Brain regulation device, electronic device, medium and computer program product

Abstract

The invention discloses brain regulation and control equipment, electronic equipment, a medium and a computer program product. The equipment comprises a control module, a mechanical wave transmitting module and a magnetic field generating module, the control module is used for determining a first intensity and a second intensity corresponding to a regulation and control area of a target object based on the effective induction electric field intensity of the target object; the mechanical wave transmitting module is used for transmitting a mechanical wave of which the intensity is the first intensity to the regulation and control area; and the magnetic field generation module is used for generating a magnetic field with the intensity being the second intensity in the regulation and control area. According to the embodiment of the invention, the non-invasive nerve regulation effect of the patient can be improved.

Description

Technical Field

[0001] This application relates to the field of non-invasive neuromodulation, specifically to a brain modulation device, electronic device, medium, and computer program product. Background Technology

[0002] Currently, the mainstream method for non-invasive neuromodulation is transcranial magnetic stimulation (TMS), which involves placing a coil in the patient's head and generating a magnetic field through a transient current, thereby modulating the activity of neurons in the brain. However, during TMS, some metallic objects can interfere with the magnetic field generated by the coil, thus reducing the therapeutic effect of non-invasive neuromodulation. However, the magnetic field of the coil cannot be increased indefinitely by simply increasing the current. To improve the therapeutic effect of non-invasive neuromodulation, mechanical waves and magnetic fields are used simultaneously to stimulate the patient's head, thereby increasing the stimulation of neurons in the brain.

[0003] However, when mechanical waves and magnetic fields are used to stimulate patients simultaneously, the mechanical waves and magnetic fields are of fixed intensity. The intensity of the mechanical waves and magnetic fields is not suitable for the patient, and the treatment effect is still very poor. Summary of the Invention

[0004] This application provides a brain modulation device, electronic device, medium, and computer program product that uses intensity matched to the target object to perform personalized modulation of the target object, thereby improving the therapeutic effect on the target object.

[0005] In a first aspect, embodiments of this application provide a brain modulation device, comprising: Control module, mechanical wave emitting module, magnetic field generating module; The control module is used to determine the first intensity and the second intensity corresponding to the control region of the target object based on the effective induced electric field intensity of the target object. The mechanical wave transmitting module is used to transmit a mechanical wave with an intensity of the first intensity into the control area; The magnetic field generating module is used to generate a magnetic field with the second intensity in the control region.

[0006] Secondly, embodiments of this application provide a brain modulation method, including: Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object; A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

[0007] Thirdly, embodiments of this application provide an electronic device, including: a processor and a memory, the processor being connected to the memory, the memory being used to store a computer program, and the processor being used to execute the computer program stored in the memory, so that the electronic device performs the method as described in the second aspect.

[0008] Fourthly, embodiments of this application provide a computer-readable storage medium storing a computer program that, when executed by a processor, implements the method described in the second aspect.

[0009] Fifthly, embodiments of this application provide a computer program product, the computer program product including a computer program, which, when executed by a processor, implements the method described in the second aspect.

[0010] Implementing the embodiments of this application has the following beneficial effects: As can be seen from the embodiments of this application, the brain modulation device includes a mechanical wave emitting module and a magnetic field generating module. It can simultaneously stimulate or modulate the modulation area of ​​the target object through magnetic fields and mechanical waves. When the modulation area of ​​the target object is stimulated or modulated by magnetic fields and mechanical waves at the same time, the control module of the brain modulation device will determine the first intensity (i.e., the intensity of mechanical waves) and the second intensity (i.e., the intensity of magnetic fields) corresponding to the modulation area based on the effective induced electric field intensity of the target object, that is, the electric field intensity that can make the brain neurons of the target object generate an effective response. In this way, the intensity matching the target object is determined. Then, the mechanical wave emitting module emits mechanical waves of the first intensity to the modulation area, and the magnetic field generating module generates magnetic fields of the second intensity in the modulation area, thereby effectively stimulating the modulation area. That is, the target object is personalizedly modulated by using the intensity matching the patient, thereby improving the treatment effect on the target object. Attached Figure Description

[0011] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0012] Figure 1 A schematic diagram of a brain modulation device provided in an embodiment of this application; Figure 2 A schematic diagram illustrating a second angle between the direction of a mechanical wave and the direction of a magnetic field, provided for an embodiment of this application; Figure 3This application provides an embodiment of the relationship between pressure value and time, and a schematic diagram of integrating the pressure value over time to obtain the effective cutting distance; Figure 4 A schematic flowchart of a brain modulation method provided in an embodiment of this application; Figure 5 This is a schematic diagram of an electronic device provided in an embodiment of this application. Detailed Implementation

[0013] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0014] The terms "first," "second," "third," and "fourth," etc., used in the specification, claims, and accompanying drawings of this application are used to distinguish different objects, not to describe a specific order. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products, or apparatuses.

