Traditional Chinese medicine liniment for relieving swelling and pain and preparation method thereof
By optimizing the ingredients and preparation process of traditional Chinese medicine, the prepared liniment has solved the problem of insufficient efficacy of traditional Chinese medicine preparations in treating purulent infections of the skin or soft tissues, eczema, and soft tissue injuries, achieving significant therapeutic effects and expanding the scope of application.
Patent Information
- Application Number
- CN202511799595.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-02
- Publication Date
- 2026-01-20
AI Technical Summary
While maintaining efficacy, existing in-house Chinese medicine preparations have shortcomings in terms of process optimization and application scope expansion, especially in treating purulent infections of the skin or soft tissues, eczema, and soft tissue injuries.
A traditional Chinese medicine liniment was prepared by using specific proportions of Chinese herbal ingredients such as rhubarb, angelica dahurica, turmeric, phellodendron bark, arisaema, tangerine peel, atractylodes lancea, magnolia bark, licorice, and trichosanthes kirilowii through steam distillation and reflux extraction. The pH value was adjusted to 4.5-5.0, and the preparation process was optimized to expand the application range.
Traditional Chinese medicine liniments have shown significant efficacy in treating purulent infections of the skin or soft tissues, eczema, and soft tissue injuries, expanding the clinical application scope of in-house traditional Chinese medicine preparations and improving treatment outcomes.
Smart Images
Figure SMS_1 
Figure SMS_3 
Figure SMS_5
Abstract
Description
TECHNICAL FIELD
[0001] The application belongs to the technical field of traditional Chinese medicine preparation, and relates to a traditional Chinese medicine liniment for detumescence and analgesia and a preparation method thereof. BACKGROUND
[0002] The medical institution preparation (hereinafter referred to as the hospital preparation) refers to the fixed prescription preparation prepared by a medical institution according to the clinical needs of the unit and only used in the hospital, which is approved by the provincial, autonomous region or municipality (food) drug supervision and management department. The hospital preparation is an important part of the pharmaceutical service provided by the hospital for patients, and is also one of the core competitiveness of the hospital. The hospital preparation is usually divided into traditional Chinese medicine hospital preparation and western medicine hospital preparation. The traditional Chinese medicine hospital preparation is a prescription transformed by the hospital doctors based on long-term clinical practice experience, which is supported by the theory of traditional Chinese medicine, is a unique preparation form in China, has the advantages of remarkable curative effect, obvious specialty characteristics, rich experience in human use, good safety, convenient use and the ability to meet the needs of different levels of clinical treatment, and is an indispensable part of the clinical use of traditional Chinese medicine. China has rich resources of traditional Chinese medicine hospital preparation. The use of traditional Chinese medicine hospital preparation is the inheritance and development of traditional Chinese medicine, which can not only promote the development of hospital specialty, but also provide patients with hospital-specific drugs and services, and create economic benefits for the hospital.
[0003] The traditional Chinese medicine hospital preparation has great potential for clinical application and becomes an important cornerstone for the research and development of new traditional Chinese medicine drugs due to its exact curative effect, fewer adverse reactions, fixed prescription and mature preparation process. At the same time, how to optimize the preparation process while maintaining the drug efficacy and how to expand the application range of the preparation are also problems that need to be faced in the development of traditional Chinese medicine hospital preparation. SUMMARY
[0004] The main purpose of the present application is to provide a traditional Chinese medicine liniment for detumescence and analgesia and a preparation method thereof. The traditional Chinese medicine liniment has the effects of clearing heat and resolving toxins, removing blood stasis and resolving masses, detumescence and analgesia.
[0005] The present application realizes the above-mentioned purpose by adopting the following technical solutions: A traditional Chinese medicine liniment for detumescence and analgesia is prepared from the following components: 40-60 parts by weight of rhubarb, 45-55 parts by weight of white yarrow, 50-55 parts by weight of turmeric, 40-55 parts by weight of yellow oak, 15-25 parts by weight of jackinthepulp, 15-20 parts by weight of dried tangerine or orange peel, 15-30 parts by weight of Chinese artichoke, 20-25 parts by weight of magnolia officinalis, 15-25 parts by weight of licorice, and 80-120 parts by weight of radix trichosanthis.
