Quick-drying medical ray protective cream as well as preparation method and application thereof

Abstract

According to the quick-drying medical ray protective cream and the preparation method and application thereof, through effective combination of a radiation-proof material and a specific film-forming system, a powerful protective film can be quickly formed on the skin surface after the protective cream is smeared, the ray shielding effect of the protective cream is superior to that of interventional protective gloves, and meanwhile, the protective cream does not contain heavy metal such as lead and the like, so that the service life of the protective cream is prolonged. The safety and non-toxicity can be ensured. The paste can be directly smeared on the skin, the problems that traditional lead gloves are heavy and inflexible and the like are solved, the paste is particularly suitable for scenes such as interventional operations, effective ray protection can be achieved, and meanwhile operation in the operation process cannot be affected.

Description

Technical Field

[0001] This invention belongs to the field of radiation protection medical devices, specifically relating to a quick-drying medical radiation protection paste, its preparation method, and its application. Background Technology

[0002] Interventional radiology refers to techniques performed under the guidance of medical imaging systems, such as percutaneous needle puncture or catheter insertion, to perform aspiration, injection, drainage, or to shape, perfuse, or embolize lumens and blood vessels for the diagnosis and treatment of diseases. During interventional procedures, medical personnel performing these procedures are inevitably exposed to X-rays due to close proximity and shared operating rooms. Since the damage caused by X-rays has a cumulative effect, the protection of medical personnel during interventional procedures is extremely important.

[0003] Currently, lead aprons, lead neck protectors, lead glasses, and lead caps are commonly used in clinical practice, but hand protection is often overlooked. Although studies have shown that wearing lead-rubber protective gloves during interventional procedures can significantly reduce hand radiation dose, the strict aseptic technique required for interventional procedures typically necessitates wearing an inner surgical glove and an outer disposable latex glove. Adding a heavy lead-rubber glove on top of this would severely impair tactile sensitivity and dexterity, affecting surgical accuracy, thus limiting its actual clinical application. In recent years, lightweight radiation protection gloves using heavy metals such as tungsten and bismuth to replace lead have appeared on the market. While these improve wearing comfort and operational performance to some extent, their high manufacturing cost and single-use nature make widespread adoption in routine interventional procedures difficult.

[0004] In addition, radiation shielding skincare products such as ULTRABLOX® X-ray attenuation cream exist abroad. These products achieve partial shielding against X-rays by forming a protective film containing heavy metals on the skin surface. However, these products have significant technical drawbacks: firstly, the film formation speed is slow, requiring a long waiting time to achieve effective protection, making them unsuitable for fast-paced interventional surgical procedures; secondly, to avoid affecting the feel of the operation, the coating thickness is strictly limited, resulting in limited actual shielding effectiveness and failing to provide sufficient hand radiation protection. In summary, existing technologies still have significant shortcomings in balancing protective effectiveness, operational flexibility, and ease of use, necessitating the development of a new hand radiation protection solution to effectively ensure the occupational safety of interventional radiology medical personnel. Summary of the Invention

[0005] To address the aforementioned issues, this application proposes a quick-drying medical radiation shielding paste, its preparation method, and its application. This shielding paste uses non-toxic, high-atomic-number inorganic functional fillers as the X-ray shielding component, combined with a water-soluble polymer with excellent film-forming properties as a flexible matrix. During film formation, the polymer rapidly adsorbs and accumulates on the surface of numerous radiation-shielding particles, significantly increasing the local concentration of its molecular chains at the particle interface, thereby rapidly forming a stable physical cross-linked network. Simultaneously, this network constructs a rich three-dimensional microporous structure, providing efficient channels for solvent evaporation. The synergistic effect of multiple mechanisms significantly shortens the film-forming time.

[0006] The resulting protective balm offers excellent shielding performance against X-rays, effectively reducing the risk of radiation exposure. Its uniform texture makes it easy to apply, and it dries quickly to form a film without affecting hand dexterity. Thanks to the water-soluble polymer matrix used, it can be easily washed off with just water or a mild detergent, leaving no residue and causing no environmental pollution.