[0015] In this document, the term "embodiment" means that a particular feature, result, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0016] See Figure 1 , Figure 1 This is a schematic diagram of a brain modulation device provided in an embodiment of this application. Figure 1 As shown, the brain modulation device includes a control module, a mechanical wave emission module, and a magnetic field generation module.

[0017] Optionally, the mechanical wave emitting module is used to emit mechanical waves. For example, if the mechanical wave emitting module includes a mechanical probe, then the mechanical wave emitting module emits mechanical waves through the mechanical probe. Optionally, the mechanical wave mentioned in this application can be a shock wave or an ultrasonic wave, and correspondingly, the mechanical probe can be a shock wave probe or an ultrasonic probe. For ease of description, this application mainly uses the example of a shock wave as the mechanical wave and a shock wave probe as the mechanical probe; however, it does not limit the types of mechanical waves and mechanical probes. Furthermore, the direction in which the mechanical wave emitting module emits mechanical waves may differ for different control areas; the specific emission direction depends on the control area.

[0018] Optionally, the magnetic field generating module is used to generate a magnetic field. Optionally, the magnetic field generating module includes a pair of permanent magnets or coils. For example, if the magnetic field generating module includes a pair of permanent magnets, a static magnetic field can be generated by the permanent magnets. For example, if the magnetic field generating module includes a coil, a magnetic field can be generated by the coil, and the magnitude of the magnetic field can be adjusted by adjusting the magnitude of the coil current, thereby generating a dynamic magnetic field. For ease of description, this application mainly uses the example of a coil generating a dynamic magnetic field. In this application, the direction of the magnetic field is mainly described as parallel to the ground or perpendicular to the head.

[0019] To facilitate understanding of the technical solution of this application, the process of obtaining the effective induced electric field intensity of the target object is first introduced. The target object is a patient requiring non-invasive neuromodulation.

[0020] Optionally, the effective induced electric field intensity of the target object is obtained by stimulating the motion area of ​​the target object in one or more rounds, wherein each round of stimulation includes multiple stimulations, and the multiple stimulations in each round use mechanical waves and magnetic fields of the same intensity to stimulate the motion area.

[0021] For example, during each stimulation process in the j-th round of stimulation, the mechanical wave emitting module sends an intensity I to the motion region. j Mechanical waves, i.e., waves with a transmission intensity of I j Mechanical waves; the magnetic field generating module generates intensity B in the moving area. j The magnetic field, that is, the magnetic field with strength B, is generated. j The magnetic field. Wherein, I j and B j It is the intensity corresponding to the j-th round of stimulation, where j is an integer greater than or equal to 1.

[0022] For example, the control module will obtain the intensity I during each stimulus process in the j-th round of stimulation. j Mechanical waves and intensity B jWhen a magnetic field stimulates the motor region, the target object's electromyographic (EMG) signals are collected. For example, the brain modulation device also includes an EMG acquisition module. The control module can then use the EMG acquisition module to detect resting-state evoked EMG activity in the contralateral arm and / or palm of the motor region to collect the target object's EMG signals. The control module then acquires the peak-to-peak value of the EMG signal for each stimulus in the j-th round of stimulation and determines whether the peak-to-peak value for each stimulus is greater than a first threshold. If it is greater than the first threshold, a statistical analysis is performed to obtain the number of stimuli in the j-th round of stimulation whose peak-to-peak value is greater than the first threshold. Then, based on the number of stimuli corresponding to the j-th round of stimulation and the total number of stimuli in the j-th round, the control module determines the proportion corresponding to the j-th round of stimulation, where the proportion is the ratio between the number of stimuli and the total number of stimuli.

[0023] Furthermore, the control module determines whether the percentage corresponding to the j-th round is greater than the second threshold.

