Traditional Chinese medicine granule for relieving sore-throat and clearing away lung-heat and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to traditional Chinese medicine granules for relieving sore-throat and clearing away lung-heat and a preparation method thereof. The granule is prepared from the following raw materials: honeysuckle flower, dried orange peel, Chinese olive, balloonflower root and licorice root, adopts a volatile oil extraction and water decoction synergistic enrichment technology, and realizes synergistic retention of volatile and water-soluble components through the steps of volatile oil independent extraction, low-temperature preservation, spray addition, low-temperature vacuum concentration and the like. The finished product is uniform in particle size, convenient to take, high in stability and suitable for chronic pharyngitis patients and people using sound for a long time. The traditional Chinese medicine composition solves the problems of active ingredient loss, poor stability and inconvenience in taking of traditional Chinese medicines, and has remarkable clinical application value.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparations, and particularly relates to a lung-clearing and throat-soothing traditional Chinese medicine granule for improving chronic pharyngitis and for long-term high-voice people and a preparation method thereof. BACKGROUND

[0002] Chronic pharyngitis is a chronic inflammation of the mucosa, submucosa and lymphoid tissue of the pharynx, and is clinically manifested as dry throat, itching, foreign body sensation, burning pain and dry cough with little sputum. The disease has a long course and is prone to recurrence, and the incidence rate is higher in adults and urban people. Teachers, broadcasters and singers are more likely to suffer from the disease due to repeated mechanical stimulation of the pharyngeal mucosa, and the symptoms are more severe, which seriously affects the professional performance and quality of life.

[0003] Modern medicine usually adopts symptomatic treatment for chronic pharyngitis: iodine agents can relieve dry mucosa, and vitamins can assist in repair, but it is difficult to fundamentally inhibit chronic inflammation; laser or cauterization therapy can remove hyperplastic tissue, but it is easy to damage the gland structure of the pharynx, leading to postoperative dry throat, even causing mucosal scarring, and the patient's tolerance is poor, so the application is limited. Therefore, the existing western medicine has obvious deficiencies in the durability and safety of the therapeutic effect.

[0004] Traditional Chinese medicine believes that "the throat is the gateway of the lungs and stomach", and chronic pharyngitis is usually caused by invasion of wind-heat evil or excessive heat due to yin deficiency. Therefore, heat-clearing and detoxifying, throat-soothing and phlegm-dissolving, yin-nourishing and fluid-producing methods should be adopted. Honeysuckle, dried tangerine or orange peel, canarium album, radix platycodi and licorice root are the classic combination for treating throat diseases. Among them, honeysuckle is the monarch drug, which is rich in chlorogenic acid, luteoloside and linalool, and has broad-spectrum antibacterial, antiviral, anti-inflammatory and antioxidant effects. The volatile oil components can quickly relieve throat itching and pain, and the water-soluble components can help long-term anti-inflammatory throat protection. Dried tangerine or orange peel regulates qi and dissolves phlegm, containing volatile oils such as limonene; canarium album removes fire and detoxifies, and produces saliva and soothes the throat; radix platycodi promotes lung and phlegm, and carries drugs upward; licorice root harmonizes various drugs, and relieves cough and inflammation. The five drugs are used together, which conforms to the principle of "monarch, minister, assistant and guide", and can synergistically play the effect of clearing the lung and soothing the throat.

[0005] However, traditional Chinese medicine dosage forms have significant limitations: decoction needs to be decocted, which is inconvenient to take, and long-time heating can easily lead to the loss of volatile oils in honeysuckle and other medicinal materials, and the degradation of heat-sensitive components such as chlorogenic acid, which may affect the efficacy; oral liquid is prone to microbial contamination, has a short storage period, and is inconvenient to transport; tablet excipients are many, the taste is poor, and the long-term compliance is low. Especially for long-term voice people, there is an urgent need for a dosage form that is easy to carry, simple to take, rapid in effect and long-term use.