[0007] This invention creatively utilizes the physical properties of high-solids-content radiation-shielding particles to reconstruct the traditional film-forming path—no longer relying on the continuous polymer phase to dominate film formation, but instead inducing polymer enrichment and cross-linking at the interface through the particle skeleton, thereby achieving a synergistic breakthrough in "rapid drying" and "high-efficiency shielding" in the medical radiation protection application scenario with extremely high time-sensitivity requirements.

[0008] Specifically, it includes the following components: 50-80 parts by weight of radiation shielding material; 2-7 parts by weight of film-forming material; 1-3 parts by weight of humectant; and 7-27 parts by weight of volatile agent. The film-forming material is one or more of polyvinylpyrrolidone, polyvinyl alcohol, and hydroxypropyl methylcellulose, wherein the degree of polymerization of polyvinyl alcohol is 300-2500 and the degree of alcoholysis is 80%-99%. The radiation shielding material is one or more of bismuth tungstate, barium sulfate, bismuth oxide, tungsten oxide, and gadolinium oxide. The particle size of the radiation shielding material is 30-75 μm.

[0009] Furthermore, the moisturizer is selected from one or more of glycerin, propylene glycol, sodium hyaluronate, and sorbitol.

[0010] Furthermore, the volatile agent is anhydrous ethanol.

[0011] Furthermore, the radiation shielding material comprises 60-75 parts by weight.

[0012] As the core component for shielding, the radiation shielding material is lead-free, avoiding the toxicity of heavy metals. When X-rays pass through the radiation shielding material, they interact with the atoms in the material (such as the photoelectric effect and Compton scattering), thus being absorbed or scattered, reducing the intensity of the rays and achieving the radiation protection effect. The mechanism by which the film-forming material works is due to the rapid evaporation of the volatile agent, which causes a sudden increase in the solid content of the system. At this time, the film-forming material changes from a dissolved state to a supersaturated state, and the distance between molecular chains shortens to the range of van der Waals forces, inducing chain segment entanglement and forming a transparent, flexible, continuous film that firmly fixes the shielding material. The moisturizer can work synergistically with the film-forming material to enhance the flexibility of the film and its skin adhesion. Anhydrous ethanol, as the core component for rapid drying of the ointment, can accelerate the evaporation process, thereby shortening the film-forming time of the ointment.

[0013] This invention also provides a method for preparing the above-mentioned quick-drying medical radiation protection paste. A film-forming material is added to deionized water at 80-90°C and stirred until completely dissolved to form a transparent gel. The solution is then cooled to room temperature. A humectant and a volatile agent are added under stirring, and after thorough mixing, a radiation-shielding material is added and stirred to form a uniform paste. After degassing, the quick-drying medical radiation protection paste is obtained. The film formed by the film-forming material exhibits good flexibility after drying, allowing the radiation-shielding material to be fixed in a specific location. Furthermore, within the conventional X-ray diagnostic energy range (e.g., 60-120 kV), it provides superior shielding effectiveness compared to interventional protective gloves.

[0014] The mass ratio of deionized water to volatile agent is 1:1.3~3.4.

[0015] The present invention also provides the application of the above-mentioned quick-drying medical radiation protection ointment.

[0016] The advantages of this invention are that it resolves the contradiction between "good shielding performance, fast film drying, and easy application". The lead-free formula eliminates the risk of heavy metals, the 60-second rapid film formation ensures operational efficiency, the radiation shielding performance is superior to traditional protective gloves, and it is easy to clean after surgery. Attached Figure Description

[0017] Figure 1 The surface SEM morphology of pure PVA (a) and Example 1 (b) after coating and forming films; Figure 2 The infrared spectra of Comparative Example 2 and pure PVA after coating and film formation are shown. Figure 3 The images are of the right hand and the unprotected left hand simultaneously placed under DSA for the application of the agent in Example 4. Figure 4 The image shows the right hand and left hand wearing interventional protective gloves simultaneously placed under DSA for the application of the sample in Example 4. Figure 5An angiographic image taken simultaneously under DSA of the right hand applying the Ultrablox radiation protection cream in Example 4 and the left hand applying the Ultrablox radiation protection cream. Detailed Implementation

[0018] The following examples are provided to further illustrate the present invention and are intended to explain the invention, not to limit its scope. Unless otherwise specified, all figures are expressed in parts by weight and weight percentages.

