Compound essential oil for improving sleep as well as preparation method and application of compound essential oil

Abstract

The invention discloses compound essential oil for improving sleep as well as a preparation method and application of the compound essential oil. The compound essential oil is prepared from rhizoma nardostachyos, frankincense, schisandra chinensis, neroli, angelica sinensis and rhodiola rosea essential oil according to a specific volume ratio, preferably 9: 1.5: 11.25: 4.5: 1.5: 7.5. The traditional Chinese and western medicine theories are fused in the formula, and the sleep improvement effect is achieved through multi-target cooperation. Animal experiment results show that the compound essential oil can significantly prolong the pentobarbital sodium induced sleep time of mice, significantly improve the subthreshold dose sleep rate and significantly shorten the sleep latency period of phenobarbital sodium, does not affect the weight gain of the mice after being continuously administered for 30 days, and has excellent efficacy and good safety. Systematic'component missing 'and'proportion over-limit' contrast experiments prove that the six components are indispensable, and the optimal effect can be achieved only when the dosage of each component is strictly limited in the range of the composition, so that an experimental basis is provided for verifying the creativity of the composition.

Description

Technical Field

[0001] This invention relates to the field of natural medicine and aromatherapy technology, specifically to a compound essential oil formulated based on the theory of integration of traditional Chinese and Western medicine, its preparation method, and its application in the preparation of sleep-improving products. Background Technology

[0002] Sleep disorders have become a global public health problem. Current main interventions—chemically synthesized sedative-hypnotic drugs (such as benzodiazepines and Z-drugs)—have clear side effects including dependence, drug tolerance, the following-day hangover effect, and cognitive impairment. Aromatherapy, with its core components of plant essential oils, is gaining attention as a non-pharmacological intervention.

[0003] However, existing sleep-aid essential oil products on the market and in literature generally suffer from the following technical defects:

[0004] (1) Arbitrary formulation: It relies heavily on empirical matching or simple superposition of single essential oils known to have sedative effects. It lacks scientific formulation logic based on systematic theory (such as TCM syndrome differentiation and treatment, modern pharmacology), and the ingredients are complex but the target is vague.

[0005] (2) One-sided efficacy: Most of them only target the single aspect of "sedation", and are difficult to comprehensively address complex sleep problems such as "difficulty falling asleep, sleep maintenance disorder (easily awakened), early awakening, and poor sleep quality (frequent dreams)".

[0006] (3) Weak verification: efficacy claims are mostly based on subjective feelings or simple behavioral screening, lacking rigorous and systematic preclinical or clinical trial data support, especially long-term safety evaluation data.

[0007] (4) Ambiguous proportions: Few studies can provide fully experimentally verified, optimized, and precise component and proportion ranges, resulting in unstable product effects and poor repeatability.

[0008] Therefore, developing a compound essential oil product with a scientifically formulated composition, clear mechanism, comprehensive efficacy, and verifiable results has significant practical importance and market value. Summary of the Invention

[0009] The primary objective of this invention is to overcome the shortcomings of existing technologies and provide a sleep-improving compound essential oil based on the theory of "integration of traditional Chinese and Western medicine and multi-target synergy." This compound essential oil, through specific essential components and their precise volume ratios, achieves a safe, effective, and non-addictive comprehensive improvement in sleep quality. Each component, within a specific and validated ratio range, produces a synergistic effect, effectively prolonging sleep time, significantly shortening sleep latency, and improving sleep stability and quality.

[0010] The technical solution of the present invention:

[0011] A blend of essential oils for improving sleep, composed of the following volume parts of single essential oils:

[0012] 8-10 parts of spikenard oil;

[0013] Frankincense essential oil 1.0-2.0 parts;

[0014] Schisandra chinensis essential oil 10-12.5 parts;

[0015] Orange blossom essential oil 4.0-5.0 parts;

[0016] Angelica sinensis essential oil 1.0-2.0 parts;

[0017] Rhodiola rosea essential oil 7.0-8.0 parts.

[0018] More preferably, the sleep-improving compound essential oil is composed of the following single essential oils in parts by volume: 9 parts spikenard oil, 1.5 parts frankincense oil, 11.25 parts schisandra chinensis oil, 4.5 parts neroli oil, 1.5 parts angelica sinensis oil, and 7.5 parts rhodiola rosea oil. This preferred ratio has been experimentally proven to have the most prominent synergistic effect.

