Traditional Chinese medicine composition for treating dizziness caused by large vestibular aqueduct syndrome as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating dizziness caused by large vestibular aqueduct syndrome as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from mother-of-pearl, oyster, concha haliotidis, poria peel, polyporus umbellatus, cortex mori radicis, semen plantaginis, rhizoma sparganii, dianthus superbus, rhizoma acori graminei and honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying spleen and inducing diuresis, and tonifying kidney and reinforcing primordial qi, and is mainly used for treating patients with dizziness caused by the large vestibular aqueduct syndrome. Compared with western medicine glucocorticoid, the traditional Chinese medicine composition has the advantages that the adverse reaction is few, the health risk is reduced, and the treatment tolerance and compliance of patients are improved. A standardized scheme for treating dizziness caused by the large vestibular aqueduct syndrome through traditional Chinese medicine is formed, clinical popularization is facilitated, more patients are benefited, a reference basis is provided for follow-up research, and related medical research is promoted.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating vertigo caused by large vestibular aqueduct syndrome, its preparation method, and its uses. Background Technology

[0002] Large Vestibular aqueduct syndrome (LVAS) is a congenital, hereditary inner ear malformation-related hearing impairment discovered in the late 1970s. It is an autosomal recessive inherited hearing disorder characterized by enlargement of the vestibular aqueduct accompanied by sensorineural hearing loss (SNHL). Clinically, it manifests primarily as sensorineural hearing loss, mainly at the high frequencies, often ranging from severe to profound hearing loss. It may be accompanied by recurrent episodes of tinnitus or vertigo, among other clinical symptoms. Onset is typically in childhood, often preceded by factors that increase intracranial pressure, such as colds, fevers, or trauma.

[0003] The pathogenesis of LVAS-induced vertigo is currently unclear, and safe and effective treatment remains a challenge in clinical practice. For vertigo symptoms, the main clinical treatment options are as follows: (1) Western medicine hormone therapy: This generally involves using drugs such as glucocorticoids to reduce potential inflammatory reactions in the inner ear and improve the inner ear environment through their anti-inflammatory and immunosuppressive effects, thereby alleviating symptoms such as hearing loss caused by inner ear lesions to some extent. It may also have some effect on vertigo symptoms. However, this method has certain side effects, such as long-term use of large doses of glucocorticoids causing gastrointestinal reactions, increased blood sugar and blood pressure, increased risk of infection, osteoporosis, etc., with an incidence rate as high as 28%; and the efficacy is unstable, failing to fundamentally solve the problem of inner ear lesions; (2) Integrated traditional Chinese and Western medicine treatment: This usually involves combining some traditional Chinese medicine therapies, such as oral Chinese medicine and acupuncture, on the basis of conventional Western medicine treatment, to improve inner ear function and alleviate symptoms such as vertigo. However, this method currently lacks standardization, and research on LVAS vertigo attacks in the field of traditional Chinese medicine has been largely nonexistent.

[0004] Through years of theoretical research and clinical practice, our team has developed a standardized TCM treatment plan for LVAS vertigo, based on the principles of strengthening the spleen and promoting diuresis, and tonifying the kidneys and nourishing the body's vital energy. This invention combines the patient's clinical manifestations with CT and MRI imaging characteristics for diagnosis and treatment, aiming to overcome the shortcomings of existing treatments. Through clinical follow-up and objective evaluation of its vertigo-relieving effect, it has developed a highly effective method for controlling LVAS vertigo. Summary of the Invention

[0005] To fill the gap in the prior art, the present invention provides a traditional Chinese medicine composition for treating vertigo caused by large vestibular aqueduct syndrome, its preparation method and uses.

[0006] Specifically, the present invention is achieved through the following technical solutions: In a first aspect, the present invention provides a traditional Chinese medicine composition for treating vertigo caused by large vestibular aqueduct syndrome, the traditional Chinese medicine composition being made from the following raw materials in parts by weight: 1-30 parts of mother-of-pearl, 1-25 parts of oyster shell, 1-30 parts of abalone shell, 1-25 parts of poria cocos peel, 1-25 parts of polyporus umbellatus, 1-25 parts of mulberry bark, 1-25 parts of plantain seed, 1-25 parts of sparganium rhizome, 1-25 parts of dianthus superbus, 1-20 parts of acorus tatarinowii, and 1-20 parts of prepared licorice root.