[0006] The preparation method of the traditional Chinese medicine liniment comprises the following steps: Step 1: removing the volatile oil from the dried tangerine or orange peel by steam distillation; and preparing the mixture after distillation for later use. Step 2, after soaking, filter the cortex phellodendri with petroleum ether to obtain pretreated cortex phellodendri powder for use; Step 3, pretreated cortex phellodendri powder in step 2, radix angelicae dahuricae, turmeric, arisaema, coix, ginger, magnolia officinalis, licorice, and radix bupleuri are added into water for reflux extraction, and then the mixture after distillation in step 1 and radix et rhizoma rhei are added and mixed uniformly, the pH is adjusted to 4.5-5.0, reflux extraction is continued, and then cooling, filtration are performed to obtain an extract; the extract is concentrated to obtain the traditional Chinese medicine liniment.
[0007] Preferably, the radix angelicae dahuricae is radix angelicae dahuricae, the coix is coir-fried coix, and the magnolia officinalis is ginger magnolia officinalis.
[0008] The application provides a specific use of the traditional Chinese medicine liniment, i.e., the use of the traditional Chinese medicine liniment in the preparation of a medicine for treating skin or soft tissue suppurative infection.
[0009] Specifically, the skin or soft tissue suppurative infection includes but is not limited to acne, folliculitis, furuncle, carbuncle, acute cellulitis, abscess, erysipelas, acute lymphangitis, paronychia, and perianal abscess.
[0010] The application provides the use of the traditional Chinese medicine liniment in the preparation of a medicine for treating eczema and psoriasis.
[0011] The application provides the use of the traditional Chinese medicine liniment in the preparation of a medicine for treating soft tissue injury and burn.
[0012] The application provides the use of the traditional Chinese medicine liniment in the preparation of a medicine for treating phlebitis, lateral epicondylitis, and knee synovitis.
[0013] The application has the following beneficial effects: The traditional Chinese medicine liniment provided by the application is upgraded on the basis of an original prescription of the hospital. The original prescription is composed of radix et rhizoma rhei, radix angelicae dahuricae, turmeric, cortex phellodendri, arisaema, pericarpium citri reticulatae, coix, magnolia officinalis, and radix bupleuri, and has the effects of clearing heat and resolving toxin, resolving stasis and resolving nodules, and relieving swelling and pain. The traditional Chinese medicine liniment is widely used in the treatment of phlebitis, lateral epicondylitis, and knee synovitis, and has good therapeutic effects on acute cellulitis, acute suppurative lymphadenitis, soft tissue injury, swelling after fracture, burn, paronychia, erysipelas, and other suppurative infections, and the treatment effect is remarkable. The hospital upgrades the preparation method of the original preparation, and the upgraded traditional Chinese medicine liniment has good therapeutic effects on eczema, and expands the clinical application range of the prescription. DETAILED DESCRIPTION
[0014] The application is further illustrated below by specific examples, and it should be understood that the examples are only used to illustrate the application and not used to limit the scope of the application. After reading the application, those skilled in the art can make modifications to various equivalent forms of the application, and the modifications fall within the scope of the claims of the application.
[0015] Example 1 Chinese medicine liniment Step 1, the dried orange peel 20 g was crushed, passed through a 100 mesh sieve, and dried orange peel powder was obtained for use; 200 g of water was added to the dried orange peel powder, and heated to distill off the volatile oil; the mixture after distillation was reserved for use; Step 2, the cortex phellodendri 50 g was crushed, passed through an 80 mesh sieve, and cortex phellodendri powder was obtained for use; 500 mL of petroleum ether was added to the cortex phellodendri powder, soaked for 1.5 h, filtered, and the filter residue was removed to remove residual petroleum ether, and pretreated cortex phellodendri powder was obtained for use; Step 3, the pretreated cortex phellodendri powder in Step 2, baizhi 50 g, shilajianhuang 50 g, tiannanxing 20 g, glutinous fried atractylodes 20 g, ginger and magnolia officinalis 20 g, licorice tablet 20 g, and tianhuafen 100 g were added to 3500 g of water, and reflux extraction was performed at 90°C for 1.5 h; the mixture after distillation in Step 1, and radix et rhizoma rhei 50 g were then added and mixed evenly, the pH was adjusted to 5.0, and reflux extraction was continued at 90°C for 0.5 h; after cooling, filtration was performed, and an extract was obtained; the extract was concentrated to 400 mL, and a Chinese medicine liniment was obtained.
