Traditional Chinese medicine composition for treating facioplegia and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and provides a traditional Chinese medicine composition for treating facioplegia and a preparation method thereof, the traditional Chinese medicine composition comprises radix paeoniae rubra, ligusticum wallichii, angelica sinensis, lumbricus, astragalus membranaceus, peach kernel, safflower, scorpion, centipede, stiff silkworm, rhizoma typhonii, divaricate saposhnikovia root and gastrodia elata. The astragalus membranaceus can tonify qi of the spleen and the lung, promote blood circulation and eliminate stasis; angelica sinensis, radix paeoniae rubra, ligusticum wallichii, peach kernel and safflower are coordinated to promote blood circulation to remove blood stasis, improve facial microcirculation and relieve muscular disorder caused by deficiency of qi and blood; lumbricus has the effects of clearing and activating channels and collaterals and enhancing blood- Scorpio, centipede and stiff silkworm are insect wind-expelling medicines, penetrate into meridians and collaterals to expel wind and relieve convulsion, and especially aim at facial muscle convulsion; rhizoma typhonii and divaricate saposhnikovia root expel wind and remove cold, and relieve facial paralysis caused by wind-cold attacks; the gastrodia elata can calm liver and stop endogenous wind and assist in controlling abnormal twitch of the face The traditional Chinese medicine composition is remarkable and stable in medicine effect, symptoms disappear after the traditional Chinese medicine composition is taken for 3-8 treatment courses, and relapse is avoided.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine composition for treating facial nerve palsy and its preparation method. Background Technology

[0002] Facial nerve palsy is a neurological deficit caused by damage to the facial nerve, resulting in paralysis of the facial muscles. Depending on the location of the facial nerve injury, facial nerve palsy can be classified as central facial nerve palsy or peripheral facial nerve palsy. Common causes include stroke, tumors, intracranial infections, Hunter syndrome, Lyme disease, encephalitis, and otitis media. Approximately 70% of patients have idiopathic facial nerve palsy, and its onset is correlated with cold weather and seasonal changes.

[0003] Currently, there are many methods of treating facial paralysis using Traditional Chinese Medicine (TCM), including herbal hot compresses, acupuncture, moxibustion, cupping, and oral medication. TCM formulas for facial paralysis include Qianzheng San, Da Qin Jiao Tang, and Xiao Xu Ming Tang. Qianzheng San consists of three herbs: Bai Fu Zi, Quan Xie, and Jiang Can. Da Qin Jiao Tang consists of Qin Jiao, Qiang Huo, Du Huo, Fang Feng, Bai Zhi, Xi Xin, Shu Di, Bai Shao, Dang Gui, Chuan Xiong, Bai Zhu, Fu Ling, Huang Qin, Shi Gao, and Gan Cao. Xiao Xu Ming Tang's main ingredients include Ma Huang, Fang Ji, Ren Shen, Huang Qin, Gui Xin, Bai Shao, Chuan Xiong, Xing Ren, Fu Zi, Fang Feng, Gan Cao, and Sheng Jiang. Besides these, there are many other existing TCM combinations for treating facial nerve palsy. However, the therapeutic effects of existing TCM formulas are not ideal. Either the treatment is very slow, requiring long-term medication, or the effect is poor, with recurrence upon discontinuation of medication. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine composition for treating facial nerve palsy and its preparation method, so as to overcome the shortcomings of the poor therapeutic effect of existing drugs for treating facial nerve palsy.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a traditional Chinese medicine composition for treating facial nerve palsy, comprising the following raw materials in parts by weight: Red peony root 10-15 parts; 5-7 parts of Ligusticum chuanxiong; Angelica sinensis 10-15 parts; 5-7 portions of earthworms; Astragalus membranaceus 55-65 parts; 10-14 parts peach kernels; 5-7 parts safflower; 14-17 portions of whole worms; 28-33 portions of silkworm pupae; 20-30 parts of white aconite; 10-15 portions of windproof; 45-55 portions of Gastrodia elata; The herbal composition also includes centipedes, with 1 to 3 centipedes added for every 10 to 15g of red peony root.

[0006] Preferably, the raw materials comprise the following parts by weight: Red peony root 11-12 parts; 5-6 parts of Ligusticum chuanxiong; Angelica sinensis 12-13 parts; 6-7 portions of earthworms; Astragalus membranaceus 58-63 parts; 12-13 parts peach kernels; 6-7 parts safflower; 14-15 portions of whole scorpions; 30-31 portions of silkworm pupae; 25-26 parts of white aconite; 12-13 parts windproof; 50-52 portions of Gastrodia elata; The herbal composition also includes centipedes, with 2 centipedes for every 11-12g of red peony root.