[0007] Alternatively, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 1-20 parts of mother-of-pearl, 1-15 parts of oyster shell, 1-20 parts of abalone shell, 1-15 parts of poria cocos peel, 1-15 parts of polyporus umbellatus, 1-15 parts of mulberry bark, 1-15 parts of plantain seed, 1-15 parts of sparganium rhizome, 1-15 parts of dianthus superbus, 1-10 parts of acorus tatarinowii, and 1-10 parts of prepared licorice root.

[0008] As an optional method, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 15 parts of mother-of-pearl, 10 parts of oyster shell, 15 parts of abalone shell, 10 parts of poria cocos peel, 10 parts of polyporus umbellatus, 10 parts of mulberry bark, 10 parts of plantain seed, 10 parts of sparganium rhizome, 10 parts of dianthus superbus, 6 parts of acorus tatarinowii and 6 parts of prepared licorice root.

[0009] Alternatively, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition has the effects of strengthening the spleen and promoting diuresis, and tonifying the kidney and nourishing the vital energy.

[0010] In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine composition described in the first aspect above, characterized in that the preparation method includes the following steps: weighing each raw material in the weight proportions according to any one of claims 1 to 4, pre-treating, extracting, and concentrating.

[0011] Preferably, in the above preparation method, the traditional Chinese medicine composition of the present invention can be prepared using conventional methods known in the art.

[0012] Preferably, the extraction methods used in this invention include, but are not limited to, decoction extraction, reflux extraction, ultrasonic extraction, and supercritical extraction.

[0013] Preferably, water, commonly used organic solvents in the art, or mixtures thereof can be used to extract the treated active pharmaceutical ingredient.

[0014] Preferably, the organic solvent is methanol, ethanol, propanol, butanol, ethyl acetate, petroleum ether, etc.

[0015] Preferably, the process includes weighing each raw material, pulverizing, extracting, and concentrating.

[0016] Preferably, the extraction method is decoction, and / or the extraction solvent is water or ethanol, and / or the number of decoctions is 1-3, and / or the decoction time for each decoction is 1-3 hours.

[0017] Preferably, water extraction is used (e.g., decoction with water).

[0018] In a third aspect, the present invention provides the use of the traditional Chinese medicine composition described in the first aspect above, or the traditional Chinese medicine composition prepared by the preparation method described in the second aspect above, in the preparation of a medicament for treating vertigo caused by large vestibular aqueduct syndrome.

[0019] Alternatively, in the above-described uses, the drug is used to treat vertigo caused by acute episodes of large vestibular aqueduct syndrome.

[0020] Alternatively, in the above-described uses, the drug may be in solid, semi-solid, or liquid form.

[0021] Alternatively, in the above-described uses, the drug may be a decoction, powder, oral liquid, ointment, granules, tablet, or capsule.

[0022] Compared with the prior art, the present invention has the following advantages: (1) High safety: Compared with Western medicine glucocorticoids, the traditional Chinese medicine composition of this invention has no adverse reactions, reduces health risks, and improves patients' treatment tolerance and compliance.

[0023] (2) Effectively relieve dizziness: The treatment method is to strengthen the spleen and promote diuresis, and nourish the kidney and replenish the body's vital energy. It targets the pathological mechanism of large vestibular aqueduct syndrome, regulates the body's functions, relieves dizziness, improves the patient's life and work status, and improves the quality of life.

[0024] (3) Advantages of personalized treatment: Combining the patient's clinical manifestations and imaging characteristics to diagnose and treat the disease, personalized treatment can better meet individual differences, use medication accurately, and improve efficacy.

[0025] (4) Filling the gap in the field of traditional Chinese medicine: Traditional Chinese medicine has previously lacked research on LVAS vertigo attacks. This invention provides new ideas, opens up new treatment pathways, and promotes the development of traditional Chinese medicine in this field.

