A traditional Chinese medicine composition for senile dementia and stroke and a preparation method thereof

By employing supercritical CO2 extraction and low-temperature dynamic circulation extraction technologies, the problems of component loss and degradation in the preparation of traditional Chinese medicine have been solved, enabling the efficient preparation of traditional Chinese medicine compositions for Alzheimer's disease and stroke. These compositions possess neurovascular unit regulatory effects and significantly improve therapeutic efficacy.

CN122140836APending Publication Date: 2026-06-05HANGZHOU JUZHISHUANG TECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANGZHOU JUZHISHUANG TECHNOLOGY CO LTD
Filing Date
2026-03-17
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

In existing technologies, the preparation processes of traditional Chinese medicine for Alzheimer's disease and stroke suffer from problems such as severe loss of lipid-soluble active ingredients, significant degradation of heat-sensitive ingredients, low extraction rate of ingredients, poor process stability, and incomplete therapeutic effects, and cannot effectively intervene in neurovascular coupling disorders simultaneously.

Method used

By employing supercritical CO2 extraction and low-temperature dynamic circulation extraction technology, lipid-soluble and water-soluble components are processed in stages. Combined with ceramic membrane microfiltration and nanofiltration membrane purification, a traditional Chinese medicine composition for Alzheimer's disease and stroke is prepared, achieving protection of component integrity and improvement of process stability.

Benefits of technology

It significantly improved the extraction and retention rates of lipid-soluble and water-soluble active ingredients, enhanced the safety and efficacy of the traditional Chinese medicine composition, achieved functional coupling and synchronous repair of neurons and vascular endothelium, and has a broad-spectrum effect in preventing and treating Alzheimer's disease and stroke.

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Abstract

The application discloses a traditional Chinese medicine composition for senile dementia and stroke and a preparation method thereof, which is prepared from the following raw medicinal materials in parts by weight: 40 parts of Schinus molle, 10 parts of American ginseng, 8 parts of Panax notoginseng, 5 parts of hawthorn, 5 parts of Chinese yam, 5 parts of Herba Epimedii, 6 parts of Radix Curcumae, 5 parts of Poria cocos, 5 parts of Astragalus membranaceus, 5 parts of Codonopsis pilosula, 3 parts of Platycladus orientalis, 3 parts of Corydalis, and 5 parts of Cannabis sativa Linn. The application has the advantages that a nerve blood vessel unit system regulation mechanism is creatively proposed, the limitation of single target treatment is broken through, the Schinus molle, which is the monarch drug in the prescription, is rich in nervonic acid and neurotrophic factor-like substances, can directly act on neuron mitochondrial energy metabolism, improves brain tissue energy supply, and on the process level, the multi-stage dynamic extraction technology of the application innovates the traditional decocting mode.
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