Gold-labeled antibody purification device

Abstract

The invention discloses a gold-labeled antibody purification device which comprises a centrifugal machine and a motor, the centrifugal machine is provided with a control program and an operation screen, the motor is fixedly connected with a fixing ring, a rotating shaft of the motor is rotatably connected with a quick-change assembly, the fixing ring is rotatably connected with the quick-change assembly, the quick-change assembly is detachably connected with a supporting frame, and the supporting frame is detachably connected with the centrifugal machine. The support frame is hinged with at least one group of test tube clamping components, the test tube clamping components can rotate by a certain angle relative to the support frame and are locked, the clamping components are provided with air bags, the air bags are used for clamping test tubes, the clamping components are connected with a fixing ring through an air path, the fixing ring is connected to an air pump through an air pipe, and the air pump is connected with the air bag. The fixing ring is further provided with a pressure sensing unit, the pressure sensing unit can make the air pump stop working, the clamping assembly can be rapidly replaced, the angle of the test tube can be adjusted, clamping is stable, the adaptability of the device is wider, and the centrifugal quality during gold-labeled antibody purification can be improved.

Description

Technical Field

[0001] This invention relates to the field of colloidal gold immunochromatographic test strip preparation technology, specifically to a gold-labeled antibody purification device. Background Technology

[0002] Colloidal gold immunochromatographic test strips are a technique for qualitative, semi-quantitative, and quantitative detection of substances in vitro. It combines colloidal gold labeling, immunoassay, chromatographic analysis, and monoclonal (polyclonal) antibody technology into a solid-phase labeling detection method. Colloidal gold solution consists of gold particles suspended in an aqueous solution in a colloidal state with a particle size of less than micrometers. It is a commonly used non-radioactive tracer in immunolabeling techniques. Preparing the gold-labeled antibody solution is a crucial step in the fabrication of colloidal gold immunochromatographic test strips. This process requires multiple centrifugation operations to purify the gold-labeled antibody.

[0003] A search revealed that patent CN 119972377 B discloses a medical high-speed benchtop centrifuge, which includes a main chamber, a power mechanism at the bottom of the main chamber, a motor, an output shaft fixedly connected to the output end of the motor, multiple wedges fixedly connected to the outside of the output shaft, and a centrifugation mechanism on the outside of the output shaft, which includes a centrifugal rotor.

[0004] The above-mentioned device also has the following problems: the angle at which it clamps the test tubes is fixed, but in the actual preparation process, the tilt angle of test tubes of different sizes is slightly different. The angle between the test tube and the shaft is usually 20 to 45 degrees so that the particles can form a precipitate on the side of the tube during separation. In addition, the above-mentioned device is prone to loosening of the clamping device when the centrifuge is rotating at high speed, causing the test tube to move and the centrifugation operation of the liquid in the test tube to fail. Although it can adapt to some different test tube sizes, when encountering test tubes that are outside the clamping range, the clamping device is cumbersome to replace, and may even require the replacement of the equipment. Summary of the Invention

[0005] To address the problems of fixed test tube clamping angle, easy loosening of test tube clamping during high-speed rotation, and cumbersome replacement of clamping parts in the prior art, this invention provides a gold-labeled antibody purification device.

[0006] The technical solution adopted by this invention to solve its technical problem is:

[0007] This invention proposes a gold-labeled antibody purification device, including a centrifuge and a motor. The centrifuge is equipped with a control program and an operation screen. The motor is fixedly connected to a retaining ring, and the motor shaft is rotatably connected to a quick-change assembly. The retaining ring is rotatably connected to the quick-change assembly. The quick-change assembly is detachably connected to a support frame. The support frame is hinged to at least one set of test tube clamping assemblies. The test tube clamping assemblies can rotate relative to the support frame at a certain angle and lock. The clamping assemblies are equipped with air bladders for clamping test tubes. The clamping assemblies are connected to the retaining ring via an air path. The retaining ring is connected to an air pump via an air tube. The retaining ring is also equipped with a pressure sensing unit that can stop the air pump from operating.

[0008] Preferably, the fixing ring is a hollow ring, the upper end of the fixing ring is provided with an air groove, the fixing ring is also provided with a third air passage, the air groove is connected to the third air passage, the third air passage is connected to the air pump through an air pipe, and the air pipe is also provided with a solenoid valve for pressure relief.