[0006] More importantly, the existing preparations generally do not solve the technical problem of synergistic retention of volatile and water-soluble active ingredients. The aromatic volatile oil of honeysuckle and the water-soluble ingredients such as chlorogenic acid together constitute the efficacy basis thereof, and the traditional water decoction process cannot take into account the extraction efficiency and stability of both. Therefore, it has important clinical value to develop a new type of traditional Chinese medicine granules which can effectively retain multiple active ingredients, have stable process, and are convenient to carry and take.

[0007] In view of this, the present application is proposed. SUMMARY

[0008] The present application provides a kind of traditional Chinese medicine granules for relieving throat and clearing lung and preparation method thereof to solve the problems of existing chronic pharyngitis treatment drugs, such as short duration of efficacy, insufficient retention of effective components of traditional Chinese medicine dosage form and inconvenience of taking. The granules realize synergistic enrichment of volatile and water-soluble active ingredients through innovative process, have advantages of fast effect, high stability and convenient taking, can effectively relieve throat discomfort, and are especially suitable for chronic pharyngitis patients and long-term voice users such as teachers and announcers, which can accurately meet the treatment needs of relieving throat and clearing lung.

[0009] The object of the present application can be achieved by the following technical solutions.

[0010] A kind of traditional Chinese medicine granules for relieving throat and clearing lung is prepared from the following raw materials by weight: honeysuckle 1-30 parts, dried tangerine or orange peel 1-30 parts, green fruit 1-30 parts, jujube 1-30 parts, licorice 1-30 parts. The particle size of the granules is passed through 12-14 mesh screen.

[0011] A preparation method of traditional Chinese medicine granules for relieving throat and clearing lung includes the following steps.

[0012] S1, raw material pretreatment and volatile oil extraction: take honeysuckle and dried tangerine or orange peel, soak in 5-15 times amount of water for 0.5-2.0 hours, extract volatile oil at 95-100℃ by steam distillation method for 2-4 hours, collect volatile oil for standby, and collect the extraction liquid in the distillation process at the same time, and reserve the residue; wash green fruit, jujube and licorice, and cut them into 0.3-0.5cm thick slices;

[0013] S2, water decoction: combine green fruit, jujube and licorice after step S1 processing with the residue obtained in step S1, add water and decoct twice, add 5-15 times amount of water for the first time, and decoct at low boiling for 1.5-2 hours, add 8-10 times amount of water for the second time, and decoct at low boiling for 1-1.5 hours, combine the decoction liquid of the two times with the extraction liquid in step S1;

[0014] S3, filtration: after coarse filtration of the combined decoction liquid through 100 mesh vibration screen, fine filtration is carried out by plate and frame filter, and the clarity of the filtrate is controlled to be ≤0.5NTU;

[0015] S4, concentration: the filtrate after fine filtration is concentrated by a double-effect concentrator, the temperature of the first effect is 50-70 DEG C, the vacuum degree is -0.05 to -0.07 MPa, the temperature of the second effect is 50-60 DEG C, the vacuum degree is -0.08 to -0.10 MPa, the concentration is to the relative density of 1.30-1.50, the extract at 50 DEG C test;

[0016] S5, granulation and drying: the obtained extract is mixed with sucrose powder and dextrin to form soft material, the soft material is granulated by passing through a 12-14 mesh sieve, the obtained wet granules are dried in a boiling bed at 45-70 DEG C to obtain dry granules with moisture content of less than 5.0%;

[0017] S6, whole particle: the dried granules are sequentially passed through a 40-60 mesh sieve to remove fine powder, and then passed through a 12-14 mesh sieve to whole particle;

[0018] S7, volatile oil addition and total mixing: the volatile oil collected in step S1 is uniformly sprayed into the granules obtained after step S6 under stirring, and then placed in a three-dimensional mixer for mixing at a speed of 6-12 r / min for 5-30 minutes to uniformly adsorb the volatile oil;

[0019] S8, sub-packaging: the qualified granules after total mixing are sub-packaged and sealed at 5-10 g per bag, and the granules are obtained.

[0020] As a further scheme of the present application: the honeysuckle, dried tangerine or orange peel, green fruit, Chinese thorowax root and licorice are all traditional Chinese medicine decoction pieces.

[0021] As a further scheme of the present application: the water involved in the preparation step, including the water for soaking in step S1 and the water for decocting in step S2, is all drinking water.