[0024] Optionally, if the proportion is less than the second threshold, the control module determines the appropriate level based on intensity I. j The intensity I of the mechanical wave corresponding to the (j+1)th round of stimulation is obtained. j+1 For example, for intensity I j Adjustments were made to obtain intensity I. j+1 For example, the intensity I can be controlled by a first preset amplitude. j Adjustments were made to obtain intensity I. j+1 For example, for intensity I j Increase the first preset amplitude to obtain intensity I. j+1 And, the control module is based on intensity B. j Determine the strength B of the magnetic field corresponding to the (j+1)th round of stimulation. j+1 For example, for intensity B j Adjustments were made to obtain strength B. j+1 For example, the intensity B can be adjusted using a second preset amplitude. j Adjustments can be made, for example, to strength B. j Increase the second preset amplitude to obtain intensity B. j+1 .

[0025] It should be noted that, since this application stimulates the target object by simultaneously stimulating neurons with both mechanical waves and magnetic fields, a change in the intensity of either the mechanical wave or the magnetic field will alter the stimulation of the neuron. Therefore, after the j-th round of stimulation, only the intensity of the mechanical wave or the intensity of the magnetic field needs to be adjusted to obtain the intensity I corresponding to the (j+1)-th round of stimulation. j+1 and intensity B j+1Specifically, the intensity that needs adjustment can be adjusted in the manner described above; if no intensity adjustment is needed, the intensity corresponding to the j-th round of stimulation is used as the intensity of the (j+1)-th round of stimulation. For example, if only the intensity of the mechanical wave needs adjustment, it can be adjusted by using a first preset amplitude to... j Adjustments were made to obtain intensity I. j+1 And directly put B j As for strength B j+1 For example, if only the strength of the magnetic field is adjusted, then B can be adjusted by a second preset amplitude. j Adjustments were made to obtain strength B. j+1 And directly put I j As strength I j+1 .

[0026] For ease of description, this application will mainly use the example of simultaneously adjusting the intensity of mechanical waves and the intensity of magnetic fields.

[0027] Furthermore, the control module determines the intensity I j+1 and intensity B j+1 After that, intensity I will be... j+1 Send to the mechanical wave transmitting module, and send intensity B j+1 If the signal is sent to the magnetic field generation module, then during each stimulation process of the (j+1)th round of stimulation, the mechanical wave emission module will emit intensity I into the motion region. j+1 The mechanical wave, and the magnetic field generating module generates an intensity of B in the moving area. j+1 The magnetic field is then determined. The control module acquires the peak-to-peak value of the electromyographic signal for each stimulus in the (j+1)th round of stimulation, thus obtaining the proportion corresponding to the (j+1)th round of stimulation. The method for acquiring the proportion corresponding to the (j+1)th round of stimulation is similar to the method for acquiring the proportion corresponding to the (j)th round of stimulation described above, and will not be repeated. If the proportion corresponding to the (j+1)th round is still less than the second threshold, the process continues to acquire the proportion of the (j+2)th round of stimulation until the determined proportion is greater than or equal to the second threshold.

[0028] It should be noted that when j=1, that is, when the target object is stimulated for the first time, the control module first obtains the intensity I1 of the mechanical wave corresponding to the first stimulus and the intensity B1 of the magnetic field.

[0029] Optionally, I1 and B1 can be pre-set, or they can be input by the user into the brain modulation device before the first round of stimulation of the target object. For example, the brain modulation device also includes a display module, through which the user can set I1 and B1, and also set the first preset amplitude and the second preset amplitude.

[0030] Optionally, if the proportion is greater than or equal to the second threshold, it indicates that an effective stimulus has been generated in the motion area of ​​the target object. Then, based on the first target intensity and the second target intensity, the effective induced electric field intensity is determined, wherein the first target intensity is the intensity of the mechanical wave emitted by the mechanical wave emitting module when the proportion is greater than or equal to the second threshold, and the second target intensity is the intensity of the magnetic field generated by the magnetic field generating module when the proportion is greater than or equal to the second threshold.

[0031] For example, the control module obtains a second angle between the direction of the mechanical wave emitted by the mechanical wave emitting module and the direction of the magnetic field generated by the magnetic field generating module; and obtains a second distance between the mechanical wave emitting module and the moving area. Specifically, as... Figure 2 As shown, the control module, based on the motion region, determines the direction of the mechanical wave emitted by the mechanical wave generating module through a neural navigation system, so that the mechanical wave can be emitted into the motion region along that direction. Regarding the direction of the magnetic field, for ease of understanding, this application primarily uses the direction perpendicular to the brain, i.e., parallel to the ground, as the direction of the magnetic field. Then, exemplarily, as... Figure 2 As shown, the control module determines the second angle, i.e., the angle between the two directions, based on the direction of the mechanical wave emitted by the mechanical wave generator and the direction of the magnetic field. The control module determines the location point of the motion area through the neural navigation system, and based on this location point, determines the second distance between the mechanical wave generating module and the motion area.

