An antibacterial and anti-mite shampoo and its preparation method

Abstract

The application discloses antibacterial and acaricidal shampoo and a preparation method thereof, and relates to the technical field of daily chemicals. When the antibacterial and acaricidal shampoo is prepared, long carbon chain alkyl acid is first reacted with 3-dimethylaminopropylamine to obtain long carbon chain amidated tertiary amine; the long carbon chain amidated tertiary amine is reacted with ethylene 2-(methacryloyloxy)ethyl phosphate to obtain phosphatidylated quaternary ammonium monomer; the phosphatidylated quaternary ammonium monomer is copolymerized with N-vinylpyrrolidone to obtain modified phosphatidylated quaternary ammonium random copolymer; and the modified phosphatidylated quaternary ammonium random copolymer is mixed with an additive and water to obtain the antibacterial and acaricidal shampoo. The antibacterial and acaricidal shampoo prepared by the application has the advantages of antibacterial property, acaricidal property, hair repair, and long-acting adsorption.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, specifically to an antibacterial and anti-mite shampoo and its preparation method. Background Technology

[0002] Shampoo, also known as hair wash, hair lotion, or hair cream, is the most widely used hair care product and one of the most commonly used hair cosmetics. As an essential hair product, shampoo has evolved with the times and changing consumer demands. Initially, people sought shampoo that could remove oil from the scalp and hair, preventing sticky hair and itchy scalp. However, sometimes over-washing strips away the natural oils, leading to dry, difficult-to-manage hair. Furthermore, daily life exposes hair to external factors such as UV rays, air and environmental pollution, and perming / dyeing, causing frizz, split ends, dullness, and poor combability. People have gradually realized that hair is a crucial factor in shaping one's image, so they aspire to healthy, natural hair and have begun to focus on daily hair care, shifting their emphasis from "the cleaning power needed to keep hair clean" to "the protective and repairing effects needed to maintain beautiful hair."

[0003] Mites are tiny animals belonging to the subclass Acari of the class Arachnida in the phylum Arthropoda. They are widely distributed and diverse, but the most harmful to humans are dust mites living in the home and Demodex mites parasitizing humans. Dust mites are a major trigger for allergic diseases, while Demodex mites can clog pores, disrupt sebum secretion, leading to dull skin, enlarged pores, and rough skin. In severe cases, they can cause acne, hair loss, dandruff, and seborrheic dermatitis. Demodex mites disrupt sebum secretion, damaging the skin's surface flora and further exacerbating dandruff. Therefore, mite removal and antibacterial treatment are crucial for controlling dandruff and maintaining healthy scalp. Existing mite-removal products are not ideal, being slow to remove mites, lacking long-lasting effects, and prone to recurrent mite infestations. Furthermore, their ingredients are often complex and have low safety profiles.

[0004] Furthermore, charged polymers offer better hydration and lubrication properties compared to ordinary cationic surfactants, which are often more irritating. Therefore, developing a polymer that can remain on the hair surface and possesses good hydration capabilities, and adding it to shampoo, could significantly improve hair's combing performance and provide antibacterial and anti-mite properties. Summary of the Invention

[0005] The purpose of this invention is to provide an antibacterial and anti-mite shampoo and its preparation method, so as to solve the problems existing in the prior art.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution: an antibacterial and anti-mite shampoo, wherein the antibacterial and anti-mite shampoo is prepared by mixing a modified phospholipidated quaternary ammonium random copolymer with an additive and water; the modified phospholipidated quaternary ammonium random copolymer is prepared by copolymerizing a phospholipidated quaternary ammonium monomer with N-vinylpyrrolidone; the phospholipidated quaternary ammonium monomer is prepared by reacting a long-chain amidated tertiary amine with ethylene 2-(methacryloyloxy)ethyl phosphate; and the long-chain amidated tertiary amine is prepared by reacting a long-chain alkyl acid with 3-dimethylaminopropylamine.

[0007] As an optimization, the additives include sodium lauryl ether sulfate, coconut oil monoethanolamide, ethylene glycol stearate diester, cetearyl alcohol, PEG-120 methyl glucotrioleate, cocamidopropyl betaine, preservatives, flavorings, citric acid, and sodium chloride.

[0008] As an optimization, the long-chain alkyl acid is one of n-decanoic acid, n-undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, and palmitic acid.

[0009] A method for preparing an antibacterial and anti-mite shampoo includes the following preparation steps:

[0010] (1) By mass fraction, 40-50 parts of long-chain alkyl acid are heated to 120°C under a nitrogen atmosphere. 3-Dimethylaminopropylamine is added dropwise at a rate of 0.8-1 ml / min according to the molar ratio of long-chain alkyl acid to 3-dimethylaminopropylamine of 2:(2.5-3). Water is separated by a water separator. The mixture is refluxed at 145-155°C and 200-300 r / min for 8-9 h. Unreacted raw materials are removed by vacuum distillation. After recrystallization with petroleum ether 3-4 times, the mixture is dried under vacuum at 50-60°C for 20-24 h to obtain long-chain amidated tertiary amine.

[0011] (2) By mass fraction, 2-3 parts of long-chain amidated tertiary amine and 20-30 parts of chloroform are mixed evenly. At room temperature, at 200-300 r / min, ethylene 2-(methacryloyloxy)ethyl phosphate is added at a molar ratio of 1:1 between the long-chain amidated tertiary amine and ethylene 2-(methacryloyloxy)ethyl phosphate. The mixture is refluxed at 90-95℃ and 200-300 r / min for 20-24 h. The chloroform is removed by rotary evaporation, and the mixture is vacuum dried at 50-60℃ for 10-12 h to obtain the phospholipidated quaternary ammonium monomer.

[0012] (3) By mass, under a nitrogen atmosphere, 2-3 parts of N-vinylpyrrolidone, 4.68-7.03 parts of phospholipidated quaternary ammonium monomer and 25-30 parts of isopropanol are mixed evenly, and 0.09-0.12 parts of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65-70℃ and 300-400r / min for 3-4h. The mixture is then poured into 180-200 parts of petroleum ether to precipitate. After filtration, the mixture is washed 2-3 times with petroleum ether and then washed 3-4 times with anhydrous ethanol. The mixture is then vacuum dried at 50-60℃ for 10-12h to obtain the modified phospholipidated quaternary ammonium random copolymer.

