Motion stage adapted for large travel and high frequency and method of using same

Abstract

The application relates to the field of biological gene detection equipment, in particular to a motion platform suitable for large-stroke high-frequency motion and a use method thereof, which comprises a base, a flexible hinge, a motion connecting plate, a cross roller guide, a motor and a counterweight cylinder. The motor drives the motion connecting plate to move along the Z-axis direction for large-stroke motion or high-frequency motion. When the motion connecting plate moves for large-stroke motion, the flexible hinge guides the motion of the motion connecting plate; when the motion connecting plate moves for high-frequency motion, the cross roller guide guides the motion of the motion connecting plate, so that the motion precision is improved. The counterweight cylinder offsets the load gravity, so that the driving force of the motor is reduced, mechanical vibration is reduced, motion stability is improved, and the service life of the equipment is prolonged.

Description

Technical Field

[0001] This invention relates to the field of biological gene detection equipment, and in particular to a motion stage adapted to large stroke and high frequency and its method of use. Background Technology

[0002] Biological gene detection equipment mainly consists of a microscope and a stage. The microscope is used to acquire detection information, while the stage is used to support the detection object (biological slide). The microscope's field of view is typically in the millimeter range, and its depth of focus is in the micrometer range. Biological slides are generally square glass slides, with a length or width of about six to seven centimeters. In order to completely detect the gene information on the biological slide, it is necessary to acquire the complete gene information of the biological slide through a reciprocating scanning method with a field of view in the millimeter range. Due to the possibility of unevenness in the flatness of the slide, it is necessary to repeatedly focus at different positions on the slide, and each position requires focusing at a high frequency of 60 Hz.

[0003] Current biological gene detection equipment typically uses a microscope lens for focusing, achieved through lens displacement. Since focusing occurs on the lens side, the lens needs to move at high frequency along the Z-axis. However, the large size and weight of microscope lenses require enormous driving force to propel these high-frequency movements, generating significant vibration and heat, reducing stability and accuracy, and shortening the equipment's lifespan. Furthermore, the very small distance between the lens and the stage in existing biological gene detection equipment leaves little room for operation, making it difficult to replace the slides on the stage. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, the purpose of this invention is to provide a motion platform adapted to large stroke and high frequency, and its usage method, which reduces mechanical vibration, improves motion stability and motion accuracy, and extends the service life of equipment.

[0005] The technical solution adopted in this invention is as follows:

[0006] A motion stage adapted to long stroke and high frequency includes:

[0007] Base;

[0008] A flexible hinge is used to guide high-frequency motion, and it includes a deformable part and a mounting plate, with the bottom of the deformable part connected to the mounting plate;

[0009] A motion connecting plate is used to support the glass slide and is connected to the top of the deformable part;

[0010] Crossed roller guides are used to guide large-stroke motion, and include a moving part and a fixed part. The moving part is connected to the mounting plate, and the fixed part is connected to the base.

[0011] The motor is used to drive the motion connecting plate to move along the Z-axis.

[0012] A counterweight cylinder is used to counteract the load's weight, and it is connected to the lower center of the mounting plate.

[0013] Preferably, two flexible hinges are symmetrically provided, and four cross roller guides are provided. The two moving parts of the two cross roller guides are connected by a first lifting seat, and the two moving parts of the other two cross roller guides are connected by a second lifting seat. Two mounting blocks are symmetrically connected to both ends of each mounting plate, and the two symmetrically arranged mounting blocks are respectively connected to the first lifting seat and the second lifting seat.

[0014] Preferably, the device also includes dampers for suppressing high-frequency vibrations, with four dampers respectively connected to the underside of four mounting blocks.

[0015] Preferably, the system also includes a position detection component for detecting motion position. The position detection component includes a grating ruler and a reading head. The base includes a base plate and a mounting seat connected to the upper side of the base plate. A first protrusion is connected to the lower side of the motion connecting plate. The grating ruler is connected to the side of the first protrusion. The reading head is disposed on one side of the grating ruler and is fixed to the mounting seat.

[0016] Preferably, it also includes a limiting protrusion for limiting the range of motion of the motion connecting plate. A second protrusion is connected to the lower side of the motion connecting plate, and the limiting protrusion is connected to the side of the second protrusion. A strip groove is provided on the mounting base, and the limiting protrusion is slidably connected to the strip groove along the Z-axis direction.

[0017] Preferably, the limiting protrusion is a bolt, and the bolt and the second protrusion are detachably connected by threads.

[0018] Preferably, the motor is a voice coil motor, and it is connected to the lower middle part of the motion connecting plate.

