. The comparative example 4 lacks betaine salicylic acid, and the penetration amount of the functional ingredients is also reduced, resulting in a slight decrease in oil control effect, and the oil content reaches 43.8 μg / cm after 4 weeks. The comparative examples 5-7 lack the addition of lemon peel extract and / or white willow bark extract, and the preferred plant ingredient auxiliary oil control function is missing, and the oil control effect decreases.

[0085] Table 2 Anti-hair loss effect test results

[0086] Group Number of hairs before use (root) Number of hairs after 2 weeks of use (root) Number of hairs after 4 weeks of use (root) Example 2 38.3 22.9 15.8 Example 3 36.5 24.8 16.5 Comparative Example 1 37.8 33.5 31.7 Comparative Example 2 39.5 33.8 30.5 Comparative Example 3 38.6 31.5 27.8 Comparative Example 4 37.3 30.9 25.9 Comparative Example 5 38.5 30.5 26.3 Comparative Example 6 38.9 31.3 27.5 Comparative Example 7 39.3 34.9 30.3 Comparative Example 8 38.3 33.3 29.5

[0087] The anti-hair loss effect is directly related to the anti-inflammatory and nutrient supply functions of the ingredients. Nicotinamide is the core ingredient of hair follicle nutrition, and after being missing in the comparative example 1, the number of hair loss reaches 31.7 after 4 weeks, which is twice that of the application example 2; capryloyl glycine not only controls oil, but also reduces the damage to hair follicles caused by oil blockage, and after being missing in the comparative example 2, the number of hair loss reaches 30.5 after 4 weeks. It is worth noting that the comparative example 7 lacks lemon peel extract and white willow bark extract, and loses the plant auxiliary anti-inflammatory soothing effect, and the inflammation of the hair follicles cannot be effectively controlled, and the number of hair loss reaches 30.3 after 4 weeks, further proving the important role of the plant ingredients lemon peel extract and white willow bark extract in the anti-hair loss system.

[0088] Table 3 Active ingredient utilization rate test results (cumulative penetration amount / (μg / cm²))

[0089] Group 2h nicotinamide cumulative permeation amount 2h octanoyl glycine cumulative permeation amount 4h nicotinamide cumulative permeation amount 4h octanoyl glycine cumulative permeation amount 6h nicotinamide cumulative permeation amount 6h octanoyl glycine cumulative permeation amount Example 2 10.8 9.3 19.5 17.6 28.3 25.5 Example 3 9.3 8.5 17.8 15.9 25.5 22.8 Comparative Example 1 - 5.8 - 10.5 - 15.9 Comparative Example 2 6.9 - 11.5 - 16.5 - Comparative Example 3 7.5 6.9 13.9 12.8 19.5 17.5 Comparative Example 4 5.8 4.5 9.7 8.9 13.9 12.5 Comparative Example 5 6.5 5.9 11.8 10.5 16.9 15.3 Comparative Example 6 7.3 6.5 13.5 12.5 19.3 17.9 Comparative Example 7 6.9 5.3 11.3 10.8 16.3 15.8 Comparative Example 8 7.9 6.3 12.5 11.9 18.3 16.5

[0090] Comparative Example 4 has only 13.9 μg / cm2 of nicotinamide 6h cumulative permeation amount, which is only 49.1% of Example 2 (28.3 μg / cm2), and the octanoyl glycine permeation amount is also reduced synchronously, which proves the key role of betaine salicylic acid in opening the stratum corneum barrier. In Examples 2-3, the permeation amounts of nicotinamide and octanoyl glycine are higher than those of Comparative Examples 1-8, which fully verifies the penetration-enhancing effect of betaine salicylic acid and the synergistic effect of the components. The appropriate amount of betaine salicylic acid can fully open the stratum corneum channel, and cooperate with the soothing effect of lemon peel extract and white willow bark extract to achieve the balance of "penetration enhancement-low irritation".

[0091] Table 4 Test results of irritation effect

[0092] Group 30min average reaction score 24h average reaction score 48h average reaction score Amount of scalp transepidermal water loss after 4 weeks of use (g / (h·m²)) Example 2 0.2 0.1 0.0 7.9 Example 3 0.4 0.3 0.1 8.3 Comparative Example 1 1.2 1.0 0.8 12.3 Comparative Example 2 0.8 0.7 0.6 13.5 Comparative Example 3 0.9 0.7 0.6 10.8 Comparative Example 4 0.1 0.0 0.0 9.5 Comparative Example 5 1.5 1.3 1.1 13.9 Comparative Example 6 1.4 1.2 1.0 13.3 Comparative Example 7 2.1 1.8 1.5 15.3 Comparative Example 8 1.0 0.8 0.6 12.5

[0093] The low average reaction score and small amount of transepidermal water loss of the scalp after 4 weeks of use of Examples 2-3 indicate that the scalp barrier function is good and the degree of irritation is small. Comparative Example 4 has low irritation due to the lack of betaine salicylic acid, but according to the results of Comparative Example 4, the permeation amounts of nicotinamide and octanoyl glycine are also low due to the lack of the penetration-enhancing effect of betaine salicylic acid. Comparative Example 5 lacks lemon peel extract, and Comparative Example 6 lacks white willow bark extract, and they have high average reaction scores and large amounts of transepidermal water loss, which fully illustrate that the present application can effectively reduce the irritation risk of the product by the cooperation of the active ingredients and the reasonable adjustment of the component ratio. Comparative Example 7 lacks both lemon peel extract and white willow bark extract, and loses the double soothing and anti-inflammatory effects, so the 24-hour average reaction score is obviously higher than that of Example 2, which further verifies the key role of the two plant extracts in reducing irritation.

