Plaster for treating facial paralysis and preparation method thereof
By optimizing the combination of traditional Chinese medicine and the extraction process, the prepared plaster significantly improved the cure rate of facial paralysis, solved the problems of low cure rate and long treatment cycle in existing treatments, and achieved a highly effective treatment for facial paralysis.
Patent Information
- Application Number
- CN202610138722.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-31
- Publication Date
- 2026-03-20
AI Technical Summary
Existing traditional Chinese medicine plasters for treating facial paralysis have low cure rates and lengthy treatment cycles, while Western medicine treatments are ineffective, difficult to cure, and often result in sequelae.
A combination of traditional Chinese medicines, including Saposhnikovia divaricata, Ligusticum chuanxiong, Lonicera japonica, Buthus martensii, Bombyx mori, Indigo naturalis powder, Litharge, and Rosin, was used. L-proline and D-mannitol were used as extraction agents. The ointment was prepared through ultrasonication, adsorption resin purification, and frying processes to improve the purity and yield of Lonicera japonica extract.
It significantly improves the cure rate of facial paralysis, shortens the treatment cycle, reduces side effects, and improves the quality of life for patients.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a plaster for treating facial paralysis and its preparation method. Background Technology
[0002] In Western medicine, facial paralysis is divided into two types: Bell's palsy, also known as idiopathic facial paralysis, and Hunter's syndrome, which is caused by herpes simplex virus infection of the facial nerve in the ear. It mainly manifests as paralysis of the facial muscles on the affected side, a crooked mouth, incomplete eyelid closure, air leakage when puffing out the cheeks, and choking while eating. It not only severely affects the patient's facial appearance and daily physiological functions but also easily leads to psychological problems such as low self-esteem and anxiety, reducing their quality of life.
[0003] The principle of Western medicine treatment for idiopathic facial paralysis is to combine hormone therapy with nerve nutrition and microcirculation improvement, supplemented by acupuncture and massage, with a cure rate of 20% to 30%. If it is Hunter syndrome, antiviral drugs are required, the treatment cycle is longer (6 to 8 months), the effect is poor, it is difficult to cure, and sequelae are common, with a cure rate of around 20%. In the field of traditional Chinese medicine treatment for facial paralysis, acupuncture, massage, and acupoint embedding are widely used, but these therapies generally have the drawbacks of long treatment cycles and slow onset of action, with the clinical routine treatment cycle often being 4 to 6 months. Meanwhile, although many traditional Chinese medicine plasters for treating facial paralysis have emerged on the market, the clinical efficacy of most products is unsatisfactory. Therefore, there is an urgent need for a plaster with significant therapeutic effects and a high cure rate for facial paralysis. Summary of the Invention
[0004] This invention proposes a plaster for treating facial paralysis and its preparation method, which solves the problem of low cure rate of plasters for treating facial paralysis in related technologies.
[0005] The technical solution of the present invention is as follows: This invention proposes a plaster for treating facial paralysis, comprising the following raw materials in parts by weight: 4-6 parts of Saposhnikovia divaricata, 4-6 parts of Ligusticum chuanxiong, 6-9 parts of Lonicera japonica, 2-4 parts of Buthus martensii, 2-4 parts of Bombyx mori, 2-4 parts of Indigo naturalis powder, 6-9 parts of Litharge, 13-17 parts of Rosin, and 4-7 parts of Charcoal powder.
[0006] As a further technical solution, the preparation method of the plaster for treating facial paralysis includes the following steps: S1. Honeysuckle is dried, pulverized, and sieved to obtain honeysuckle powder. The honeysuckle powder is added to the extractant, ultrasonicated, and filtered to obtain honeysuckle extract. S2. The honeysuckle extract was purified by macroporous adsorption resin to obtain an eluent, which was then dried to obtain the honeysuckle extract. S3. Heat sesame oil to 130~150℃, add saposhnikovia root and chuanxiong rhizome, fry until crispy, remove, then add scorpion and silkworm, fry a second time, remove, turn off the heat, add indigo powder, litharge, rosin, charcoal powder, honeysuckle extract, stir, cool, spread on cotton cloth, to obtain the plaster for treating facial paralysis.