[0007] Preferably, the raw materials comprise the following parts by weight: 12 parts of red peony root; Chuanxiong (Ligusticum striatum) 6 parts; 12 parts of Angelica sinensis; 6 portions of earthworm; Astragalus membranaceus 60 portions; 12 portions of peach kernels; Six parts of safflower; 15 samples of whole insects; 30 portions of silkworm pupae; 25 portions of Aconitum carmichaelii; 12 portions of windproof; 50 portions of Gastrodia elata; The herbal composition also includes centipedes, with 2 centipedes for every 12g of red peony root.

[0008] This invention provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps: Soak the centipede and whole insect in water and then pre-boil them to obtain a centipede and whole insect decoction. Add all remaining ingredients to the centipede decoction for the first decoction, and filter to obtain the first decoction and the first dregs. Add water to the first batch of dregs again, boil for a second time, and filter to obtain the second batch of liquid. The first and second medicinal solutions are combined to obtain the final product.

[0009] Preferably, the soaking time is 30-40 minutes; The pre-cooking process involves boiling the food and then reducing the heat to a simmer for 20-40 minutes.

[0010] Preferably, the first simmering involves bringing the water to a boil and then reducing the heat to a simmer for 30-50 minutes.

[0011] Preferably, the second simmering involves bringing the water to a boil and then reducing the heat to a simmer for 30-50 minutes.

[0012] The present invention also provides tablets, capsules, and granules prepared from the aforementioned traditional Chinese medicine composition.

[0013] The beneficial effects of this invention are as follows: In this invention, Astragalus membranaceus tonifies the Qi of the spleen and lungs, promotes blood circulation, and eliminates stagnation; Angelica sinensis, Paeonia lactiflora, Ligusticum chuanxiong, Prunus persica, and Carthamus tinctorius work synergistically to invigorate blood circulation, remove blood stasis, improve facial microcirculation, and alleviate muscle dysfunction caused by insufficient Qi and blood; Pheretima aspergillum unblocks meridians and enhances the efficacy of blood-activating herbs; Scorpion, Scolopendra subspinipes, and Bombyx mori are insect-based wind-dispelling herbs that penetrate deep into the meridians to dispel wind and stop spasms, especially for facial muscle twitching; Aconitum carmichaelii and Saposhnikovia divaricata dispel wind and cold, relieving facial paralysis caused by external wind-cold invasion; Gastrodia elata calms the liver and extinguishes wind, assisting in controlling abnormal facial twitching. Verification shows that the traditional Chinese medicine composition for treating facial nerve paralysis provided by this invention has significant and stable efficacy. After 3-8 courses of treatment, symptoms disappeared, and no recurrence was observed. Detailed Implementation

[0014] In this invention, the centipede's head and legs are removed before use.

[0015] In this invention, the soaking time is 30-40 minutes, preferably 34-38 minutes, and more preferably 35 minutes; The pre-cooking process involves boiling the water and then reducing it to a simmer for 20 to 40 minutes, preferably 25 to 35 minutes, and more preferably 30 minutes. The first simmering involves bringing the water to a boil and then reducing it to a simmer for 30 to 50 minutes, preferably 35 to 45 minutes, and more preferably 40 minutes. The second simmering involves bringing the water to a boil and then reducing the heat to a simmer for 30-50 minutes, preferably 35-45 minutes, and more preferably 40 minutes.

[0016] In this invention, the water level should be 2-3 cm above the surface of the herbs during the initial decoction, 3-5 cm above the surface of the herbs during the first decoction, and 2-3 cm above the surface of the herbs during the second decoction.

[0017] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention. Example

[0018] Weigh the raw materials: Red peony root 12g; Chuanxiong 6g; Angelica sinensis 12g; Earthworm 6g; Astragalus membranaceus 60g; 12g of peach kernels; 6g of safflower; 15g of whole scorpion; 30g of silkworm pupae; 25g of white aconite root; 12g of windproof; 50g of Gastrodia elata; Two centipedes.

[0019] Soak the centipede and whole worm in water for 30 minutes and then pre-decoct. During pre-decocting, the water should be 3cm above the surface of the herbs. Pre-decocting means bringing the water to a boil and then reducing it to a simmer for 30 minutes to obtain the centipede and whole worm decoction. Add all remaining ingredients to the centipede decoction. When decocting for the first time, the water level should be 4cm above the herbs. After boiling, adjust to a simmer and decoct for 40 minutes. Filter to obtain the first decoction and the first dregs. Add water to the first batch of dregs again. When decocting for the second time, the water level should be 2.5cm above the dregs. After boiling, adjust the heat to a simmer and decoct for 40 minutes. Filter to obtain the second decoction. The first and second medicinal solutions are combined to obtain the final product.