[0019] Unless otherwise specified, the raw materials used in this invention are all conventional commercially available products; unless otherwise specified, the methods used in this invention are all conventional methods in the field.

[0020] This invention was tested according to the following standards: Lead equivalent test: The test was conducted according to the industry standard "YY / T 0292.1-2020 Medical Diagnostic X-ray Radiation Protection Apparatus Part 1: Determination of Material Attenuation Performance" at a tube voltage of 120kV. Generally, a lead equivalent > 0.025mmPb is considered sufficient for good shielding effect as an interventional protective glove.

[0021] Shielding efficiency test: After preheating the X-ray irradiator and stabilizing the dose, place the dosimeter 50cm away from the focal point at the center of the radiation field. Set the tube voltage to 60kV, 80kV, 100kV, and 120kV, the tube current to 1.0mA, and the exposure time to 10s, with three exposures per setting. Measure the dose value before shielding using a thermoluminescent dosimeter and calculate the average of the three exposures. Place the dosimeter on the back of the paste (0.3mm thickness) and position it in the same location as in the previous step. Set the tube voltage to 60kV, 80kV, 100kV, and 120kV, the tube current to 1mA, and the exposure time to 60s, with three exposures per setting. Measure the dose value after shielding using a thermoluminescent dosimeter and calculate the average of the three exposures. Using the calculated average dose values ​​before and after shielding, calculate the radiation attenuation rate (%) of the paste according to the following formula: X-ray attenuation rate % = (Cumulative dose without shielding (mSv) - Cumulative dose with shielding (mSv) / Cumulative dose without shielding (mSv) × 100%)

[0022] Film formation time determination: The paste was uniformly coated onto an acrylic plate with a thickness of 0.3 mm using a wire bar coater. The plate was placed in a 37°C chamber, and the time required for coating to be completed and for a continuous, defect-free, and stable film to form on the surface was recorded.

[0023] Mechanical property testing: A paste film was prepared on a polytetrafluoroethylene (PTFE) plate using a 0.3 mm wire bar applicator, and then cured at 37°C. The resulting film was cut into 50 mm × 15 mm strips, and the maximum tensile force (N) was determined using a universal tensile testing machine.

[0024] Cleanability test: Apply 0.3mm thick medical radiation protection cream to both hands, rinse with running water after 10 minutes, and assess the ease of cleaning and residue.

[0025] Fineness (uniformity of finished product) test: Use a wire bar applicator to evenly apply the paste to an acrylic plate with a thickness of 0.3mm. Visually inspect the fineness of the paste spread and the presence of large particles visible to the naked eye under sufficient light.

[0026] Spreadability test (indirect evaluation): The spreadability of the paste is indirectly evaluated by measuring its viscosity.

[0027] Stability / redispersibility test: After vortexing the paste, let it stand for 24 hours (separation is allowed), then shake it manually and observe whether it can return to a uniform state.

[0028] The embodiments of the present invention will be further described below with reference to several examples.

[0029] It should be understood that the described embodiments are merely some, not all, of the embodiments in this application. All other embodiments obtained by those skilled in the art based on the embodiments in this application without inventive effort are within the scope of protection of this application.

[0030] The terminology used in the embodiments of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of this application. The singular forms “a,” “the,” and “the” used in the embodiments of this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise.

[0031] Example 1 Add 5 parts by weight of polyvinyl alcohol 1788 (degree of polymerization 1700, degree of hydrolysis 88%) to deionized water at 90°C, stir until completely dissolved to form a transparent gel, cool to room temperature, then add 2 parts by weight of humectant and 20 parts by weight of volatile agent and 13 parts by weight of water under stirring, mix evenly, then add 60 parts by weight of 30μm barium sulfate powder, stir to form a uniform paste, and after degassing, obtain quick-drying medical radiation protection paste.