[0022] As a further scheme of the present application: the volatile oil extracted by the steam distillation method in step S1 is collected in a special collector and sealed and stored at 2-10 DEG C, and the storage period is not more than 2 months; the extraction liquid generated during the extraction of the volatile oil is separately collected in a clean storage tank, and needs to be combined with the subsequent water decocting liquid within 24 hours.

[0023] As a further scheme of the present application: the fine filtration in step S3 uses a plate and frame filter with a built-in 300 mesh filter cloth, and the filtration pressure is controlled at 0.1-0.2 MPa.

[0024] As a further scheme of the present application: the total amount of sucrose powder and dextrin is calculated according to the formula: batch (bags) x amount per bag (g) / 1000-extract amount (kg) x extract solid content (%), and the mass ratio of sucrose powder to dextrin is (2-3):1.

[0025] As a further scheme of the present application: the air inlet temperature of the boiling dryer is controlled at 45-70 DEG C, the material temperature is controlled at 30-45 DEG C, and the drying time is 40-60 minutes.

[0026] As a further scheme of the present application: the volatile oil needs to be filtered to remove moisture before being added by spraying, and the material temperature should be controlled below 30 DEG C during the spraying process; the addition amount of the volatile oil is 0.05-0.2 mL per bag of finished product; the sub-packaging adopts a four-side sealing packaging machine, the longitudinal sealing temperature is controlled at 110-130 DEG C, the transverse sealing temperature is controlled at 100-160 DEG C, the machine speed is 20-35 times / min, the sealing difference is ensured to be within ±4%, and the sealing property is 100%.

[0027] The present application has the following beneficial effects:

[0028] The active ingredients are more fully retained: through the process of "volatile oil extraction + low-temperature preservation + spray addition", the volatile components in honeysuckle and dried tangerine or orange peel can be effectively retained; combined with the process of "low-temperature vacuum concentration + gentle drying", the degradation of water-soluble heat-sensitive components is avoided, the synergistic enrichment of volatile and water-soluble components is realized, and the drug efficacy is improved by more than 30% compared with traditional decoction;

[0029] The process parameters are accurately controllable: from the volatile oil extraction temperature and filtration pressure to the auxiliary material quantitative calculation and total mixing speed, clear parameter ranges are set for each step, and details such as "auxiliary material calculation publicity" and "sub-packaging temperature control" are added, so that the quality of different batches of products is stable and fully meets the requirements of GMP industrial production;

[0030] The product stability is higher: through "fractionated filtration" to improve the purity of filtrate, "moisture ≤5.0% control" to avoid mold growth, and "four-side sealing sub-packaging" to isolate external influences, the room temperature storage period of the product is extended to 48 months, which is much better than traditional oral liquid with a storage period of 6-12 months;

[0031] The taking and carrying are more convenient: the granules are packaged in independent small bags, which can be taken by being dissolved in hot water, and the single dose is accurate, so that it is convenient for long-term use by people and can be taken at any time, solving the problems of inconvenience of traditional decoction and difficulty of transportation of oral liquid;

[0032] The safety and compliance are high: the raw materials are all commonly used traditional Chinese medicines, and the auxiliary materials are food-grade sucrose powder and dextrin, and there is no irritating component; the taste is adjusted by sucrose to avoid the bitter taste of traditional Chinese medicines, and the long-term compliance is significantly improved, which is especially suitable for people who need long-term protection such as teachers and radio announcers. BRIEF DESCRIPTION OF DRAWINGS

[0033] In order to facilitate the understanding of those skilled in the art, the present application will be further described below with reference to the accompanying drawings.

[0034] Figure 1The traditional Chinese medicine extraction flowchart of the present application shows the complete process steps from raw material preparation, volatile oil extraction, decoction liquid preparation, filtration to concentration. DETAILED DESCRIPTION

[0035] The technical solutions of the present application will be described clearly and completely below in conjunction with the embodiments. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the present application.

[0036] Embodiment 1

[0037] Take honeysuckle 15 kg, dried tangerine or orange peel 12 kg, green fruit 10 kg, platycodon 8 kg, and licorice 5 kg.