[0009] Preferably, the pressure sensing unit includes a push rod slidably connected to the fixing ring, with the upper end of the push rod extending out of the fixing ring and the lower end extending into the fixing ring and communicating with the third air passage. The push rod is threadedly connected to an adjusting plate, and a fourth spring is inserted through the push rod. The fourth spring is located between the adjusting plate and the fixing ring, and adjusting the position of the adjusting plate can adjust the elastic force of the fourth spring. The fixing ring is also fixedly connected to a switch, which can cooperate with the push rod.

[0010] Preferably, the quick-change assembly includes a rotating seat, the motor shaft passes through the fixed ring and is rotatably connected to the rotating seat, the rotating seat is rotatably connected to the fixed ring, the rotating seat is provided with a second air passage, and when the rotating seat rotates relative to the fixed ring, the second air passage is always connected to the air groove.

[0011] Preferably, the rotating seat has a hollow cavity structure, and a top plate is slidably connected inside the rotating seat. A first spring is provided between the top plate and the rotating seat. A through groove is provided on the top of the rotating seat. At least one set of slots is provided at the upper end of the hollow cavity of the rotating seat. The slots are distributed at an angle to the through groove. A protrusion is provided at a suitable position at the lower end of the support frame. After the lower end of the support frame passes through the through groove and rotates 90 degrees, the protrusion can be engaged in the slot with the cooperation of the top plate.

[0012] Preferably, the support frame is provided with a first air passage, and when the support frame cooperates with the rotating seat, the first air passage is connected to the second air passage.

[0013] Preferably, the test tube clamping assembly includes a test tube holder, which is hinged to the support frame. One side of the air bladder is fixedly connected to the test tube holder. The center of the air bladder is annular for fixing the test tube. The air bladder is connected to the first air passage through a flexible tube. An auxiliary clamp is symmetrically arranged at a suitable position on the test tube holder. The auxiliary clamp is slidably connected to the test tube holder through a fifth spring.

[0014] Preferably, a number of latches are provided at a suitable position at one end of the test tube holder hinged together, the support frame is slidably connected to the latch rod by a second spring, the end of the latch rod away from the latch is connected to the first air passage, and the latch rod can slide into the latch under the action of air pressure to constrain the rotation of the test tube holder.

[0015] Preferably, a number of ratchet teeth are provided at a suitable position at one end of the test tube holder hinge, and the support frame is slidably connected to the pawl by a third spring. The pawl and the ratchet teeth cooperate to allow the test tube holder to rotate arbitrarily relative to the support frame and then be fixed in place.

[0016] Preferably, a positioning block is fixed at a suitable position of the test tube holder, and a stop block is fixed at a suitable position of the support frame. When the stop block and the positioning block cooperate, the test tube holder and the support frame are in a horizontal state.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. By setting the through groove and slot of the rotating seat, the present invention enables the support frame to be quickly assembled and separated from the rotating seat with the assistance of the first spring and the top plate, making the test tube seat replacement quick and improving the applicability of the device.

[0019] 2. The present invention is provided by hinged connection between the support frame and the test tube holder, and a pawl is slidably provided on the support frame. The test tube holder is provided with several sets of ratchet teeth that cooperate with the pawl, which allows the test tube holder to adjust the angle between itself and the support frame arbitrarily within the allowable tilt angle range of the test tube.

[0020] 3. The present invention provides an airbag on a test tube holder, a sliding connecting rod on a support frame, and several sets of latches on the test tube holder that cooperate with the latches. Air pressure is used to clamp the test tube with the airbag, and after clamping a certain air pressure, the latches connected to the first air passage slide into the latches to lock the angle of the test tube holder, so that the airbag can effectively clamp the test tube and prevent the test tube from moving.