[0020] The selected cases were all patients with one or more typical symptoms of facial nerve palsy (widened palpebral fissure, shallow nasolabial fold, drooping corner of mouth, lisping speech, drooling, inability to smoothly perform actions such as frowning, closing the eyes, and whistling, and loss of facial expression on the same side of the face, etc.), totaling 17 cases. Among them, there were 9 males and 8 females, all aged between 19 and 53 years. The herbal liquid was prepared according to the method in Example 1, and the patients took it orally twice a day, morning and evening, for 14 days as one course of treatment. After 3 to 8 courses of treatment, the symptoms disappeared in all cases, and no recurrence was observed.

[0021] The specific details are shown in Table 1 below.

[0022] Table 1. Patient Details Serial Number gender age symptom Treatment results 1 male 37 Facial asymmetry Cured after 3 courses of medication, with no recurrence. 2 male 46 crooked mouth The patient was cured after four courses of medication and has not relapsed. 3 male 19 I've been staying up late a lot and haven't been keeping warm, and I'm experiencing pain behind my ears and dry eyes. The patient was cured after five courses of medication and has not relapsed. 4 male 23 Abnormal taste and hearing, facial muscle weakness The patient was cured after four courses of medication and has not relapsed. 5 male 42 numbness on the left side of the face The patient was cured after six courses of medication and has not relapsed. 6 male 51 The face is uncoordinated on both sides, accompanied by slight swelling. The patient was cured after five courses of medication and has not relapsed. 7 male 29 Diminished sense of taste, drooping corner of mouth The patient was cured after four courses of medication and has not relapsed. 8 male 25 Incomplete eyelid closure and crooked mouth The patient was cured after four courses of medication and has not relapsed. 9 male 36 Facial swelling, drooping left corner of mouth Cured after 3 courses of medication, with no recurrence. 10 female 34 Ear pain, facial stiffness The patient was cured after eight courses of medication and has not relapsed. 11 female 20 The patient's lack of sleep deprivation and failure to keep warm resulted in a slight drooping of the corner of the mouth. Cured after 3 courses of medication, with no recurrence. 12 female 48 Ear pain, dry mouth, numbness in facial muscles The patient was cured after six courses of medication and has not relapsed. 13 female 37 Drooling, lisping, crooked mouth The patient was cured after seven courses of medication and has not relapsed. 14 female 41 Facial stiffness, decreased sense of taste Cured after 5 courses of medication, with no recurrence. 15 female 30 numbness on the left side of the face Cured after 3 courses of medication, with no recurrence. 16 female 29 Dry eyes, weak facial muscles, ear pain The patient was cured after four courses of medication and has not relapsed. 17 female 51 Incomplete eyelid closure, crooked mouth, and decreased sense of taste. The patient was cured after four courses of medication and has not relapsed. Example

[0023] Weigh the raw materials: Red peony root 11g; 7g of Ligusticum chuanxiong; Angelica sinensis 12g; Earthworm 7g; Astragalus membranaceus 58g; 13g of peach kernels; 6g of safflower; 16g of whole scorpion; 28g of silkworm pupae; 24g of white aconite root; 13g of windproof material; Gastrodia elata 51g; Two centipedes.

[0024] Soak the centipede and whole scorpion in water for 35 minutes and then pre-decoct. During pre-decocting, the water should be 3cm above the surface of the herbs. Pre-decocting means bringing the water to a boil and then reducing it to a simmer for 35 minutes to obtain the centipede and whole scorpion decoction. Add all remaining ingredients to the centipede decoction. When decocting for the first time, the water level should be 4cm above the herbs. After boiling, adjust to a simmer and decoct for 45 minutes. Filter to obtain the first decoction and the first dregs. Add water to the first batch of dregs again. When boiling for the second time, the water level should be 2.5cm above the dregs. After boiling, adjust the heat to low and boil for 35 minutes. Filter to obtain the second decoction. The first and second medicinal solutions are combined to obtain the final product. Example

[0025] Weigh the raw materials: Red peony root 13g; 5g of Ligusticum chuanxiong; Angelica sinensis 13g; Earthworm 7g; Astragalus membranaceus 62g; 11g of peach kernels; 7g of safflower; 16g of whole scorpion; 29g of silkworm pupae; 24g of white aconite root; 13g of windproof material; 48g of Gastrodia elata; Two centipedes.