[0019] This invention also provides a method for using a motion stage adapted to large stroke and high frequency, comprising the following steps:

[0020] S1. Mount the glass slide with the sample onto the motion connection plate;

[0021] S2. The start-up counterweight cylinder generates a supporting force on the mounting plate that is equal in magnitude and opposite in direction to the weight of the load consisting of the flexible hinge, the moving connecting plate, the glass slide and the moving part of the cross roller guide, so that the moving platform is in a state of force balance.

[0022] S3. The motion connecting plate is driven by the voice coil motor to move upward along the Z-axis in a large stroke. At the same time, the motion connecting plate causes the deformation part of the flexible hinge to deform slightly. Then, the moving part of the cross roller guide is dragged by the mounting plate of the flexible hinge to move together, and the current position of the grating ruler is read in real time by the reading head.

[0023] S4. When the current position of the grating ruler reaches the preset first position, control the motion connecting plate to stop moving. At this time, the slide moves to the vicinity of the microscope's focusing position.

[0024] S5. Start the voice coil motor to run at a high frequency, thereby driving the motion connecting plate to perform high-frequency, micro-amplitude reciprocating motion to find the optimal position and achieve focusing of the slide and microscope. At this time, the motion connecting plate drives the deformation part of the flexible hinge to produce micro-elastic deformation, while the cross roller guide rail is in a relatively static state due to inertia and friction.

[0025] S6. When it is necessary to disassemble or replace the glass slide, the voice coil motor drives the motion connecting plate to move downward along the Z-axis in a large stroke. At the same time, the motion connecting plate drives the deformation part of the flexible hinge to make a slight deformation. Then, the mounting plate of the flexible hinge drags the moving part of the cross roller guide to move together, and the current position of the grating ruler is read in real time through the reading head.

[0026] S7. When the current position of the grating ruler reaches the preset second position, control the motion connecting plate to stop moving, so that the slide is away from the microscope above, in order to provide operating space.

[0027] The beneficial effects of this invention are as follows:

[0028] This motion platform, adapted for large stroke and high frequency, is driven by a motor to perform large stroke or high frequency motion of the motion connecting plate along the Z-axis. When the motion connecting plate performs large stroke motion, the motion is guided by a flexible hinge. When the motion connecting plate performs high frequency motion, the motion is guided by a cross roller guide, thereby improving motion accuracy. The counterweight cylinder counteracts the load gravity, thereby reducing the driving force of the motor, reducing mechanical vibration, improving motion stability, and extending the service life of the equipment. Attached Figure Description

[0029] Figure 1 A three-dimensional schematic diagram of a motion stage designed to accommodate large strokes and high frequencies.

[0030] Figure 2 A first exploded diagram of a motion stage designed to accommodate large strokes and high frequencies.

[0031] Figure 3 A second exploded view of the motion stage designed to accommodate large strokes and high frequencies.

[0032] Figure 4 for Figure 3 Enlarged diagram of point A in the middle.

[0033] Figure 5 A transverse sectional view of a motion stage designed to accommodate large strokes and high frequencies.

[0034] Figure 6 A longitudinal sectional view of a motion stage designed to accommodate large strokes and high frequencies.

[0035] Figure 7 This is a schematic diagram of the base structure.

[0036] Figure 8 A flowchart illustrating the usage method of a motion stage adapted to large stroke and high frequency.

[0037] In the diagram: 1. Base; 101. Base plate; 102. Mounting seat; 2. Flexible hinge; 201. Deformation part; 202. Mounting plate; 3. Motion connecting plate; 4. Cross roller guide rail; 401. Moving part; 402. Fixed part; 5. Voice coil motor; 6. Counterweight cylinder; 7. First lifting seat; 8. Second lifting seat; 9. Mounting block; 10. Damper; 11. Grating ruler; 12. Reading head; 13. First protrusion; 14. Limiting protrusion; 15. Second protrusion; 16. Strip groove. Detailed Implementation