[0007] As a further technical solution, the extractant is composed of L-proline and D-mannitol.
[0008] In this invention, by using L-proline and D-mannitol as extraction agents, the purity and yield of honeysuckle extract are improved. L-proline itself has antioxidant activity, which can scavenge free radicals generated during the extraction process and prevent the phenolic hydroxyl groups in honeysuckle from being oxidized and destroyed, thereby ensuring the chemical stability and purity of the extract. D-mannitol, as a polyol, can bind to the active ingredients in honeysuckle through hydrogen bonds. The eutectic solvent formed by L-proline and D-mannitol can bind to chlorogenic acid molecules through hydrogen bonds, significantly enhancing the solubility and selectivity of chlorogenic acid. Thus, while improving the extraction yield, it reduces the dissolution of impurities and improves the purity of the product.
[0009] As a further technical solution, the molar ratio of L-proline to D-mannitol is 1:2~3.
[0010] As a further technical solution, the preparation method of the extractant includes the following steps: mixing L-proline and D-mannitol, adding water, and stirring to obtain the extractant.
[0011] As a further technical solution, the stirring temperature is 70~80℃ and the stirring time is 20~30min.
[0012] As a further technical solution, the mass-to-volume ratio of honeysuckle and extractant is 1g:12~14mL.
[0013] As a further technical solution, the temperature of the ultrasound is 40~50℃, and the duration of the ultrasound is 50~60min.
[0014] As a further technical solution, the macroporous adsorption resin is one of NKA-II, AB-8 and X-5; Preferably, the macroporous adsorption resin is of type NKA-II.
[0015] As a further technical solution, the secondary frying time is 3-5 minutes.
[0016] As a further technical solution, the mass-to-volume ratio of the saposhnikovia root and sesame oil is 1g:10~14mL.
[0017] The present invention also proposes the application of a plaster for treating facial paralysis or a plaster for treating facial paralysis prepared by the aforementioned preparation method in the treatment of facial paralysis.
[0018] The working principle and beneficial effects of this invention are as follows: In this invention, the cure rate of facial paralysis is improved by optimizing the formula components. Fangfeng (Saposhnikovia divaricata) can dispel wind from the surface and relieve dampness and pain, responsible for removing wind-evil invading the facial meridians. Chuanxiong (Ligusticum striatum) can ascend to the head and eyes, invigorate blood and qi, dispel wind and relieve pain, improve facial microcirculation, and provide nutrition to nerve and muscle tissues. Jinyinhua (Lonicera japonica) can clear heat toxins from the face and reduce inflammation and edema of the facial nerves. Quanxie (Scorpion) specifically enters the liver meridian and has a strong penetrating power for stubborn wind-evil and spasms. Jiangcan (Bombyx mori) can dispel wind, calm the nerves, resolve phlegm, and dissipate nodules. Qingdai (Indigofera tinctoria) has a strong effect of clearing heat and detoxifying, cooling blood and reducing swelling, which can assist Jinyinhua in clearing facial heat stagnation, preventing heat-toxin reactions at the plaster application site, and helping to reduce congestion and edema of nerve tissue. Rosin serves as the main matrix. It has the characteristics of strong adhesion and good breathability, which allows the medicine to adhere to the skin for a long time. Huangdan not only serves as an excipient, but also has the effects of detoxification, tissue regeneration, insecticidal and antipruritic effects, which helps to draw out toxins from the face. The combined use of various medicines treats both the symptoms and the root cause, improving the cure rate of facial paralysis. In addition, the formula of this invention also includes charcoal powder. Charcoal powder has a huge specific surface area and adsorption capacity. In the plaster, it can adsorb the sweat and oil excreted by the facial skin, keep the application site dry, and prevent allergies and infections. At the same time, the porous structure of charcoal powder helps the sustained release and transdermal absorption of drug molecules. Therefore, the addition of charcoal powder further improves the cure rate of facial paralysis. Detailed Implementation
[0019] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.