[0013] (4) According to the formula, dissolve the modified phospholipidated quaternary ammonium random copolymer in 50 times its mass of water, and stir at 60°C and 200-300 r / min until completely dissolved to obtain solution A. Add sodium lauryl ether sulfate to an equal mass of water, and stir at 75-85°C and 200-300 r / min until completely dissolved. Add coconut oil monoethanolamide, ethylene glycol stearate diester, and cetearyl alcohol, and continue stirring until completely dissolved. Add solution A, and continue stirring until dissolved. Then, cool the mixture to 50°C, add cocamidopropyl betaine, stir until dissolved, then add PEG-120 methyl glucotrioleate, stir at 200-300 rpm for 50-60 minutes to disperse, and continue stirring while allowing it to cool naturally to 30°C. Add sodium chloride, and after cooling to room temperature, add preservatives and fragrance, add the remaining water, add citric acid to adjust the pH to 6.5, and stir at 200-300 rpm for 50-60 minutes until evenly dispersed to obtain an antibacterial and anti-mite shampoo.

[0014] As an optimization, the reaction process of the long-chain amidation of the tertiary amine in step (1) is as follows:

[0015]

[0016] R = 8~14.

[0017] As an optimization, the reaction process of the phospholipidation of the quaternary ammonium monomer in step (2) is as follows:

[0018]

[0019] R = 8~14.

[0020] As an optimization, the reaction process of the modified phospholipidated quaternary ammonium random copolymer in step (3) is as follows:

[0021]

[0022] R = 8~14.

[0023] As an optimization, the formulation in step (4) is as follows: 18~22wt% sodium lauryl ether sulfate, 0.9~1.1wt% coconut oil monoethanolamide, 1.4~1.5wt% ethylene glycol stearate diester, 0.7~0.8wt% cetearyl alcohol, 2.5~3wt% PEG-120 methyl glucotrioleate, 3.5~4wt% cocamidopropyl betaine, 1~1.2wt% modified phospholipidated quaternary ammonium random copolymer, 0.06~0.8wt% preservative, 0.1~0.2wt% fragrance, 0.02~0.2wt% citric acid, 0.8wt% sodium chloride, and the balance being water.

[0024] Compared with the prior art, the beneficial effects achieved by the present invention are as follows: In the preparation of antibacterial and anti-mite shampoo, the present invention first reacts a long-chain alkyl acid with 3-dimethylaminopropylamine to obtain a long-chain amidated tertiary amine; reacts the long-chain amidated tertiary amine with ethylene 2-(methacryloyloxy)ethyl phosphate to obtain a phospholipidated quaternary ammonium monomer; copolymerizes the phospholipidated quaternary ammonium monomer with N-vinylpyrrolidone to obtain a modified phospholipidated quaternary ammonium random copolymer; and mixes the modified phospholipidated quaternary ammonium random copolymer with additives and water to obtain the antibacterial and anti-mite shampoo.

[0025] First, the long-chain alkyl acid undergoes an amidation reaction with 3-dimethylaminopropylamine to obtain a long-chain amidated tertiary amine with an amide group and a long carbon chain. Subsequently, the long-chain amidated tertiary amine undergoes a ring-opening quaternization reaction with ethylene 2-(methacryloyloxy)ethyl phosphate. The phosphate ester ring on ethylene 2-(methacryloyloxy)ethyl phosphate is opened and undergoes a quaternization reaction with the tertiary amine group, forming a structure similar to phosphocholine, which is similar to the phospholipid structure of skin cell membranes, thereby improving compatibility with the skin. The amide group, quaternary ammonium group, and phosphate ester group all have a beneficial effect on improving compatibility and can reduce skin irritation. The presence of zwitterions gives it good emulsifying, foaming, and foam-stabilizing abilities, and good compatibility, allowing it to be well-blended with other shampoo ingredients, thereby improving stability. Carbon-carbon double bonds are also introduced into the monomer, which can be used to participate in copolymerization.

[0026] Secondly, a modified phospholipid-modified quaternary ammonium monomer was prepared by random copolymerization with N-vinylpyrrolidone. N-vinylpyrrolidone adsorbs onto the scalp and hair strands during shampooing through electrostatic and hydrophobic interactions. The phospholipid-modified quaternary ammonium monomer, being amphoteric, exhibits excellent hydrophilicity and can effectively bind water molecules in a wet state to form a lubricating layer, improving the wet combing performance of the hair and reducing friction. Furthermore, after the hair dries, due to the electrostatic effect of N-vinylpyrrolidone and the compatibility of the phospholipid-modified quaternary ammonium monomer with the scalp and hair, and compared to small-molecule amphoteric surfactants, the modified phospholipid-modified quaternary ammonium random copolymer has a stronger adsorption capacity, allowing for greater adsorption onto the scalp after shampooing. It provides continuous repair capabilities and improves dry combing performance on the scalp and hair surface, reducing the coefficient of friction during dry combing. The modified phospholipidated quaternary ammonium random copolymer also contains long carbon chains and quaternary ammonium cations, exhibiting excellent antibacterial and anti-mite properties. Under weakly acidic pH conditions, the modified phospholipidated quaternary ammonium random copolymer exhibits the characteristics of a cationic surfactant. The quaternary ammonium cations can be adsorbed onto the bacterial surface through electrostatic interactions, while the hydrophobic chains bind to the lipid bilayer of the bacterial cell membrane, disrupting the integrity of the cell membrane, leading to leakage of cell contents, and ultimately causing bacterial lysis and death. Combined with its excellent adsorption properties on the hair and scalp surface, it can provide long-lasting antibacterial properties, reducing bacterial damage to the scalp and hair, and repelling or killing mites, reducing damage from mites and providing continuous protection.