[0019] The present invention also provides a method for preparing the compound essential oil, comprising: weighing each single essential oil according to the above ratio, placing them in a clean container, and stirring and mixing at room temperature for 20-40 minutes until uniform.

[0020] This invention also provides the use of the compound essential oil in the preparation of topical products for improving sleep, calming the nerves, or relieving anxiety. The improvement of sleep includes shortening sleep latency, prolonging sleep duration, and / or improving sleep stability. The topical products include, but are not limited to, aromatherapy liquids, massage oils, foot bath liquids, sleep aid sprays, scented candles, or sleep patches.

[0021] Mechanism of formulation:

[0022] The formulation of this invention follows the logic of "integration of traditional Chinese and Western medicine, three-dimensional regulation":

[0023] Neuromodulation layer (symptomatic relief): Nardostachys jatamansi essential oil quickly calms anxiety and reduces sympathetic nerve excitability; neroli essential oil regulates the limbic system of the brain, soothes emotional disturbances, and creates a relaxed mood. Together, they create the neural conditions necessary for rapid sleep onset.

[0024] Circulation and Material Foundation Layer (Strengthening the Foundation): Angelica sinensis essential oil nourishes the blood and heart, improves microcirculation in the heart and brain, and provides the material foundation for "the heart governing the mind"; Rhodiola rosea essential oil combats fatigue and repairs nerve stress damage. The two work synergistically to improve physiological depletion caused by long-term sleep deprivation.

[0025] Synergistic and Integrative Effects (Enhanced): Schisandra chinensis essential oil serves as the core, calming the mind and soothing the nerves; modern research has confirmed that it can prolong deep sleep cycles. Frankincense essential oil promotes blood circulation and regulates inhibitory neurotransmitters such as GABA in the brain, stabilizing sleep structure. These two ingredients work synergistically and interact with the first two layers of components to achieve a comprehensive intervention from "promoting sleep onset" to "improving sleep depth and quality."

[0026] The beneficial effects and inventiveness of this invention are as follows:

[0027] 1. Comprehensive efficacy and solid data: Through standardized animal experimental models (mouse pentobarbital sodium sleep time prolongation experiment, subthreshold dose hypnosis experiment, phenobarbital sodium sleep latency experiment), the compound essential oil of this invention has been proven to simultaneously and significantly prolong total sleep time, improve sleep susceptibility, and shorten sleep latency, comprehensively improving sleep quality from three core dimensions, overcoming the shortcomings of existing products with single efficacy.

[0028] 2. High safety for long-term use: Through a 30-day long-term animal experiment monitoring the basic safety indicator of weight gain, it was confirmed that the use of the preferred formulation of this invention has no adverse effects on the normal growth and development of experimental animals, indicating that it has good long-term safety and solving the pain point of insufficient safety assessment of natural products in the market.

[0029] 3. The components and proportions are not obvious, and the synergistic effect constitutes a technical barrier: The core of the invention's inventiveness lies in demonstrating through a large number of systematic comparative experiments (see specific implementation methods):

[0030] a. Necessity of Components: The six specific components selected in this invention (Nardostachys jatamansi, Frankincense, Schisandra chinensis, Orange blossom, Angelica sinensis, and Rhodiola rosea) are indispensable for achieving the remarkable sleep-improving effects described above. The absence of any one of them significantly reduces the overall effect, proving that it is not a simple superposition of functions, but rather constitutes a unique synergistic network.

[0031] b. Precision of Proportion: The amount of each component must be strictly limited to the narrow range described in the claims (e.g., 8-10 parts of Nardostachys jatamansi, 10-12.5 parts of Schisandra chinensis, etc.). Experiments have shown that any reduction or increase in the amount of any single component (outside this range) will lead to a significant deterioration in the overall efficacy and may be accompanied by safety hazards. This indicates that the proportion range described in this invention is a "golden window" that has been extensively screened and optimized, and its discovery requires creative labor.

[0032] c. Innovative integration of theories: The formulation design integrates the fundamental theory of traditional Chinese medicine, which is to "nourish the heart and blood, calm the mind and spirit, and soothe the liver qi," with the symptomatic theory of regulating emotions and stabilizing neurotransmitters in modern aromatherapy and neuroscience. This forms a self-consistent three-dimensional action model of "neural regulation-circulatory basis-pharmacological synergy," which provides the product with profound theoretical support and a clear explanation of its mechanism of action.