[0038] S1, take honeysuckle and dried tangerine or orange peel, soak in 10 times amount of drinking water for 1.0 hour, and extract volatile oil at 98℃ for 3 hours by using water vapor distillation method; collect about 320L of extraction liquid during the distillation process, introduce into a clean storage tank, control the storage tank temperature at 45℃ for temporary storage; collect 0.16L of volatile oil, transfer into a special container for sealed storage at 5℃ for standby; retain the residue; wash green fruit, platycodon and licorice, and cut into 0.4cm thick slices.

[0039] S2, combine the above slices and the residue after oil extraction, put into a multifunctional extraction tank, add 12 times amount of water, and boil gently for 1.8 hours, filter about 1200L of medicinal liquid; add 9 times amount of drinking water to the residue, and boil gently for 1.2 hours, filter about 880L of medicinal liquid; combine the two times of decoction liquid (about 2000L) and the volatile oil extraction liquid (320L) temporarily stored in step (1), to obtain total decoction liquid about 2320L.

[0040] S3, first filter the total decoction liquid through a 100 mesh vibrating screen, and then perform precision filtration by using a plate and frame filter with built-in 300 mesh filter cloth under 0.15MPa pressure, and the measured clarity of the filtrate is 0.4NTU.

[0041] S4, pump the precision filtered liquid into a double-effect concentrator, control the temperature of the first effect at 65℃, the vacuum degree at -0.06MPa, the temperature of the second effect at 55℃, and the vacuum degree at -0.09MPa, concentrate to the extract at 50℃, the relative density of which is 1.38, the extract output is 210kg, and the solid content of the extract is 52%.

[0042] S5, according to the batch of 48,000 bags, each bag of 10 g, the total amount of sucrose powder and dextrin is calculated according to the formula: 480-(210*0.52)=370.8 kg. According to the ratio of sucrose powder:dextrin=2.5:1, 265 kg of sucrose powder and 106 kg of dextrin are weighed, and the extract is mixed in a tank mixer to make soft material, and granulated through a 14 mesh sieve.

[0043] S6, the wet granules are placed in a fluidized bed dryer, the inlet temperature is controlled at 60℃, and the material temperature is controlled at 38℃, and dried for 50 minutes, and the moisture content of the granules is measured to be 4.2%. The dry granules are first passed through a 50 mesh sieve to remove fine powder, and then passed through a 14 mesh sieve to size.

[0044] S7, the preserved volatile oil is filtered and dehydrated through anhydrous sodium sulfate bed, and then sprayed into the sized granules under stirring at a pressure of 0.3 MPa, and the material temperature is controlled at 28℃ during the spraying process. Then the granules are placed in a three-dimensional mixer and mixed at a speed of 8 r / min for 15 minutes. The volatile oil content in each bag of finished product is 0.033 mL.

[0045] S8, four-side sealing packaging machine is used for sub-packaging, the longitudinal sealing temperature is controlled at 120℃, the transverse sealing temperature is controlled at 140℃, the machine speed is 28 bags / min, and each bag of 10 g product is sub-packaged. The detection shows that the weight difference is ±3.5%, and the sealing rate is 100%.

[0046] Example 2

[0047] Take honeysuckle 10 kg, dried tangerine or orange peel 8 kg, green fruit 15 kg, platycodon 6 kg, and licorice 4 kg.

[0048] S1, take honeysuckle, dried tangerine or orange peel, add 8 times the amount of drinking water, soak for 1.5 hours, steam distillation extraction at 95℃ for 4 hours; collect about 180L of extraction liquid synchronously, store in a clean storage tank, control the temperature at 40℃ for temporary storage; collect 0.18L of volatile oil and store at 2℃; keep the residue; cut the green fruit, platycodon and licorice into 0.3 cm thick slices.

[0049] S2, the residue and the slices are added with 5 times the amount of drinking water and micro-boiled for 2 hours, filtered, and about 650L of medicinal liquid is obtained; 10 times the amount of drinking water is added for the second time, micro-boiled for 1 hour, filtered, and about 1200L of medicinal liquid is obtained; the two medicinal liquids (1850L) and the volatile oil extraction liquid (180L) temporarily stored are combined, and the total decoction liquid is about 2030L.

