Medical device special for long-term drug delivery of skull marrow and use method

Abstract

The invention relates to the technical field of medical devices, in particular to a medical device special for long-term drug delivery of skull marrow and a use method. According to the technical scheme, the skull drilling device comprises a drill rod for drilling a hole in a skull, the outer ring of the drill rod is sleeved with a first positioning sleeve, and the first positioning sleeve is used for limiting the drilling depth and preventing the skull from being drilled through to cause brain tissue damage; the dosing tube is used for dosing into the drill hole, one end of the dosing tube is fixed in the drill hole, a second positioning sleeve is arranged on the outer ring of the dosing tube in a sleeving manner, and the second positioning sleeve is used for limiting the depth of the dosing tube entering the drill hole. The skull bone marrow long-term stable drug delivery can be achieved, the limitation of the blood brain barrier on drug delivery is broken through, clinical transformation of an efficient drug delivery pathway is promoted, and the treatment effect of central nervous system diseases is improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a medical device and method of use specifically for long-term administration of bone marrow to the skull. Background Technology

[0002] The blood-brain barrier, a unique physiological structure of the central nervous system, has dual physiological functions. On the one hand, it effectively isolates harmful substances and interfering factors from the peripheral circulation, creating a stable internal environment for brain tissue and serving as a crucial defense line for maintaining the homeostasis of the central nervous system. On the other hand, this barrier also hinders the permeability of most therapeutic drugs, leading to low efficiency in drug treatments for central nervous system diseases such as brain tumors and neurodegenerative diseases, becoming a core bottleneck restricting the improvement of clinical efficacy.

[0003] In recent years, with the deepening research into the physiological pathways of the central nervous system, a natural drug delivery route that can bypass the blood-brain barrier and directly reach the brain parenchyma has been discovered—a potential hidden channel connecting the skull bone marrow and meninges. The discovery of this channel provides a new direction for achieving efficient and targeted intracerebral drug delivery, breaking through the inherent limitations of traditional drug delivery methods. Subsequent in-depth research has further clarified the complete mechanism of this pathway, proposing the concept of a skull bone marrow-dura mater-lymphatic-like channel. Related studies have confirmed that this pathway can achieve efficient drug transport from the skull bone marrow to the brain parenchyma, possessing significant value as a preferred clinical intracerebral drug delivery route.

[0004] Despite its significant advantages in drug delivery and the new hope it brings to the treatment of central nervous system diseases, the development of drug delivery devices targeting this specific pathway is severely lagging. Among existing medical devices, there is a severe shortage of dedicated drug delivery devices adapted to this pathway, especially those capable of meeting clinical application needs and achieving stable long-term drug delivery. This greatly limits clinical translation and application, preventing the potential drug delivery advantages from being translated into actual therapeutic effects. Therefore, this application proposes a medical device and method of use specifically for long-term intracranial bone marrow drug delivery. Summary of the Invention

[0005] The purpose of this invention is to address the problem that the blood-brain barrier hinders the treatment of central nervous system diseases in the background art. The cranial bone marrow-dura mater-lymphoid pathway provides a new direction for efficient drug delivery. However, there is a severe shortage of dedicated medical devices for long-term stable drug delivery that are adapted to this pathway and meet clinical needs, which limits the clinical translation and application of this pathway. This invention proposes a medical device and method of use specifically for long-term drug delivery through the cranial bone marrow.

[0006] In a first aspect, the present invention proposes a medical device specifically for long-term administration of bone marrow to the skull, comprising a drill rod for drilling a hole in the skull, wherein a first positioning sleeve is fitted around the outer ring of the drill rod to limit the drilling depth and prevent drilling through the skull and causing brain tissue damage; and an administration tube for administering medication into the drill hole, wherein one end of the administration tube is fixed in the drill hole, and a second positioning sleeve is fitted around the outer ring of the administration tube to limit the depth to which the administration tube enters the drill hole.