[0026] (5) Standardized treatment plan: A standardized treatment plan for LVAS with traditional Chinese medicine has been developed, which is conducive to clinical promotion, can benefit more patients, provide reference for subsequent research, and promote related medical research. Detailed Implementation

[0027] The traditional Chinese medicine composition of this invention is made from raw materials such as mother-of-pearl, oyster shell, abalone shell, poria cocos peel, polyporus umbellatus, mulberry bark, plantain seed, sparganium rhizome, dianthus superbus, acorus tatarinowii, and prepared licorice root. It has the effects of strengthening the spleen and promoting diuresis, and tonifying the kidney and nourishing the body. It is mainly used to treat patients with vertigo caused by large vestibular aqueduct syndrome.

[0028] The herbal composition of this invention uses mother-of-pearl, oyster shell, and abalone shell. The three ingredients work together to calm the liver and subdue yang, soothe the mind and relieve dizziness caused by endolymphatic sac effusion, thus treating the symptoms in an acute situation. Poria peel promotes diuresis and eliminates dampness, Polyporus umbellatus warms yang and promotes diuresis, Plantago asiatica promotes urination and relieves strangury, and Morus alba root bark drains the lungs and descends downward. Together, they play the role of strengthening the spleen and eliminating dampness, promoting yang and diuresis, and activating blood circulation. As assistant herbs, they relieve the symptoms of endolymphatic effusion caused by enlargement of the vestibular duct. Sparganium rhizome and Dianthus superbus activate blood circulation, remove blood stasis and promote qi circulation, and Acorus tatarinowii clears the head and eyes as adjuvant herbs. Licorice is used as the guiding herb to moderate the properties of the herbs.

[0029] The efficacy and indications of each herb in the traditional Chinese medicine composition described in this invention are as follows: "Mother-of-pearl" refers to the triangular sail mussel, a species of mussel in the family Claviidae. Hyriopsis cumingii (Lea), pleated crown mussel Crystal folded (Leach) or the pearl oyster of the family Pteropodidae. Pteria martensii (Dunker) Seashells. Salty in taste and cold in nature; they enter the liver and heart meridians. They have the effects of calming the liver and suppressing yang, soothing the mind and relieving fright, and improving eyesight and clearing away pterygium. They are mainly used to treat headaches and dizziness, palpitations and insomnia, red eyes with pterygium, and blurred vision.

[0030] "Oyster" refers to the Pacific oyster, an animal belonging to the genus Oyster in the family Ostreida Giant oyster Thunberg Dalian Bay Oysters Oyster talienwhanensis Crosse Or Omi oyster Gould's river oyster Seashells. Salty in taste, slightly cold in nature; enters the liver, gallbladder, and kidney meridians. It has the effects of calming the mind, nourishing yin and yang, softening hardness and dissipating nodules. It is mainly used to treat palpitations, insomnia, dizziness, tinnitus, scrofula, phlegm nodules, and abdominal masses.

[0031] "Shi Jue Ming" refers to the variegated abalone, an animal belonging to the genus *Abalone* of the family Haliotis diversicolor. Haliotis diversicolor Reeve Wrinkled abalone Haliotis discus hannai Ino Lamb and abalone Haliotis ovina Gmelin Australian abalone Red sea bream (Leach) abalone Haliotis asinina Linnaeus Or white abalone Haliotis laevigata (Donovan) Seashells. Salty in taste and cold in nature; enters the liver meridian. It has the effects of calming the liver and suppressing yang, clearing the liver and improving eyesight. It is used for headaches, dizziness, red and pterygium eyes, blurred vision, night blindness, and nystagmus.

[0032] "Poria peel" refers to the fungus Poria cocos (Polyporaceae family). Poria cocos (Schw.) WolfThe dried outer skin of the sclerotium. It has a sweet and bland taste, and is neutral in nature. It enters the lung, spleen, and kidney meridians. It has the effect of promoting diuresis and reducing swelling. It is mainly used to treat edema and difficulty urinating.

[0033] "Zhu Ling" refers to the fungus *Polyporus umbellatus*, belonging to the genus *Polyporus* of the family Polyporaceae. Polyporus umbellatus (Pers.) Fries The dried sclerotium of the fungus. It has a sweet and bland taste, and is neutral in nature; it enters the kidney and bladder meridians. It has the effects of promoting diuresis and reducing swelling, and eliminating dampness. It is mainly used to treat edema, difficulty urinating, beriberi, diarrhea, urinary tract infections, and leukorrhea.