[0016] Example 2 Chinese medicine liniment Step 1, the dried orange peel 15 g was crushed, passed through a 100 mesh sieve, and dried orange peel powder was obtained for use; 150 g of water was added to the dried orange peel powder, and heated to distill off the volatile oil; the mixture after distillation was reserved for use; Step 2, the cortex phellodendri 40 g was crushed, passed through an 80 mesh sieve, and cortex phellodendri powder was obtained for use; 400 mL of petroleum ether was added to the cortex phellodendri powder, soaked for 1 h, filtered, and the filter residue was removed to remove residual petroleum ether, and pretreated cortex phellodendri powder was obtained for use; Step 3, the pretreated cortex phellodendri powder in Step 2, baizhi 45 g, shilajianhuang 55 g, tiannanxing 15 g, glutinous fried atractylodes 30 g, ginger and magnolia officinalis 20 g, licorice tablet 15 g, and tianhuafen 120 g were added to 2700 g of water, and reflux extraction was performed at 80°C for 1.5 h; the mixture after distillation in Step 1, and radix et rhizoma rhei 60 g were then added and mixed evenly, the pH was adjusted to 4.5, and reflux extraction was continued at 80°C for 0.5 h; after cooling, filtration was performed, and an extract was obtained; the extract was concentrated to 400 mL, and a Chinese medicine liniment was obtained.
[0017] Example 3 Chinese medicine liniment Step 1, the dried orange peel 20 g was crushed, passed through a 100 mesh sieve, and dried orange peel powder was obtained for use; 200 g of water was added to the dried orange peel powder, and heated to distill off the volatile oil; the mixture after distillation was reserved for use; Step 2, the cortex phellodendri 55 g was crushed, passed through an 80 mesh sieve, and cortex phellodendri powder was obtained for use; 550 mL of petroleum ether was added to the cortex phellodendri powder, soaked for 1.5 h, filtered, and the filter residue was removed to remove residual petroleum ether, and pretreated cortex phellodendri powder was obtained for use; Step 3, pretreated with step 2 Cortex Phellodendri powder, 55g Bai Zhi, 50g Shu Jianghuang, 25g Tian Nansheng, 15g Fried Cangzhu, 25g Jiang Houpu, 25g Gancao tablets, 80g Tianhuafen, 3300g water was refluxed at 85℃ for 1.5h, then add the mixture after distillation in step 1, 50g Radix et Rhizoma Rhei mixed evenly, adjust the pH to 5.0, continue to reflux at 85℃ for 0.5h, cool, filter, get the extract; the extract was concentrated to 400mL, the traditional Chinese medicine liniment was obtained.
[0018] Comparative Example 1 Take 50g Radix et Rhizoma Rhei, 50g Bai Zhi, 50g Shu Jianghuang, 50g Cortex Phellodendri, 20g Pericarpium Citri Reticulatae, 20g Fried Cangzhu, 20g Jiang Houpu, 20g Gancao tablets, 100g Tianhuafen, add 3200g water and decoct twice, 1h each time, combine the decoction, filter, concentrate to 40mL, the traditional Chinese medicine preparation was obtained.
