A non-guanidine salt type compatible nucleic acid extraction virus preservation solution, preparation method and application thereof

By using a virus preservation solution containing P(HEMA-BAMPD) hydrochloride binding buffer, chelating agent, and sugar stabilizer, the safety and compatibility issues of existing virus preservation solutions have been resolved. This solution achieves efficient virus inactivation and nucleic acid protection, making it suitable for long-distance transportation and long-term preservation of virus samples.

CN121975914BActive Publication Date: 2026-06-26JIANGSU NINGPU MEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU NINGPU MEDICAL TECH CO LTD
Filing Date
2026-04-09
Publication Date
2026-06-26

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Abstract

The present application relates to a kind of non-guanidine salt type compatible nucleic acid extraction virus preservative and preparation method and application, the virus preservative, including P (HEMA-BAMPD) hydrochloride, buffer, chelating agent, saccharide stabilizer and osmotic pressure regulator.The present application replaces guanidine salt and small molecule quaternary ammonium salt with P (HEMA-BAMPD) hydrochloride, and the inactivation rate effect of SARS-CoV-2 virus, influenza virus and other envelope type RNA / DNA viruses is good, and there is no irritability, and it is friendly to operating personnel and environment;Polymer structure realizes multiple point adsorption, and the ability of resistance to organic interference is strong, and a small amount of blood, sputum and other components in sample do not affect inactivation effect.Moreover, P (HEMA-BAMPD) hydrochloride, chelating agent and saccharide stabilizer synergistic effect can effectively inhibit RNase, DNase activity.
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Citation Information

Patent Citations

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