Dynamic light field regulation and control contact lens for visual training

Abstract

The invention discloses a dynamic light field regulation and control contact lens for visual training, and belongs to the technical field of intelligent medical instruments and wearable equipment. Comprising a dynamic variable-focus optical module, a near-infrared nerve stimulation module and a control module which are integrated on a lens. The control module is configured to execute a co-stimulation procedure, so that the dynamic variable-focus optical stimulation and the near-infrared stimulation are in time sequence linkage. The co-stimulation program comprises a split-vision training mode and an alternating stimulation mode. The synergistic mechanism can actively train the eye regulation function, induce subconscious rhythm movement of pupils and promote neuroplasticity, so that the intervention effect superior to that of a single mode is achieved in the aspects of myopia active prevention and control, asthenopia relief and neurovision rehabilitation. According to the invention, all functions are seamlessly integrated in a conventional contact lens.

Description

Technical Field

[0001] This invention belongs to the field of intelligent wearable devices and medical devices technology, and in particular, it is an intelligent contact lens based on the synergistic effect of dynamic light field modulation and near-infrared nerve stimulation, which is used for visual training, myopia prevention and control and neurovisual rehabilitation. Background Technology

[0002] The occurrence and development of myopia are closely related to the visual accommodation dysfunction caused by prolonged close-range eye use. Existing solutions, such as orthokeratology lenses or bifocals, mainly control myopia by passively reshaping the eye or providing a fixed focal band, but they cannot actively train the eye's accommodation function.

[0003] In the field of neurovisual rehabilitation, such as visual field defects or amblyopia after stroke, existing training tools are mostly external devices, which have poor patient compliance and are difficult to provide continuous and personalized stimulation in daily life.

[0004] Patent application CN2023800813748 has disclosed a device for achieving electronically controlled zoom using the principle of liquid crystal lenses. However, these devices are functionally limited, typically used only to replace traditional zoom optical systems, lacking active intervention and training functions for the visual system, and not involving synergistic applications with neural stimulation. Summary of the Invention

[0005] The technical problem to be solved by this invention is an intelligent visual intervention platform that integrates dynamic optical control and neurophysiological stimulation and can be used seamlessly in daily life.

[0006] This invention provides a contact lens, comprising:

[0007] Contact lens substrate;

[0008] A dynamic zoom optical module, integrated into the optical area of ​​the contact lens substrate, is used to change the focal length;

[0009] The near-infrared nerve stimulation module is integrated into the non-optical area of ​​the contact lens base and is used to emit near-infrared light toward the iris or the edge of the pupil; specifically, it emits near-infrared light toward the pupillary sphincter and dilator muscles within the iris.

[0010] A control and power supply module, integrated at the edge of the contact lens base, is used to control the coordinated operation of the dynamic zoom optical module and the near-infrared nerve stimulation module, and to supply power to the dynamic zoom optical module and the near-infrared nerve stimulation module; wherein, the control and power supply module is configured to execute at least one preset coordinated stimulation program, so that the dynamic zoom optical module and the near-infrared nerve stimulation module are linked in time.

[0011] Furthermore, the contact lens substrate is a hydrogel or silicone hydrogel material.

[0012] Furthermore, the dynamic zoom optical module includes a microcavity liquid crystal matrix driven by MXene transparent electrodes, wherein the microcavities are fully filled with liquid crystal, and the diameter of the liquid crystal is 10-50 micrometers.

[0013] Furthermore, the near-infrared neural stimulation module includes one or more independently addressable near-infrared micro-LEDs; the wavelength range of the light emitted by the near-infrared micro-LEDs is 800nm ​​to 1100nm.

[0014] The near-infrared nerve stimulation module emits a light spot with a diameter of 0.5 mm to 1.5 mm, and the irradiance in the iris region is no greater than 100 mW / cm².

[0015] Furthermore, the synergistic stimulation program includes an alternating stimulation mode, wherein the dynamic variable focus optical module alternately switches between a preset near focal length and a far focal length at a frequency of 0.2 Hz to 0.5 Hz; when the near-infrared nerve stimulation module switches to the near focal length, it emits a near-infrared light pulse with a pulse width of 100 ms to 500 ms.

[0016] Furthermore, the synergistic stimulation program includes a split-vision training mode suitable for simultaneous use of two contact lenses: controlling the dynamic zoom optical module in one contact lens to apply high-frequency micro-vibration; and controlling the near-infrared nerve stimulation module in the other contact lens to provide continuous or pulsed stimulation. Specifically, the high-frequency micro-vibration is achieved by applying a 5 Hz to 50 Hz drive frequency to the dynamic zoom optical module through a control and power supply module, and associated with a high-frequency oscillating voltage signal that generates a refractive power variation amplitude of ±0.1 D to ±0.5 D.