[0019] Comparative Example 2 Step 1, Pericarpium Citri Reticulatae 20g, Cortex Phellodendri 50g were crushed, after 80 mesh sieve was added 700mL petroleum ether, soaked for 1.5h, filtered, the filter residue was removed, the residual petroleum ether was removed, and the pretreated mixed powder was obtained for use; Step 2, the pretreated mixed powder in step 2, 50g Bai Zhi, 50g Shu Jianghuang, 20g Tian Nansheng, 20g Fried Cangzhu, 20g Jiang Houpu, 20g Gancao tablets, 100g Tianhuafen, 50g Radix et Rhizoma Rhei, 3500g water was refluxed at 90℃ for 2h, filtered, the extract was obtained; the extract was concentrated to 400mL, the traditional Chinese medicine liniment was obtained.
[0020] Performance test I. The improvement effect of different traditional Chinese medicine liniments on eczema 1. Test and method This test was carried out in the pharmacology and toxicology research center of our hospital, and the existing literature was referred to for modeling.
[0021] Screen barrier environment SD rats, body weight 200±20g, mouse age 8 weeks, half male and half female, license number: SYXK(Tianjin)2025-0004. Rats were adaptively fed for 7 days before the test.
[0022] Eczema modeling: the back and abdomen of rats were shaved respectively, with a diameter of 2cm. 80% of the dinitrochlorobenzene solution (solvent is acetone: olive oil = 4:1, v / v) 100μL was applied to the sensitization of the shaved area on the abdomen of rats, once a day, for 2 consecutive days. On the 6th day, 0.5% of the dinitrochlorobenzene solution (solvent is acetone: olive oil = 4:1, v / v) 100μL was applied to the excitation of the shaved area on the back, once every 5 days, until the symptoms of redness, scabbing, papules and other symptoms appeared on the back skin of rats, which met the diagnostic criteria of chronic eczema, indicating that the eczema modeling was successful, and the excitation was stopped.
[0023] The rats with successful eczema modeling were randomly divided into a model group, a positive drug group, test groups 1-5. Another normal rat was operated according to the above modeling method, and was smeared with distilled water as a blank group. The rats in the positive drug group were smeared with 0.20 g mometasone furoate cream (Guojiazhunzi H20074090), the rats in test group 1 were smeared with 0.5 mL of the traditional Chinese medicine liniment of Example 1 (the crude drug concentration was 0.88 g / mL), the rats in test group 2 were smeared with 0.5 mL of the traditional Chinese medicine liniment of Example 2 (the crude drug concentration was 0.89 g / mL), the rats in test group 3 were smeared with 0.5 mL of the traditional Chinese medicine liniment of Example 3 (the crude drug concentration was 0.88 g / mL), the rats in test group 4 were smeared with 0.5 mL of the traditional Chinese medicine liniment of Comparative Example 1 (the crude drug concentration was 0.88 g / mL), and the rats in test group 5 were smeared with 0.5 mL of the traditional Chinese medicine liniment of Comparative Example 2 (the crude drug concentration was 0.88 g / mL). Each was given drug once a day in the morning and evening, and the drug was given continuously for 7 days. The rats in the blank group and the model group were smeared with 0.5 mL of distilled water.
[0024] The skin lesions of the rats were observed. The clinical manifestations of the skin lesions were divided into 5 types, namely erythema, edema / papules, exfoliation with scratch marks, exudation or scabbing, and mossy phenomenon. Each type of manifestation was scored according to the severity, and the scoring standard was 0-3 points, wherein 0 points indicated no, the sign could not be determined even after careful observation; 1 point indicated light, the sign existed but required careful observation; 2 points indicated medium, the sign could be observed; and 3 points indicated heavy, the sign was obvious. In each level of scoring, half a level of 0.5 points could be taken according to the actual situation. The total score of the 5 symptoms was taken as the final skin lesion score.
[0025] The specific manifestations of the signs were as follows: erythema manifested as red or dark red inflammatory patches, which faded after pressing; edema / papules manifested as the appearance of needle-like size papules or papulovesicles on the skin lesions, or slightly raised red patches, i.e. slightly raised erythema edema; exfoliation with scratch marks manifested as skin damage caused by scratching, including linear erosion on the skin lesions and fissures on the keratinized skin lesions; exudation or scabbing manifested as the wet state of the skin lesions, including scabbing formed after exudate dried; and mossy phenomenon manifested as infiltration and hypertrophy, and hyperkeratosis.