[0034] "Mulberry bark" refers to the bark of the mulberry tree (Morus alba), a plant belonging to the genus Morus in the family Moraceae. Mulberry L. The root bark of the plant. It has a sweet taste and cold properties; it enters the lung meridian. It has the effects of purging lung heat and relieving asthma, promoting diuresis and reducing swelling. It is mainly used to treat cough and asthma due to lung heat, edema with abdominal distension and scanty urine, and facial and skin edema.

[0035] "Plantago seed" refers to the plant Plantago asiatica, belonging to the Plantaginaceae family. Plantago asiatica L. Or flatcar Plantago depressa Willd. The dried, mature seeds of this plant are produced in most parts of China. They are sweet in taste and cold in nature, and enter the liver, kidney, lung, and small intestine meridians. They have the effects of clearing heat and promoting diuresis, relieving strangury, eliminating dampness and stopping diarrhea, improving eyesight, and resolving phlegm. They are mainly used to treat painful strangury due to heat, edema and abdominal distension, summer-heat diarrhea, red and swollen eyes, and cough with phlegm and heat.

[0036] "Sanleng" refers to the black sparganium, a plant belonging to the genus *Sparganium* in the family Sparganaceae. Sparganium stoloniferum Buch.-Ham. The dried tubers of [unspecified plant]. Mainly produced in Jiangsu, Henan, Shandong, and Jiangxi provinces. Neutral in nature, pungent and bitter in taste, and enters the liver and spleen meridians. It has the effects of promoting blood circulation, regulating qi, eliminating stagnation, and relieving pain. It is mainly used to treat abdominal masses, dysmenorrhea, amenorrhea due to blood stasis, chest pain, and abdominal distension due to food stagnation.

[0037] "Dianthus superbus" refers to the plant Dianthus superbus, belonging to the genus Dianthus in the family Caryophyllaceae. Dianthus superbus L. and carnation Carnation Chinese L. The dried aerial parts of the plant. It tastes bitter and is cold in nature; it enters the heart and small intestine meridians. It has diuretic and blood-activating effects, and is used to treat urinary tract infections, hematuria, urinary stones, dysuria, painful urination, and amenorrhea due to blood stasis.

[0038] "Sweet flag" refers to the plant *Acorus gramineus*, belonging to the genus *Acorus* in the family Araceae. Acorus tatarinowii Schott The dried rhizome. It is warm in nature, pungent and bitter in taste, and enters the heart and stomach meridians. It has the effects of clearing the orifices and resolving phlegm, refreshing the mind and improving intelligence, and resolving dampness and stimulating appetite. It is mainly used to treat delirium, epilepsy, forgetfulness, insomnia, tinnitus, deafness, epigastric fullness and lack of appetite, and diarrhea with loss of appetite.

[0039] "Roasted licorice" refers to licorice, a plant belonging to the legume family. Glycyrrhiza uralensis Fisch. licorice root Glycyrrhiza inflata Bat. Or licorice root Glycyrrhiza glabra L.The dried roots and rhizomes of licorice are processed through cleaning, cutting, and honey-roasting. This product is produced in Inner Mongolia, Shaanxi, Gansu, and Northeast China. Licorice has a sweet taste and a neutral to slightly warm nature, and it enters the heart, lung, spleen, and stomach meridians. Its main functions are to tonify the spleen and stomach, replenish qi, and restore pulse. It is commonly used to treat symptoms such as spleen and stomach weakness, fatigue, insufficient heart qi, palpitations, and irregular pulse.

[0040] The present invention will be further described below with reference to specific embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of the invention.

[0041] Where specific techniques or conditions are not specified in the examples, they shall be performed in accordance with the techniques or conditions described in the literature in this field, or in accordance with the product instructions. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased through legitimate channels.

[0042] Unless otherwise specified, the experimental methods used in the following embodiments are conventional methods. Unless otherwise specified, the experimental materials used in the following embodiments are commercially available products.

[0043] Preparation Example: A traditional Chinese medicine composition for treating vertigo caused by large vestibular aqueduct syndrome, the composition being made from the following raw materials: 15 g of mother-of-pearl, 10 g of oyster shell, 15 g of abalone shell, 10 g of poria cocos peel, 10 g of polyporus umbellatus, 10 g of mulberry bark, 10 g of plantain seed, 10 g of sparganium rhizome, 10 g of dianthus superbus, 6 g of acorus tatarinowii, and 6 g of prepared licorice root.