[0032] Then, the control module determines the effective induced electric field strength based on the second angle, the second distance, the first target intensity, and the second target intensity.

[0033] For example, the control module determines the cutting speed of the brain tissue based on the first target intensity, the second distance, the attenuation rate of the mechanical wave in the brain tissue, and the propagation speed of the mechanical wave in the brain tissue. Here, the brain tissue mentioned in this application can also be understood as brain neurons, i.e., neurons in the brain. The cutting speed can be understood as the cutting speed of the brain tissue within the magnetic field generated by the magnetic field generating module, that is, the speed of movement of the brain tissue within the magnetic field of the second target intensity.

[0034] For example, based on the first target intensity, the second distance, and the attenuation rate of the mechanical wave in brain tissue, a third intensity of the mechanical wave of the first target intensity reaching the motor region is determined. The third intensity can be understood as the intensity of the mechanical wave of the first target intensity reaching the motor region after being attenuated by brain tissue of a length of the second distance, i.e., the intensity of the mechanical wave when it reaches the positioning point of the motor region.

[0035] For example, the third intensity can be represented by formula (1): Formula (1); in, The first target intensity, For decay rate, The second distance, It is the third intensity.

[0036] It should be noted that if the mechanical wave is a shock wave, then the shock wave is an instantaneously emitted mechanical wave. After its emission, the intensity of the shock wave changes non-linearly with time. Therefore, the intensity of the first target is a time-varying intensity, and this time-varying relationship can be expressed by a function or equation. Thus, if the intensity of the first target is a time-varying intensity, it can be expressed through... This represents the intensity of the first target. Correspondingly, the third intensity is also an intensity that varies over time, which can be... Substituting into the above formula (1), we can obtain the third intensity that varies with time, i.e. .

[0037] For ease of understanding, this application mainly uses the example of a mechanical wave emitting module emitting mechanical waves of a fixed intensity, that is, continuously emitting mechanical waves of a fixed intensity within a preset stimulation duration. Therefore, when the mechanical wave emitting module continuously emits mechanical waves with an intensity of the first target intensity within the preset stimulation duration, mechanical waves of the third intensity will be continuously generated in the motion area.

[0038] Furthermore, based on the third intensity, the density of brain tissue, and the propagation speed of mechanical waves in brain tissue, the pressure value generated by the mechanical wave of the third intensity in the motion area is determined.

[0039] For example, the pressure value can be expressed by formula (2): Formula (2); Where P is the pressure value. For the third intensity mentioned above, Let be the density of brain tissue, and c be the propagation speed of mechanical waves in brain tissue.

[0040] It is understandable that if the third intensity changes with time, then the aforementioned pressure value P also changes with time, and through... This indicates the pressure value as it changes over time.

[0041] Furthermore, based on the density of brain tissue and the aforementioned propagation speed, the impedance of brain tissue is determined.

[0042] For example, the impedance of brain tissue can be expressed by formula (3): Formula (3); Where Z is the impedance.

[0043] Furthermore, the cutting speed is determined based on the pressure value and the impedance.

[0044] For example, the cutting speed can be expressed by formula (4): Formula (4); Where V is the cutting speed.

[0045] It's understandable that if the pressure value changes with time, then the cutting speed also changes with time. Therefore, the cutting speed that changes with time is called... ,but .

[0046] Furthermore, based on the cutting speed and the preset stimulation duration, the effective cutting distance of the brain tissue in the magnetic field of the second target intensity is determined. For example, based on the cutting speed and the stimulation duration, the distance the brain tissue moves in the magnetic field of the second target intensity within the stimulation duration can be determined, and this distance is taken as the effective cutting distance.

[0047] For example, the effective cutting distance can be expressed by formula (5): Formula (5); Where L is the effective cutting distance and T is the preset stimulation duration.

[0048] It's understandable if the cutting speed changes over time. Then the effective cutting distance L can be expressed by formula (6): Formula (6); Where L is the effective cutting distance.