[0020] Example 1 A plaster for treating facial paralysis includes the following ingredients in parts by weight: 4 parts of Saposhnikovia divaricata, 4 parts of Ligusticum chuanxiong, 6 parts of Lonicera japonica, 2 parts of Buthus martensii, 2 parts of Bombyx mori, 2 parts of Indigo naturalis powder, 6 parts of Litharge, 13 parts of Rosin, and 4 parts of Charcoal powder. The preparation method of the extractant includes the following steps: L-proline and D-mannitol are mixed in a molar ratio of 1:2, water is added, and the mixture is stirred at 70°C for 30 minutes to obtain the extractant, wherein the water content is 30 wt%. A method for preparing a plaster for treating facial paralysis includes the following steps: S1. Honeysuckle is dried, pulverized, and passed through a 40-mesh sieve to obtain honeysuckle powder. The honeysuckle powder is added to the extractant, and the mass-volume ratio of honeysuckle to extractant is 1g:12mL. The mixture is sonicated at 40℃ for 60min and filtered to obtain honeysuckle extract. S2. Add anhydrous ethanol to the honeysuckle extract for dilution (the volume ratio of honeysuckle extract to anhydrous ethanol is 1:1). After adsorption by macroporous adsorption resin NKA-II, elute with a 70% ethanol aqueous solution to obtain the eluent. Dry the eluent to obtain the honeysuckle extract. S3. Heat the sesame oil to 130℃, add 4 parts of Saposhnikovia divaricata and 4 parts of Ligusticum chuanxiong, fry until crispy, remove, then add 2 parts of scorpion and 2 parts of silkworm, fry a second time for 5 minutes, remove, turn off the heat, add 2 parts of indigo powder, 6 parts of litharge, 13 parts of rosin, 4 parts of charcoal powder, and honeysuckle extract made from 6 parts of honeysuckle, stir until uniform, cool, spread on cotton cloth to obtain a plaster for treating facial paralysis, wherein the mass-volume ratio of Saposhnikovia divaricata and sesame oil is 1g:10mL.
[0021] Example 2 A plaster for treating facial paralysis includes the following ingredients in parts by weight: 6 parts of Saposhnikovia divaricata, 6 parts of Ligusticum chuanxiong, 9 parts of Lonicera japonica, 4 parts of Buthus martensii, 4 parts of Bombyx mori, 4 parts of Indigo naturalis powder, 9 parts of Litharge, 17 parts of Rosin, and 7 parts of Charcoal powder. The preparation method of the extractant includes the following steps: L-proline and D-mannitol are mixed in a molar ratio of 1:3, water is added, and the mixture is stirred at 80°C for 20 minutes to obtain the extractant, wherein the water content is 30 wt%. A method for preparing a plaster for treating facial paralysis includes the following steps: S1. Honeysuckle is dried, pulverized, and passed through a 40-mesh sieve to obtain honeysuckle powder. The honeysuckle powder is added to the extractant, and the mass-volume ratio of honeysuckle to extractant is 1g:14mL. The mixture is sonicated at 50℃ for 50min and then filtered to obtain honeysuckle extract. S2. Add anhydrous ethanol to the honeysuckle extract for dilution (the volume ratio of honeysuckle extract to anhydrous ethanol is 1:1). After adsorption by macroporous adsorption resin NKA-II, elute with a 70% ethanol aqueous solution to obtain the eluent. Dry the eluent to obtain the honeysuckle extract. S3. Heat the sesame oil to 150℃, add 6 parts of Saposhnikovia divaricata and 6 parts of Ligusticum chuanxiong, fry until crispy, remove, then add 4 parts of scorpion and 4 parts of silkworm, fry a second time for 3 minutes, remove, turn off the heat, add 4 parts of indigo powder, 9 parts of litharge, 17 parts of rosin, 7 parts of charcoal powder, and 9 parts of honeysuckle extract made from honeysuckle, stir until uniform, cool, spread on cotton cloth to obtain a plaster for treating facial paralysis, wherein the mass-volume ratio of Saposhnikovia divaricata and sesame oil is 1g:14mL.