[0044] The preparation method of the traditional Chinese medicine composition includes the following steps: Use a clay pot; iron or copper pots are prohibited. Verify the medicinal materials and remove impurities. Add clean, cold water, ensuring the water level is 2-3 cm above the material. Soak the materials for 30 minutes. Bring to a boil over high heat, then reduce to a simmer and decoct for 20 minutes. Add warm water to the dregs and decoct for another 20 minutes. Combine the two decoctions, filter, and administer in two divided doses while warm. Do not consume the burnt or mushy decoction.

[0045] Example of effect: 1. Overall Experimental Design: Eighty patients with LVAS (Lower-Low Pathological Ankylosing Spondylitis) in the acute phase (all able to cooperate with behavioral audiometry) were enrolled and divided into an experimental group (n=40) and a control group (n=40) using a preference design. The experimental group received treatment with the herbal composition prepared in the above-described preparation examples. The control group received treatment with methylprednisolone tablets combined with methylcobalamin tablets, ginkgo biloba extract drops, and betahistine mesylate tablets. After 7 days of drug treatment, the improvement of vertigo, an accompanying symptom, was observed in both groups.

[0046] 2. Test methods: The grouping method employed a preference design. When subjects met the inclusion criteria and entered the study, they were randomly assigned to either a preference group or a non-preference group. Patients in the preference group chose their own treatment plan, while those in the non-preference group were further randomly assigned using a random number method (blinding was not feasible due to the significant differences in drug formulations between the two different treatment methods). The efficacy indicators were collected and compiled by personnel unaware of the group assignments, thus implementing a separation of investigator and statistician, i.e., group concealment.

[0047] Experimental group: The traditional Chinese medicine composition of the present invention prepared in the above preparation examples is as follows: Dosage and administration method: Adults take one dose daily. The above-mentioned medicinal materials constitute one standard dose. The decoction yields 300 mL, which is divided into two warm doses of 150 mL each. Administration method: Normally taken warm at around 38°C. This formula is primarily taken warm. Take 30 minutes after meals. Deteriorated or burnt decoction is strictly prohibited from use. Special medicinal materials should be decocted first / wrapped according to requirements (mother-of-pearl, oyster shell, and abalone shell should be decocted first; plantain seeds should be wrapped before decoction).

[0048] Control group: Hormone therapy: Methylprednisolone tablets should be taken in gradually decreasing doses: Dosage: (4 mg / 4#, bid, po) for 4 days, (4 mg / 3#, bid, po) for 3 days, for a total of 7 days.

[0049] Mecobalamin tablets: Dosage: (0.5 mg / day, twice daily, orally) for 7 days. Ginkgo biloba extract drops: Usage: (1 mL, twice daily, orally), for a total of 7 days. Betahistine Mesylate Tablets: Dosage: (6 mg / #, bid, po) for 7 days.

[0050] Note: Medications used by patients in each control group were as follows: Methylprednisolone tablets (4 mg / #) manufactured by Pfizer Italia Srl; Mecobalamin tablets (0.5 mg / #) manufactured by Eisai (China) Pharmaceutical Co., Ltd.; Ginkgo biloba extract drops (30 mL / bottle) manufactured by Dr. Wimälschpe Pharmaceuticals, Germany; and Betahistine mesylate tablets (6 mg / #) manufactured by Eisai (China) Pharmaceutical Co., Ltd. All traditional Chinese medicines were purchased from reputable chain pharmacies.

[0051] The efficacy of the treatment was compared between the two groups of patients before and after treatment by comparing their Vestibular Symptom Indicator (VSI), Dizziness Handicap Inventory (DHI) scores, and Berg Balabce Scale (BBS) scores.

[0052] The VSI index primarily scores six symptoms: balance, dizziness, vertigo, nausea, visual sensitivity, and headache. Each symptom is scored from 0 to 10, with 0 indicating complete normality and 10 indicating the most severe condition. The DHI scale consists of 25 questions with a total score of 100. Higher scores indicate more severe vertigo. The BBS scale assesses a patient's balance ability through 14 actions with a total score of 56. Higher scores indicate better balance.