[0007] Optionally, the drill rod includes an installation rod, one end of which is fixedly connected to a first scale segment, the end of which away from the installation rod is provided with a first threaded segment, and the end of which away from the first threaded segment is fixedly connected to a drill bit.

[0008] Optionally, the outer side of the first scale segment is provided with equally spaced scale lines.

[0009] Optionally, the outer ring of the first threaded section is provided with equidistant cylindrical threads, and the first positioning sleeve is threadedly connected to the outer ring of the first threaded section. The equidistant cylindrical threads of the outer ring of the first threaded section are opposite to the direction of the drill bit's spiral pattern.

[0010] Optionally, the drug delivery tube includes an inlet section, a delivery section fixedly connected to the smaller diameter end of the inlet section, a second scale section provided at the end of the delivery section away from the inlet section, a second threaded section fixedly connected to the end of the second scale section away from the delivery section, a fixed section fixedly connected to the end of the second threaded section away from the second scale section, the outer side of the fixed section being tapered, the end of the fixed section away from the second threaded section having a smaller diameter and being fixedly connected to a drug delivery section, the end of the drug delivery section away from the fixed section being closed, a drug delivery hole being provided at the end of the drug delivery section away from the fixed section, and multiple sets of side holes being provided on the outer ring of the drug delivery section, the multiple sets of side holes being distributed in a ring array.

[0011] Optionally, the outer side of the second scale segment is provided with equally spaced scale lines.

[0012] Optionally, the outer ring of the second threaded section is provided with equidistant cylindrical threads, the second positioning sleeve is threadedly connected to the outer ring of the second threaded section, and the outer ring of the fixed section is provided with equidistant tapered threads. The equidistant cylindrical threads of the outer ring of the second threaded section are opposite in direction to the equidistant tapered threads of the outer ring of the fixed section.

[0013] Optionally, the outer ring of the conveyor section is fixedly connected with two sets of symmetrically arranged rotors.

[0014] Optionally, a sealing cap is threaded to the end of the liquid inlet section away from the conveying section, and a sealing plug is fixedly connected to the side of the sealing cap near the liquid inlet section, with the sealing plug located in the liquid inlet section.

[0015] Secondly, the present invention provides a method of using a medical device specifically for long-term administration of medication to the skull and bone marrow, comprising the following steps: S1. Based on the patient's cranial imaging results, determine the drilling location and the skull thickness at that location, select 1 / 2 to 2 / 3 of the skull thickness as the preset drilling depth, and connect one end of the drill rod to the drilling machine or drilling tool. S2, rotate the first positioning sleeve to adjust the length of the drill bit extending out of the first positioning sleeve. Use the equidistant scale lines on the outside of the first scale segment to accurately read and calibrate the extension length of the drill bit to ensure that it is consistent with the preset drilling depth. S3, start the drill and drive the drill rod to rotate. The drill bit drills a hole in the skull. The first positioning sleeve fits the surface of the skull and restricts the drill bit from going deeper. S4, disassemble the drill rod, rotate the second positioning sleeve to adjust the length of the fixed section extending out of the second positioning sleeve, thereby limiting the depth of the drug delivery tube entering the borehole; S5, with the help of two sets of symmetrical rotors, rotates the drug delivery tube to screw the fixed section into the borehole, so as to achieve a stable fixation of the drug delivery tube in the borehole. S6. Connect one end of the administration tube tightly to the micro-infusion extension tube, connect the other end of the micro-infusion extension tube to the screw-in syringe, and then place the screw-in syringe on the micro-infusion pump. Set the administration rate, dosage and duration of administration through the micro-infusion pump to achieve adjustable long-term administration of cranial bone marrow.

