Healthcare ointment for treating arthralgia and activating collaterals and preparation method

Abstract

The invention relates to the technical field of traditional Chinese medicine external health-care preparations, in particular to arthralgia and collateral activating health-care ointment and a preparation method thereof.The arthralgia and collateral activating health-care ointment is prepared from, by weight, 40-60 g of asiatic toddalia roots, 30-50 g of periploca forrestii schltr, 15-25 g of beautiful millettia roots, 20-40 g of myrrh, 40-60 g of schizophragma integrifolium, 40-60 g of prepared radix clematidis, 30-50 g of garden balsam stems and 10-30 g of pubescent holly roots. The preparation method comprises the following steps: S1, crushing and screening; s2, ethanol reflux extraction; s3, vacuum concentration; the arthralgia and collateral activating health-care ointment and the preparation method thereof have the beneficial effects that by optimizing the compatibility of monarch, minister, assistant and guide and a preparation process, the dissolution rate and transdermal efficiency of effective components are remarkably improved, the irritation to skin is greatly reduced, the allergy rate is low, skin allergy caused by long-term use can be effectively avoided, and the health-care ointment has a good application prospect. The traditional Chinese medicine composition has the advantages of good transdermal absorption, fast effect taking and long lasting action time, and can well meet the use requirements of people.

Description

Technical Field

[0001] This invention relates to the field of external application health care preparations of traditional Chinese medicine, specifically to a pain-relieving and blood-activating health care ointment and its preparation method. Background Technology

[0002] Currently, existing pain-relieving plasters for wind-cold-dampness syndrome mostly contain chemical anti-inflammatory ingredients (such as diclofenac), which can easily cause skin allergies with long-term use; while pure traditional Chinese medicine preparations generally suffer from poor transdermal absorption and slow onset of action, failing to adequately meet people's needs. Therefore, this paper proposes a pain-relieving and blood-activating health plaster and its preparation method. Summary of the Invention

[0003] To overcome the technical deficiencies in the prior art and effectively solve the technical problems in the background art, the present invention provides the following technical solution:

[0004] A pain-relieving and blood-activating health care plaster, wherein the pain-relieving and blood-activating health care plaster is composed of the following components by weight: 40-60 grams of *Pterocarya stenoptera*, 30-50 grams of *Ipomoea aquatica*, 15-25 grams of *Achyranthes bidentata*, 20-40 grams of myrrh, 40-60 grams of *Gnaphalium affine*, 40-60 grams of processed *Clematis chinensis*, 30-50 grams of *Hedyotis diffusa*, and 10-30 grams of *Ilex pubescens*.

[0005] As a preferred technical solution of the present invention, the pain relief and blood circulation health care ointment is composed of the following components by weight: 50g of Flying Dragon Palm Blood, 40g of Black Bone Vine, 20g of Ox Strength Lily, 30g of Myrrh, 50g of Drilling Ground Wind, 50g of Prepared Clematis chinensis, 40g of Thoroughgrass, and 20g of Hairy Wintergreen.

[0006] As a preferred technical solution of the present invention, the pain relief and blood circulation health care ointment is composed of the following components by weight: 40g of Flying Dragon Palm Blood, 30g of Black Bone Vine, 15g of Ox Strength, 20g of Myrrh, 40g of Drilling Ground Wind, 40g of Prepared Clematis, 30g of Thoroughgrass, and 10g of Hairy Wintergreen.

[0007] As a preferred technical solution of the present invention, the pain relief and blood circulation health care ointment is composed of the following components by weight: 60g of Flying Dragon Palm Blood, 50g of Black Bone Vine, 25g of Ox Strength, 40g of Myrrh, 60g of Drilling Ground Wind, 60g of Prepared Clematis, 50g of Thoroughgrass, and 30g of Hairy Wintergreen.

[0008] A method for preparing a pain-relieving and blood-activating health-preserving plaster includes the following steps:

[0009] S1: Crushing and sieving: Take the above-mentioned medicinal materials according to the proportion, crush the medicinal materials separately, and pass them through an 80-mesh sieve;

[0010] S2: Ethanol reflux extraction: All the medicinal materials after being crushed and sieved in step S1 are refluxed twice with 8 times the amount of 70% ethanol, each time for 1.5 hours;

[0011] S3: Concentration under reduced pressure: Combine the extracts from step S2 and concentrate under reduced pressure to a relative density of 1.25;

[0012] S4: Mixing and dispensing with transdermal enhancement matrix: Add the transdermal enhancement matrix to the concentrated mixture from step S3, stir and mix evenly, and dispense into light-proof containers under aseptic conditions to obtain the final product.