[0026] Soak the centipede and whole scorpion in water for 30 minutes and then pre-decoct. During pre-decocting, the water should be 3cm above the surface of the herbs. Pre-decocting means bringing the water to a boil and then reducing it to a simmer for 40 minutes to obtain the centipede and whole scorpion decoction. Add all remaining ingredients to the centipede decoction. When decocting for the first time, the water level should be 4cm above the herbs. After boiling, adjust to a simmer and decoct for 40 minutes. Filter to obtain the first decoction and the first dregs. Add water to the first batch of dregs again. When decocting for the second time, the water level should be 2.5cm above the dregs. After boiling, adjust the heat to a simmer and decoct for 40 minutes. Filter to obtain the second decoction. The first and second medicinal solutions are combined to obtain the final product.

[0027] As can be seen from the above embodiments, in this invention, Astragalus membranaceus can replenish the Qi of the spleen and lungs, promote blood circulation, and eliminate stagnation; Angelica sinensis, Paeonia lactiflora, Ligusticum chuanxiong, Prunus persica, and Carthamus tinctorius work synergistically to invigorate blood circulation, remove blood stasis, improve facial microcirculation, and alleviate muscle dysfunction caused by insufficient Qi and blood; Pheretima aspergillum unblocks meridians and enhances the efficacy of blood-activating medicine; Scorpion, Scolopendra subspinipes, and Bombyx mori are insect-based wind-dispelling medicines that penetrate deep into the meridians to dispel wind and stop spasms, especially for facial muscle twitching; Aconitum carmichaelii and Saposhnikovia divaricata dispel wind and cold, relieving facial paralysis caused by external wind-cold invasion; Gastrodia elata calms the liver and extinguishes wind, assisting in controlling abnormal facial twitching. Verification shows that the traditional Chinese medicine composition for treating facial nerve paralysis provided by this invention has significant and stable efficacy. After 3-8 courses of treatment, symptoms disappeared, and no recurrence was observed.

[0028] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating facial nerve palsy, characterized in that, Raw materials comprising the following parts by weight: Red peony root 10-15 parts; 5-7 parts of Ligusticum chuanxiong; Angelica sinensis 10-15 parts; 5-7 portions of earthworms; Astragalus membranaceus 55-65 parts; 10-14 parts peach kernels; 5-7 parts safflower; 14-17 portions of whole scorpions; 28-33 portions of silkworm pupae; 20-30 parts of white aconite; 10-15 portions of windproof; 45-55 portions of Gastrodia elata; The herbal composition also includes centipedes, with 1 to 3 centipedes added for every 10 to 15g of red peony root.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Raw materials comprising the following parts by weight: Red peony root 11-12 parts; 5-6 parts of Ligusticum chuanxiong; Angelica sinensis 12-13 parts; 6-7 portions of earthworms; Astragalus membranaceus 58-63 parts; 12-13 parts peach kernels; 6-7 parts safflower; 14-15 portions of whole scorpions; 30-31 portions of silkworm pupae; 25-26 parts of white aconite; 12-13 parts windproof; 50-52 portions of Gastrodia elata; The herbal composition also includes centipedes, with 2 centipedes for every 11-12g of red peony root.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, Raw materials comprising the following parts by weight: 12 parts of red peony root; Chuanxiong (Ligusticum striatum) 6 parts; 12 parts of Angelica sinensis; 6 portions of earthworm; Astragalus membranaceus 60 portions; 12 portions of peach kernels; Six parts of safflower; 15 samples of whole insects; 30 portions of silkworm pupae; 25 portions of Aconitum carmichaelii; 12 portions of windproof; 50 portions of Gastrodia elata; The herbal composition also includes centipedes, with 2 centipedes for every 12g of red peony root.

4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that, It includes the following steps: Soak the centipede and whole insect in water and then pre-boil them to obtain a centipede and whole insect decoction. Add all remaining ingredients to the centipede decoction for the first decoction, and filter to obtain the first decoction and the first dregs. Add water to the first batch of dregs again, boil for a second time, and filter to obtain the second batch of liquid. The first and second medicinal solutions are combined to obtain the final product.

5. The method for preparing the traditional Chinese medicine composition according to claim 4, characterized in that, The soaking time is 30-40 minutes; The pre-cooking process involves boiling the food and then reducing the heat to a simmer for 20-40 minutes.

6. The method for preparing the traditional Chinese medicine composition according to claim 4 or 5, characterized in that, The first simmering involves bringing the water to a boil and then reducing the heat to a simmer for 30-50 minutes.

7. The method for preparing the traditional Chinese medicine composition according to claim 6, characterized in that, The second simmering involves bringing the water to a boil and then reducing the heat to a simmer for 30-50 minutes.

8. Tablets, capsules, or granules prepared from the traditional Chinese medicine composition according to any one of claims 1 to 3.