[0032] The resulting quick-drying medical radiation protection paste is easy to clean, has a delicate feel, and a viscosity of 12930 cP.

[0033] The surface morphology of the membrane was observed by SEM. Figure 1The smooth morphology of pure PVA films stems from a slow "self-assembly" film-forming process in its homogeneous solution system: as water evaporates, PVA molecular chains gradually approach each other through spontaneous motion and form a three-dimensional network through hydrogen bonds. This process is accompanied by significant viscoelastic flow and contraction in the later stages, and is time-consuming. In contrast, PVA / bismuth oxide composite films ( Figure 1 (b) The film-forming kinetics are fundamentally altered by the bismuth oxide network. At the moment moisture begins to evaporate, PVA chains do not passively wait for collisions, but are rapidly adsorbed and anchored onto the surface of countless bismuth oxide particles. This causes a sharp increase in the local concentration of PVA chains on the particle surface, rapidly forming stable cross-linking points. Simultaneously, the microporous structure facilitated by this network provides more rapid channels for solvent evaporation, thus synergistically shortening the film-forming time from multiple perspectives.

[0034] Example 2 Add 4 parts by weight of polyvinyl alcohol 1788 (degree of polymerization 1700, degree of hydrolysis 88%) to deionized water at 80°C, stir until completely dissolved to form a transparent gel, cool to room temperature, then add 1 part by weight of humectant and 25 parts by weight of volatile agent and 10 parts by weight of water under stirring, mix evenly, then add 60 parts by weight of 30μm barium sulfate powder, stir to form a uniform paste, and after degassing, obtain quick-drying medical radiation protection paste.

[0035] The protective cream prepared in this embodiment has a viscosity of 4800 cP, exhibiting good spreadability and extensibility, and can quickly form a film on the skin surface within 60 seconds. After standing for 24 hours, some particles settled and separated, which could be restored to a homogeneous state by manual shaking.

[0036] Example 3 Add 5 parts by weight of polyvinyl alcohol 1788 (degree of polymerization 1700, degree of hydrolysis 88%) to deionized water at 80°C, stir until completely dissolved to form a transparent gel, cool to room temperature, then add 2 parts by weight of humectant and 21 parts by weight of volatile agent and 12 parts by weight of water under stirring, mix evenly, then add 60 parts by weight of 50μm bismuth oxide powder, stir to form a uniform paste, and after degassing, obtain a quick-drying medical radiation protection paste.

[0037] The resulting quick-drying medical radiation protection paste is easy to clean, has a smooth texture, and a viscosity of 6500 cP. After application and air drying, the film thickness is 0.1 mm, the lead equivalent is 0.035 mmPb, and the film formation time is <30 s. After standing for 24 hours, some particles settled and separated, which could be restored to a uniform state by manual shaking.

[0038] Example 4 Two parts by weight of polyvinyl alcohol 1788 (degree of polymerization 1700, degree of hydrolysis 88%) were added to deionized water at 85°C and stirred until completely dissolved to form a transparent gel. The gel was then cooled to room temperature. Subsequently, one part by weight of humectant, 15 parts by weight of volatile agent, and 7 parts by weight of water were added under stirring. After mixing evenly, 75 parts by weight of 30μm barium sulfate powder were added and stirred to form a uniform paste. After degassing, a quick-drying medical radiation protection paste was obtained.

[0039] A continuous, dense, and crack-free film rapidly forms on the skin surface within 30 seconds. The film thickness after complete drying is 0.10 mm. Preliminary radiation tests show that it has a significant attenuation effect on commonly used diagnostic X-ray energies (e.g., 60-120 kV), and is superior to interventional protective gloves (Jialoway, single-sided thickness 0.20-0.26 mm). Data are shown in the table below.