[0027] Finally, the modified phospholipid-modified quaternary ammonium random copolymer was mixed with additives and water to prepare an antibacterial and anti-mite shampoo. The modified phospholipid-modified quaternary ammonium random copolymer has a zwitterionic and phosphoric acid-choline-like structures, and has good compatibility with other additives. The resulting antibacterial and anti-mite shampoo has good stability. At the same time, the phosphoric acid-choline-like structure has excellent cell compatibility and low irritation, which can effectively reduce the damage of shampoo to the scalp and hair. In addition, during the shampooing process, the modified phospholipid-modified quaternary ammonium random copolymer can be adsorbed on the hair cuticle, thereby providing a repairing effect. The modified phospholipid-modified quaternary ammonium random copolymer also has antibacterial and anti-mite capabilities, and can provide long-lasting antibacterial and anti-mite performance. Detailed Implementation

[0028] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0029] The following information is provided for the raw materials used in all the examples and comparative examples: Sodium lauryl polyoxyethylene ether sulfate: model llb75354, purchased from Wuhan Lanabai Pharmaceutical Chemical Co., Ltd.; Coconut oil monoethanolamide: purchased from Suzhou Kening Polyol Co., Ltd.; Cetearyl alcohol: purchased from Suzhou Kening Polyol Co., Ltd.; PEG-120 methyl glucotrioleate: purchased from Hubei Xingyan New Material Technology Co., Ltd.; Cocamidopropyl betaine: model CAB-35, purchased from Shandong Boxing County Haolong Chemical Co., Ltd.; Preservative: Phenoxyethanol; Fragrance: Lemon fragrance, purchased from Shandong Ruiyu Trading Co., Ltd.; Long-chain alkyl acid: Lauric acid.

[0030] The formulations used in all the following examples and comparative examples are as follows: 20 wt% sodium lauryl ether sulfate, 1 wt% coconut oil monoethanolamide, 1.5 wt% ethylene glycol stearate diester, 0.8 wt% cetearyl alcohol, 3 wt% PEG-120 methyl glucotrioleate, 3.5 wt% cocamidopropyl betaine, 1.1 wt% modified phospholipidated quaternary ammonium random copolymer, 0.4 wt% preservative, 0.15 wt% fragrance, 0.8 wt% sodium chloride, with the balance being water, and citric acid added depending on the pH.

[0031] Example 1

[0032] A method for preparing an antibacterial and anti-mite shampoo, the method comprising the following preparation steps:

[0033] (1) By mass fraction, 40 parts of long-chain alkyl acid were heated to 120°C under a nitrogen atmosphere. 3-Dimethylaminopropylamine was added dropwise at a rate of 0.8 ml / min according to the molar ratio of long-chain alkyl acid to 3-dimethylaminopropylamine of 2:2.5. Water was separated by a water separator. The reaction was refluxed at 145°C and 200 r / min for 9 h. Unreacted raw materials were removed by vacuum distillation. After recrystallization with petroleum ether three times, the mixture was dried under vacuum at 50°C for 24 h to obtain long-chain amidated tertiary amine.

[0034] (2) By mass fraction, 2 parts of long-chain amidated tertiary amine and 20 parts of chloroform were mixed evenly. At room temperature, at 200 r / min, ethylene 2-(methacryloyloxy)ethyl phosphate was added at a molar ratio of 1:1 between the long-chain amidated tertiary amine and ethylene 2-(methacryloyloxy)ethyl phosphate. The mixture was refluxed at 90 °C and 200 r / min for 24 h. The chloroform was removed by rotary evaporation, and the mixture was vacuum dried at 50 °C for 12 h to obtain the phospholipidated quaternary ammonium monomer.

[0035] (3) By mass, under a nitrogen atmosphere, 2 parts of N-vinylpyrrolidone, 4.68 parts of phospholipidated quaternary ammonium monomer and 25 parts of isopropanol were mixed evenly, 0.09 parts of azobisisobutyronitrile were added, sealed, and stirred at 65°C and 300 r / min for 4 h. The mixture was poured into 180 parts of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed three times with anhydrous ethanol. The mixture was then dried under vacuum at 50°C for 12 h to obtain the modified phospholipidated quaternary ammonium random copolymer.

[0036] (4) According to the formula, the modified phospholipidated quaternary ammonium random copolymer was dissolved in 50 times its mass of water. The mixture was stirred at 60°C and 200 r / min until completely dissolved to obtain solution A. Sodium lauryl ether sulfate was added to an equal mass of water and stirred at 75°C and 200 r / min until completely dissolved. Coconut oil monoethanolamide, ethylene glycol stearate diester, and cetearyl alcohol were added and stirred until completely dissolved. Solution A was added and stirred. The mixture was allowed to cool naturally to 50°C. Cocamidopropyl betaine was added and stirred until dissolved. PEG-120 methyl glucotrioleate was added and stirred at 200 r / min for 60 min to disperse. The mixture was allowed to cool naturally to 30°C while stirring. Sodium chloride was added and the mixture was allowed to cool to room temperature. Preservatives and fragrances were added and the remaining water was added. Citric acid was added to adjust the pH to 6.5 and stirred at 200 r / min for 60 min until evenly dispersed to obtain antibacterial and anti-mite shampoo.

[0037] Example 2

[0038] A method for preparing an antibacterial and anti-mite shampoo, the method comprising the following preparation steps:

[0039] (1) By mass fraction, 45 parts of long-chain alkyl acid were heated to 120°C under a nitrogen atmosphere, and 3-dimethylaminopropylamine was added dropwise at a rate of 0.9 ml / min according to the molar ratio of long-chain alkyl acid to 3-dimethylaminopropylamine of 2:2.8. Water was separated by a water separator, and the reaction was refluxed at 150°C and 250 r / min for 8.5 h. Unreacted raw materials were removed by vacuum distillation, and the mixture was recrystallized three times with petroleum ether and then dried under vacuum at 55°C for 22 h to obtain long-chain amidated tertiary amine.

[0040] (2) By mass fraction, 2.5 parts of long-chain amidated tertiary amine and 25 parts of chloroform were mixed evenly. At room temperature, at 250 r / min, ethylene 2-(methacryloyloxy)ethyl phosphate was added at a molar ratio of 1:1. The mixture was refluxed at 90 °C and 250 r / min for 22 h. Chloroform was removed by rotary evaporation. The mixture was then vacuum dried at 55 °C for 11 h to obtain the phospholipidated quaternary ammonium monomer.