[0021] 4. This invention adjusts the position of the adjusting plate by rotating the top rod, thereby adjusting the length of the fourth spring to adjust the gas pressure required for the adjusting plate to move. This allows the air bladder on the test tube holder to adjust the clamping gas pressure according to the test tube to be clamped, thereby preventing the test tube from shifting position during centrifugal motion. Attached Figure Description

[0022] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0023] Figure 1 This is a three-dimensional schematic diagram of the external shape of the present invention;

[0024] Figure 2 This is a schematic diagram of the internal structure of the present invention;

[0025] Figure 3 This is the present invention. Figure 2 Enlarged view of point A in the middle;

[0026] Figure 4 This is the present invention. Figure 2 Enlarged view of point B in the middle;

[0027] Figure 5 This is the present invention. Figure 2 Enlarged view of point C in the middle;

[0028] Figure 6 This is the present invention. Figure 2 Diagram of the K-direction;

[0029] Figure 7 This is a half-sectional schematic diagram of the rotating seat of the present invention;

[0030] Figure 8 This is a schematic diagram of the lower end of the support frame of the present invention;

[0031] Figure 9 This is a three-dimensional schematic diagram of the fixing ring of the present invention.

[0032] Explanation of reference numerals in the attached figures:

[0033] 1. Centrifuge; 2. Test tube; 3. Motor; 4. Air pump; 5. Fixing ring; 6. Air tank; 7. Rotating seat; 8. First spring; 9. Top plate; 10. Support frame; 11. Test tube holder; 12. Tube; 13. First air passage; 14. Air bag; 15. Second air passage; 16. Third air passage; 17. Clamping rod; 18. Bay; 19. Pawl; 20. Ratchet; 21. Top rod; 22. Switch; 23. Stop block; 24. Positioning block; 25. Through groove; 26. Slot; 27. Protrusion; 28. Adjusting plate; 29. ​​Solenoid valve; 30. Auxiliary clamp. Detailed Implementation

[0034] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0035] Example 1

[0036] like Figure 1-9 The gold-labeled antibody purification device shown includes a centrifuge 1 and a motor 3. The centrifuge 1 is equipped with a control program and an operation screen. The control program is built-in, while the operation screen is externally displayed and equipped with corresponding buttons. Both the centrifuge 1 and the motor 3 are mature technologies in the market. Under the control of the control program, the speed of the motor 3 can be adjusted as needed.

[0037] The motor 3 is fixedly connected to a fixed ring 5, which is a hollow ring. The rotating shaft of the motor 3 passes through the center of the fixed ring 5 and is rotatably connected to the rotating seat 7. The rotating seat 7 is rotatably connected to the fixed ring 5. The upper end of the fixed ring 5 is provided with an air groove 6. The fixed ring 5 is also provided with a third air passage 16. The air groove 6 is connected to the third air passage 16. The rotating seat 7 is provided with a second air passage 15. When the rotating seat 7 rotates relative to the fixed ring 5, the second air passage 15 is always connected to the air groove 6.

[0038] The centrifuge 1 is also equipped with an air pump 4. The third air passage 16 is connected to the air pump 4 through an air pipe. The air pipe is also equipped with a solenoid valve 29 for depressurization after the work is completed. The solenoid valve 29 is controlled by a built-in program.

[0039] Specifically, solenoid valve 29 is a mature product on the market; you can choose to purchase it according to your needs.

[0040] The rotating seat 7 has a hollow cavity structure. A top plate 9 is slidably connected inside the rotating seat 7. A first spring 8 is provided between the top plate 9 and the rotating seat 7. A through groove 25 is provided on the top of the rotating seat 7. At least one set of slots 26 is provided at the upper end of the hollow cavity of the rotating seat 7. The slots 26 are distributed at a 90-degree angle to the through groove 25. A protrusion 27 is provided at a suitable position at the lower end of the support frame 10. After the lower end of the support frame 10 passes through the through groove 25 and rotates 90 degrees, the protrusion 27 can be inserted into the slot 26 with the cooperation of the top plate 9. The support frame 10 is provided with a first air passage 13. When the support frame 10 and the rotating seat 7 are locked together under the action of the top plate 9, the first air passage 13 is connected to the second air passage 15. With the cooperation of the slots 26 and the protrusion 27 with the top plate 9, the support frame 10 and the rotating seat 7 can be quickly assembled and separated, which facilitates the quick replacement of the support frame 10 to better match the test tube 2.

[0041] The support frame 10 is hinged to a test tube holder 11, and the test tube holder 11 is provided with an air bladder 14. One side of the air bladder 14 is fixedly connected to the test tube holder 11. The center of the air bladder 14 is annular for fixing the test tube 2. The air bladder 14 is connected to the first air passage 13 through a hose 12. An auxiliary clamp 30 is symmetrically arranged at a suitable position on the test tube holder 11. The auxiliary clamp 30 is slidably connected to the test tube holder 11 through a fifth spring. One end of the fifth spring is connected to the auxiliary clamp 30, and the other end of the fifth spring is connected to the test tube holder 11. A rubber layer is provided on the side of the auxiliary clamp 30 that contacts the test tube 2.