[0033] 4. The compound essential oil of this invention achieves the following breakthroughs through "integration of traditional Chinese and Western medicine formulation + multi-target synergistic regulation + precise compatibility":

[0034] a. Innovative formulation logic: Integrating the TCM theory of "regulating the internal organs and calming the mind" (Schisandra chinensis, Angelica sinensis) with the Western aromatherapy theory of "plant energy regulating the nerves" (Boswellia carterii, Neroli oleracea, Rhodiola rosea), it breaks through the "single field" limitation of traditional products and provides a cross-cultural solution for sleep intervention.

[0035] b. Synergistic effect of multiple targets: Through the three-dimensional pathway of "nerve soothing (orange blossom, frankincense) → circulation optimization (angelica, rhodiola rosea) → efficacy enhancement (schisandra, frankincense)," it solves complex sleep problems such as "difficulty falling asleep, easy awakening, and excessive dreaming," achieving both "treating the symptoms and the root cause."

[0036] c. Precise compatibility verification: Based on pharmacokinetic studies of essential oils and small-sample clinical tests, the dosage of each component ensures both the efficacy concentration threshold of "calming the mind and soothing the nerves" and the pharmacological conflict between "promoting blood circulation" and "calming the mind", thus achieving "maximum efficacy + minimum irritation".

[0037] d. Immersive Aromatherapy: Constructing a "three-part narrative fragrance" - the top note of orange blossom refreshes and dispels anxiety, the middle note of frankincense + orange blossom woody and herbal aromas intertwine to calm nerve agitation, and the base note of schisandra + angelica medicinal aromas nourish and strengthen the "peace of mind" suggestion, making sleep aid a ritual of healing for the five senses.

[0038] e. Natural safety and universality: The entire formula uses high-purity single essential oils (without chemical synthetic agents or alcohol preservatives), which aligns with the trend of "natural health preservation"; it supports multiple application scenarios such as aromatherapy, massage, and foot bath, meeting personalized needs at home, in the office, and while traveling.

[0039] f. Clinically validated efficacy: Non-clinical studies (mouse sleep function experiments) have confirmed that the compound essential oil of this invention can significantly prolong the sleep time induced by sodium pentobarbital in mice, increase the sleep onset rate induced by subthreshold doses of sodium pentobarbital, and shorten the sleep latency induced by phenobarbital, thus verifying its pharmacological activity in improving sleep. Attached Figure Description

[0040] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the following detailed description to explain the invention, but should not be construed as limiting the invention. In the drawings:

[0041] Figure 1 This is a schematic diagram showing the comparison of sleep status in mice after intervention with the compound essential oil of this invention;

[0042] Figure 2 This is a schematic diagram of the three-dimensional synergistic mechanism of the compound essential oils of the present invention.

[0043] Figure 1 In the figures, A and B show mice in a deep sleep state after using the compound essential oil of Example 1 of the present invention, which are characterized by curled-up bodies, relaxed postures, and steady breathing; C and D show mice in the blank control group in a conscious and active state. Detailed Implementation

[0044] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings, embodiments, comparative examples, and experimental data. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the scope of protection of the invention.

[0045] I. Preparation of Experimental Samples

[0046] 1. Preparation of samples (E1-E4) in the embodiments of the present invention

[0047] Test substances (single essential oils): Nardostachys jatamansi essential oil, Schisandra chinensis essential oil, Angelica sinensis essential oil, Rhodiola rosea essential oil, Neroli essential oil, Frankincense essential oil.

[0048] The aforementioned essential oils—Nardostachys chinensis, Frankincense, Schisandra chinensis, Neroli, Angelica sinensis, and Rhodiola rosea—are all single-ingredient essential oils prepared using conventional techniques in the field (such as steam distillation and supercritical CO2 extraction) and conforming to the Chinese Pharmacopoeia or relevant industry standards. The key to this invention lies in the combination and proportioning of these six specific single-ingredient essential oils.