[0053] 3. Experimental Results: This study included 80 patients with dizziness who met the criteria, and they were randomly divided into a traditional Chinese medicine treatment group (experimental group) and a hormone treatment group (control group), with 40 patients in each group. There were no statistically significant differences in age, gender, and disease duration between the two groups before treatment (P>0.05), indicating comparability. After treatment, the Vestibular Symptom Index (VSI) and Vertigo Disability Rating Scale (DHI) scores of both groups were significantly lower than before treatment, while the Berg Balance Scale (BBS) scores were significantly higher than before treatment, with statistically significant differences (P<0.05). This suggests that both treatment regimens can improve vestibular function, reduce the degree of vertigo disability, and enhance balance ability.

[0054] Further inter-group comparisons showed that the experimental group had significantly lower VSI and DHI scores than the control group after treatment, while the experimental group had significantly higher BBS scores, all with statistically significant differences (P<0.05). Specific experimental results for each group are shown in Tables 1 to 3.

[0055] Table 1 Comparison of effects before and after traditional Chinese medicine treatment

[0056] Table 2 Comparison of effects before and after hormone therapy

[0057] Table 3 Comparison of the effects of the herbal composition of the present invention in the treatment group and the hormone treatment group

[0058] Note: All statistical analyses were performed using SPSS 22.0 software. Quantitative data are expressed as (x±s). Paired t-tests were used for comparisons within groups before and after treatment, and independent samples t-tests were used for comparisons between groups. Categorical data are expressed as percentages (%) and were analyzed using the χ² test. P<0.05 was considered statistically significant.

[0059] The above results indicate that both the herbal decoction and hormone therapy of the present invention can effectively improve vestibular function and clinical symptoms in patients with dizziness. However, the herbal treatment is more effective in relieving vestibular symptoms, reducing the impact of dizziness on daily life, and improving limb balance. In particular, it shows a significant advantage in improving the degree of dizziness symptoms, providing a more advantageous option for the clinical treatment of dizziness.

[0060] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A traditional Chinese medicine composition for treating vertigo caused by large vestibular aqueduct syndrome, characterized in that: The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 1-30 parts of mother-of-pearl, 1-25 parts of oyster shell, 1-30 parts of abalone shell, 1-25 parts of poria cocos peel, 1-25 parts of polyporus umbellatus, 1-25 parts of mulberry bark, 1-25 parts of plantain seed, 1-25 parts of sparganium rhizome, 1-25 parts of dianthus superbus, 1-20 parts of acorus tatarinowii, and 1-20 parts of prepared licorice root.

2. The traditional Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 1-20 parts of mother-of-pearl, 1-15 parts of oyster shell, 1-20 parts of abalone shell, 1-15 parts of poria cocos peel, 1-15 parts of polyporus umbellatus, 1-15 parts of mulberry bark, 1-15 parts of plantain seed, 1-15 parts of sparganium rhizome, 1-15 parts of dianthus superbus, 1-10 parts of acorus tatarinowii, and 1-10 parts of prepared licorice root.

3. The traditional Chinese medicine composition according to claim 2, characterized in that: The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 15 parts mother-of-pearl, 10 parts oyster shell, 15 parts abalone shell, 10 parts poria cocos peel, 10 parts polyporus umbellatus, 10 parts mulberry bark, 10 parts plantain seed, 10 parts sparganium rhizome, 10 parts dianthus superbus, 6 parts acorus tatarinowii and 6 parts prepared licorice root.

4. The traditional Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition has the effects of strengthening the spleen and promoting diuresis, and tonifying the kidneys and nourishing the body's vital energy.

5. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The preparation method includes the following steps: weighing each raw material according to the weight proportions of any one of claims 1 to 4, pre-treating, extracting, and concentrating.

6. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4, or the traditional Chinese medicine composition prepared by the preparation method according to claim 5, in the preparation of a medicament for treating vertigo caused by large vestibular aqueduct syndrome.

7. The use according to claim 6, characterized in that: The drug is used to treat vertigo caused by acute attacks of large vestibular aqueduct syndrome.

8. The use according to claim 6, characterized in that: The drug is in solid, semi-solid, or liquid form.

9. The use according to claim 8, characterized in that: The medicine is in the form of decoction, powder, oral liquid, ointment, granules, tablets or capsules.

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