[0041] (3) By mass, under a nitrogen atmosphere, 2.5 parts of N-vinylpyrrolidone, 5.86 parts of phospholipidated quaternary ammonium monomer and 28 parts of isopropanol were mixed evenly, and 0.105 parts of azobisisobutyronitrile were added. The mixture was sealed and stirred at 65°C and 350 r / min for 3.5 h. The mixture was poured into 190 parts of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed four times with anhydrous ethanol. The mixture was then dried under vacuum at 55°C for 11 h to obtain the modified phospholipidated quaternary ammonium random copolymer.

[0042] (4) According to the formula, the modified phospholipidated quaternary ammonium random copolymer was dissolved in 50 times its mass of water. The mixture was stirred at 60°C and 250 r / min until completely dissolved to obtain solution A. Sodium lauryl polyoxyethylene ether sulfate was added to an equal mass of water. The mixture was stirred at 80°C and 250 r / min until completely dissolved. Coconut oil monoethanolamide, ethylene glycol stearate diester, and cetearyl alcohol were added. The mixture was stirred until completely dissolved. Solution A was added. The mixture was stirred and cooled naturally to 50°C. Cocamidopropyl betaine was added and stirred until dissolved. PEG-120 methyl glucotrioleate was added and stirred at 250 r / min for 55 min to disperse. The mixture was stirred and cooled naturally to 30°C. Sodium chloride was added. After cooling to room temperature, preservatives and fragrances were added. The remaining water was added. Citric acid was added to adjust the pH to 6.5. The mixture was stirred at 250 r / min for 55 min until evenly dispersed to obtain antibacterial and anti-mite shampoo.

[0043] Example 3

[0044] A method for preparing an antibacterial and anti-mite shampoo, the method comprising the following preparation steps:

[0045] (1) By mass fraction, 50 parts of long-chain alkyl acid were heated to 120°C under a nitrogen atmosphere, and 3-dimethylaminopropylamine was added dropwise at a rate of 1 ml / min according to the molar ratio of long-chain alkyl acid to 3-dimethylaminopropylamine of 2:3. Water was separated by a water separator, and the reaction was refluxed at 155°C and 300 r / min for 8 h. Unreacted raw materials were removed by vacuum distillation, and the mixture was recrystallized 4 times with petroleum ether and then dried under vacuum at 60°C for 20 h to obtain long-chain amidated tertiary amine.

[0046] (2) By mass fraction, 3 parts of long-chain amidated tertiary amine and 30 parts of chloroform were mixed evenly. At room temperature, at 300 r / min, ethylene 2-(methacryloyloxy)ethyl phosphate was added at a molar ratio of 1:1. The mixture was refluxed at 95 °C and 300 r / min for 20 h. Chloroform was removed by rotary evaporation. The mixture was then vacuum dried at 60 °C for 10 h to obtain the phospholipidated quaternary ammonium monomer.

[0047] (3) By mass, under a nitrogen atmosphere, 3 parts of N-vinylpyrrolidone, 7.03 parts of phospholipidated quaternary ammonium monomer and 30 parts of isopropanol were mixed evenly, 0.12 parts of azobisisobutyronitrile were added, sealed, and stirred at 70°C and 400 r / min for 3 h. The mixture was poured into 200 parts of petroleum ether to precipitate, filtered, washed 3 times with petroleum ether, and then washed 4 times with anhydrous ethanol. The mixture was then dried under vacuum at 60°C for 10 h to obtain the modified phospholipidated quaternary ammonium random copolymer.

[0048] (4) According to the formula, the modified phospholipidated quaternary ammonium random copolymer was dissolved in 50 times its mass of water. The mixture was stirred at 60°C and 300 r / min until completely dissolved to obtain solution A. Sodium lauryl ether sulfate was added to an equal mass of water and stirred at 85°C and 300 r / min until completely dissolved. Coconut oil monoethanolamide, ethylene glycol stearate diester, and cetearyl alcohol were added and stirred until completely dissolved. Solution A was added and stirred. The mixture was allowed to cool naturally to 50°C. Cocamidopropyl betaine was added and stirred until dissolved. PEG-120 methyl glucotrioleate was added and stirred at 300 r / min for 50 min to disperse. The mixture was allowed to cool naturally to 30°C while stirring. Sodium chloride was added and the mixture was allowed to cool to room temperature. Preservatives and fragrances were added and the remaining water was added. Citric acid was added to adjust the pH to 6.5 and stirred at 300 r / min for 50 min until evenly dispersed to obtain antibacterial and anti-mite shampoo.

[0049] Comparative Example 1:

[0050] The difference between the preparation method of the antibacterial and anti-mite shampoo in Comparative Example 1 and Example 2 lies in step (3). Step (3) is modified as follows: By mass, under a nitrogen atmosphere, 2.5 parts of N-vinylpyrrolidone, 2.93 parts of phospholipidated quaternary ammonium monomer, and 28 parts of isopropanol are mixed evenly, and 0.105 parts of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65°C and 350 r / min for 3.5 h. The mixture is then poured into 190 parts of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed four times with anhydrous ethanol. The mixture is then vacuum dried at 55°C for 11 h to obtain the modified phospholipidated quaternary ammonium random copolymer. The remaining steps are the same as in Example 2.

[0051] Comparative Example 2:

[0052] The difference between the preparation method of the antibacterial and anti-mite shampoo in Comparative Example 2 and that in Example 2 lies in step (3). Step (3) is modified as follows: By mass, under a nitrogen atmosphere, 2.5 parts of N-vinylpyrrolidone, 4.39 parts of phospholipidated quaternary ammonium monomer, and 28 parts of isopropanol are mixed evenly, and 0.105 parts of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65°C and 350 r / min for 3.5 h. The mixture is then poured into 190 parts of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed four times with anhydrous ethanol. The mixture is then vacuum dried at 55°C for 11 h to obtain the modified phospholipidated quaternary ammonium random copolymer. The remaining steps are the same as in Example 2.