[0016] Compared with the prior art, this application includes at least one of the following beneficial technical effects: The present invention, through the setting of the first positioning sleeve and the second positioning sleeve, completely eliminates the problem of drilling through the skull and damaging brain tissue during the drilling and drug administration stages, while taking into account both operational accuracy and safety. This invention achieves visual indication of drilling depth and drug delivery tube fixation depth by matching the first positioning sleeve, the second positioning sleeve with the first scale segment and the second scale segment, making it specifically suitable for thin bone tissue such as the skull. Furthermore, by setting up the drug delivery port and the annular array of side holes, the drug solution can be evenly diffused into the skull bone marrow tissue. The inlet section can be tightly connected to the micro-infusion extension tube and the screw-in syringe. With the micro-infusion pump, the drug delivery rate, dosage and duration can be precisely controlled to meet the long-term drug delivery needs of about 7 days. Furthermore, by using a cap and a plug, the tubing can be sealed when medication is paused to prevent contamination and leakage, thereby further improving the stability and reliability of long-term medication administration. In summary, this invention enables stable long-term intracranial drug delivery, overcomes the limitations of the blood-brain barrier on drug delivery, promotes the clinical translation of efficient drug delivery pathways, and improves the treatment efficacy of central nervous system diseases. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the drill pipe structure; Figure 2 for Figure 1 A schematic diagram of the cross-sectional structure; Figure 3 This is a schematic diagram of the drug delivery tube. Figure 4 for Figure 3 A schematic diagram of the cross-sectional structure; Figure 5 yes Figure 4 Enlarged diagram of point A in the middle.

[0018] Figure label: 1. Drill pipe; 11. Mounting rod; 12. First graduated section; 13. First threaded section; 14. Drill bit; 2. First positioning sleeve; 3. Drug delivery tube; 31. Liquid inlet section; 32. Delivery section; 33. Second graduation section; 34. Second threaded section; 35. Fixing section; 36. Drug delivery section; 37. Drug delivery port; 38. Side port; 39. Rotor; 4. Second positioning sleeve; 5. Sealing cap; 51. Sealing plug. Detailed Implementation

[0019] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that, unless otherwise specified, the following embodiments and features described therein can be combined with each other.

[0020] Example like Figure 1 and Figure 2As shown, this invention proposes a medical device specifically for long-term bone marrow administration via the skull, comprising a drill rod 1 for drilling holes in the skull, with a first positioning sleeve 2 fitted around the outer ring of the drill rod 1. The first positioning sleeve 2 is used to limit the drilling depth to prevent penetration of the skull and subsequent brain tissue damage. The drill rod 1 includes a mounting rod 11, one end of which is connected to a drilling machine or drilling tool. A first graduated section 12 is fixedly connected to one end of the mounting rod 11. A first threaded section 13 is provided at the end of the first graduated section 12 away from the mounting rod 11. A drill bit 14 is fixedly connected to the end of the first threaded section 13 away from the first graduated section 12. The drill bit 14 drills holes in the skull when rotating. The outer ring of the first threaded section 13 is provided with equidistant cylindrical threads. The first positioning sleeve 2 is threadedly connected to the outer ring of the first threaded section 13. When rotating, the first positioning sleeve 2 moves along the length direction of the drill rod 1, thereby adjusting the length of one end of the drill bit 14 extending out of the first positioning sleeve 2, and thus adjusting the depth of the drill bit 14 entering the skull to prevent penetration of the skull and subsequent brain tissue damage. Simultaneously, equidistant graduations are provided on the outer side of the first graduation segment 12 to accurately read the drilling depth. In actual operation, the drilling depth is determined based on approximately 1 / 2 to 2 / 3 of the skull thickness at the drilling location, obtained from the patient's cranial imaging examination. The height of the first positioning sleeve 2 is set according to the graduations on the first graduation segment 12 of the skull to accurately read the drilling depth and prevent drilling through the skull and causing brain tissue damage. The outer ring of the first threaded segment 13 has equidistant cylindrical threads that run in the opposite direction to the threads of the drill bit 14 to prevent displacement after the first positioning sleeve 2 contacts the skull during drilling due to rotation in the same direction.