[0042] Specifically, when fixing test tube 2, the auxiliary clamp 30 is used to position the upper 1 / 3 of test tube 2 within the working area of ​​air bag 14. After the air pump 4 injects gas into air bag 14, air bag 14 expands, thus clamping test tube 2. The contact part between air bag 14 and test tube 2 is provided with an anti-slip layer, which allows air bag 14 to firmly clamp test tube 2 under air pressure.

[0043] Several sets of ratchet teeth 20 are provided at a suitable position on one end of the test tube holder 11. The support frame 10 is slidably connected to the pawl 19 through the third spring. One end of the third spring is connected to the pawl 19, and the other end of the third spring is connected to the support frame 10. The pawl 19 and the ratchet teeth 20 cooperate to allow the test tube holder 11 to be manually rotated at any angle relative to the support frame 10 within the allowable tilt angle range of the test tube 2 and then fixed. When the external force overcomes the elastic force of the third spring, the test tube holder 11 can be rotated.

[0044] Several sets of latches 18 are set at appropriate positions on one hinged end of the test tube holder 11. The support frame 10 is slidably connected to the clamping rod 17 through the second spring. One end of the second spring is connected to the clamping rod 17, and the other end of the second spring is connected to the support frame 10. The elastic force of the second spring is less than the maximum clamping force that causes deformation when the test tube 2 is clamped by the airbag 14, so as to avoid deformation of the test tube 2 caused by the airbag 14. The end of the clamping rod 17 away from the latches 18 is connected to the first air passage 13. Under the action of air pressure, the clamping rod 17 can slide into the latches 18 to constrain the rotation of the test tube holder 11. After the air pressure disappears, the clamping rod 17 can be reset under the action of the second spring. When reset, the clamping rod 17 disengages from the latches 18, so that the test tube holder 11 can be rotated again to adjust the angle.

[0045] Furthermore, the angle between the test tube and the rotating shaft is usually 20 to 45 degrees. In order to better adjust the angle of the test tube holder 11 and the support frame 10, the pawl 19 and the lever 17 are distributed at 90-degree intervals, and the moving direction of the lever 17 is horizontal.

[0046] The fixed ring 5 is slidably connected to the top rod 21. The upper end of the top rod 21 extends out of the fixed ring 5, and the lower end of the top rod 21 extends into the fixed ring 5 and can be connected to the third air passage 16. The connected passage is square. The top rod 21 is threadedly connected to an adjustment plate 28. The adjustment plate 28 is also square due to the shape of the passage. This allows the adjustment plate 28 to be moved and adjusted along the axis of the top rod 21 by means of threaded transmission. The adjustment plate 28 will not rotate during adjustment. A fourth spring is inserted through the top rod 21. The fourth spring is located between the adjustment plate 28 and the fixed ring 5. Adjusting the position of the adjustment plate 28 can adjust the spring force of the fourth spring. The maximum working spring force of the fourth spring is less than the maximum clamping force that causes deformation when the test tube 2 is clamped by the air bag 14. The spring force of the fourth spring is greater than the spring force of the second spring. The fixed ring 5 is also fixedly connected to a switch 22, which can cooperate with the top rod 21.

[0047] Specifically, when the top rod 21 rises to activate the switch 22, the control program stops the air pump 4 and maintains pressure, while simultaneously activating the motor 3, which drives the rotating seat 7 to rotate, thereby causing the support frame 10 to rotate the test tube holder 11, causing the test tube 2 to separate under centrifugal force.

[0048] Specifically, switch 22 is a push-button spring switch, a mature product on the market, and can be selected according to needs.

[0049] Specifically, a push-button spring switch typically consists of a push button, a spring, a mounting base, and conductive contacts. The push button is usually made of plastic or metal and possesses a certain degree of pressing performance and mechanical strength. The spring's function is to allow the button to automatically return to its original position and to ensure its elasticity when pressed. The mounting base is used to secure the button and spring, ensuring their positions do not change. The conductive contacts are the crucial part connecting the circuit; pressing the button connects or disconnects the circuit through the contacts, thus achieving the switch function.