[0053] Comparative Example 3:

[0054] The difference between the preparation method of the antibacterial and anti-mite shampoo in Comparative Example 3 and Example 2 lies in step (3). Step (3) is modified as follows: By mass, under a nitrogen atmosphere, 2.5 parts of N-vinylpyrrolidone, 7.32 parts of phospholipidated quaternary ammonium monomer, and 28 parts of isopropanol are mixed evenly, and 0.105 parts of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65°C and 350 r / min for 3.5 h. The mixture is then poured into 190 parts of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed four times with anhydrous ethanol. The mixture is then vacuum dried at 55°C for 11 h to obtain the modified phospholipidated quaternary ammonium random copolymer. The remaining steps are the same as in Example 2.

[0055] Comparative Example 4:

[0056] The difference between the preparation method of the antibacterial and anti-mite shampoo in Comparative Example 4 and Example 2 lies in step (3). Step (3) is modified as follows: By mass, under a nitrogen atmosphere, 2.5 parts of N-vinylpyrrolidone, 8.78 parts of phospholipidated quaternary ammonium monomer, and 28 parts of isopropanol are mixed evenly, and 0.105 parts of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65°C and 350 r / min for 3.5 h. The mixture is then poured into 190 parts of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed four times with anhydrous ethanol. The mixture is then vacuum dried at 55°C for 11 h to obtain the modified phospholipidated quaternary ammonium random copolymer. The remaining steps are the same as in Example 2.

[0057] Comparative Example 5:

[0058] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 5 differs from that in Example 2 in that the amount of modified phospholipidated quaternary ammonium random copolymer added to the formula is different, and the amount added is modified to 0 wt%. The remaining steps are the same as in Example 2.

[0059] Comparative Example 6:

[0060] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 6 differs from that in Example 2 in that the amount of modified phospholipidated quaternary ammonium random copolymer added to the formula is different, and the amount added is modified to 0.5 wt%. The remaining steps are the same as in Example 2.

[0061] Comparative Example 7:

[0062] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 7 differs from that in Example 2 in that the amount of modified phospholipidated quaternary ammonium random copolymer added to the formula is different, and the amount added is modified to 0.8 wt%. The remaining steps are the same as in Example 2.

[0063] Comparative Example 8:

[0064] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 8 differs from that in Example 2 in that the amount of modified phospholipidated quaternary ammonium random copolymer added to the formula is different, and the amount added is modified to 1.5 wt%. The remaining steps are the same as in Example 2.

[0065] Comparative Example 9:

[0066] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 9 differs from that in Example 2 in that the amount of modified phospholipidated quaternary ammonium random copolymer added to the formula is different, and the amount added is modified to 1.8 wt%. The remaining steps are the same as in Example 2.

[0067] Comparative Example 10:

[0068] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 10 differs from that in Example 2 in that step (1) is omitted, and step (2) is modified as follows: 2.5 parts by mass of lauryl dimethyl tertiary amine and 25 parts by mass of chloroform are mixed evenly. At room temperature, at 250 r / min, ethylene 2-(methacryloyloxy)ethyl phosphate is added at a molar ratio of lauryl dimethyl tertiary amine to ethylene 2-(methacryloyloxy)ethyl phosphate of 1:1. The mixture is refluxed at 90°C and 250 r / min for 22 h. The chloroform is removed by rotary evaporation, and the mixture is vacuum dried at 55°C for 11 h to obtain the phospholipidated quaternary ammonium monomer. The remaining steps are the same as in Example 2.

[0069] Comparative Example 11:

[0070] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 11 differs from that in Example 2 in step (2). Step (2) is modified as follows: 2.5 parts by mass of long-chain amidated tertiary amine and 25 parts by mass of chloroform are mixed evenly. At room temperature, at 250 r / min, 2-chloromethacrylate is added at a molar ratio of 1:1 (long-chain amidated tertiary amine to ethyl 2-chloromethacrylate). The mixture is refluxed at 90°C and 250 r / min for 22 h. The chloroform is removed by rotary evaporation, and the mixture is vacuum dried at 55°C for 11 h to obtain the phospholipidated quaternary ammonium monomer. The remaining steps are the same as in Example 2.

[0071] Comparative Example 12:

[0072] The preparation method of the antibacterial and anti-mite shampoo in Comparative Example 12 differs from that in Example 2 in that steps (1) and (2) are omitted, and step (3) is modified as follows: In a nitrogen atmosphere, 2.5 parts by mass of N-vinylpyrrolidone, 5.86 parts by mass of 2-methyl-2-acrylate-2-(phosphonooxy)ethyl ester, and 28 parts by mass of isopropanol are mixed evenly, and 0.105 parts by mass of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65°C and 350 r / min for 3.5 h. The mixture is then poured into 190 parts by mass of petroleum ether to precipitate, filtered, washed twice with petroleum ether, and then washed four times with anhydrous ethanol. The mixture is then vacuum dried at 55°C for 11 h to obtain the modified phospholipidated quaternary ammonium random copolymer. The remaining steps are the same as in Example 2.

[0073] Test Example 1:

[0074] Antibacterial and anti-mite performance test: The antibacterial and anti-mite performance of the modified phospholipidated quaternary ammonium random copolymers prepared in step (3) of Examples 1-3 and Comparative Examples 5-12 and the antibacterial and anti-mite shampoo prepared in step (4) were evaluated by comparing their antibacterial and anti-mite performance. The specific test methods are as follows: Preparation of copolymer test samples: The modified phospholipidated quaternary ammonium random copolymers prepared in step (3) of each example and comparative example were dissolved in water to prepare a 2wt% solution to obtain copolymer test samples; Antibacterial performance test: The antibacterial performance was tested in accordance with QB / T2738-2012. The strains were Staphylococcus aureus, Escherichia coli and Candida albicans. The bactericidal test was carried out in accordance with the quantitative suspension method. The sample was either a copolymer test sample or an antibacterial and anti-mite shampoo with 5 ml added. The duration was 1 hour. Each group was tested in parallel 5 times, and the average value was recorded. Anti-mite performance test: (1) Obtaining human Demodex mites: Demodex mites were obtained by the transparent tape method. The specific steps were as follows: the subject washed his face with water before going to sleep, and then applied a 6 cm long and 1.5 cm wide transparent tape to the forehead, cheeks, nose, chin and other parts. The tape was removed the next morning and then stuck to the tape. The samples were examined under a microscope and sealed on a glass slide. (2) Test grouping: the antibacterial and anti-mite shampoo and copolymer test sample prepared in each example and comparative example were dropped onto each glass slide. The amount of dropping was 0.1 mg / cm. 2 The sample was spread out evenly to ensure full contact between the sample and the mites. It was placed in an environment of 60% RH and 25℃. After 1 hour, the survival of the demodicid mites was observed under a microscope. Observation was performed continuously for 3 minutes under a 400× microscope; mites whose claws or legs did not move were considered dead.