[0050] S3, the filtrate is coarsely filtered through a 100 mesh sieve, and then refined at a pressure of 0.10 MPa by using a plate and frame filter with a built-in 300 mesh filter cloth, and a filtrate with a clarity of 0.5 NTU is obtained.

[0051] S4, double-effect concentration: one effect 50℃ / -0.07MPa, two effect 50℃ / -0.10MPa, concentrated to 50℃ relative density 1.30 of extract, extract output 180kg, extract solid content 50%.

[0052] S5, according to 30,000 bags × 5g / bag, total amount of auxiliary materials = 150- (180 × 0.5) = 60kg, according to the proportion of sucrose: dextrin = 2:1, sucrose 40kg, dextrin 20kg were weighed, mixed with extract to make soft material, and granulated through 12 mesh sieve.

[0053] S6, fluidized bed drying: inlet air 45℃, material 30℃, time 60 minutes, moisture 4.9%. Whole granulation: first pass through 60 mesh sieve to remove fine powder, then pass through 12 mesh sieve.

[0054] S7, after the volatile oil is filtered, it is sprayed at 25℃, three-dimensional mixing 6r / min for 30 minutes. The volatile oil content in each bag of finished product is 0.06ml.

[0055] S8, packaging: longitudinal seal 110℃, horizontal seal 100℃, machine speed 20 bags / min, each bag 5g, packing amount difference ±3.8%.

[0056] Example 3

[0057] Take honeysuckle 30kg, dried tangerine or orange peel 15kg, green fruit 20kg, platycodon 12kg, licorice 8kg.

[0058] S1, take honeysuckle, dried tangerine or orange peel, add 15 times the amount of drinking water, soak for 0.5 hours, steam distillation extraction at 100℃ for 2 hours; collect about 680L of extraction liquid at the same time, store in a clean storage tank, control the temperature at 50℃ for temporary storage; collect volatile oil 0.25L, store at 10℃; drug residue remains; cut green fruit, platycodon, and licorice into 0.5cm thin slices.

[0059] S2, add 15 times the amount of drinking water to the drug residue and slices, and micro-boil decoct for 1.5 hours, filter to obtain about 2200L of medicinal liquid; add 8 times the amount of drinking water for the second time, micro-boil decoct for 1.5 hours, filter to obtain about 1450L of medicinal liquid; combine the two medicinal liquids (3650L) with the temporarily stored volatile oil extraction liquid (680L), and the total decocting liquid is about 4330L.

[0060] S3, after the filtrate is coarsely filtered through a 100 mesh sieve, it is precision filtered at a pressure of 0.20MPa using a plate and frame filter with a built-in 300 mesh filter cloth, to obtain a filtrate with a clarity of 0.2NTU.

[0061] S4, double-effect concentration: one effect 50℃ / -0.07MPa, two effect 50℃ / -0.10MPa, concentrated to 50℃ relative density 1.30 of extract, extract output 180kg, extract solid content 50%.

[0062] S5, total amount of adjuvants = 160 - (230 x 0.55) = 33.5 kg, according to the proportion of sucrose: dextrin = 3:1, sucrose 25.1 kg, dextrin 8.4 kg are weighed, mixed with extract to make soft material, and granulated through 14 mesh screen.

[0063] S6, fluidized bed drying: inlet air 70℃, material 45℃, time 40 minutes, moisture 3.8%. Whole granulation: first pass through 40 mesh screen to remove fine powder, then pass through 14 mesh screen.

[0064] S7, after the volatile oil is filtered, it is sprayed at 30℃, and mixed for 5 minutes at 12r / min. The volatile oil content in each bag of finished product is 0.125ml.

[0065] S8, packaging: longitudinal seal 130℃, transverse seal 160℃, machine speed 35 bags / min, each bag 8g, weight difference ±2.9%.

[0066] Example 4

[0067] Take honeysuckle 8kg, dried tangerine or orange peel 10kg, green fruit 12kg, platycodon 5kg, licorice 3kg.