[0049] For example, if the mechanical wave is a shock wave, then the mechanical wave generates [something] in the moving area. satisfy Figure 3 The relationship shown indicates that after emitting mechanical waves, it is possible to... Perform time integration and divide the area of ​​the shaded region integrated within the preset stimulus duration T by [the area of ​​the shaded region]. It can obtain the effective cutting distance of brain tissue, that is, brain neurons.

[0050] Furthermore, the effective induced electric field strength is determined based on the second target intensity, the effective cutting distance, the cutting speed, and the second angle.

[0051] For example, the effective induced electric field strength can be expressed by formula (7): Formula (7); Where E is the effective induced electric field strength, and B is the second target strength. It's the second angle.

[0052] Where B is determined by the number of turns of the coil and the magnitude of the current, that is, B=N·i, where N is the number of turns of the coil and i is the magnitude of the current in the coil.

[0053] For example, when it is necessary to regulate (i.e. stimulate) the regulation area of ​​the target object, the control module determines the first intensity and the second intensity corresponding to the regulation area based on the effective induced electric field strength of the target object. The first intensity is the intensity of the mechanical wave to be emitted into the regulation area, and the second intensity is the intensity of the magnetic field to be generated in the regulation area.

[0054] It should be noted that while the effectiveness of stimulation of motor areas can be determined by observing electromyographic (EMG) signals, the effectiveness of stimulation of non-motor areas cannot be determined by EMG signal detection. Therefore, it is impossible to subjectively judge when stimulation of non-motor areas is effective. Thus, this application primarily uses a non-motor area of ​​the brain (e.g., the frontal region) as an example to illustrate how to determine the intensity of the mechanical waves and magnetic fields corresponding to the non-motor area.

[0055] It should be noted that the aforementioned effective induced electric field strength is the induced electric field strength that the target brain neurons can generate when stimulated; or, in other words, if the stimulation of the target brain neurons results in an electric field strength greater than or equal to this effective induced electric field strength, then the stimulation is considered effective. Therefore, the effective induced electric field strength can be understood as the electric field strength that produces an effective response from the target brain neurons.

[0056] Therefore, by first calculating the effective induced electric field strength of the target object, this application can determine that stimulating the non-moving region of the target object requires generating an electric field with an intensity equal to the effective induced electric field strength for the stimulation to be effective. This predetermines the required electric field strength for stimulating the non-moving region of the target object. Therefore, using the effective induced electric field strength, it is possible to calculate in reverse the required mechanical wave and magnetic field strength to be applied to the non-moving region to generate an electric field strength equal to the effective induced electric field strength.

[0057] For example, a first angle is obtained between the emission direction of the mechanical wave emitting module when emitting a mechanical wave into the control area and the magnetic field direction of the magnetic field generated by the magnetic field generating module in the control area. The method for obtaining the first angle is similar to the method for obtaining the second angle described above, and will not be described again. Also, a first distance is obtained between the mechanical wave emitting module and the control area. The method for obtaining the first distance is similar to the method for obtaining the second distance described above, and will not be described again.

[0058] Then, based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field strength, the first intensity and the second intensity are determined.

[0059] For example, a correlation is determined based on the first angle, the first distance, the preset stimulation duration, the attenuation rate of the mechanical wave in the brain tissue, the density of the brain tissue, the propagation speed of the mechanical wave in the brain tissue, and the effective induced electric field strength. The correlation is the relationship between the intensity of the mechanical wave and the intensity of the magnetic field when an electric field with an intensity equal to the effective induced electric field strength is generated in the control region.

[0060] Specifically, by substituting the first angle, the first distance, the preset stimulation duration, the attenuation rate of the mechanical wave in the brain tissue, the density of the brain tissue, the propagation speed of the mechanical wave in the brain tissue, and the effective induced electric field strength into the above formula (7), it is possible to determine the correlation between the first intensity of the emitted mechanical wave and the second intensity of the generated magnetic field in order to generate an electric field with the intensity of the effective induced electric field at the first angle and the first distance. That is, the product between the first intensity and the second intensity is a fixed value.

[0061] Finally, the control module determines the first intensity and the second intensity based on this correlation. Specifically, if the product of the first intensity and the second intensity is a fixed value, then any two values ​​that satisfy this product relationship can be used as the first intensity and the second intensity; or, based on the first value range corresponding to the magnetic field intensity and the second value range corresponding to the mechanical wave intensity, values ​​that satisfy the above product relationship are obtained within the first value range and the second value range, and such values ​​are used as the first intensity and the second intensity.

