Bionic stomach micro-fluidic chip based on liquid drop micro-fluidic control and mechanical force stimulation and application of bionic stomach micro-fluidic chip

By combining droplet microfluidic technology with mechanical stimulation, monodisperse droplets are generated and periodic compression is applied, which solves the problem of insufficient mechanical shear force of chyme boluses in the stomach in existing microfluidic chips, and realizes high-throughput and highly biomimetic gastric digestion simulation.

CN121869481APending Publication Date: 2026-04-17WUHAN TEXTILE UNIV
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Patent Information

Application Number
CN202511933187.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-19
Publication Date
2026-04-17

AI Technical Summary

Technical Problem

Existing microfluidic gastric chips are insufficient in simulating the mechanical shearing force of chyme boluses in the stomach and have low throughput, making them difficult to effectively apply to the simulation of digestion processes in complex chemical microenvironments and dynamic physical fields.

Method used

Monodisperse water-in-oil droplets are generated using droplet microfluidic technology, and periodic mechanical extrusion is applied in the flow channel to simulate the shear force caused by gastric peristalsis. By combining the droplet generation module and the mechanical force stimulation module, highly biomimetic gastric digestion simulation is achieved.

Benefits of technology

It achieves high-throughput, low-consumption simulation of gastric digestion, accurately replicating the mechanical kneading effect of gastric peristalsis on the chyme bolus, thus improving the physiological relevance and efficiency of the simulation.

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Abstract

The invention provides a bionic stomach micro-fluidic chip based on liquid drop micro-fluidic control and mechanical force stimulation and application of the bionic stomach micro-fluidic chip. The bionic stomach micro-fluidic chip comprises a liquid drop generation module and a mechanical force stimulation module. The liquid drop generation module is used for dispersing artificial stomach digestive juice and a to-be-digested Newtonian fluid sample in an oil phase by utilizing a micro-fluidic chip structure to form monodispersed water-in-oil liquid drops to simulate a discrete chyme group; and the mechanical force stimulation module is provided with a micro-channel with a periodically variable cross section. When liquid drops flow through the flow channel, the liquid drops are extruded and deformed periodically, a complex flow field is generated in the liquid drops, and the mechanical kneading effect of stomach wall wriggling on chyme balls is simulated. By limiting biochemical reaction in micro-droplets and applying controllable physical shear force, collaborative high-fidelity simulation of chemical and mechanical effects in the gastric digestion process is realized, and the problems that a traditional static model is low in simulation degree and large dynamic equipment is low in flux and high in cost are solved. And a brand new high-throughput research platform is provided for the fields of food and medicine.
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