[0075] The data recorded in Table 1 are as follows: the left side shows the copolymer test sample data, and the right side shows the antibacterial and anti-mite shampoo data.

[0076] The results are shown in Table 1.

[0077]

[0078] A comparison of the experimental data from Examples 1-3 and Comparative Examples 5-12 in Table 1 reveals that the antibacterial and anti-mite shampoo prepared in this invention has excellent antibacterial and anti-mite properties.

[0079] The data comparison in the table shows that when the modified phospholipidated quaternary ammonium random copolymer is not added to the antibacterial and anti-mite shampoo, the original antibacterial and anti-mite performance of the system is insufficient. It is difficult to provide higher antibacterial performance by relying solely on a small amount of added preservatives and other surfactants.

[0080] The data in the table shows that when the amount of modified phospholipidated quaternary ammonium random copolymer added is small, the improvement in antibacterial and mite-removing properties is small, and it is difficult to maximize the antibacterial and mite-removing properties.

[0081] The data comparison in the table shows that the introduction of amide bonds in the modified phospholipidated quaternary ammonium random copolymer improves the adsorption performance, allowing the acaricide to be better adsorbed onto mites, thereby killing them.

[0082] By comparing the data in the table, the data in Comparative Example 11 shows that the introduction of phosphate groups in the modified phospholipidated quaternary ammonium random copolymer improves the mite-killing performance. The phosphate groups have a phospholipid structure similar to that on the cell surface, which can effectively adsorb and thus improve the mite-killing efficiency of the quaternary ammonium structure.

[0083] By comparing the data in the table, the data in Comparative Example 12 shows that the quaternary ammonium structure in the modified phospholipidated quaternary ammonium random copolymer is the main active ingredient for antibacterial and mite removal. Its cationic structure and long carbon chain give it good antibacterial and mite removal properties.

[0084] Test Example 2:

[0085] Hair repair performance test: The hair repair performance of the modified phospholipidated quaternary ammonium random copolymers prepared in step (3) of Examples 1-3 and Comparative Examples 5-12 and the antibacterial and anti-mite shampoo prepared in step (4) was evaluated by the change rate of friction force on the hair samples when wet combed and dry combed. The specific test methods are as follows: Copolymer test sample preparation: The modified phospholipidated quaternary ammonium random copolymers prepared in step (3) of each example and comparative example were dissolved in water to prepare a 2wt% solution to obtain copolymer test samples; Shampoo sample preparation: The antibacterial and anti-mite shampoo prepared in each example and comparative example was diluted 10 times to obtain shampoo samples; Pre-treated hair samples: head Natural black Chinese hair samples were selected and washed sequentially with acetone, anhydrous ethanol, and deionized water using ultrasonic treatment for 15 minutes. After rinsing with deionized water, the hair samples were air-dried at a relative humidity of 50%RH and a temperature of 20℃. For wet combing, 1g of pretreated hair sample was immersed in 50ml of copolymer test sample or shampoo sample and shaken in a constant temperature water bath for 30 minutes. The sample was then rinsed with pure water. For dry combing, the wet hair sample was air-dried at 20℃ and 50%RH for 4 hours. The friction coefficient was tested according to T / GDCA 025-2023 "Evaluation Method for Hair Nourishing Efficacy of Hair Products," which measures the rate of change of friction K. The formula for calculating K was used in the standard document. Each group of samples was tested in parallel 20 times, and the average value was recorded. The results are shown in Table 2.

[0086]

[0087] A comparison of the experimental data from Examples 1-3 and Comparative Examples 5-12 in Table 2 reveals that the antibacterial and anti-mite shampoo prepared in this invention has excellent hair repair properties.

[0088] By comparing the data in the table, the data in Comparative Example 5 shows that when modified phospholipidated quaternary ammonium random copolymer is not added to the antibacterial and anti-mite shampoo, other surfactants are difficult to remain on the hair surface due to their lack of adsorption properties, resulting in lower repair performance.

[0089] The data in the table shows that when the amount of modified phospholipidated quaternary ammonium random copolymer added to the antibacterial and anti-mite shampoo is small, the repair effect is poor due to the low adsorption capacity.

[0090] By comparing the data in the table, the data in Comparative Example 10 shows that the amide groups introduced into the modified phospholipidated quaternary ammonium random copolymer increase the adsorption amount of the modified phospholipidated quaternary ammonium random copolymer on the hair surface through hydrogen bonding and other means, thereby improving the repair effect.

[0091] The data comparison in the table shows that the phospholipid groups introduced into the modified phospholipidated quaternary ammonium random copolymer have a good hydration effect, which can effectively reduce friction and improve the repair effect.

[0092] The data comparison in the table shows that the quaternary ammonium groups introduced into the modified phospholipidated quaternary ammonium random copolymer have a good hydration effect, which can effectively reduce friction and improve the repair effect.

[0093] Test Example 3:

[0094] Adsorption performance test: The antibacterial and mite-removing properties of the modified phospholipidated quaternary ammonium random copolymers prepared in step (3) of Examples 1-3 and Comparative Examples 5-12 and the antibacterial and mite-removing shampoo prepared in step (4) after washing hair samples for 8 hours were evaluated by comparing the data with those in Test Example 2. The specific test method is as follows: Copolymer test sample preparation: The modified phospholipidated quaternary ammonium random copolymers prepared in step (3) of each example and comparative example were dissolved in water to prepare a 2wt% solution to obtain copolymer test samples.

[0095] Shampoo sample preparation: The antibacterial and anti-mite shampoos prepared in each example and comparative example were diluted 5 times to obtain shampoo samples.