[0049] According to the four different proportions shown in Table 1 (all within the scope of the claims of this invention), each high-purity single essential oil was accurately weighed and placed in a glass container. The mixture was stirred at a constant speed for 30 minutes at room temperature using a magnetic stirrer to ensure thorough mixing, thus obtaining compound essential oil samples E1-E4. E1 is a preferred embodiment of this invention.

[0050] Table 1: Formulation ratios of the embodiments of the present invention (volume parts refer to the volume ratio of each essential oil under standard atmospheric pressure and 25°C).

[0051] Components Example 1 (E1) Example 2 (E2) Example 3 (E3) Example 4 (E4) Nardostachys essential oil 9 8 10 9.5 Frankincense essential oil 1.5 1.0 2.0 1.3 Schisandra chinensis essential oil 11.25 10 12.5 11.5 Orange blossom essential oil 4.5 4.0 5.0 4.8 Angelica essential oil 1.5 1.0 2.0 1.2 Rhodiola rosea essential oil 7.5 7.0 8.0 7.8

[0052] 2. Preparation of Comparative Sample I (lacking a single component, CD1-CD6)

[0053] To verify the indispensability of the components, six comparative sample samples (CD: Component Deficient) were prepared. Each sample was strictly missing only one component listed in Table 2, while the types and amounts of the other five components were exactly the same as those in preferred embodiment E1.

[0054] Table 2: Comparative designs lacking a single component

[0055] Comparative numbering Missing specific components Simulate missing functional components CD1 Nardostachys essential oil Quickly calm and reduce anxiety CD2 Frankincense essential oil Neurotransmitter regulation and stabilization of sleep structure CD3 Schisandra chinensis essential oil Core benefits: calms the mind and soothes the nerves, prolongs deep sleep CD4 Orange blossom essential oil Emotional relief, regulation of the limbic system CD5 Angelica essential oil Nourishing blood and heart, improving microcirculation CD6 Rhodiola rosea essential oil Anti-fatigue and repair of nerve stress damage

[0056] 3. Preparation of Comparative Samples II (Ratios outside the scope of this invention, OR1-OR12): To rigorously verify the accuracy and criticality of the component proportion ranges defined in this invention, 12 comparative samples (OR: Out of Range) were prepared. For each sample, only one component was adjusted to a value outside the scope of the claims of this invention (insufficient or excessive), while the types and amounts of the other five components remained strictly consistent with E1, as detailed in Table 3.

[0057] Table 3: Comparative Design of Mixtures Exceeding Limits (Volume Parts)

[0058] serial number Variable components Set number of copies state serial number Variable components Set number of copies state OR1 spikenard 6 insufficient OR7 Orange blossom 3.0 insufficient OR2 spikenard 12 excess OR8 Orange blossom 6.0 excess OR3 mastic 0.5 insufficient OR9 Angelica sinensis 0.5 insufficient OR4 mastic 3.0 excess OR10 Angelica sinensis 3.0 excess OR5 Schisandra chinensis 8 insufficient OR11 Rhodiola rosea 5.0 insufficient OR6 Schisandra chinensis 14 excess OR12 Rhodiola rosea 10.0 excess

[0059] II. Systematic animal experimental verification

[0060] 1. Experimental Animals and Grouping: The experimental animals were SPF-grade ICR female mice, weighing 18-22g. After 3 days of acclimatization, they were randomly divided into 23 groups, with 10 mice in each group. The groups were as follows: blank control group (Ctrl, aspirating pure water), the embodiment group of this invention (E1-E4, 4 groups in total), the comparison group of the missing component (CD1-CD6, 6 groups in total), and the comparison group of the ratio exceeding the limit (OR1-OR12, 12 groups in total).

[0061] 2. Dosing regimen

[0062] Drug administration was performed using a self-made standardized acrylic aromatherapy box (68cm × 50cm × 42cm). Each experimental sample was diluted with pure water to a volume concentration of 0.5%, and an equal volume was added to an ultrasonic aromatherapy diffuser. Mice of the corresponding groups were placed in the aromatherapy box at a fixed time each day and inhaled the atomized sample for 1 hour in a sealed environment for 30 consecutive days. The control group inhaled pure water atomized gas in the same manner. Throughout the experiment, the animals had free access to food and water.

[0063] 3. Observation Indicators and Detection Methods

[0064] General condition and weight: Observe the animal’s behavior and physical signs daily, and weigh and record the weight at regular intervals each week (initially W0, W1-W4 in weeks 1, 2, 3 and 4).