[0062] For example, the mechanical wave emitting module emits a mechanical wave with an intensity of the first intensity toward the control area. For example, the control module can send the first intensity to the mechanical wave emitting module, then the mechanical wave emitting module can emit a mechanical wave of the first intensity toward the control area along a first angle via a mechanical probe.

[0063] For example, the magnetic field generating module generates a magnetic field of a second intensity in the control region. Specifically, the magnetic field generating module generates the magnetic field through a coil. Therefore, after determining the second intensity, a current value corresponding to the second intensity is determined based on the number of turns of the coil; then, a current of the magnitude of the second current value is output to the coil, thereby generating a magnetic field of the second intensity.

[0064] As can be seen from the embodiments of this application, the brain modulation device includes a mechanical wave emitting module and a magnetic field generating module. It can simultaneously stimulate or modulate the modulation area of ​​the target object through magnetic fields and mechanical waves. When the magnetic field and mechanical waves simultaneously stimulate or modulate the modulation area of ​​the target object, the control module of the brain modulation device will determine the first intensity (i.e., the intensity of the mechanical wave) and the second intensity (i.e., the intensity of the magnetic field) corresponding to the modulation area based on the effective induced electric field intensity of the target object, that is, the electric field intensity that can make the brain neurons of the target object generate an effective response. In this way, the intensity matching the target object is determined. Then, the mechanical wave emitting module emits a mechanical wave with the first intensity to the modulation area, and the magnetic field generating module generates a magnetic field with the second intensity in the modulation area, thereby effectively stimulating the modulation area. That is, the target object is personalizedly modulated using the matching intensity, thereby improving the therapeutic effect on the target object.

[0065] See Figure 4 , Figure 4 This is a flowchart illustrating a brain modulation method provided in an embodiment of this application. The method is applied to the aforementioned brain modulation device. The method includes, but is not limited to, the following steps: S401: Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object.

[0066] S402: Transmit a mechanical wave with the first intensity to the control region.

[0067] S403: Generate a magnetic field with the second strength in the controlled region.

[0068] It should be noted that the specific implementation methods of S401~S403 mentioned above can refer to the specific implementation process of the brain modulation device mentioned above, and will not be described in detail here.

[0069] See Figure 5 , Figure 5 This is a schematic diagram of an electronic device provided in an embodiment of this application. The electronic device 500 can be the aforementioned brain modulation device.

[0070] Electronic device 500 includes a memory 501, a processor 502, a communication interface 503, and a bus 504. The memory 501, processor 502, and communication interface 503 are interconnected via the bus 504.

[0071] The memory 501 can be a read-only memory (ROM), a static storage device, a dynamic storage device, or a random access memory (RAM). The memory 501 can store programs; when the electronic device 500 is the brain modulation device described above, when the program stored in the memory 501 is executed by the processor 502, the processor 502 and the communication interface 503 are used to execute the various steps performed by the brain modulation device in the brain modulation method of this application embodiment.

[0072] The processor 502 may be a general-purpose central processing unit (CPU), microprocessor, application specific integrated circuit (ASIC), graphics processing unit (GPU), or one or more integrated circuits, used to execute relevant programs to implement the brain modulation method in the embodiments of this application.

[0073] The processor 502 can also be an integrated circuit chip with signal processing capabilities. In implementation, each step of the brain modulation method of this application can be completed by the integrated logic circuitry in the hardware of the processor 502 or by instructions in software form. The processor 502 can also be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, or discrete hardware components. It can implement or execute the methods, steps, and logic block diagrams disclosed in the embodiments of this application. The general-purpose processor can be a microprocessor or any conventional processor. The steps of the methods disclosed in the embodiments of this application can be directly embodied in the execution of a hardware decoding processor, or can be executed by a combination of hardware and software modules in the decoding processor. The software modules can be located in random access memory, flash memory, read-only memory, programmable read-only memory, electrically erasable programmable memory, registers, or other mature storage media in the art. The storage medium is located in memory 501, and processor 502 reads the information in memory 501 to execute the various steps of the brain modulation method.

[0074] The communication interface 503 can be a transceiver device such as a transceiver to enable communication between the electronic device 500 and other devices or communication networks. The communication interface 503 can also be an input-output interface to enable data transmission between the electronic device 500 and input-output devices, including but not limited to keyboards, mice, displays, USB flash drives, and hard drives. For example, the processor 502 can receive signals through the communication interface 503.