[0038] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0039] Please see Figures 1-7This invention provides a technical solution: a motion platform adapted to large stroke and high frequency, comprising a base 1, a flexible hinge 2, a motion connecting plate 3, a cross roller guide rail 4, a motor, and a counterweight cylinder 6. The base 1 provides overall support and a mounting foundation. The flexible hinge 2 is used to guide high-frequency motion and includes a deformation part 201 and a mounting plate 202. The bottom of the deformation part 201 is connected to the mounting plate 202. Through the elastic deformation of the deformation part 201, the flexible hinge 2 allows the motion connecting plate 3 to perform micro-amplitude reciprocating motion during high-frequency motion, reducing friction and wear while providing precise guidance. The deformation part 201 is made of flexible material with high fatigue strength, ensuring long-term reliability. The motion connecting plate 3 carries a glass slide and is connected to the top of the deformation part 201. The motion connecting plate 3 is equipped with a clamping mechanism (not shown in the figure) to facilitate fixing the glass slide. To ensure the slide does not shift during movement and improve detection accuracy, the cross roller guide 4 is used to guide large-stroke movement. It includes a moving part 401 and a fixed part 402. The cross roller guide 4 reduces movement resistance through rolling friction, allowing the moving connecting plate 3 to move with a large stroke while maintaining high rigidity and accuracy. The moving part 401 is connected to the mounting plate 202, and the fixed part 402 is connected to the base 1. The motor drives the moving connecting plate 3 to move along the Z-axis. The counterweight cylinder 6 is used to counteract the load weight and is connected to the lower middle part of the mounting plate 202. The load is composed of the flexible hinge 2, the moving connecting plate 3, the slide, and the moving part 401 of the cross roller guide 4. The counterweight cylinder 6 generates a supporting force that is equal in magnitude and opposite in direction to the load weight, keeping the moving stage in a state of force balance, reducing the driving force of the voice coil motor 5, and reducing vibration.

[0040] To facilitate improved guiding accuracy and motion stability, in this embodiment, preferably, two flexible hinges 2 are symmetrically arranged, and four cross roller guides 4 are arranged. The two moving parts 401 of two cross roller guides 4 are connected by a first lifting seat 7, and the two moving parts 401 of the other two cross roller guides 4 are connected by a second lifting seat 8. Two mounting blocks 9 are symmetrically connected to both ends of each mounting plate 202, and the two symmetrically arranged mounting blocks 9 are respectively connected to the first lifting seat 7 and the second lifting seat 8. The purpose is to ensure motion balance through a symmetrical layout structure. The two moving parts 401 are connected by the first lifting seat 7, and the other two moving parts 401 are connected by the second lifting seat 8, forming a stable frame structure, improving structural rigidity and stability, and achieving synchronous and consistent motion, preventing jamming, ensuring that the motion connecting plate 3 is subjected to uniform force during motion, preventing uneven loading, improving guiding accuracy, and thus improving motion accuracy and stability.

[0041] To facilitate the suppression of high-frequency vibration, this embodiment preferably includes a damper 10 for suppressing high-frequency vibration. The damper 10 has four units and is respectively connected to the lower side of the four mounting blocks 9. The purpose is to absorb and dissipate the vibration energy of the flexible hinge 2 through the damper 10, reduce the mechanical vibration during high-frequency motion, reduce resonance phenomenon, quickly bring the motion to a steady state, and ensure the stability during high-frequency motion.

[0042] To facilitate the detection of motion position, this embodiment preferably includes a position detection component for detecting motion position. The position detection component includes a grating ruler 11 and a reading head 12. The base 1 includes a base plate 101 and a mounting seat 102 connected to the upper side of the base plate 101. A first protrusion 13 is connected to the lower side of the motion connecting plate 3. The grating ruler 11 is connected to the side of the first protrusion 13. The reading head 12 is disposed on one side of the grating ruler 11 and is fixed to the mounting seat 102. The purpose is to read the position information of the grating ruler 11 in real time through the reading head 12, thereby monitoring the position of the motion connecting plate 3 in real time, realizing accurate position feedback and closed-loop control, and thus accurately controlling the stroke of the motion connecting plate 3.

[0043] To facilitate limiting the movement range of the motion connecting plate 3, this embodiment preferably includes a limiting protrusion 14 for limiting the movement range of the motion connecting plate 3. A second protrusion 15 is connected to the lower side of the motion connecting plate 3, and the limiting protrusion 14 is connected to the side of the second protrusion 15. A strip groove 16 is provided on the mounting base 102, and the limiting protrusion 14 is slidably connected in the strip groove 16 along the Z-axis direction. The purpose is to prevent the motion connecting plate 3 from moving beyond its travel range by cooperating with the limiting protrusion 14 and the strip groove 16, thereby improving safety.

[0044] For ease of adjustment and disassembly, in this embodiment, preferably, the limiting protrusion 14 is a bolt, and the bolt is detachably connected to the second protrusion 15 by a thread. The purpose is to allow the bolt to be threaded into different threaded holes in the vertical direction of the second protrusion 15, so as to facilitate adjustment of the limiting position and disassembly.