[0021] For further details, please refer to Figures 3 to 5The aforementioned medical device includes a drug delivery tube 3 for administering medication into a borehole, with one end of the drug delivery tube 3 fixed in the borehole. A second positioning sleeve 4 is fitted around the outer ring of the drug delivery tube 3 to limit the depth of the drug delivery tube 3 entering the borehole. The drug delivery tube 3 includes an inlet section 31, with a delivery section 32 fixedly connected to the smaller diameter end of the inlet section 31. A second graduation section 33 is provided at the end of the delivery section 32 away from the inlet section 31. A second threaded section 34 is fixedly connected to the end of the second graduation section 33 away from the delivery section 32. A fixing section 35 is fixedly connected to the end of the second threaded section 34 away from the second graduation section 33. The outer side of the fixing section 35 is tapered. The end of the fixing section 35 away from the second threaded section 34 has a smaller diameter and is fixedly connected to a drug delivery section 36. The end of the drug delivery section 36 away from the fixing section 35 is closed, and a drug delivery hole 37 is provided at the end of the drug delivery section 36 away from the fixing section 35 to facilitate the outflow of medication for drug delivery. The outer ring of the drug delivery section 36 has multiple sets of side holes 38 arranged in a ring array to facilitate uniform drug delivery through multiple flow channels. The second positioning sleeve 4 is threaded to the outer ring of the second threaded section 34. The outer ring of the fixing section 35 has equidistant conical threads to facilitate drilling the fixing section 35 into the hole opened in the drill rod 1. The outer ring of the second threaded section 34 has equidistant cylindrical threads. When the second positioning sleeve 4 rotates, it moves along the length of the drug delivery tube 3, thereby adjusting the length of one end of the fixing section 35 extending beyond the second positioning sleeve 4, and thus adjusting the depth of the drug delivery tube 3 into the skull, preventing brain tissue damage from penetrating the skull. The outer side of the second scale section 33 has equidistantly distributed scale lines. After adjusting the position of the second positioning sleeve 4, accurate scale values ​​are read, allowing the drug delivery tube 3 to be screwed into the drill hole, achieving visible skull fixation depth and long-term retention of skull bone marrow. The outer ring of the delivery section 32 is fixedly connected to two sets of symmetrically arranged rotors 39 to facilitate rotation of the drug delivery tube 3. The outer ring of the second threaded section 34 has equidistant cylindrical threads that are opposite in direction to the outer ring of the fixed section 35 with equidistant conical threads. This prevents displacement after the second positioning sleeve 4 contacts the skull when the drug delivery tube 3 is fixed, due to rotation in the same direction.

[0022] It is worth mentioning that the first positioning sleeve 2 and the second positioning sleeve 4 may be provided with top screws on their sides, which can be locked after the position is adjusted to prevent accidental movement.

[0023] Furthermore, the inlet section 31 is threaded at the end away from the delivery section 32 and is tightly connected to the micro-infusion extension tube. The other end of the micro-infusion extension tube is connected to a screw-in syringe, which is placed on the micro-infusion pump for adjustable long-term drug delivery.

[0024] It is worth mentioning that the hollow part of the administration tube 3 has a diameter of 2.0 mm. When blockage occurs at the administration port 37 and the side port 38, a syringe needle can be used for flushing.

[0025] Finally, a sealing cap 5 is threadedly connected to the end of the inlet section 31 away from the delivery section 32. A sealing plug 51 is fixedly connected to the side of the sealing cap 5 closest to the inlet section 31, and the sealing plug 51 is located in the inlet section 31. By setting the sealing cap 5 and the sealing plug 51, the drug delivery tube 3 can be temporarily closed when transcranial bone marrow infusion is suspended.