[0050] A positioning block 24 is fixed at a suitable position on the test tube holder 11, and a stop 23 is fixed at a suitable position on the support frame 10. When the stop 23 cooperates with the positioning block 24, the test tube holder 11 and the support frame 10 are in a horizontal state, so as to better realize the placement and removal of the test tube 2 on the test tube holder 11.

[0051] Specifically, a power supply is also provided to provide the power required by this device. The power supply can be in the form of a built-in battery or an external power supply, which is a mature technology in the market. The motor 3, air pump 4, switch 22, and solenoid valve 29 are all connected to the power supply and are controlled by the built-in program.

[0052] A method for using a gold-labeled antibody purification device, comprising the following steps:

[0053] S1: Select a support frame 10 with a suitable test tube seat 11 hinged according to the specifications of test tube 2;

[0054] According to the force required for the deformation of test tube 2, rotate the top rod 21 to adjust the position of the adjustment plate 28, thereby adjusting the length of the fourth spring to adjust the gas pressure required for the adjustment plate 28 to move;

[0055] By pressing the buttons on the operation screen, you can adjust the built-in program and the required centrifugation time.

[0056] S2: The lower end of the support frame 10 passes through the through slot 25 on the rotating seat 7 and rotates 90 degrees, so that the protrusion 27 is engaged in the slot 26. With the assistance of the first spring 8 and the top plate 9, the support frame 10 is tightly connected to the rotating seat 7, realizing the connection between the first air passage 13 and the second air passage 15.

[0057] S3: Use the auxiliary clamp 30 to position the upper 1 / 3 of the test tube 2 within the working area of ​​the airbag 14;

[0058] According to the optimal tilt angle of test tube 2, manually pull test tube holder 11 to rotate. When test tube holder 11 rotates, ratchet 20 overcomes the resistance of the third spring and causes pawl 19 to retract and avoid it. After adjusting to the required angle, stop. At this time, pawl 19 re-engages with ratchet 20 to prevent test tube holder 11 from rotating.

[0059] After all steps are completed, close the top cover of the device for safe operation.

[0060] S4: By using an external button, start the air pump 4. The gas generated by the air pump 4 enters the third air passage 16 through the air tube, then enters the second air passage 15 after passing through the air groove 6, and then enters the first air passage 13. The gas enters the air bag 14 through the hose, causing the air bag 14 to expand and clamp the test tube 2.

[0061] S5: After the airbag 14 reaches the clamping force, the air pressure causes the locking rod 17 to overcome the elastic force of the second spring and slide into the bayonet 18, thereby locking the test tube seat 11.

[0062] S6: Continuous pressurization. At this time, the air pressure pushes the adjustment plate 28 to compress the fourth spring, causing the top rod 21 to rise and touch the switch 22. At this time, the built-in program stops the air pump 4 and maintains the pressure. At the same time, the motor 3 is started. The motor 3 drives the rotating seat 7 to rotate. During the rotation of the rotating seat 7, the second air passage 15 can always be connected to the third air passage 16 under the action of the air groove 6 to ensure the air pressure required for the air bag 14 to hold the test tube.

[0063] S7: After the centrifugal rotation time is completed by the built-in program, the motor 3 stops rotating and controls the solenoid valve 29 to open, so that the gas in the air bag 14 can be depressurized, so that the test tube 2 can be removed.

[0064] After the pressure is released, the lever 17 separates from the bayonet 18, and the test tube holder 11 can rotate back to its original position.

[0065] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A gold-labeled antibody purification device, comprising a centrifuge (1) and a motor (3), wherein the centrifuge (1) is equipped with a control program and an operation screen, characterized in that, The motor (3) is fixedly connected to a fixing ring (5). The rotating shaft of the motor (3) is rotatably connected to a quick-change assembly. The fixing ring (5) is rotatably connected to the quick-change assembly. The quick-change assembly is detachably connected to a support frame (10). The support frame (10) is hinged to at least one set of test tube clamping assemblies. The test tube clamping assemblies can rotate relative to the support frame (10) at a certain angle and lock. The clamping assembly is provided with an airbag (14). The airbag (14) is used to clamp the test tube (2). The clamping assembly is connected to the fixing ring (5) through an air passage. The fixing ring (5) is connected to the air pump (4) through an air pipe. The fixing ring (5) is also provided with a pressure sensing unit. The pressure sensing unit can stop the air pump (4) from working.