[0040] The right hand coated with Formula 21 and the unprotected left hand were simultaneously placed under DSA for side-by-side contrast imaging. The results showed a stark contrast: the internal skeletal structure of the unprotected left hand was clearly visible; while the skeletal image of the right hand was almost completely obscured due to the shielding effect of the protective cream, directly demonstrating the excellent radiation protection effect of the formula. Figure 3 In a simultaneous comparison with existing interventional protective gloves and similar products certified by the FDA (Ultrablox radiation protection cream), this application demonstrates superior protective efficacy. Figure 4 and Figure 5 ).

[0041] Example 5 Add 4 parts by weight of polyvinylpyrrolidone K30 to deionized water at 85°C and stir until completely dissolved to form a transparent gel. Cool to room temperature, then add 2 parts by weight of humectant sorbitol and 11 parts by weight of volatile agent and 8 parts by weight of water under stirring. After mixing evenly, add 75 parts by weight of 75μm bismuth oxide powder and stir to form a uniform paste. After degassing, a quick-drying medical radiation protection paste is obtained.

[0042] The prepared protective cream has good spreadability and extensibility, and can form a film quickly on the skin surface (60s). After standing for 24 hours, some particles settled and separated, but manual shaking restored it to a homogeneous state.

[0043] Example 6 Add 3 parts by weight of hydroxypropyl methylcellulose to deionized water at 85°C and stir until completely dissolved to form a transparent gel. Cool to room temperature, then add 1 part by weight of humectant propylene glycol and 12 parts by weight of volatile agent anhydrous ethanol and 9 parts by weight of water under stirring. After mixing evenly, add 75 parts by weight of 75μm bismuth oxide powder and stir to form a uniform paste. After degassing, a quick-drying medical radiation protection paste is obtained.

[0044] The prepared protective cream has good spreadability and extensibility, and can form a film quickly on the skin surface (60s). After standing for 24 hours, some particles settled and separated, but manual shaking restored it to a homogeneous state.

[0045] Example 7 Quick-drying medical radiation protection paste was prepared using polyvinyl alcohol with different degrees of polymerization and hydrolysis. 50 μm bismuth oxide was selected as the radiation protection material, and the quick-drying medical radiation protection paste was prepared using the method described in Example 3.

[0046] Sample 1: Degree of polymerization 300, degree of alcoholysis 88%.

[0047] Sample 2: Degree of polymerization 500, degree of alcoholysis 88%.

[0048] Sample 3: Degree of polymerization 1700, degree of alcoholysis 88%.

[0049] Sample 4: Degree of polymerization 2400, degree of alcoholysis 88%.

[0050] Sample 5: Degree of polymerization 500, degree of alcoholysis 80%.

[0051] Sample 6: Degree of polymerization 2400, degree of alcoholysis 80%.

[0052] Sample 7: Degree of polymerization 500, degree of alcoholysis 99%.

[0053] Sample 8: Degree of polymerization 1700, degree of alcoholysis 99%.

[0054] Within the range of polyvinyl alcohol polymerization degree (300-2500) and alcoholysis degree (80%-99%) selected in this invention, the prepared products exhibit different performance differences in water solubility, film-forming properties, and washability. Among these, the alcoholysis degree has a significant impact on the solubility of the formulation. When the alcoholysis degree increases to 99%, due to the high molecular chain regularity and strong hydrogen bonding between hydroxyl groups, its solubility decreases significantly, requiring higher temperatures and longer times for the product to dissolve in water. In this embodiment, the protective cream prepared from polyvinyl alcohol with different polymerization and alcoholysis degrees has good spreadability and extensibility, and can quickly form a film on the skin surface. After standing for 24 hours, some particles settled and stratified; manual shaking restored it to a homogeneous state.

[0055] Example 8 Add 7 parts by weight of polyvinyl alcohol 1788 to deionized water at 85°C and stir until completely dissolved to form a transparent gel. Cool to room temperature, then add 3 parts by weight of humectant propylene glycol and 27 parts by weight of volatile agent anhydrous ethanol and 13 parts by weight of water under stirring. After mixing evenly, add 50 parts by weight of 30μm bismuth oxide powder and stir to form a uniform paste. After degassing, a quick-drying medical radiation protection paste is obtained.