[0065] Pentobarbital sodium sleep duration prolongation experiment: 30 minutes after the last administration, pentobarbital sodium solution was injected intraperitoneally at a dose of 40 mg / kg. Sleep time (in minutes) was defined as the time from the disappearance to the recovery of the righting reflex in mice. To comply with animal experimental ethics and prevent the risk of pentobarbital sodium overdose, sleep time exceeding 180 minutes was counted as 180 minutes.

[0066] Subthreshold dose-induced hypnosis experiment with sodium pentobarbital: 30 minutes after the last administration, sodium pentobarbital solution was injected intraperitoneally at a dose of 32 mg / kg. The number of mice whose righting reflex was absent for more than 60 seconds within the following 30 minutes was recorded, and the sleep induction rate was calculated.

[0067] Phenobarbital sodium sleep latency test: Phenobarbital sodium solution was injected intraperitoneally at a dose of 180 mg / kg 30 minutes after the last administration. The time required from the start of injection to the disappearance of the righting reflex in mice for 60 seconds was recorded as the sleep latency (minutes).

[0068] 4. Statistical Methods

[0069] Experimental data are expressed as mean ± standard deviation. Statistical analysis was performed using software. For continuous data, normality and homogeneity of variance were first tested. For data meeting the criteria, one-way ANOVA and LSD method were used for pairwise comparisons; for data not meeting the criteria, the nonparametric Kruskal-Wallis test and Dunnett's T3 method were used. For categorical data (sleep onset rate), the chi-square test was used. A p-value < 0.05 was considered statistically significant, and a p-value < 0.01 was considered highly statistically significant.

[0070] III. Data Results and Analysis of All Experimental Groups

[0071] 1. Effects on mouse body weight (long-term safety indicator): Table 4 lists the final body weight data of all experimental groups (23 groups in total) and their statistical comparison results with the blank control group. This indicator is used to assess the safety of long-term use.

[0072] Table 4: Final body weight and safety analysis of mice in all experimental groups (g, mean ± standard deviation, n=10)

[0073]

[0074] Analysis: The data clearly show that there was no statistically significant difference in final body weight between all embodiments of the present invention (E1-E4) and the blank control group (P>0.05), proving that long-term use within the formulation range of the claims of the present invention is safe. However, some comparative examples showed significant weight loss (P<0.05), mainly concentrated in two categories: ① lack of core calming components (CD3 lacking Schisandra chinensis, CD5 lacking Angelica sinensis); ② serious imbalance in the proportions of key components, especially when overdosed (OR2 excessive Nardostachys jatamansi, OR6 excessive Schisandra chinensis, OR8 excessive Orange blossom, OR10 excessive Angelica sinensis), as well as insufficient Nardostachys jatamansi (OR1) and insufficient Schisandra chinensis (OR5). This conversely proves that the complete components and precise proportions determined by the present invention are key to maintaining the long-term safety of the product.

[0075] 2. Effects on mouse sleep function (core efficacy indicators) Table 5 lists the specific data of all experimental groups in the three sleep function experiments, and comprehensively demonstrates the differences in efficacy.

[0076] Table 5: Effects of all experimental groups on sleep function in mice

[0077]

[0078]

[0079] (Note: * indicates P<0.05 compared with the blank control group; ** indicates P<0.01.)

[0080] Detailed analysis and creative argumentation:

[0081] The superior and comprehensive efficacy of the embodiments of this invention: Data clearly shows that all four embodiments of this invention (E1-E4) exhibit highly consistent and significant improvements in the three core sleep indicators. Specifically, the sleep duration extension and sleep latency were significantly improved compared to the blank control group (P<0.01); the sleep onset rate was also significantly improved (P<0.05). This proves that within the ratio range defined in claim 1 of this invention, a comprehensive and effective sleep improvement effect can be stably reproduced, with the preferred embodiment E1 showing the best data.

[0082] The comparative examples of "missing components" (CD1-CD6) confirm the necessity and synergy of the components: all comparative examples lacking a single component showed overall efficacy that was significantly inferior to the embodiments of the present invention. Specifically:

[0083] The CD3 (without Schisandra chinensis) and CD5 (without Angelica sinensis) results were the worst, with many indicators approaching those of the blank control group, indicating near-ineffectiveness. This proves that Schisandra chinensis (the core ingredient for calming the mind and soothing the nerves) and Angelica sinensis (the foundation for nourishing blood and the heart) play an irreplaceable supporting role in this invention.