[0068] S1, take honeysuckle, dried tangerine or orange peel, add 5 times the amount of drinking water, soak for 2.0 hours, steam distillation extraction at 97℃ for 3.5 hours; collect about 120L of extraction liquid simultaneously, store in a clean storage tank, control the temperature at 42℃ for temporary storage; collect volatile oil 0.12L, store at 8℃; drug residue is left; green fruit, platycodon, and licorice are cut into 0.3cm thin slices.

[0069] S2, add 10 times the amount of drinking water to the drug residue and slices, and micro-boil for 1.7 hours, filter, get about 750L of medicinal liquid; add 9 times the amount of drinking water for the second time, micro-boil for 1.3 hours, filter, get about 680L of medicinal liquid; combine the two medicinal liquids (1430L) and the volatile oil extraction liquid (120L) temporarily stored, and the total decoction liquid is about 1550L.

[0070] S3, after the filtrate is coarsely filtered through a 100 mesh screen, it is precision filtered at a pressure of 0.12MPa using a plate and frame filter with a built-in 300 mesh filter cloth, and a filtrate with a clarity of 0.4NTU is obtained.

[0071] S4, double-effect concentration: one effect 58℃ / -0.065MPa, two effect 55℃ / -0.085MPa, concentrate to 50℃ relative density 1.35 of extract, extract output 150kg, extract solid content 48%.

[0072] S5, total amount of adjuvants = 160 - (230 x 0.55) = 33.5 kg, according to the proportion of sucrose: dextrin = 3:1, sucrose 25.1 kg, dextrin 8.4 kg are weighed, mixed with extract to make soft material, and granulated through 14 mesh screen.

[0073] S6, fluidized drying: inlet air 55℃, material 35℃, time 55 minutes, moisture 4.5%. Whole grain: first pass through 45 mesh sieve to remove fine powder, then pass through 13 mesh sieve.

[0074] S7, after the volatile oil is filtered, it is sprayed at 26℃, three-dimensional mixing 10r / min for 20 minutes. The volatile oil content in each bag of finished product is 0.024ml.

[0075] S9, sub-packaging: longitudinal sealing 115℃, transverse sealing 125℃, machine speed 25 bags / min, each bag 7g, loading difference ±3.2%.

[0076] Example 5

[0077] Take honeysuckle 20kg, dried tangerine peel 15kg, green fruit 12kg, platycodon 10kg, licorice 6kg.

[0078] S1, take honeysuckle, dried tangerine peel, add 12 times the amount of drinking water, soak for 1.2 hours, steam distillation extraction at 99℃ for 2.5 hours; collect about 420L of extraction liquid synchronously, store in a clean storage tank, control the temperature at 48℃ for temporary storage; collect volatile oil 0.20L, store at 4℃; drug residue remains; green fruit, platycodon, and licorice are cut into 0.4cm thin slices.

[0079] S2, drug residue and thin slices are added with 13 times the amount of drinking water and micro-boiled for 1.6 hours, filtered to obtain about 1500L of medicinal liquid; for the second time, 10 times the amount of drinking water is added and micro-boiled for 1.1 hours, filtered to obtain about 1180L of medicinal liquid; combine the medicinal liquid of the two times (2680L) with the temporarily stored volatile oil extraction liquid (420L), and the total decoction liquid is about 3100L.

[0080] S3, after the filtrate is coarsely filtered through a 100 mesh sieve, it is precision filtered at a pressure of 0.18MPa using a plate and frame filter machine with a built-in 300 mesh filter cloth to obtain a filtrate with a clarity of 0.3NTU.

[0081] S4, double-effect concentration: one effect 62℃ / -0.055MPa, two effect 58℃ / -0.090MPa, concentrate to 50℃ relative density 1.42 of extract, extract output 200kg, extract solid content 54%.

[0082] S5, according to 35000 bags × 9g / bag, the total amount of auxiliary materials = 315- (200×0.54) = 207kg, according to the proportion of sucrose: dextrin = 2.8:1, weigh sucrose 154kg, dextrin 53kg, mix with extract to make soft material, pass through 14 mesh sieve to granulate.

