Traditional Chinese medicine composition for treating cognitive impairment associated with cerebral small vessel disease and preparation method thereof

Abstract

This invention relates to the field of treatment technology for phlegm-stasis type cerebral small vessel disease, and particularly to a traditional Chinese medicine composition and its preparation method for treating cognitive impairment related to cerebral small vessel disease. The traditional Chinese medicine composition is made from the following traditional Chinese medicines in parts by weight: 10 parts of Trichosanthes kirilowii, 10 parts of Pinellia ternata, 15 parts of Citrus reticulata peel, 12 parts of Atractylodes macrocephala, 12 parts of Ligusticum chuanxiong, 30 parts of Salvia miltiorrhiza, 6 parts of Hirudo medicinalis, 15 parts of Crataegus pinnatifida (roasted), 12 parts of Polygala tenuifolia, 12 parts of Cistanche deserticola, 6 parts of Glycyrrhiza uralensis, 15 parts of Spatholobus suberectus, and 15 parts of Acorus tatarinowii. The traditional Chinese medicine composition and its preparation method provided by this invention target the core pathogenesis of cognitive impairment in cerebral small vessel disease, namely "phlegm and blood stasis obstructing the orifices." Through multiple pathways of action—resolving phlegm and removing blood stasis, clearing the channels and opening the orifices, and benefiting intelligence and calming the mind—it improves cerebral microcirculation, reduces neuroinflammation, and protects neurons, thereby improving cognitive function.

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