[0013] As a preferred embodiment of the present invention, the extraction temperature in step 3 is 60°C.

[0014] As a preferred embodiment of the present invention, the transdermal promoting matrix in step 4 is glycerol, carbomer 940 and azone, in a ratio of glycerol: carbomer 940: azone = 15: 3: 1.

[0015] As a preferred embodiment of the present invention, the dispensing container in step 4 is a 150mL brown glass spray bottle.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: The Bi Tong Huo Luo Health Care Ointment and its preparation method, through optimization of the combination of principal, assistant, adjuvant and guide ingredients and preparation process, significantly improve the dissolution rate and transdermal efficiency of effective ingredients, greatly reduce skin irritation, have a low allergy rate, can effectively avoid skin allergies caused by long-term use, have good transdermal absorption, fast onset of action, and long duration of action, which can well meet people's needs.

[0017] In this invention, the relationships between the principal, assistant, adjuvant, and guide components of the formulation and their medicinal properties are analyzed as follows:

[0018]

[0019] Features of the formulation: By synergistically enhancing the efficacy of the two principal herbs, the combination of Clematis chinensis and Ilex pubescens forms a "transdermal guidance system", which solves the penetration problem of traditional ointments.

[0020] The product description of this invention is as follows:

[0021]

Product Type

[0022] [Suitable for] People in a sub-healthy state.

[0023] [Not suitable for] This product is contraindicated for individuals with allergies to it, those with broken skin, infants, pregnant women, and breastfeeding mothers.

[0024]

Instructions for use

[0025]

Precautions

[0026] 2. This product is for external use only and should not be ingested. Keep out of reach of children to avoid accidental ingestion.

[0027] 3. If redness, swelling, itching, or other discomfort occurs while using this product, please discontinue use immediately or seek medical attention.

[0028] 4. Please read the instructions carefully and use as directed, or use under the guidance of a doctor.

[0029]

Storage Method

[0030] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions in the embodiments of this invention will be described more clearly and completely below. Obviously, the described embodiments are only some embodiments of this invention, and not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0031] This invention provides a technical solution: a pain-relieving and blood-activating health care plaster, which, by weight, is composed of the following components: 40-60 grams of *Pterocarya stenoptera*, 30-50 grams of *Ipomoea aquatica*, 15-25 grams of *Achyranthes bidentata*, 20-40 grams of myrrh, 40-60 grams of *Gnaphalium affine*, 40-60 grams of prepared *Clematis chinensis*, 30-50 grams of *Hedyotis diffusa*, and 10-30 grams of *Ilex pubescens*.

[0032] A method for preparing a pain-relieving and blood-activating health-preserving plaster includes the following steps:

[0033] S1: Crushing and sieving: Take the above-mentioned medicinal materials according to the proportion, crush the medicinal materials separately, and pass them through an 80-mesh sieve;

[0034] S2: Ethanol reflux extraction: All the medicinal materials after being crushed and sieved in step S1 were refluxed twice with 8 times the amount of 70% ethanol, each time for 1.5 hours (extraction temperature was 60℃).

[0035] S3: Concentration under reduced pressure: Combine the extracts from step S2 and concentrate under reduced pressure to a relative density of 1.25;

[0036] S4: Mix and dispense with transdermal enhancement matrix: Add the transdermal enhancement matrix (glycerol: carbomer 940: azone = 15:3:1) to the concentrated mixture in step S3, stir and mix evenly, and dispense into light-proof containers (150mL brown glass spray bottles) under aseptic conditions to obtain the final product.

[0037] Example 1:

[0038] Formula: 50g of Flying Dragon Palm Blood, 40g of Black Bone Vine, 20g of Ox Strength, 30g of Myrrh, 50g of Drilling Ground Wind, 50g of Prepared Clematis, 40g of Thoroughgrass, and 20g of Hairy Wintergreen.

[0039] Preparation: As described in the preparation method above, the medicinal materials are pulverized, extracted by ethanol reflux, concentrated under reduced pressure, and mixed with a transdermal promoting matrix and packaged to obtain the final product.

[0040] Example 2:

[0041] Formula: 40g of Flying Dragon Palm Blood, 30g of Black Bone Vine, 15g of Ox Strength, 20g of Myrrh, 40g of Drilling Ground Wind, 40g of Prepared Clematis, 30g of Thoroughgrass, and 10g of Hairy Holly.