[0075] Bus 504 may include a pathway for transmitting information between various components of device electronics 500 (e.g., memory 501, processor 502, communication interface 503).

[0076] It should be noted that, although Figure 5 The illustrated electronic device 500 only shows the memory, processor, and communication interface. However, those skilled in the art should understand that in specific implementations, the electronic device 500 may also include other devices necessary for normal operation. Furthermore, depending on specific needs, those skilled in the art should understand that the electronic device 500 may also include hardware devices for implementing other additional functions. Moreover, those skilled in the art should understand that the electronic device 500 may only include the devices necessary for implementing the embodiments of this application, and may not necessarily include... Figure 5 All the devices shown.

[0077] This application also provides a computer-readable storage medium storing a computer program that is executed by a processor to implement some or all of the steps of any of the brain modulation methods described in the above method embodiments.

[0078] This application also provides a computer program product, which includes a non-transitory computer-readable storage medium storing a computer program operable to cause a computer to perform some or all of the steps of any of the brain modulation methods described in the above method embodiments.

[0079] It should be noted that, for the sake of simplicity, the foregoing method embodiments are all described as a series of actions. However, those skilled in the art should understand that this application is not limited to the described order of actions, as some steps may be performed in other orders or simultaneously according to this application. Furthermore, those skilled in the art should also understand that the embodiments described in the specification are all optional embodiments, and the actions and modules involved are not necessarily essential to this application.

[0080] In the above embodiments, the descriptions of each embodiment have different focuses. For parts not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.

[0081] In the several embodiments provided in this application, it should be understood that the disclosed apparatus can be implemented in other ways. For example, the apparatus embodiments described above are merely illustrative; for instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be through some interfaces; the indirect coupling or communication connection between devices or units may be electrical or other forms.

[0082] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0083] Furthermore, the functional units in the various embodiments of this application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software program module.

[0084] If the integrated unit is implemented as a software program module and sold or used as an independent product, it can be stored in a computer-readable storage device (CMD). Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or all or part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a memory and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of this application. The aforementioned memory includes various media capable of storing program code, such as USB flash drives, read-only memory (ROM), random access memory (RAM), portable hard drives, magnetic disks, or optical disks.

[0085] Those skilled in the art will understand that all or part of the steps in the various methods of the above embodiments can be implemented by a program instructing related hardware. The program can be stored in a computer-readable storage device, which may include: a flash drive, a read-only memory (ROM), a random access memory (RAM), a magnetic disk, or an optical disk, etc.

[0086] The embodiments of this application have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this application. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A brain modulation device, characterized in that, include: Control module, mechanical wave emitting module, magnetic field generating module; The control module is used to determine the first intensity and the second intensity corresponding to the control region of the target object based on the effective induced electric field intensity of the target object; specifically, it is used for: Obtain a first angle between the direction in which the mechanical wave emitting module emits the mechanical wave into the control area and the direction in which the magnetic field generating module generates the magnetic field in the control area; obtain a first distance between the mechanical wave emitting module and the control area; Based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field strength, the first intensity and the second intensity are determined; The mechanical wave transmitting module is used to transmit a mechanical wave with an intensity of the first intensity into the control area; The magnetic field generating module is used to generate a magnetic field with the second intensity in the control region.

2. The device according to claim 1, characterized in that, In determining the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity, the control module is specifically used for: Based on the first angle, the first distance, the preset stimulation duration, the attenuation rate of the mechanical wave in the brain tissue, the density of the brain tissue, the propagation speed of the mechanical wave in the brain tissue, and the effective induced electric field strength, a correlation is determined, wherein the correlation is the relationship between the intensity of the mechanical wave and the intensity of the magnetic field when an electric field with an intensity equal to the effective induced electric field strength is generated in the control region. Based on the aforementioned correlation, the first strength and the second strength are determined.