[0026] In this embodiment, the drilling location and skull thickness at that location are first determined based on the patient's cranial imaging results. One-half to two-thirds of the skull thickness is selected as the preset drilling depth. The drilling assembly is then assembled, with one end of the mounting rod 11 of the drill rod 1 connected to the drilling machine or drilling tool. Drilling preparation is completed using the integrated structure of the mounting rod 11, the first graduated section 12, the first threaded section 13, and the drill bit 14. Since the first positioning sleeve 2 is threaded to the outer ring of the first threaded section 13 of the drill rod 1, and the first threaded section 13 has equidistant cylindrical threads, rotating the first positioning sleeve 2 allows it to move along the length of the drill rod 1, thereby adjusting the length of the drill bit 14 extending beyond the first positioning sleeve 2. During this process, the extension length of the drill bit 14 is accurately read and calibrated using the equidistant graduations on the outer side of the first graduated section 12, ensuring consistency with the preset drilling depth. During drilling, the drill is started to rotate the drill rod 1, and the drill bit 14 drills a hole in the skull. The first positioning sleeve 2 fits against the surface of the skull to restrict the drill bit 14 from going deeper, effectively preventing the drill bit from penetrating the skull and damaging the brain tissue 14, thus achieving a safe and controllable skull drilling operation.

[0027] After drilling is completed, the drill rod 1 and the first positioning sleeve 2 are disassembled, and the drug delivery assembly is assembled and installed. First, the position of the second positioning sleeve 4 on the drug delivery tube 3 is adjusted according to the drilling depth and the need for bone marrow administration. The second positioning sleeve 4 is threaded to the outer ring of the second threaded section 34 of the drug delivery tube 3. The second threaded section 34 has equidistant cylindrical threads. Rotating the second positioning sleeve 4 allows it to move along the length of the drug delivery tube 3, thereby adjusting the length of the fixed section 35 extending beyond the second positioning sleeve 4, thus limiting the depth to which the drug delivery tube 3 enters the borehole. The adjusted position of the second positioning sleeve 4 is read and confirmed through the equidistant scale lines on the outer side of the second scale section 33, ensuring that the drug delivery section 36 of the drug delivery tube 3 accurately reaches the target area of ​​the bone marrow.

[0028] Subsequently, using the two sets of symmetrical rotors 39 fixed to the outer ring of the delivery section 32 of the drug delivery tube 3, the drug delivery tube 3 is rotated to screw the fixed section 35 into the borehole. Because the outer side of the fixed section 35 is tapered and the outer ring has equidistant conical threads, it can tightly engage with the inner wall of the borehole, achieving stable fixation of the drug delivery tube 3 in the borehole while avoiding additional damage to the skull and surrounding tissues. One end of the drug delivery section 36 of the drug delivery tube 3 is closed, forming a multi-channel drug delivery structure only through the drug delivery hole 37 at the end and multiple sets of side holes 38 distributed in a ring array on the outer ring, laying the foundation for subsequent uniform drug delivery.

[0029] After the drug delivery tube 3 is fixed, the drug delivery tubing is connected. The threaded end of the inlet section 31 of the drug delivery tube 3, away from the delivery section 32, is tightly connected to the micro-infusion extension tube. The other end of the micro-infusion extension tube is connected to a screw-in syringe, which is then placed on the micro-infusion pump. The drug delivery rate, dosage, and duration are set by the micro-infusion pump to achieve adjustable long-term drug delivery to the skull and bone marrow, such as maintaining continuous drug delivery for about 7 days. The drug solution enters the delivery section 32 through the inlet section 31, flows sequentially through the second graduation section 33, the second threaded section 34, and the fixing section 35 before reaching the drug delivery section 36. Finally, it diffuses evenly into the skull and bone marrow tissue through the drug delivery port 37 and multiple sets of side ports 38, efficiently delivering the drug to the brain parenchyma.

[0030] If blockage is found in the administration port 37 or side port 38 during administration, the syringe needle can be inserted directly into the administration tube 3 to flush it and ensure that the administration channel is unobstructed.