[0026] Detection of changes in inflammatory factors. The rats were taken blood from the eye sockets, and the serum was separated. The content of interleukin-2 (IL-2) and interleukin-4 (IL-4) in the serum was detected by ELISA.
[0027] 2. Results and analysis 2.1 Comparison of skin lesions in rats The skin tissues of the rats in the test group 1, the test group 2 and the test group 3 are obviously improved after the treatment, the scabs are fallen off, and the redness and swelling are relieved, and the recovery conditions are basically the same as those of the positive drug group, the skin tissue improvement conditions of the rats in the test group 4 and the test group 5 are relatively poor, but are obviously relieved, and the recovery time is relatively long, and the results are shown in Table 1.
[0028] Table 1 Comparison of skin lesion conditions of rats Note: P < 0.05 indicates that the model group is compared with the model group; # indicates that the positive drug group is compared with the positive drug group.
[0029] 2.2 Comparison of changes of inflammatory factors The content of inflammatory factors in the serum of the rats after modeling is obviously increased, and the content of inflammatory factors of the rats in the positive drug group and the test group 1-6 is decreased after the treatment, wherein the data of the rats in the test group 1-3 is basically the same as that of the rats in the positive drug group; the data of the rats in the test group 4-5 is different from that of the positive drug group, which indicates that the prepared traditional Chinese medicine liniment can obviously reduce the content of inflammatory factors of the rats, and has a high treatment effect on eczema.
[0030] Table 2 Comparison of content of inflammatory factors of rats Note: P < 0.05 indicates that the model group is compared with the model group; # indicates that the positive drug group is compared with the positive drug group.
[0031] II. Treatment effect of different traditional Chinese medicine liniments on soft tissue injury 1. Test and method The test is carried out in the pharmacological and toxicological research center of the hospital, and the modeling is carried out according to the existing literature.
[0032] Barrier environment SD rats are selected, the weight is 200±20g, the rat age is 8 weeks, and the male and female are half and half, and the license number is SYXK (Tianjin) 2025-0004. The rats are adaptively fed for 7 days before the test.
[0033] Modeling method: after the right hind leg of the rat is washed clean after shaving, the right hind leg is fixed after anesthesia, the qualified weight impactor is vertically and freely dropped at 40cm high on the right hind leg of the rat, 2.5-3cm above the ankle joint, the skin swelling and congestion but no obvious skin damage are observed, and the diagnosis is no fracture, which is considered as successful modeling of soft tissue injury.
[0034] The successfully modeled rats are randomly divided into a model group, a positive drug group, a test group 1-4; another normal rat is only shaved on the right hind leg without impact treatment, which is a blank group. The rats are respectively given drugs in the following ways.
[0035] The positive drug group rats were smeared with 0.20 g Qingpeng ointment (Guo Yao Zhu Zhi Z54020140), the test 1 group rats were smeared with 0.5 mL of the traditional Chinese medicine liniment of Example 1 (the crude drug concentration was 0.88 g / mL), the test 2 group rats were smeared with 0.5 mL of the traditional Chinese medicine liniment of Comparative Example 1 (the crude drug concentration was 0.88 g / mL), and the test 3 group rats were smeared with 0.5 mL of the traditional Chinese medicine liniment of Comparative Example 2 (the crude drug concentration was 0.88 g / mL), and each was given the drug once a day in the morning and evening, and the continuous drug administration lasted for 7 days. The blank group and the model group were smeared with 0.5 mL of distilled water.
[0036] The physical signs were divided into four types, namely subcutaneous congestion, muscle color, muscle swelling degree and activity disorder, and were scored according to the following standards: Subcutaneous congestion: 0 points for no congestion, 1 point for a small amount of point-like congestion, and 2 points for a large amount of block-like congestion; Muscle color: 0 points for normal color, 1 point for dark red, and 2 points for dark purple; Muscle swelling degree: 0 points for no swelling, 1 point for slight swelling, and 2 points for obvious swelling; Activity disorder: 0 points for no lameness, 1 point for slight lameness, and 3 points for obvious lameness.