2. The gold-labeled antibody purification device according to claim 1, characterized in that, The fixing ring (5) is a hollow ring. An air groove (6) is provided at the upper end of the fixing ring (5). The fixing ring (5) is also provided with a third air passage (16). The air groove (6) is connected to the third air passage (16). The third air passage (16) is connected to the air pump (4) through an air pipe. The air pipe is also provided with a solenoid valve (29) for depressurization.

3. The gold-labeled antibody purification device according to claim 2, characterized in that, The pressure sensing unit includes a push rod (21), which is slidably connected to the fixing ring (5). The upper end of the push rod (21) extends out of the fixing ring (5), and the lower end of the push rod (21) extends into the fixing ring (5) and can communicate with the third air passage (16). The push rod (21) is threadedly connected to an adjustment plate (28). A fourth spring is inserted through the push rod (21). The fourth spring is located between the adjustment plate (28) and the fixing ring (5). Adjusting the position of the adjustment plate (28) can adjust the elastic force of the fourth spring. The fixing ring (5) is also fixedly connected to a switch (22), which can cooperate with the push rod (21).

4. The gold-labeled antibody purification device according to claim 2, characterized in that, The quick-change assembly includes a rotating seat (7), the shaft of the motor (3) passes through the fixed ring (5) and is rotatably connected to the rotating seat (7), the rotating seat (7) is rotatably connected to the fixed ring (5), the rotating seat (7) is provided with a second air passage (15), when the rotating seat (7) rotates relative to the fixed ring (5), the second air passage (15) is always connected to the air groove (6).

5. The gold-labeled antibody purification device according to claim 4, characterized in that, The rotating seat (7) has a hollow cavity structure. A top plate (9) is slidably connected inside the rotating seat (7). A first spring (8) is provided between the top plate (9) and the rotating seat (7). A through groove (25) is provided on the top of the rotating seat (7). At least one set of slots (26) is provided at the upper end of the hollow cavity of the rotating seat (7). The slots (26) are distributed at a 90-degree angle to the through groove (25). A protrusion (27) is provided at a suitable position at the lower end of the support frame (10). After the lower end of the support frame (10) passes through the through groove (25) and rotates 90 degrees, the protrusion (27) can be inserted into the slot (26) with the cooperation of the top plate (9).

6. The gold-labeled antibody purification device according to claim 4, characterized in that, The support frame (10) is provided with a first air passage (13). When the support frame (10) cooperates with the rotating seat (7), the first air passage (13) is connected to the second air passage (15).

7. The gold-labeled antibody purification apparatus according to claim 6, characterized in that, The test tube clamping assembly includes a test tube holder (11), which is hinged to the support frame (10). One side of the airbag (14) is fixedly connected to the test tube holder (11). The center of the airbag (14) is annular for fixing the test tube (2). The airbag (14) is connected to the first air passage (13) through a hose (12). An auxiliary clamp (30) is symmetrically arranged at a suitable position on the test tube holder (11). The auxiliary clamp (30) is slidably connected to the test tube holder (11) through a fifth spring.

8. The gold-labeled antibody purification apparatus according to claim 7, characterized in that, The test tube holder (11) is hinged at one end and a number of slots (18) are provided at a suitable position. The support frame (10) is slidably connected to the lever (17) by a second spring. The end of the lever (17) away from the slot (18) is connected to the first air passage (13). Under the action of air pressure, the lever (17) can slide into the slot (18) to constrain the rotation of the test tube holder (11).

9. The gold-labeled antibody purification apparatus according to claim 7, characterized in that, The test tube holder (11) is hinged at a suitable position with a number of ratchet teeth (20). The support frame (10) is slidably connected to the pawl (19) by a third spring. The pawl (19) cooperates with the ratchet teeth (20) to allow the test tube holder (11) to rotate arbitrarily relative to the support frame (10) and then be fixed.

10. The gold-labeled antibody purification apparatus according to claim 7, characterized in that, A positioning block (24) is fixed at a suitable position on the test tube holder (11), and a stop block (23) is fixed at a suitable position on the support frame (10). When the stop block (23) and the positioning block (24) cooperate, the test tube holder (11) and the support frame (10) are in a horizontal state.

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