[0022] Example 3 A plaster for treating facial paralysis includes the following ingredients in parts by weight: 5 parts of Saposhnikovia divaricata, 5 parts of Ligusticum chuanxiong, 7 parts of Lonicera japonica, 3 parts of Buthus martensii, 3 parts of Bombyx mori, 3 parts of Indigo naturalis powder, 7 parts of Litharge, 15 parts of Rosin, and 5 parts of Charcoal powder. The preparation method of the extractant includes the following steps: L-proline and D-mannitol are mixed in a molar ratio of 1:2.5, water is added, and the mixture is stirred at 75°C for 25 minutes to obtain the extractant, wherein the water content is 30 wt%. A method for preparing a plaster for treating facial paralysis includes the following steps: S1. Honeysuckle is dried, pulverized, and passed through a 40-mesh sieve to obtain honeysuckle powder. The honeysuckle powder is added to the extractant, and the mass-volume ratio of honeysuckle to extractant is 1g:13mL. The mixture is sonicated at 45℃ for 55min and filtered to obtain honeysuckle extract. S2. Add anhydrous ethanol to the honeysuckle extract for dilution (the volume ratio of honeysuckle extract to anhydrous ethanol is 1:1). After adsorption by macroporous adsorption resin NKA-II, elute with a 70% ethanol aqueous solution to obtain the eluent. Dry the eluent to obtain the honeysuckle extract. S3. Heat the sesame oil to 140℃, add 5 parts of Saposhnikovia divaricata and 5 parts of Ligusticum chuanxiong, fry until crispy, remove, then add 3 parts of scorpion and 3 parts of silkworm, fry a second time for 4 minutes, remove, turn off the heat, add 3 parts of indigo powder, 7 parts of litharge, 15 parts of rosin, 5 parts of charcoal powder, and honeysuckle extract made from 7 parts of honeysuckle, stir until uniform, cool, spread on cotton cloth to obtain a plaster for treating facial paralysis, wherein the mass-volume ratio of Saposhnikovia divaricata and sesame oil is 1g:12mL.
[0023] Example 4 The only difference between this embodiment and Example 3 is that L-proline is replaced with betaine.
[0024] Example 5 The only difference between this embodiment and Example 3 is that D-mannitol is replaced with L-lactic acid.
[0025] Example 6 The only difference between this embodiment and Embodiment 3 is that D-mannitol is replaced with xylitol.
[0026] Example 7 The only difference between this embodiment and Embodiment 3 is that D-mannitol is replaced with malic acid.
[0027] Comparative Example 1 The only difference between this comparative example and Example 3 is that charcoal powder is not added.
[0028] Experimental Example 1 The purity of the honeysuckle extracts obtained in Examples 1-7 was tested, and the purity was calculated based on the chlorogenic acid content in the honeysuckle extracts, and the yield was also calculated. Yield = mass of honeysuckle extract × purity / mass of chlorogenic acid in honeysuckle × 100%, the results are shown in Table 1 below; Table 1. Purity and yield of honeysuckle extract
[0029] By comparing the data from Examples 1-3 and Examples 4-7, it was found that Examples 1-3, by using L-proline and D-mannitol as eutectic solvents, had higher purity and yield of honeysuckle extract than Examples 4-7. This indicates that using L-proline and D-mannitol as eutectic solvents can improve the purity and yield of honeysuckle extract.