[0045] To facilitate improved driving efficiency and accuracy, in this embodiment, preferably, the motor is a voice coil motor 5, which is connected to the lower middle part of the motion connecting plate 3. The purpose is to leverage the fast response and high precision of the voice coil motor 5 to provide high-frequency, high-precision linear motion, enabling the motion connecting plate 3 to quickly perform fine-tuning and focusing.

[0046] To facilitate complete detection of the genetic information on the slide, this embodiment preferably includes a translation mechanism (not shown in the figure). The translation mechanism is connected to the motion stage and is used to drive the motion stage to move along the X-axis and Y-axis. The purpose is to move different positions of the slide directly below the microscope (not shown in the figure) by driving the motion stage to move along the X-axis and Y-axis, thereby obtaining complete genetic information of the slide through repeated scanning. The translation mechanism can also be connected to the microscope to drive the microscope to move along the X-axis and Y-axis to move directly above different positions of the slide.

[0047] Please see Figure 8 The present invention also provides a method for using a motion stage adapted to large stroke and high frequency, comprising the following steps:

[0048] S1. Mount the glass slide with the sample onto the motion connecting plate 3;

[0049] S2. The start-up counterweight cylinder 6 generates a supporting force on the mounting plate 202 that is equal in magnitude and opposite in direction to the weight of the load consisting of the flexible hinge 2, the motion connecting plate 3, the glass slide and the moving part 401 of the cross roller guide 4, so that the moving platform is in a state of force balance.

[0050] S3. The motion connecting plate 3 is driven to move upward along the Z-axis by the voice coil motor 5. At the same time, the motion connecting plate 3 drives the deformation part 201 of the flexible hinge 2 to undergo slight deformation. Then, the moving part 401 of the cross roller guide rail 4 is dragged by the mounting plate 202 of the flexible hinge 2 to move together. The current position of the grating ruler 11 is read in real time by the reading head 12.

[0051] S4. When the current position of the grating ruler 11 reaches the preset first position, control the motion connecting plate 3 to stop moving. At this time, the slide moves to the vicinity of the microscope's focusing position.

[0052] S5. Start the voice coil motor 5 to run at a high frequency, thereby driving the motion connecting plate 3 to perform high-frequency, micro-amplitude reciprocating motion to find the optimal position and achieve focusing of the slide and microscope. At this time, the motion connecting plate 3 drives the deformation part 201 of the flexible hinge 2 to produce micro-elastic deformation, while the cross roller guide rail 4 is in a relatively static state due to inertia and friction.

[0053] S6. When it is necessary to disassemble or replace the glass slide, the voice coil motor 5 drives the motion connecting plate 3 to move downward along the Z-axis in a large stroke. At the same time, the motion connecting plate 3 drives the deformation part 201 of the flexible hinge 2 to undergo slight deformation. Then, the mounting plate 202 of the flexible hinge 2 drags the moving part 401 of the cross roller guide rail 4 to move together. The current position of the grating ruler 11 is read in real time by the reading head 12.

[0054] S7. When the current position of the grating ruler 11 reaches the preset second position, control the motion connecting plate 3 to stop moving, so that the slide is away from the microscope above, in order to provide operating space.

[0055] The working principle of this invention is as follows: the counterweight cylinder 6 balances the load gravity, the voice coil motor 5 drives the motion connecting plate 3 to perform large stroke or high frequency movement. During large stroke movement, the cross roller guide rail 4 provides guidance, and during high frequency movement, the flexible hinge 2 provides guidance. The position detection component ensures the motion accuracy, the damper 10 reduces vibration, and the limiting protrusion 14 prevents overshoot. The entire system achieves stable and accurate large stroke and high frequency movement, which is suitable for focusing and replacing glass slides in biological gene detection equipment.

[0056] Specific usage steps: Clamp the glass slide onto the motion connecting plate 3, start the counterweight cylinder 6 to balance the load, and drive the motion connecting plate 3 upward to the vicinity of the focusing position through the voice coil motor 5. Then, perform high-frequency fine-tuning to focus. After focusing, the microscope above performs gene detection on the sample on the glass slide. After detection, move the glass slide downward to provide operating space. Throughout the process, the motion connecting plate 3 is subjected to uniform force, moves smoothly, and has high precision.