[0031] When it is necessary to pause transcranial bone marrow infusion, disassemble the micro-infusion extension tubing and thread the sealing cap 5 onto the end of the inlet section 31 furthest from the delivery section 32. At this time, the sealing plug 51 on the side of the sealing cap 5 closest to the inlet section 31 is embedded inside the inlet section 31, achieving a sealed enclosure of the drug delivery tubing 3, preventing external contaminants from entering the tubing and causing infection, while also avoiding leakage of residual drug solution inside the tubing, thus preparing for subsequent resumption of drug delivery or final disassembly of the device.

[0032] A method of using a medical device specifically designed for long-term administration of medication to the skull and bone marrow includes the following steps: S1. Based on the patient's cranial imaging examination results, determine the drilling location and the skull thickness at that location, select 1 / 2 to 2 / 3 of the skull thickness as the preset drilling depth, and connect one end of the mounting rod 11 of the drill rod 1 to the drilling machine or drilling tool. S2, rotate the first positioning sleeve 2, adjust the length of the drill bit 14 extending out of the first positioning sleeve 2, and accurately read and calibrate the extension length of the drill bit 14 through the equidistant scale lines on the outside of the first scale segment 12 to ensure that it is consistent with the preset drilling depth; S3, start the drill and drive the drill rod 1 to rotate. The drill bit 14 drills a hole in the skull. The first positioning sleeve 2 fits against the surface of the skull and restricts the drill bit 14 from going deeper. S4, disassemble drill rod 1, rotate the second positioning sleeve 4 to adjust the length of the fixed section 35 extending out of the second positioning sleeve 4, thereby limiting the depth of the drug delivery tube 3 entering the borehole; S5, with the help of two sets of symmetrical rotors 39, rotate the drug delivery tube 3 so that the fixed section 35 is screwed into the borehole, thereby achieving a stable fixation of the drug delivery tube 3 in the borehole. S6. Connect one end of the administration tube 3 tightly to the micro-infusion extension tube, and connect the other end of the micro-infusion extension tube to the screw-in syringe. Then place the screw-in syringe on the micro-infusion pump and set the administration rate, dosage and duration through the micro-infusion pump to achieve adjustable long-term administration of cranial bone marrow.

[0033] The above specific embodiments are merely optional embodiments of the present invention. Based on the technical solutions of the present invention and the relevant teachings of the above embodiments, those skilled in the art can make various alternative improvements and combinations to the above specific embodiments.

Claims

1. A medical device specifically designed for long-term administration of medication to the skull and bone marrow, characterized in that, include: A drill rod (1) for drilling holes in the skull, wherein a first positioning sleeve (2) is fitted around the outer ring of the drill rod (1), and the first positioning sleeve (2) is used to limit the drilling depth to prevent drilling through the skull and causing brain tissue damage. A drug delivery tube (3) for administering drugs into a borehole, one end of which is fixed in the borehole. A second positioning sleeve (4) is fitted around the outer ring of the drug delivery tube (3) to limit the depth of the drug delivery tube (3) into the borehole.

2. A medical device specifically for long-term administration of medication to the skull and bone marrow according to claim 1, characterized in that, The drill rod (1) includes an installation rod (11), one end of which is fixedly connected to a first scale segment (12), and the end of the first scale segment (12) away from the installation rod (11) is provided with a first threaded segment (13), and the end of the first threaded segment (13) away from the first scale segment (12) is fixedly connected to a drill bit (14).

3. A medical device specifically for long-term administration of medication to the skull and bone marrow according to claim 2, characterized in that, The first scale segment (12) has equidistant scale lines on its outer side.

4. A medical device specifically for long-term administration of medication to the skull and bone marrow according to claim 2, characterized in that, The outer ring of the first threaded section (13) is provided with equidistant cylindrical threads. The first positioning sleeve (2) is threadedly connected to the outer ring of the first threaded section (13). The equidistant cylindrical threads of the outer ring of the first threaded section (13) are opposite to the spiral direction of the drill bit (14).