[0084] CD1 (without spikenard) and CD4 (without neroli) primarily affect sleep latency and sleep onset rate, verifying their crucial role in the "rapid sleep initiation" process.

[0085] CD2 (without frankincense) and CD6 (without rhodiola rosea) showed a significantly weakened effect on prolonging sleep time, reflecting their function in the "maintaining and deepening sleep" stage.

[0086] Conclusion: The effects of the six components are not simply additive, but rather form a synergistic network where each component is interconnected and indispensable. The absence of any one component will cause the network to collapse, significantly reducing the overall effect. This synergistic effect resulting from this specific combination is not obvious to those skilled in the art.

[0087] The "out-of-range" comparative examples (OR1-OR12) confirm the accuracy and criticality of the proportions: this data provides more in-depth evidence of inventive step. It demonstrates that even when all six essential components are retained, simply changing the amount of one of them, once outside the narrow range described in this invention, fails to achieve optimal results.

[0088] Taking Schisandra chinensis as an example (verifying the scope of the claims: 10-12.5 parts):

[0089] OR5 (8 copies, insufficient): The effect is similar to CD3 (completely missing), which is extremely poor, proving that "10 copies" is the necessary lower limit for effectiveness.

[0090] OR6 (14 doses, overdose): While the effect (18.9 min, 55%) was better than that of the underdose, it was significantly lower than that of the embodiments within the scope of this invention (e.g., E1: 29.2 min, 80%), and there was a safety risk (weight loss). This demonstrates that "12.5 doses" is the upper limit that balances efficiency and safety.

[0091] Taking spikenard as an example (verifying the scope of claims 8-10):

[0092] OR1 (6 portions, insufficient) was ineffective.

[0093] OR2 (12 servings, overdose) showed better efficacy (22.1 min, 65%) than underdose, but still lower than E1, and resulted in a significant reduction in body weight. This suggests that 8-10 servings is the optimal window.

[0094] A recurring pattern was observed: OR2, OR4, OR8, OR10, and OR12 (all "excessive" groups) generally exhibited a pattern of "some indicators being effective, but the overall effect being inferior to E1, and often accompanied by safety concerns." This indicates that while excessive use may produce strong stimuli on certain single pathways, it disrupts the system's balance and fails to achieve the safe, synergistic, and comprehensive superior effects of the optimal ratio of this invention.

[0095] Visual evidence of sleep state: such as Figure 1 As shown, Figure 1 This diagram illustrates the comparison of sleep states in mice after intervention with the compound essential oil of this invention. Figures A and B show mice in a deep sleep state after using the compound essential oil of Example 1 of this invention, exhibiting a curled-up body, relaxed posture, and stable breathing. Figures C and D show mice in the blank control group in an active, awake state. The mice in Example 1 (A and B) exhibited a typical deep sleep state (curled-up body, relaxed posture) after intervention, contrasting sharply with the active, awake state of the blank control mice (C and D). This provides intuitive visual evidence for the aforementioned quantitative data and vividly demonstrates the sleep-aiding effect of the compound essential oil of this invention. The comparison shows that the compound essential oil can significantly improve the sleep state of mice, providing intuitive experimental evidence for clinical efficacy. This invention has been verified through non-clinical studies (mouse sleep function experiments). The dosage of each component, the compatibility logic, and the application method all possess scientific validity and innovation, enabling industrial application in the field of sleep improvement.

[0096] Mechanism of compound essential oil formulation:

[0097] like Figure 2 As shown, the formulation of this invention follows the logic of "integration of traditional Chinese and Western medicine, three-dimensional regulation":

[0098] 1. Neuromodulation Layer (Symptomatic Relief): Nardostachys jatamansi essential oil quickly calms anxiety and reduces sympathetic nerve excitability; neroli essential oil regulates the limbic system of the brain, soothes emotional disturbances, and creates a relaxed mood. The two work together to create the neural conditions for falling asleep quickly.