[0094] Table 5 Test results of hair care effect

[0095] Group Breaking strength before use (cN) Breaking strength after 4 weeks of use (cN) Glossiness before use (GU) Glossiness after 4 weeks of use (GU) Example 2 145.8 185.5 38.5 60.3 Example 3 148.3 182.9 39.3 58.5 Comparative Example 1 146.1 160.5 39.5 48.9 Comparative Example 2 144.5 158.7 38.9 47.5 Comparative Example 3 145.2 162.3 39.8 49.1 Comparative Example 4 144.8 165.2 38.2 50.9 Comparative Example 5 145.3 161.9 38.1 49.7 Comparative Example 6 145.9 162.5 38.7 49.8 Comparative Example 7 145.5 155.6 39.6 45.2 Comparative Example 8 144.2 152.9 38.9 44.6

[0096] The hair breaking strength and gloss after 4 weeks of use of Examples 2-3 are better than those of each comparative example, which indicates that the hair care effect of Examples 2-3 is better than that of Comparative Examples 1-9. Each comparative example cannot synergistically play the role of nourishing and caring for hair due to the lack of part of the active components or the mismatch of the component ratio, and has poor hair care effect. The active components in the scalp oil control composition for preventing seborrheic alopecia of the present application have synergistic effects, and Examples 2-3 have good oil control and anti-hair loss effects, high active ingredient utilization rate, low irritation, and good hair care effect.

[0097] Finally, it should be noted that the above examples are merely intended to illustrate the technical solutions of the present application and not to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present application.

Claims

1. A scalp oil-controlling composition for preventing seborrheic alopecia, characterized in that, By weight, it comprises the following components: 5.0-10.0 parts nicotinamide, 3.0-5.0 parts capryloyl glycine, 0.5-1.0 parts piroctone olamine salt, 1.5-3.0 parts betaine salicylic acid, 4.0-8.0 parts lemon peel extract, 3.0-5.0 parts white willow bark extract, and 25.0-50.0 parts rice fermentation filtrate; It also includes appropriate excipients, including humectants, penetration enhancers, thickeners, preservatives, and pH adjusters; The humectant is at least one of betaine, sodium hyaluronate, and ceramide; the thickener is at least one of carbomer, xanthan gum, guar gum, and polyquaternium-10; the penetration enhancer is at least one of menthol, PEG-60 hydrogenated castor oil, or lauryl acetone; the preservative is at least one of phenoxyethanol, caprylyl glycol, sodium benzoate, and ethylhexylglycerin; and the rice fermentation filtrate contains Bifida ferment lysate.

2. The method for preparing the scalp oil-controlling composition according to claim 1, characterized in that, Includes the following steps: (1) Weigh out nicotinamide, capryloyl glycine, piroctone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract, rice fermentation filtrate and excipients according to the proportions; (2) Mix the required deionized water and thickener according to the formula, heat, stir and dissolve completely to obtain mixture A; (3) Add nicotinamide, capryloyl glycine, and piroctone ethanolamine salt to mixture A and stir until completely dissolved to obtain mixture B; (4) Add appropriate amounts of moisturizer, penetration enhancer, and betaine salicylic acid to mixture B, stir until completely dissolved, and obtain solution C; (5) Add lemon peel extract, white willow bark extract and rice fermentation filtrate to mixture C, stir until well mixed, and obtain solution D; (6) Add preservatives and pH adjusters, and stir until the mixture is uniform to obtain the scalp oil control composition.

3. The preparation method according to claim 2, characterized in that, In step (2), the deionized water should be sterile production water, and its addition amount should be 10-20 times that of the thickener. The stirring temperature should be 30-60℃ and the stirring rate should be 35-60r / min.

4. The preparation method according to claim 2, characterized in that, In step (4), the amount of penetration enhancer added is 0.5-2.0 parts, and the stirring temperature is 55-60℃.

5. The preparation method according to claim 2, characterized in that, In step (5), the stirring temperature is 45-48℃ and the stirring rate is 35-60r / min.

6. The use of the scalp oil-control composition according to claim 1 in the preparation of shampoo and conditioner products for preventing seborrheic alopecia.

7. The application according to claim 6, characterized in that, The hair care products mentioned are any one of shampoo, conditioner, and scalp nourishing solution.