5. A medical device for long-term administration of medication to the skull and bone marrow according to claim 1, characterized in that, The drug delivery tube (3) includes an inlet section (31), a delivery section (32) is fixedly connected to the small diameter end of the inlet section (31), a second scale section (33) is provided at the end of the delivery section (32) away from the inlet section (31), a second threaded section (34) is fixedly connected at the end of the second scale section (33) away from the delivery section (32), a fixed section (35) is fixedly connected at the end of the second threaded section (34) away from the second scale section (33), the outer side of the fixed section (35) is tapered, the diameter of the fixed section (35) away from the second threaded section (34) is small and a drug delivery section (36) is fixedly connected thereto, the end of the drug delivery section (36) away from the fixed section (35) is closed, a drug delivery hole (37) is opened at the end of the drug delivery section (36) away from the fixed section (35), and multiple sets of side holes (38) are opened on the outer ring of the drug delivery section (36), and the multiple sets of side holes (38) are distributed in a ring array.

6. A medical device for long-term administration of medication to the skull and bone marrow according to claim 5, characterized in that, The second scale segment (33) has equidistant scale lines on its outer side.

7. A medical device for long-term administration of medication to the skull and bone marrow according to claim 5, characterized in that, The outer ring of the second threaded section (34) is provided with equidistant cylindrical threads, the second positioning sleeve (4) is threadedly connected to the outer ring of the second threaded section (34), the outer ring of the fixed section (35) is provided with equidistant tapered threads, and the equidistant cylindrical threads of the outer ring of the second threaded section (34) are opposite in direction to the equidistant tapered threads of the outer ring of the fixed section (35).

8. A medical device for long-term administration of medication to the skull and bone marrow according to claim 5, characterized in that, The outer ring of the conveying section (32) is fixedly connected with two sets of symmetrically arranged rotors (39).

9. A medical device for long-term administration of medication to the skull and bone marrow according to claim 5, characterized in that, The inlet section (31) is threaded with a sealing cap (5) at the end away from the conveying section (32). A sealing plug (51) is fixedly connected to the side of the sealing cap (5) near the inlet section (31). The sealing plug (51) is located in the inlet section (31).

10. A method of using a medical device for long-term administration of medication to the skull and bone marrow according to any one of claims 1-9, characterized in that, Includes the following steps: S1. Based on the results of the patient's cranial imaging examination, determine the drilling location and the thickness of the skull at that location, select 1 / 2 to 2 / 3 of the skull thickness as the preset drilling depth, and connect one end of the mounting rod (11) of the drill rod (1) to the drilling machine or drilling tool. S2, rotate the first positioning sleeve (2) and adjust the length of the drill bit (14) extending out of the first positioning sleeve (2). Through the equidistant scale lines on the outside of the first scale segment (12), accurately read and calibrate the extension length of the drill bit (14) to ensure that it is consistent with the preset drilling depth. S3, start the drill and drive the drill rod (1) to rotate, and the drill bit (14) drills a hole in the skull. The first positioning sleeve (2) fits against the skull surface and restricts the drill bit (14) from going deeper. S4, disassemble the drill rod (1), rotate the second positioning sleeve (4) to adjust the length of the fixed section (35) extending out of the second positioning sleeve (4), thereby limiting the depth of the drug delivery tube (3) into the borehole; S5, with the help of two sets of symmetrical rotors (39), rotate the drug delivery tube (3) so that the fixed section (35) is screwed into the borehole, thereby achieving a stable fixation of the drug delivery tube (3) in the borehole; S6, connect one end of the administration tube (3) tightly to the micro-infusion extension tube, connect the other end of the micro-infusion extension tube to the screw-in syringe, and then place the screw-in syringe on the micro-infusion pump. Set the administration rate, administration dose and administration duration through the micro-infusion pump to achieve adjustable long-term administration of skull bone marrow.

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