[0017] Furthermore, the control and power supply module includes an embedded chip, a wireless communication unit, and a power supply module; the embedded chip is used to control the dynamic zoom optical module and the near-infrared nerve stimulation module to work in sequence via the wireless communication unit. The power supply module is used to supply power to the dynamic zoom optical module and the near-infrared nerve stimulation module.

[0018] Furthermore, when a voltage of 1-3V is applied between the electrodes, the dynamic zoom optical module drives the liquid crystal molecules to reorient and align, thereby changing the focal length.

[0019] Beneficial effects: Compared with the prior art, the present invention has the following significant advantages:

[0020] 1. For the first time, dynamic optical focusing and near-infrared neural stimulation are integrated and time-linked to forcefully train accommodation and pupil function in combination, with effects far exceeding those of single-modal stimulation.

[0021] 2. Upgrading from passive correction to active training provides a brand-new physical intervention solution for myopia prevention and control in adolescents.

[0022] 3. Through programmable stimulation modes, it provides a portable and personalized new tool for the rehabilitation treatment of neurological eye diseases such as amblyopia and visual field defects.

[0023] 4. All functions are integrated into a standard-sized contact lens, making it convenient for daily use and resulting in high user compliance. Attached Figure Description

[0024] Figure 1 This is a structural diagram of a dynamic light field modulated contact lens used for vision training.

[0025] Figure 2 is a cross-sectional view of the dynamic zoom optical region.

[0026] Figure 3 This is a flowchart of the alternating stimulation pattern of dynamic light field modulation contact lenses for visual training.

[0027] Figure 4 This is a flowchart of the split-view training mode for dynamic light field modulation contact lenses in visual training.

[0028] 1. Embedded ASIC chip; 2. Dynamic zoom optical region; 3. Liquid crystal molecule matrix; 4. Near-infrared nerve stimulation region; 5. Near-infrared micro LED array; 6. Flexible micro battery; 7. MXene thin film electrode. Detailed Implementation

[0029] This invention provides a dynamic light field modulation contact lens for visual training, comprising a contact lens substrate, a dynamic variable focus optical module, a near-infrared nerve stimulation module, and a control and power supply module.

[0030] The dynamic zoom optical module is integrated into the optical region of the contact lens substrate, including a microcavity liquid crystal molecule matrix 3 driven by MXene transparent electrodes, which is used to change the local focal length in real time under the control of electrical signals. The area where the dynamic zoom optical module is located is the dynamic zoom optical region 2.

[0031] The near-infrared nerve stimulation module is integrated into the non-optical area of ​​the contact lens substrate, including one or more independently addressable near-infrared micro-LEDs for emitting near-infrared light in a specific pattern. The area where the near-infrared nerve stimulation is located is the near-infrared nerve stimulation region 4.

[0032] The control and power supply module is integrated into the edge of the contact lens substrate and includes an embedded ASIC chip 1, a wireless communication unit, and a flexible micro battery 6 for controlling the coordinated operation of the dynamic zoom optical module and the near-infrared neurostimulation module.

[0033] The contact lens base is a commercially available hydrogel or silicone hydrogel contact lens.

[0034] The dynamic zoom optical module has a three-layer structure. The upper and lower layers are transparent MXene thin film electrodes 7, and the middle layer is a micro transparent cavity filled with liquid crystal molecules with a diameter of 10-50 micrometers.

[0035] As shown in Figure 2, Figure 2(a) shows that when no voltage is applied between the MXene thin film electrodes 7, the liquid crystal molecules are arranged in a disordered manner, and the lens is in the initial refractive state; Figure 2(b) shows that when a low voltage (1-3V) is applied to the microcavity electrodes of the dynamic zoom optical module by controlling the embedded ASIC chip 1, the electric field drives the liquid crystal molecules in the region to rearrange themselves, thereby changing the refractive index of the dynamic zoom optical region 2.

[0036] One or more independently addressable near-infrared micro-LEDs in the near-infrared nerve stimulation module use near-infrared light with wavelengths between 800nm ​​and 1100nm. This wavelength band has good biological modulation effects on nerve cells and is highly safe. Moreover, the human eye cannot detect light in this wavelength band, so it will not affect the normal wearing experience.

[0037] The control module is configured to execute at least one preset co-stimulation program, which defines the timing-based co-operation logic between the dynamic zoom optical module and the near-infrared neurostimulation module.

[0038] Co-stimulation programs include alternating stimulation patterns and dissociative training patterns.