[0056] After standing for 24 hours, some particles of the prepared protective balm settled and separated into layers. Manual shaking restored the balm to a uniform state. The balm exhibits good spreadability and extensibility, forming a film quickly on the skin surface (60 seconds) with a lead equivalent of 0.025 mmPb. Mechanical property testing of the dried film revealed a maximum tensile strength of 1.06 N.

[0057] Example 9 Add 2 parts by weight of polyvinyl alcohol 1788 to deionized water at 85°C and stir until completely dissolved to form a transparent gel. Cool to room temperature, then add 3 parts by weight of humectant glycerin, 9 parts by weight of volatile agent anhydrous ethanol, and 6 parts by weight of water under stirring. After mixing evenly, add 80 parts by weight of 30μm bismuth oxide powder and stir to form a uniform paste. After degassing, a quick-drying medical radiation protection paste is obtained.

[0058] The prepared protective cream has good spreadability and extensibility, and can quickly form a film on the skin surface (30s) with a film thickness of 0.1mm and a lead equivalent of 0.051mmPb. After standing for 24 hours, some particles settled and separated, but manual shaking restored the cream to a uniform state.

[0059] Comparative Example 1 The difference from Example 1 is that the amount of radiation-shielding material added is 30 parts by weight. The resulting protective paste has a film-forming time of >10 minutes. Comparing the time before and after adding the radiation-shielding material, the film-forming time of the system is sharply reduced from >10 minutes to only 30 seconds (a reduction of more than 20 times), clearly revealing that the radiation-shielding material is the core of achieving instantaneous film formation; at the same time, the higher the solid content, the faster the film formation. The high content of radiation-shielding solid particles rapidly constructs a tightly packed particle skeleton, which itself provides immediate rigid support, realizing the rapid "fixation" of the system. At this time, the function of the film-forming material is simplified to a small amount of "glue", the main role of which is to bond the fixed particle structure more firmly.

[0060] Comparative Example 2 The difference from Example 2 is that the amount of bismuth oxide added is 81 parts by weight. The resulting film is easily damaged.

[0061] Bismuth oxide is an inorganic, rigid particle insoluble in the solvent of the system. When its content increases, these particles come into contact with each other during film formation, forming a large number of rigid networks and pore channels. These pores provide faster escape paths for solvent evaporation, significantly accelerating the solvent escape rate and thus shortening the film formation time. At such high loading levels, the ratio of PVA / glycerol as the continuous polymer phase is severely compressed. The resulting film structure is more akin to an accumulation of bismuth oxide powder held together by a small amount of polymer "glue." The curing of this structure no longer depends on the slow entanglement and drying of polymer chains, but rather on the close packing of particles after rapid solvent evaporation. Therefore, the film formation process shifts from polymer-dominated to particle packing-dominated, resulting in faster film formation but weakened mechanical properties. Infrared spectroscopy confirmed that there is no significant chemical interaction between bismuth oxide and PVA (see [link to infrared spectroscopy]). Figure 2 After the addition of Bi₂O₃, no further observable changes occurred in the vibrational modes of the OH and CO bonds in PVA itself. This indicates that no strong chemical interactions (such as hydrogen bonds, coordination bonds, or covalent bonds) formed between Bi₂O₃ and PVA, and the primary chemical environment of PVA remained unchanged. Therefore, the film-forming promoting effect of bismuth oxide on PVA is not achieved through chemical modification (such as altering the conformation or reactivity of the polymer chain), but rather purely based on physical effects.

[0062] Comparative Example 3 The difference from Example 2 is that the bismuth oxide sizes are 500 nm, 1 μm, and 100 μm, respectively.

[0063] The results showed that the pastes prepared from bismuth oxide at 500 nm and 1 μm had many small particles, and the viscosities were 40180 cP and 23160 cP, respectively, making it difficult to restore the uniform state after separation.

[0064] While the paste prepared from 100μm bismuth oxide is relatively fine, it settles quickly and is difficult to obtain a stable paste.