[0030] Application Example 1 The plasters for treating facial paralysis prepared in Example 3 and Comparative Example 1 were used in a clinical efficacy study: Two hundred patients with facial paralysis who met the diagnostic criteria were selected and randomly divided into an experimental group and a control group, with 100 patients in each group. Patients in the experimental group applied the facial paralysis treatment plaster prepared in Example 3, while patients in the control group applied the plaster prepared in Comparative Example 1. The application sites for both groups were bilateral temples and Fengchi acupoints. The application method was continuous application, with 14 days as one course of treatment. Both groups applied the plaster for two consecutive courses. During the treatment period, all other oral and topical medications and physical therapies for facial paralysis were discontinued. Changes in patients' symptoms were recorded. The clinical treatment results are shown in Table 2 below; Table 2 Clinical treatment results
[0031] By comparing the data in Table 2, the total effective rate of the experimental group was 92%, of which the clinical cure rate (complete disappearance of symptoms and normal facial function) was 78% and the significant efficacy rate (significant improvement of symptoms, basic recovery of facial function, and only slight asymmetry) was 14%; the total effective rate of the control group was 65%, of which the clinical cure rate was 42% and the significant efficacy rate was 23%. This shows that the formulas in Examples 1-3 have a good curative effect on facial paralysis.
[0032] Typical clinical trial case: After applying the plaster prepared in Example 3, Ms. Lü experienced significant recovery of facial muscle function on the affected side after two courses of treatment (28 days). Her eyelids could close completely, the corners of her mouth returned to their normal positions, and her facial symmetry was good, meeting the clinical cure criteria.
[0033] After applying the plaster prepared in Example 3, Mr. Bai's oral function was fully restored after two courses of treatment (28 days). His mouth corners returned to normal, he could easily close his lips, perform actions such as pursing his lips flexibly, speak clearly, and his facial muscle tension returned to normal, thus meeting the clinical cure standard.
[0034] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.
Claims
1. A plaster for treating facial paralysis, characterized in that, The ingredients include the following components by weight: 4-6 parts of Saposhnikovia divaricata, 4-6 parts of Ligusticum chuanxiong, 6-9 parts of Lonicera japonica, 2-4 parts of Buthus martensii, 2-4 parts of Bombyx mori, 2-4 parts of Indigo naturalis powder, 6-9 parts of Litharge, 13-17 parts of Rosin, and 4-7 parts of Charcoal powder.
2. A method for preparing a plaster for treating facial paralysis, used to prepare the plaster for treating facial paralysis as described in claim 1, characterized in that, Includes the following steps: S1. Honeysuckle is dried, pulverized, and sieved to obtain honeysuckle powder. The honeysuckle powder is added to the extractant, ultrasonicated, and filtered to obtain honeysuckle extract. S2. The honeysuckle extract was purified by macroporous adsorption resin to obtain an eluent, which was then dried to obtain the honeysuckle extract. S3. Heat sesame oil to 130~150℃, add saposhnikovia root and chuanxiong rhizome, fry until crispy, remove, then add scorpion and silkworm, fry a second time, remove, turn off the heat, add indigo powder, litharge, rosin, charcoal powder, honeysuckle extract, stir, cool, spread on cotton cloth, to obtain the plaster for treating facial paralysis.
3. The method for preparing a plaster for treating facial paralysis according to claim 2, characterized in that, The extractant consists of L-proline and D-mannitol.
4. The method for preparing a plaster for treating facial paralysis according to claim 3, characterized in that, The molar ratio of L-proline to D-mannitol is 1:2~3.
5. The method for preparing a plaster for treating facial paralysis according to claim 3, characterized in that, The preparation method of the extractant includes the following steps: mixing L-proline and D-mannitol, adding water, and stirring to obtain the extractant.
6. The method for preparing a plaster for treating facial paralysis according to claim 2, characterized in that, The stirring temperature is 70~80℃, and the stirring time is 20~30min.
7. The method for preparing a plaster for treating facial paralysis according to claim 2, characterized in that, The mass-to-volume ratio of honeysuckle to extract is 1g:12~14mL.
8. The method for preparing a plaster for treating facial paralysis according to claim 2, characterized in that, The temperature of the ultrasound is 40~50℃, and the duration of the ultrasound is 50~60min.
9. A method for preparing a plaster for treating facial paralysis according to claim 2, characterized in that, The second frying time is 3-5 minutes.
10. The application of the plaster for treating facial paralysis according to claim 1 or the plaster for treating facial paralysis prepared by the preparation method according to claims 2-9 in the treatment of facial paralysis.