[0037] The above scores can be taken half a grade of 0.5 points according to the actual situation, and the total score of each physical sign is taken as the comprehensive score.
[0038] 2. Results and analysis From the results in Table 3, it can be seen that the soft tissue injury score of the rats using the traditional Chinese medicine liniment prepared by the present application decreased obviously, and was basically the same as that of the positive drug group; the scores of the test 2-4 groups also decreased, but there was still a certain gap compared with the positive drug group. It can be seen that the traditional Chinese medicine liniment of the present application also has a good therapeutic effect on soft tissue injury.
[0039] Table 3 Comparison of recovery of soft tissue injury in rats Note: P<0.05 indicates that compared with the model group, P<0.05; # indicates that compared with the positive drug group, P<0.05.
[0040] Summary: Comparative Example 1 does not use the original prescription of the present application, and the present application improves the process based on the original prescription. It is found that after removing the volatile oil in Pericarpium Citri Reticulatae and the fat-soluble components in Cortex Phellodendri, the traditional Chinese medicine liniment obtained by batch extraction has a good effect on the treatment of eczema. The original prescription and the liniment prepared by the preparation process have poor effects on the treatment of eczema, and the present application expands the clinical application range of the original prescription of the present application. Moreover, the traditional Chinese medicine liniment obtained by improvement also has improved therapeutic effect on the treatment of soft tissue injury, and the effect is significant.
Claims
1. A traditional Chinese medicine liniment for relieving swelling and pain, characterized in that, The traditional Chinese medicine liniment is prepared from the following ingredients: 40-60 parts by weight of rhubarb, 45-55 parts by weight of white pie, 50-55 parts by weight of turmeric, 40-55 parts by weight of yellow oak, 15-25 parts by weight of rhizoma arisaematis, 15-20 parts by weight of dried tangerine or orange peel, 15-30 parts by weight of atractylodes, 20-25 parts by weight of magnolia officinalis, 15-25 parts by weight of licorice, and 80-120 parts by weight of radix trichosanthis.
2. The traditional Chinese medicine liniment according to claim 1, characterized in that, The preparation method of the traditional Chinese medicine liniment comprises the following steps: Step 1: The dried tangerine or orange peel is removed by steam distillation; the distillation mixture is prepared; Step 2: The yellow oak is soaked in petroleum ether, and then filtered to obtain pretreated yellow oak powder; Step 3: The pretreated yellow oak powder, white pie, sliced turmeric, rhizoma arisaematis, bran-fried atractylodes, ginger magnolia officinalis, licorice and radix trichosanthis are added into water for reflux extraction, and then the distillation mixture in step 1 and rhubarb are added and uniformly mixed, the pH value is adjusted to 4.5-5.0, the reflux extraction is continued, and then the extract is obtained after cooling and filtering; and the traditional Chinese medicine liniment is obtained after the extract is concentrated.
3. The traditional Chinese medicine liniment according to claim 1 or 2, characterized in that, The turmeric is sliced turmeric, the atractylodes is bran-fried atractylodes, and the magnolia officinalis is ginger magnolia officinalis.
4. Use of the traditional Chinese medicine liniment in claim 1 or 2 in the preparation of a drug for treating skin or soft tissue suppurative infection.
5. Use as claimed in claim 4, characterised in that, The skin or soft tissue suppurative infection includes acne, folliculitis, furuncle, carbuncle, acute cellulitis, abscess, erysipelas, acute lymphangitis, paronychia, perianal abscess.
6. Use of the traditional Chinese medicine liniment in claim 1 or 2 in the preparation of a drug for treating eczema and psoriasis.
7. Use of the traditional Chinese medicine liniment in claim 1 or 2 in the preparation of a drug for treating soft tissue injury and burn.
8. Use of the traditional Chinese medicine liniment in claim 1 or 2 in the preparation of a drug for treating phlebitis, lateral epicondylitis and knee synovitis.