[0057] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for using a motion stage adapted to large stroke and high frequency, wherein, Motion stages adapted to long stroke and high frequency include: Base (1); A flexible hinge (2) is used to achieve high-frequency motion guidance, and the flexible hinge (2) includes a deformable part (201) and a mounting plate (202), the bottom of which is connected to the mounting plate (202); The motion connecting plate (3) is used to support the glass slide, and the motion connecting plate (3) is connected to the top of the deformable part (201); The cross roller guide (4) is used to guide large stroke motion, and the cross roller guide (4) includes a moving part (401) and a fixed part (402). The moving part (401) is connected to the mounting plate (202), and the fixed part (402) is connected to the base (1). The motor is used to drive the motion connecting plate (3) to move along the Z-axis direction; A counterweight cylinder (6) is used to counteract the load weight, and the counterweight cylinder (6) is connected to the lower middle part of the mounting plate (202); It also includes a position detection component for detecting motion position, the position detection component includes a grating ruler (11) and a reading head (12), the base (1) includes a base plate (101) and a mounting seat (102) connected to the upper side of the base plate (101), the lower side of the motion connecting plate (3) is connected to a first protrusion (13), the grating ruler (11) is connected to the side of the first protrusion (13), the reading head (12) is disposed on one side of the grating ruler (11) and the reading head (12) is fixed on the mounting seat (102); The motor is a voice coil motor (5), and the voice coil motor (5) is connected to the lower middle part of the motion connecting plate (3); The method for using a motion stage adapted to large stroke and high frequency is characterized by the following steps: S1. Mount the glass slide with the sample onto the motion connecting plate (3); S2. The start counterweight cylinder (6) generates a supporting force on the mounting plate (202) that is equal in magnitude and opposite in direction to the weight of the load consisting of the flexible hinge (2), the motion connecting plate (3), the glass slide and the moving part (401) of the cross roller guide (4), so that the motion platform adapted to large stroke and high frequency is in a state of force balance. S3. The motion connecting plate (3) is driven to move upward along the Z-axis direction by the voice coil motor (5). At the same time, the motion connecting plate (3) drives the deformation part (201) of the flexible hinge (2) to undergo slight deformation. Then, the moving part (401) of the cross roller guide (4) is dragged by the mounting plate (202) of the flexible hinge (2) to move together. The current position of the grating ruler (11) is read in real time by the reading head (12). S4. When the current position of the grating ruler (11) reaches the preset first position, control the motion connecting plate (3) to stop moving. At this time, the slide moves to the vicinity of the microscope's focusing position. S5. Start the voice coil motor (5) to run at a high frequency, thereby driving the motion connecting plate (3) to perform high-frequency, small-amplitude reciprocating motion to find the best position and achieve focusing of the slide and microscope. At this time, the motion connecting plate (3) drives the deformation part (201) of the flexible hinge (2) to produce a small-amplitude elastic deformation, while the cross roller guide (4) is in a relatively static state due to inertia and friction. S6. When it is necessary to disassemble or replace the glass slide, the motion connecting plate (3) is driven by the voice coil motor (5) to move downward along the Z-axis in a large stroke. At the same time, the motion connecting plate (3) drives the deformation part (201) of the flexible hinge (2) to undergo slight deformation. Then, the moving part (401) of the cross roller guide (4) is dragged by the mounting plate (202) of the flexible hinge (2) to move together. The current position of the grating ruler (11) is read in real time by the reading head (12). S7. When the current position of the grating ruler (11) reaches the preset second position, control the motion connecting plate (3) to stop moving, so that the slide is away from the microscope above, in order to provide operating space.

2. The method of using the motion stage adapted to large stroke and high frequency according to claim 1, characterized in that: Two flexible hinges (2) are symmetrically provided, and four cross roller guides (4) are provided. The two moving parts (401) of two cross roller guides (4) are connected by a first lifting seat (7), and the two moving parts (401) of the other two cross roller guides (4) are connected by a second lifting seat (8). Two mounting blocks (9) are symmetrically connected to both ends of each mounting plate (202), and the two symmetrically arranged mounting blocks (9) are respectively connected to the first lifting seat (7) and the second lifting seat (8).

3. The method of using the motion stage adapted to large stroke and high frequency according to claim 2, characterized in that: It also includes dampers (10) for suppressing high-frequency vibrations, the dampers (10) being provided in four and respectively connected to the underside of four mounting blocks (9).

4. The method of using the motion stage adapted to large stroke and high frequency according to claim 1, characterized in that: It also includes a limiting protrusion (14) for limiting the range of motion of the motion connecting plate (3). The lower side of the motion connecting plate (3) is connected to a second protrusion (15). The limiting protrusion (14) is connected to the side of the second protrusion (15). The mounting base (102) is provided with a strip groove (16). The limiting protrusion (14) is slidably connected in the strip groove (16) along the Z-axis direction.

5. The method of using the motion stage adapted to large stroke and high frequency according to claim 4, characterized in that: The limiting protrusion (14) is a bolt, and the bolt is detachably connected to the second protrusion (15) by a thread.

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