[0065] Excessively small particle size can easily lead to powder agglomeration, making dispersion in the matrix difficult and ultimately affecting the smoothness of the finished product. Conversely, excessively large particle size accelerates the settling of suspended particles, resulting in poor redispersibility during use and rapid layering of the paste, significantly impacting the user experience. Furthermore, smaller particle size generally results in higher product viscosity, possibly because a smaller particle size significantly increases the total surface area of ​​the particles, requiring more medium for wetting (reducing the free-flowing phase). Additionally, the enhanced interparticle interactions and flocculation tendency caused by smaller particle size significantly increase flow resistance. Moreover, under the same formulation, smaller bismuth oxide particle size leads to higher viscosity and shorter film-forming time. This is likely because smaller bismuth oxide particles have a dramatically increased specific surface area, enhancing interparticle interactions and increasing viscosity. Simultaneously, the formation of a denser capillary network generates strong capillary forces, accelerating solvent migration and evaporation, thus shortening film-forming time.

[0066] Comparative Example 4 The difference from Example 1 is that the barium sulfate used has a particle size of 500 nm and 1 μm.

[0067] The results showed that the protective paste prepared with 500nm barium sulfate was finer, containing a few small particles, and had a viscosity of 330,000 cP. The protective paste prepared with 1μm barium sulfate was even finer, with a viscosity of 180,000 cP. Under the same particle size, the bismuth oxide formulation had better flowability than the barium sulfate formulation. Bismuth oxide has a higher density, and the system exhibits more obvious "particle-liquid separation" behavior during shearing, resulting in lower flow resistance. Barium sulfate has a lower density, better suspension properties, and a higher probability of contact between particles, making it easier to form a weak flocculated structure (especially when stationary), leading to increased viscosity and decreased flowability.

[0068] In summary, the medical radiation protection paste developed in this invention possesses the combined advantages of low viscosity, easy application, rapid film formation, and high shielding performance. By combining micron-level particle size control with optimized formulation of the ethanol / water solvent system, it creatively utilizes the physical properties of high-content solid particles, overturning the traditional film formation path and thus achieving the crucial rapid film formation characteristic for the specific application scenario of radiation protection.

[0069] The above embodiments describe in detail the structure, features, and effects of the present invention. The above description is only a preferred embodiment of the present invention. Any changes made in accordance with the concept of the present invention, or equivalent embodiments modified to have equivalent changes, shall still fall within the scope of protection of the present invention if they do not exceed the scope covered by the specification.

Claims

1. A quick-drying medical radiation protection cream, characterized in that, It includes the following components: 50-80 parts by weight of radiation shielding material; 2-7 parts by weight of film-forming material; 1-3 parts by weight of humectant; The volatile agent comprises 7-27 parts by weight; the film-forming material is one or more of polyvinylpyrrolidone, polyvinyl alcohol, and hydroxypropyl methylcellulose, wherein the degree of polymerization of polyvinyl alcohol is 300-2500 and the degree of alcoholysis is 80%-99%; the radiation shielding material is one or more of bismuth tungstate, barium sulfate, bismuth oxide, tungsten oxide, and gadolinium oxide; the particle size of the radiation shielding material is 30-75 μm.

2. The quick-drying medical radiation protection cream according to claim 1, characterized in that, The moisturizer is selected from one or more of glycerin, propylene glycol, sodium hyaluronate, and sorbitol.

3. The quick-drying medical radiation protection cream according to claim 1, characterized in that, The volatile agent is anhydrous ethanol.

4. The quick-drying medical radiation protection cream according to claim 1, characterized in that, The radiation shielding material is 60-75 parts by weight.

5. A method for preparing the quick-drying medical radiation protection cream as described in claim 1, characterized in that, Add the film-forming material to deionized water at 80-90°C, stir until completely dissolved to form a transparent gel, cool to room temperature, then add a humectant and a volatile agent under stirring, mix evenly, add the radiation protection material, stir to form a uniform paste, and after degassing, obtain a quick-drying medical radiation protection paste.

6. The method according to claim 5, characterized in that, The mass ratio of deionized water to volatile agent is 1:1.3-3.

4.

7. The application of the quick-drying medical radiation protection cream as described in claim 1.

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