[0042] Preparation: Same as in Example 1.

[0043] Example 3:

[0044] Formula: 60g of Flying Dragon Palm Blood, 50g of Black Bone Vine, 25g of Ox Strength, 40g of Myrrh, 60g of Drilling Ground Wind, 60g of Prepared Clematis, 50g of Thoroughgrass, and 30g of Hairy Wintergreen.

[0045] Preparation: Same as in Example 1.

[0046] The relevant experimental data are as follows:

[0047] 1. Transdermal absorption assay (Franz diffusion cell method)

[0048]

[0049] 2. Analgesic effect (mice acetic acid writhing test)

[0050]

[0051] Conclusion: While maintaining the characteristics of pure traditional Chinese medicine, the transdermal penetration rate of this invention is increased by 65% ​​compared with traditional products, and the analgesic effect is close to that of chemical drugs.

[0052] The data compared with similar products is as follows:

[0053]

[0054] Conclusion: Compared with traditional products of the same type, the allergy rate of the present invention is significantly lower than that of traditional products, the duration of action is significantly longer than that of traditional products, and the adverse effects of skin irritation caused by traditional products are avoided.

[0055] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pain-relieving and blood-activating health-preserving plaster, characterized in that: The pain relief and blood circulation health care ointment, by weight, consists of the following components: 40-60g of Flying Dragon Palm Blood, 30-50g of Black Bone Vine, 15-25g of Ox Strength, 20-40g of Myrrh, 40-60g of Drill Ground Wind, 40-60g of Prepared Clematis chinensis, 30-50g of Thoroughgrass, and 10-30g of Hairy Wintergreen.

2. The pain-relieving and blood-activating health-preserving ointment according to claim 1, characterized in that: The pain relief and blood circulation health care ointment, by weight, consists of the following components: 50g of Flying Dragon Palm Blood, 40g of Black Bone Vine, 20g of Ox Strength, 30g of Myrrh, 50g of Drilling Ground Wind, 50g of Prepared Clematis, 40g of Thoroughgrass, and 20g of Hairy Wintergreen.

3. The pain-relieving and blood-activating health-preserving ointment according to claim 1, characterized in that: The pain relief and blood circulation health care ointment, by weight, consists of the following components: 40g of Flying Dragon Palm Blood, 30g of Black Bone Vine, 15g of Ox Strength, 20g of Myrrh, 40g of Drilling Ground Wind, 40g of Prepared Clematis, 30g of Thoroughgrass, and 10g of Hairy Wintergreen.

4. The pain-relieving and blood-activating health-preserving ointment according to claim 1, characterized in that: The pain relief and blood circulation health care ointment, by weight, consists of the following components: 60g of Flying Dragon Palm Blood, 50g of Black Bone Vine, 25g of Ox Strength, 40g of Myrrh, 60g of Drilling Ground Wind, 60g of Prepared Clematis, 50g of Thoroughgrass, and 30g of Hairy Wintergreen.

5. The method for preparing the pain-relieving and blood-activating health-preserving plaster according to any one of claims 1-4, characterized in that: Includes the following steps: S1: Crushing and sieving: Take the above-mentioned medicinal materials according to the proportion, crush the medicinal materials separately, and pass them through an 80-mesh sieve; S2: Ethanol reflux extraction: All the medicinal materials after being crushed and sieved in step S1 are refluxed twice with 8 times the amount of 70% ethanol, each time for 1.5 hours; S3: Concentration under reduced pressure: Combine the extracts from step S2 and concentrate under reduced pressure to a relative density of 1.25; S4: Mixing and dispensing with transdermal enhancement matrix: Add the transdermal enhancement matrix to the concentrated mixture from step S3, stir and mix evenly, and dispense into light-proof containers under aseptic conditions to obtain the final product.

6. The method for preparing the pain-relieving and blood-activating health-preserving ointment according to claim 5, characterized in that: The extraction temperature in step 3 is 60℃.

7. The method for preparing the pain-relieving and blood-activating health-preserving plaster according to claim 5, characterized in that: The transdermal enhancement matrix in step 4 consists of glycerol, carbomer 940, and azone, in a ratio of glycerol:carbomer 940:azone = 15:3:

1.

8. The method for preparing the pain-relieving and blood-activating health-preserving ointment according to claim 5, characterized in that: The dispensing container in step 4 is a 150mL brown glass spray bottle.

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