Use of allyl isothiocyanate for improving mental disorders

Abstract

The application discloses application of allyl isothiocyanate in preparation of a medicine for improving mental disorders and belongs to the technical field of medicines. The application of allyl isothiocyanate in preparation of a medicine for improving mental disorders has a rapid, convenient and efficient intervention potential for depression, emotional disorder, social difficulty, bipolar emotional fluctuation, anxiety and autism spectrum symptoms. Specific experimental verification: in a depression model constructed by using social frustration stress, the component can obviously reverse typical depression-like behaviors of the mouse, such as social avoidance tendency and behavior despair state. In a model induced by chronic unpredictable stress, allyl isothiocyanate effectively relieves anxiety and depression symptoms of the mouse and restores the hedonic experience ability of the mouse. In a medicine-induced bipolar affective disorder model, the component significantly suppresses the mania onset and depression alternating behavior of the mouse. In a mouse model of autism, allyl isothiocyanate effectively relieves the repetitive stereotyped behavior of the mouse.

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