3. The device according to claim 1 or 2, characterized in that, During each stimulus in the j-th round of stimulation, The mechanical wave emitting module is also used to send intensity I to the motion region of the target object. j Mechanical waves; The magnetic field generating module is also used to generate intensity B in the motion region. j Magnetic field; The control module is also used to control the intensity I each time it passes. j Mechanical waves and intensity B j When the magnetic field stimulates the motor area, it is determined whether the peak-to-peak value of the electromyographic signal of the target object is greater than a first threshold, and the number of stimuli with peak-to-peak values ​​greater than the first threshold during the j-th round of stimulation is obtained; and, based on the number of stimuli and the total number of stimuli in the j-th round of stimulation, the proportion corresponding to the j-th round of stimulation is determined. If the proportion is less than the second threshold, then based on the I j The intensity I of the mechanical wave corresponding to the (j+1)th round of stimulation is obtained. j+1 and based on the intensity B j Determine the strength B of the magnetic field corresponding to the (j+1)th round of stimulation. j+1 In each stimulation process of the (j+1)th round of stimulation, intensity I is used j+1 Mechanical waves and intensity B j+1 The magnetic field stimulates the motion area to obtain the proportion corresponding to the (j+1)th round of stimulation, until the proportion is greater than or equal to the second threshold. If the proportion is greater than or equal to the second threshold, the effective induced electric field strength is determined based on the first target strength and the second target strength, wherein the first target strength is the strength of the mechanical wave emitted by the mechanical wave emitting module when the proportion is greater than or equal to the second threshold, and the second target strength is the strength of the magnetic field generated by the magnetic field generating module when the proportion is greater than or equal to the second threshold.

4. The device according to claim 3, characterized in that, In determining the effective induced electric field strength based on the first target intensity and the second target intensity, the control module is specifically used for: Obtain a second angle between the direction of the mechanical wave emitted by the mechanical wave emitting module and the direction of the magnetic field generated by the magnetic field generating module; Obtain the second distance between the mechanical wave emitting module and the motion area; The effective induced electric field strength is determined based on the second angle, the second distance, the first target intensity, and the second target intensity.

5. The device according to claim 4, characterized in that, In determining the effective induced electric field strength based on the second angle, the second distance, the first target intensity, and the second target intensity, the control module is specifically used for: The cutting speed of the brain tissue is determined based on the first target intensity, the second distance, the attenuation rate of the mechanical wave in the brain tissue, and the propagation speed of the mechanical wave in the brain tissue. Based on the cutting speed and the preset stimulation duration, the effective cutting distance of the brain tissue in the magnetic field of the second target strength is determined; The effective induced electric field strength is determined based on the second target intensity, the effective cutting distance, the cutting speed, and the second angle.

6. The device according to claim 5, characterized in that, In determining the cutting speed of brain tissue based on the first target intensity, the second distance, the attenuation rate of the mechanical wave in brain tissue, and the propagation speed of the mechanical wave in brain tissue, the control module is specifically used for: Based on the first target intensity, the second distance, and the attenuation rate of the mechanical wave in brain tissue, a third intensity is determined for the mechanical wave of the first target intensity to reach the motor region. Based on the third intensity, the density of brain tissue, and the propagation speed of mechanical waves in brain tissue, the pressure value generated by the mechanical wave of the third intensity in the motor region is determined. The impedance of brain tissue is determined based on the density and the propagation speed; The cutting speed is determined based on the pressure value and the impedance.

7. An electronic device, characterized in that, The electronic device is used to implement the steps performed by the brain modulation device according to any one of claims 1-6, the electronic device comprising: a processor and a memory, the processor being connected to the memory, the memory being used to store a computer program, and the processor being used to execute the computer program stored in the memory, so that the electronic device performs the following steps: Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object, including: Obtain a first angle between the direction of the mechanical wave emitted by the mechanical wave emission module toward the control area and the direction of the magnetic field generated by the magnetic field generation module in the control area; obtain a first distance between the mechanical wave emission module and the control area; and determine the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity. A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

8. A computer-readable storage medium, characterized in that, The computer-readable storage medium is used to implement the steps performed by the brain modulation device according to any one of claims 1-6, wherein the computer-readable storage medium stores a computer program that is executed by a processor to implement the following steps: Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object, including: Obtain a first angle between the direction of the mechanical wave emitted by the mechanical wave emission module toward the control area and the direction of the magnetic field generated by the magnetic field generation module in the control area; obtain a first distance between the mechanical wave emission module and the control area; and determine the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity. A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

9. A computer program product, characterized in that, The computer program product is used to implement the steps performed by the brain modulation device according to any one of claims 1-6, the computer program product comprising a computer program that, when executed by a processor, performs the following steps: Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object, including: Obtain a first angle between the direction of the mechanical wave emitted by the mechanical wave emission module toward the control area and the direction of the magnetic field generated by the magnetic field generation module in the control area; obtain a first distance between the mechanical wave emission module and the control area; and determine the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity. A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

Images