ATSP-1, a carrageenan-like polysaccharide derived from Taxus chinensis and its applications

By extracting and purifying carrageenan polysaccharide ATSP-1 from Taxus chinensis, the limitations of traditional carrageenan structure have been overcome, achieving highly efficient anti-tumor immunomodulatory activity and safety, making it suitable for large-scale production and meeting market demand.

CN121574278BActive Publication Date: 2026-05-26GUANGDONG OCEAN UNIVERSITY +1
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
CN202610120941.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-01-29
Publication Date
2026-05-26
Estimated Expiration
2046-01-29

AI Technical Summary

Technical Problem

In the existing technology, the structure of traditional carrageenan limits its immunomodulatory activity, which cannot meet the needs of highly effective immune enhancers and anti-tumor related products. The key active components of Taxodium asparagus and its mechanism of action have not yet been clarified.

Method used

A carrageenan-like polysaccharide, ATSP-1, with a triple helix conformation, was extracted and purified from Taxobacterium tumefaciens. It was modified by specific unit linkage and sulfation, and had a weight-average molecular weight of 700-750 kDa. The unique structure of ATSP-1 was isolated by hot water extraction combined with column chromatography.

Benefits of technology

ATSP-1 can significantly improve the efficiency of immune signal transduction, activate CD4+/CD8+ T cell-mediated specific immune responses, activate the p53 apoptosis pathway, and achieve a tumor inhibition rate of 43.14%. Its activity is similar to that of the positive control, and it has high safety, making it suitable for large-scale production.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN121574278B_ABST
    Figure CN121574278B_ABST
Patent Text Reader

Abstract

This invention belongs to the field of natural product extraction and biomedicine technology, and discloses a carrageenan polysaccharide ATSP-1 derived from Taxus chinensis and its applications. This polysaccharide, obtained through hot water extraction and purification, has a triple helix conformation, is mainly composed of galactose, has a weight-average molecular weight of 725.95 kDa, and its backbone contains specific glycosidic bonds and differentiated sulfation patterns. ATSP-1 can upregulate the expression of MHC-I / II molecules in colonic tissue through the antigen presentation signaling pathway, thereby activating CD4+. + / CD8 + It induces specific immune responses mediated by T cells; simultaneously activates the p53 apoptosis pathway, induces tumor cell apoptosis, achieves a tumor inhibition rate of 43.14%, and has no significant liver toxicity. It can be used to prepare immune-related anti-tumor products and provides natural active polysaccharide resources.
Need to check novelty before this filing date? Find Prior Art