[0096] Hair sample preparation: Natural black Chinese hair was selected as the hair sample. It was washed with acetone, anhydrous ethanol and deionized water by ultrasonic treatment for 15 minutes in sequence. After taking out the hair sample, it was rinsed with deionized water and dried in the air at a relative humidity of 50%RH and a temperature of 20℃. Then, 1g of hair sample was soaked in 50ml of copolymer test sample or shampoo sample and shaken in a constant temperature water bath shaker for 30 minutes. After rinsing with pure water, it was naturally air-dried at 20℃ and 50%RH for 8 hours to obtain the hair sample.

[0097] Antibacterial test: The antibacterial test method in Appendix C of GB / T 15979-2002 was followed. The strains were Staphylococcus aureus, Escherichia coli and Candida albicans. The test method for the antibacterial performance of non-dissolving antibacterial products was followed. The sample tablet was replaced with 0.75g of sample. Each group was tested in parallel for 5 times and the average value was recorded.

[0098] Mite removal performance test: The mite removal performance test was conducted according to the repellency method in GB / T 24253-2009. The mite species used was house dust mite, and the sample was hair mite. The test was conducted in parallel for 5 times, and the average value was recorded.

[0099] The data recorded in Table 3 are as follows: the left side shows the copolymer test sample data, and the right side shows the antibacterial and anti-mite shampoo data.

[0100] The results are shown in Table 3.

[0101]

[0102] A comparison of the experimental data from Examples 1-3 and Comparative Examples 1-12 in Table 3 reveals that the antibacterial and anti-mite shampoo prepared in this invention has good adsorption properties and long-lasting antibacterial and anti-mite properties.

[0103] By comparing the data in the table, the data of Comparative Examples 1 and 2 show that reducing the addition of phospholipidated quaternary ammonium monomers in the copolymerization of step (3) leads to a decrease in the content of antibacterial and anti-mite groups on the copolymer, resulting in a decline in antibacterial and anti-mite performance.

[0104] By comparing the data in the table, the data of Comparative Examples 3 to 4 show that the addition of phospholipidated quaternary ammonium monomers in the copolymerization of step (3) results in a decrease in the molecular weight of polymer segments and a decrease in the content of N-vinylpyrrolidone groups due to the presence of more sterically hindered groups on the copolymer chain. This leads to a decrease in adsorption performance, resulting in a reduction in the effective antibacterial and anti-mite molecules remaining after a long period of drying, thus reducing the long-lasting antibacterial and anti-mite performance.

[0105] The data comparison in the table shows that when modified phospholipidated quaternary ammonium random copolymer is not added to antibacterial and anti-mite shampoos, they basically do not have long-lasting antibacterial and anti-mite properties.

[0106] By comparing the data in the table, the data from Comparative Examples 6 and 7 show that when the amount of modified phospholipidated quaternary ammonium random copolymer added to the antibacterial and anti-mite shampoo is small, its adsorption capacity is correspondingly reduced, the residual amount after long-term drying is also reduced, and the long-lasting antibacterial and anti-mite performance is reduced.

[0107] By comparing the data in the table, the data in Comparative Example 10 shows that the introduction of amide groups on the modified phospholipidated quaternary ammonium random copolymer increases its adsorption capacity through hydrogen bonding and other means, thereby improving its long-lasting antibacterial and mite-removing effects.

[0108] By comparing the data in the table, the data in Comparative Example 11 shows that the introduction of phospholipid groups on the modified phospholipidated quaternary ammonium random copolymer gives it higher cell compatibility, allowing it to be better adsorbed onto the hair surface, increasing the adsorption amount, and thus improving its long-lasting antibacterial and anti-mite performance.

[0109] By comparing the data in the table, the data in Comparative Example 12 shows that the quaternary ammonium groups on the modified phospholipidated quaternary ammonium random copolymer are the main antibacterial and anti-mite active groups, which provide the main antibacterial and anti-mite properties.

[0110] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. An antibacterial and anti-mite shampoo, characterized in that, The antibacterial and anti-mite shampoo is prepared by mixing a modified phospholipidated quaternary ammonium random copolymer with additives and water; the modified phospholipidated quaternary ammonium random copolymer is prepared by copolymerizing a phospholipidated quaternary ammonium monomer with N-vinylpyrrolidone; the phospholipidated quaternary ammonium monomer is prepared by reacting a long-chain amidated tertiary amine with ethylene 2-(methacryloyloxy)ethyl phosphate; the long-chain amidated tertiary amine is prepared by reacting a long-chain alkyl acid with 3-dimethylaminopropylamine; the long-chain amidated tertiary amine is prepared by reacting 40-50 parts by weight. Under a nitrogen atmosphere, the long-chain alkyl acid is heated to 120°C, and 3-dimethylaminopropylamine is added dropwise at a rate of 0.8-1 ml / min at a molar ratio of 2:(2.5-3). Water is separated using a water separator, and the reaction is stirred and refluxed at 145-155°C for 8-9 hours. Unreacted raw materials are removed by vacuum distillation, and the product is recrystallized with petroleum ether and then vacuum dried at 50-60°C for 20-24 hours to obtain the final product. The phospholipidated quaternary ammonium monomer is obtained by adding 2-3 parts by mass of long-chain amidation... A tertiary amine and 20-30 parts of chloroform are mixed evenly and stirred at room temperature. Ethylene 2-(methacryloyloxy)ethyl phosphate is added at a molar ratio of 1:1 (long-chain amidated tertiary amine to ethylene 2-(methacryloyloxy)ethyl phosphate). The mixture is stirred and refluxed at 90-95°C for 20-24 hours. The chloroform is removed by rotary evaporation, and the mixture is vacuum dried at 50-60°C for 10-12 hours. The modified phospholipidated quaternary ammonium random copolymer is prepared by adding 2-3 parts of N-vinylpyrrolidone, ... 4.68-7.03 parts of phospholipidated quaternary ammonium monomer and 25-30 parts of isopropanol are mixed evenly, and 0.09-0.12 parts of azobisisobutyronitrile are added. The mixture is sealed and stirred at 65-70℃ for 3-4 hours. The mixture is then poured into 180-200 parts of petroleum ether to precipitate the precipitate. The precipitate is filtered, washed with petroleum ether, and then washed with anhydrous ethanol. The precipitate is then dried under vacuum at 50-60℃ for 10-12 hours to obtain the final product. The long-chain alkyl acid is one of n-decanoic acid, n-undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, and palmitic acid.