[0039] like Figure 3 As shown, the synergistic stimulation program controls the dynamic variable focus optical module to alternate between a preset near focal length and a far focal length at a frequency of 0.2 Hz to 0.5 Hz; at the same time, it controls the near-infrared nerve stimulation module to emit near-infrared light pulses with a pulse width of 100 ms to 500 ms at the instant of switching to the near focal length.

[0040] like Figure 4 As shown, the split vision training mode involves controlling the dynamic zoom optical module of one contact lens to apply high-frequency micro-vibration when both eyes are wearing contact lenses, while simultaneously controlling the near-infrared nerve stimulation module of the other contact lens to provide continuous or pulsed stimulation.

[0041] The near-infrared nerve stimulation module emits a light spot with a diameter of 0.5 mm to 1.5 mm, an irradiance of no more than 100 mW / cm² in the iris region, and a wavelength range of 800 nm to 1100 nm.

[0042] In this embodiment, a smart contact lens for myopia control was fabricated, and the dynamic zoom optical module adopts Ti3C2T. x MXene electrodes drive microcavities (20 μm in diameter) filled with nematic liquid crystal. The near-infrared neurostimulation module uses a miniature LED with a wavelength of 810 nm, placed around the periphery of the contact lens substrate.

[0043] Implement a synergistic stimulation procedure (alternating stimulation pattern):

[0044] The dynamic zoom optical module switches between +2.0D (near) and -0.5D (far) at a frequency of 0.3Hz. Whenever the focal length switches to +2.0D, the near-infrared LED immediately emits a light pulse lasting 300ms with an irradiance of 50mW / cm². The device is worn and trained for a cumulative total of 2 hours.

[0045] Experimental Verification: To verify the effectiveness of near-infrared stimulation in inducing pupillary response, an in vitro experiment was conducted. Using an isolated pig eye, the contact lens of this invention was fitted with the parameters described above. High-speed infrared cameras recorded rhythmic contractions and dilations of the pupil synchronized with the light pulse, with an amplitude of 7% of the original area. This result confirms the effectiveness of this method.

Claims

1. A contact lens, characterized in that, include: Contact lens substrate; A dynamic zoom optical module, integrated into the optical area of ​​the contact lens substrate, is used to change the focal length; A near-infrared nerve stimulation module, integrated into the non-optical area of ​​the contact lens base, is used to emit near-infrared light; A control and power supply module, integrated at the edge of the contact lens base, is used to control the coordinated operation of the dynamic zoom optical module and the near-infrared nerve stimulation module; wherein, the control and power supply module is configured to execute at least one preset coordinated stimulation program, so that the dynamic zoom optical module and the near-infrared nerve stimulation module are linked in time.

2. The contact lens according to claim 1, characterized in that, The contact lens substrate is a hydrogel or silicone hydrogel material.

3. The contact lens according to claim 1, characterized in that, The dynamic zoom optical module includes a microcavity liquid crystal matrix driven by MXene transparent electrodes.

4. The contact lens according to claim 1, characterized in that, The microcavity is fully filled with liquid crystal, and the diameter of the liquid crystal is 10-50 micrometers.

5. The contact lens according to claim 1, characterized in that, The near-infrared neurostimulation module includes one or more independently addressed near-infrared micro-LEDs; The near-infrared micro-LED emits light in the wavelength range of 800nm ​​to 1100nm.

6. The contact lens according to claim 5, characterized in that, The diameter of the light spot emitted by the near-infrared nerve stimulation module is 0.5 mm to 1.5 mm, and the irradiance in the iris region is no more than 100 mW / cm².

7. The contact lens according to claim 1, characterized in that, The co-stimulation procedure includes an alternating stimulation pattern, wherein: The dynamic zoom optical module alternates between a preset near focal length and a far focal length at a frequency of 0.2 Hz to 0.5 Hz. When the near-infrared nerve stimulation module switches to near-focal distance, it emits a near-infrared light pulse with a pulse width of 100 to 500 milliseconds.

8. The contact lens according to claim 1, characterized in that, The co-stimulation procedure includes a split-vision training mode, which is suitable for situations where two contact lenses are used simultaneously: Control the dynamic zoom optical module in one of the contact lenses to apply high-frequency micro-vibrations; Control the near-infrared nerve stimulation module in the other contact lens to provide continuous or pulsed stimulation.

9. The contact lens according to claim 1, characterized in that, The control and power supply module includes an embedded chip, a wireless communication unit, and a power supply module; The embedded chip is used to control the dynamic zoom optical module and the near-infrared neurostimulation module to work together in a timely manner via a wireless communication unit.

10. The contact lens according to claim 3, characterized in that, When a 1-3V voltage is applied between the electrodes, the dynamic zoom optical module drives the liquid crystal molecules to reorient and align, thereby changing the focal length.

Images