[0083] S6, fluidized drying: inlet air 65℃, material 40℃, time 45 minutes, moisture 4.0%. Whole grain: first pass through 55 mesh sieve to remove fine powder, then pass through 14 mesh sieve.

[0084] S7, volatile oil was added by spraying after filtration at 27°C, and three-dimensional mixing was carried out at 9 r / min for 18 minutes. The volatile oil content in each bag of finished product was 0.057 mL.

[0085] S8, dispensing: longitudinal sealing at 125°C, transverse sealing at 150°C, machine speed 30 bags / min, each bag 9 g, loading difference ±3.0%.

[0086] Example 6

[0087] Take honeysuckle 25 kg, dried tangerine peel 20 kg, green fruit 18 kg, platycodon 12 kg, and licorice 10 kg.

[0088] S1, take honeysuckle and dried tangerine peel, soak in 7 times the amount of drinking water for 1.8 hours, steam distillation extraction at 96°C for 3.2 hours; collect about 350L of extraction liquid simultaneously, store in a clean storage tank, control the temperature at 46°C for temporary storage; collect volatile oil 0.22L, store at 6°C; drug residue is retained; green fruit, platycodon and licorice are cut into 0.5cm thin slices.

[0089] S2, drug residue and thin slices are added with 7 times the amount of drinking water and micro-boiled for 1.9 hours, filtered, and about 1200L of medicinal liquid is obtained; 8 times the amount of drinking water is added for the second time, micro-boiled for 1.4 hours, filtered, and about 1380L of medicinal liquid is obtained; combine the two medicinal liquids (2580L) with the temporarily stored volatile oil extraction liquid (350L), and the total decoction liquid is about 2930L.

[0090] S3, after the filtrate is coarsely filtered through a 100-mesh sieve, it is precision filtered at a pressure of 0.14 MPa using a plate and frame filter machine with a built-in 300-mesh filter cloth, and a filtrate with a clarity of 0.4 NTU is obtained.

[0091] S4, double-effect concentration: one effect at 67°C / -0.062 MPa, and two effects at 52°C / -0.088 MPa, concentrate to 50°C relative density 1.45 of extract, out of extract 220 kg, extract solid content 56%.

[0092] S5, according to 42,000 bags × 6 g / bag, the total amount of auxiliary materials = 252- (220 × 0.56) = 122.8 kg, according to the ratio of sucrose: dextrin = 2.5:1, weigh sucrose 87.7 kg and dextrin 35.1 kg, mix with extract to make soft material, and granulate through a 12-mesh sieve.

[0093] S6, fluidized bed drying: inlet air 48°C, material 42°C, time 50 minutes, moisture 4.7%. Whole granulation: first pass through a 50-mesh sieve to remove fine powder, then pass through a 12-mesh sieve.

[0094] S7, volatile oil was added by spraying after filtration at 29°C, and three-dimensional mixing was carried out at 7 r / min for 25 minutes. The volatile oil content in each bag of finished product was 0.052 mL.

[0095] S8, Sub-packing: longitudinal seal 122°C, transverse seal 135°C, machine speed 32 bags / min, 6 g per bag, packing amount difference ±3.6%.

[0096] The preferred embodiments of the application disclosed above are only to help explain the application. The preferred embodiments do not describe all the details of the application, and do not limit the application to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of the specification. The specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the application, so that those skilled in the art can well understand and utilize the application. The application is limited only by the claims and their full scope and equivalents.

Claims

1. A throat-soothing and lung-clearing traditional Chinese medicine granule, characterized in that, It is prepared from raw materials with the following weight parts: honeysuckle 1-30 parts, dried tangerine or orange peel 1-30 parts, green fruit 1-30 parts, platycodon 1-30 parts, and licorice 1-30 parts; the granules have a particle size passing through a 12-14 mesh sieve.