2. The antibacterial and anti-mite shampoo according to claim 1, characterized in that, The additives include sodium lauryl ether sulfate, coconut oil monoethanolamide, ethylene glycol stearate diester, cetearyl alcohol, PEG-120 methyl glucotrioleate, cocamidopropyl betaine, preservatives, flavorings, citric acid, and sodium chloride.

3. A method for preparing an antibacterial and anti-mite shampoo, characterized in that, The preparation steps include the following: (1) Under a nitrogen atmosphere, the long-chain alkyl acid was heated and 3-dimethylaminopropylamine was added dropwise. Water was separated by a water separator, and the reaction was carried out under reflux. The reaction was carried out under reduced pressure, recrystallized, and dried to obtain a long-chain amidated tertiary amine. (2) Mix long-chain amidated tertiary amine and chloroform, stir at room temperature, add ethylene 2-(methacryloyloxy)ethyl phosphate, heat under reflux, evaporate by rotary evaporation, and dry to obtain phospholipidated quaternary ammonium monomer; (3) Under a nitrogen atmosphere, N-vinylpyrrolidone, phospholipidated quaternary ammonium monomer and isopropanol were mixed, azobisisobutyronitrile was added, the mixture was sealed, heated and stirred to react, and then poured into petroleum ether to precipitate. The mixture was filtered, washed and dried to obtain the modified phospholipidated quaternary ammonium random copolymer. (4) According to the formula, add the modified phospholipidated quaternary ammonium random copolymer to water and dissolve it. Heat and stir until completely dissolved to obtain solution A. Add sodium lauryl polyoxyethylene ether sulfate to water and heat and stir until completely dissolved. Add coconut oil monoethanolamide, ethylene glycol stearate diester, and cetearyl alcohol. Continue stirring until completely dissolved. Add solution A and continue stirring. Allow to cool naturally to 50°C. Add cocamidopropyl betaine and stir until dissolved. Add PEG-120 methyl glucotrioleate and stir to disperse. Keep stirring and allow to cool naturally. Add sodium chloride. After cooling to room temperature, add preservatives and flavorings. Sufficient water is added, citric acid is added to adjust the pH, and the mixture is stirred until evenly dispersed to obtain an antibacterial and anti-mite shampoo; the long-chain alkyl acid mentioned in step (1) is one of n-decanoic acid, n-undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, and palmitic acid; the long-chain amidated tertiary amine mentioned in step (1) is prepared by adding 40-50 parts of long-chain alkyl acid to 120°C under a nitrogen atmosphere, and adding 3-dimethylaminopropylamine dropwise at a rate of 0.8-1 ml / min according to the molar ratio of long-chain alkyl acid to 3-dimethylaminopropylamine of 2:(2.5-3), and separating the water using a water separator. The reaction was carried out under reflux at 145-155℃ for 8-9 hours. Unreacted raw materials were removed by vacuum distillation. The product was then recrystallized with petroleum ether and dried under vacuum at 50-60℃ for 20-24 hours. The phospholipidated quaternary ammonium monomer in step (2) was prepared by mixing 2-3 parts of long-chain amidated tertiary amine and 20-30 parts of chloroform by mass, stirring at room temperature, and adding ethylene 2-(methacryloyloxy)ethyl phosphate at a molar ratio of 1:

1. The reaction was carried out under reflux at 90-95℃ for 20-24 hours. The unreacted raw materials were removed by rotary evaporation. Chloroform was obtained by vacuum drying at 50-60℃ for 10-12 hours; the modified phospholipidated quaternary ammonium random copolymer in step (3) was prepared by mixing 2-3 parts of N-vinylpyrrolidone, 4.68-7.03 parts of phospholipidated quaternary ammonium monomer, and 25-30 parts of isopropanol by mass under a nitrogen atmosphere, adding 0.09-0.12 parts of azobisisobutyronitrile, sealing, stirring and reacting at 65-70℃ for 3-4 hours, precipitating in 180-200 parts of petroleum ether, filtering, washing with petroleum ether, washing with anhydrous ethanol, and vacuum drying at 50-60℃ for 10-12 hours.

4. The method for preparing an antibacterial and anti-mite shampoo according to claim 3, characterized in that, The formula described in step (4) is as follows: 18~22wt% sodium lauryl ether sulfate, 0.9~1.1wt% coconut oil monoethanolamide, 1.4~1.5wt% ethylene glycol stearate diester, 0.7~0.8wt% cetearyl alcohol, 2.5~3wt% PEG-120 methyl glucotrioleate, 3.5~4wt% cocamidopropyl betaine, 1~1.2wt% modified phospholipidated quaternary ammonium random copolymer, 0.06~0.8wt% preservative, 0.1~0.2wt% fragrance, 0.02~0.2wt% citric acid, 0.8wt% sodium chloride, and the balance being water.

5. The method for preparing an antibacterial and anti-mite shampoo according to claim 3, characterized in that, The antibacterial and anti-mite shampoo in step (4) is prepared by dissolving the modified phospholipidated quaternary ammonium random copolymer in 50 times its mass of water according to the formula, stirring at 60°C until completely dissolved to obtain solution A, adding sodium lauryl ether sulfate to an equal mass of water, stirring at 75~85°C until completely dissolved, adding coconut oil monoethanolamide, ethylene glycol stearate diester, and cetearyl alcohol, continuing to stir until completely dissolved, adding solution A, continuing to stir, naturally cooling to 50°C, adding cocamidopropyl betaine, stirring until dissolved, then adding PEG-120 methyl glucotrioleate, stirring for 50~60 minutes to disperse, maintaining stirring and naturally cooling to 30°C, adding sodium chloride, cooling to room temperature, adding preservatives and fragrance, adding the remaining water, adding citric acid to adjust the pH to 6.5, stirring for 50~60 minutes until evenly dispersed to obtain the product.

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