[0099] 2. Circulation and Material Foundation Layer (Strengthening the Foundation): Angelica sinensis essential oil nourishes the blood and heart, improves microcirculation in the heart and brain, and provides the material foundation for "the heart governing the mind"; Rhodiola rosea essential oil combats fatigue and repairs nerve stress damage. The two work synergistically to improve physiological depletion caused by long-term sleep deprivation.

[0100] 3. Synergistic and Integrative Effects (Enhanced Efficacy): Schisandra chinensis essential oil serves as the core, calming the mind and soothing the nerves; modern research has confirmed its ability to prolong deep sleep cycles. Frankincense essential oil promotes blood circulation and regulates inhibitory neurotransmitters such as GABA in the brain, stabilizing sleep structure. These two ingredients work synergistically and interact with the components in the first two layers to achieve a comprehensive intervention from "promoting sleep onset" to "improving sleep depth and quality."

[0101] In conclusion, this invention provides a compound essential oil composed of six specific essential components (Nardostachys jatamansi, Frankincense, Schisandra chinensis, Neroli oleracea, Angelica sinensis, and Rhodiola rosea) combined within a precisely defined volume ratio range. This compound essential oil produces an unexpected synergistic effect, achieving a comprehensive and safe improvement in sleep. Systematic comparative experiments (CD1-CD6, OR1-OR12) rigorously demonstrated, with detailed data, the necessity and non-obviousness of the six-component combination from two dimensions: "component absence" and "ratio deviation." 2. The precision, criticality, and optimization of the stated ratio range. These constitute the outstanding substantive features and significant technical advancements of this invention, demonstrating a high degree of inventiveness.

[0102] IV. Application Examples

[0103] Sleep-aiding aromatherapy liquid: Take 3-5 drops of the compound essential oil prepared in Example 1 of this invention, add it to an aromatherapy diffuser with water, and diffuse it in the bedroom 1 hour before bedtime for 1-2 hours.

[0104] Calming Massage Oil: Take 5 drops of the compound essential oil prepared in Example 1 of this invention and mix it evenly with 10 ml of jojoba oil. Before bedtime, apply an appropriate amount to the inside of the wrists, temples, Tanzhong acupoint, and Yongquan acupoint on the soles of the feet, and massage gently for 5-10 minutes.

[0105] Soothing foot bath solution: Add 3 drops of the compound essential oil prepared in Example 1 of this invention to 3 liters of warm water at about 40°C, stir well and soak your feet for 15-20 minutes.

[0106] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A sleep-improving compound essential oil, characterized by, consists of the following volume parts of single essential oils: Essential oil of Gancao 8-10 parts; Essential oil of Ru Xiang 1.0-2.0 parts; Essential oil of Wuweizi 10-12.5 parts; Essential oil of Orange flower 4.0-5.0 parts; Essential oil of Danggui 1.0-2.0 parts; Essential oil of Hongjingtian 7.0-8.0 parts.

2. The sleep-improving compound essential oil according to claim 1, characterized by, consists of the following volume parts of single essential oils: Essential oil of Gancao 9 parts, Essential oil of Ru Xiang 1.5 parts, Essential oil of Wuweizi 11.25 parts, Essential oil of Orange flower 4.5 parts, Essential oil of Danggui 1.5 parts, Essential oil of Hongjingtian 7.5 parts.

3. A method of preparing the sleep-improving compound essential oil according to claim 1 or 2, characterized by, comprises the following steps: weighing each single essential oil according to the ratio, mixing and stirring until uniform.

4. The method of claim 3, wherein, The stirring time is 20-40 minutes.

5. Use of the compound essential oil for improving sleep according to claim 1 or 2 in the preparation of a product for improving sleep.

6. Use according to claim 5, characterized in that, The improvement of sleep includes shortening of sleep latency, prolonging of sleep time and / or improving sleep stability.

7. Use according to claim 5, characterized in that, The product is an external preparation.

8. Use according to claim 7, characterized in that, The external preparation is a fragrance liquid, a massage oil, a foot bath liquid, a sleep-aiding spray or a fragrance candle.

9. A sleep-improving aromatherapy liquid, characterized by, The product comprises the compound essential oil for improving sleep according to claim 1 or 2 and water or a volatile solvent.

10. A massage oil for improving sleep, characterized by, The product comprises the compound essential oil for improving sleep according to claim 1 or 2 and a skin-friendly base oil.

Images