2. The preparation method of the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 1, characterized in that, It comprises the following steps: S1, raw material pretreatment and extraction of volatile oil: take honeysuckle and dried tangerine or orange peel, soak in 5-15 times the amount of water for 0.5-2.0 hours, extract volatile oil at 95-100℃ by steam distillation for 2-4 hours, collect the volatile oil for standby, and collect the extraction liquid in the distillation process at the same time, and leave the residue; wash green fruit, platycodon, and licorice, cut them into 0.3-0.5 cm thick slices; S2, water decoction: combine the green fruit, platycodon, and licorice treated in step S1 with the residue obtained in step S1, add water and decoct twice, add 5-15 times the amount of water for the first time, decoct at a low boil for 1.5-2 hours, add 8-10 times the amount of water for the second time, decoct at a low boil for 1-1.5 hours, combine the decoction liquid of the two times with the extraction liquid in step S1; S3, filtration: after the combined decoction liquid is coarsely filtered through a 100 mesh vibrating screen, it is then precisely filtered using a plate and frame filter, and the clarity of the filtrate is controlled to be ≤0.5 NTU; S4, concentration: the precisely filtered filtrate is concentrated using a double-effect concentrator, the temperature of the first effect is 50-70℃, the vacuum degree is -0.05 to -0.07 MPa, the temperature of the second effect is 50-60℃, and the vacuum degree is -0.08 to -0.10 MPa, the filtrate is concentrated to a relative density of 1.30-1.50, and the extract is tested at 50℃; S5, granulation and drying: the obtained extract is mixed with sucrose powder and dextrin to form a soft material, the soft material is granulated by passing through a 12-14 mesh sieve, the obtained wet granules are dried in a boiling bed at 45-70℃ until the moisture content is ≤5.0%, and dry granules are obtained; S6, whole granulation: the dried granules are passed through a 40-60 mesh sieve to remove fine powder, and then passed through a 12-14 mesh sieve for whole granulation; S7, volatile oil addition and total mixing: the volatile oil collected in step S1 is uniformly sprayed into the whole granules obtained in step S6 under stirring, and then placed in a three-dimensional mixer for mixing at a speed of 6-12 r / min for 5-30 minutes to uniformly adsorb the volatile oil; S8, packaging: the qualified granules after total mixing are packaged and sealed at 5-10 g per bag, and the granules are obtained. The honeysuckle, dried tangerine or orange peel, green fruit, platycodon, and licorice are all traditional Chinese medicine decoction pieces.

3. The throat-soothing and lung-clearing granules of traditional Chinese medicine according to claim 1, characterized in that, The water involved in each step of claim 2, including the water used for soaking in step S1 and the water used for decoction in step S2, is all drinking water.

4. The preparation method of the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 2, characterized in that, The volatile oil extracted by the steam distillation method in step S1 is collected in a special collector and stored at 2-10℃ after being sealed, and the storage period is not more than 2 months; 5. The preparation method of the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 2, characterized in that, The extraction liquid produced during the extraction of volatile oil is separately collected in a clean storage tank, and needs to be combined with the subsequent water decoction liquid within 24 hours. The precise filtration in step S3 uses a plate and frame filter with a built-in 300 mesh filter cloth, and the filtration pressure is controlled at 0.1-0.2 MPa.

6. The preparation method of the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 2, characterized in that, The total amount of sucrose powder and dextrin is calculated according to the formula: batch (bags) × amount per bag (g) / 1000 - extract amount (kg) × solid content of extract (%), and the mass ratio of sucrose powder to dextrin is (2-3):

1.

7. The method for preparing the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 2, characterized in that, ​ 8. The preparation method of the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 2, characterized in that, The air inlet temperature of the fluidized dryer is controlled at 45-70℃, the material temperature is controlled at 30-45℃, and the drying time is 40-60 minutes.

9. The method for preparing the throat-soothing and lung-clearing traditional Chinese medicine granules according to claim 2, characterized in that, The volatile oil needs to be filtered to remove moisture before being added by spraying, and the material temperature should be controlled below 30℃ during the spraying process; the addition amount of the volatile oil is 0.05-0.2 mL per bag of finished product; the four-side sealing packaging machine is used for the sub-packaging, the longitudinal sealing temperature is controlled at 110-130℃, the transverse sealing temperature is controlled at 100-160℃, the machine speed is 20-35 times / min, and the sealing tightness is 100%.

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