A constant temperature and humidity drying system and control method for drying bioactive microplates.

Abstract

This application relates to the technical field of biological detection product manufacturing equipment, and provides a constant temperature and humidity drying system and control method for drying bioactive microplates. The method includes: collecting real-time temperature and humidity parameters inside the drying chamber; comparing the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment and control commands; controlling the operation of the processing fan according to the adjustment and control commands to adjust the flow rate of the circulating air into the drying chamber; controlling the operation of the dehumidification rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment and control commands to adjust the dehumidification amount of the circulating air; controlling the operation of the cooling and temperature control unit according to the adjustment and control commands to adjust the dehumidified air to a set temperature before sending it into the drying chamber; and achieving uniform drying of the bioactive microplates by maintaining a constant temperature and humidity clean environment in the drying chamber.

Description

Technical Field

[0001] This application relates to the field of equipment technology for manufacturing biological detection products, and in particular to a constant temperature and humidity drying system and control method for drying bioactive microplates. Background Technology

[0002] In the production of in vitro diagnostic bioassay products, bioactive microplates are the core detection carriers. The stability of the bioactive substances such as antigens, antibodies, and enzymes coated on their surface directly determines the sensitivity, accuracy, and batch consistency of the test products. In the microplate production process, the drying step is crucial for ensuring stable adhesion of bioactive substances and preventing inactivation. It places extremely high demands on the temperature, humidity, cleanliness, and airflow uniformity of the drying environment. Uniform drying must be achieved in a clean environment with constant temperature and humidity to avoid problems such as denaturation of bioactive substances and excessive drying differences between wells caused by temperature and humidity fluctuations. Summary of the Invention

[0003] This application provides a constant temperature and humidity drying system and control method for drying bioactive microplates, which aims to solve the following problems.

[0004] In a first aspect, embodiments of this application provide a control method for a constant temperature and humidity drying system for drying bioactive microplates, the method comprising: The system collects real-time temperature and humidity parameters inside the drying chamber; compares the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment and control commands; and controls the operation of the processing fan and adjusts the flow rate of the circulating air into the drying chamber according to the adjustment and control commands. The system controls the operation of the dehumidification rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment and control commands, adjusts the dehumidification amount of the circulating air, and discharges the moisture adsorbed by the dehumidification rotor through the regeneration airflow; the system also controls the operation of the cooling and temperature control unit according to the adjustment and control commands, adjusts the dehumidified air to the set temperature, and sends it into the drying chamber body. The system monitors the operating status of each component in the constant temperature and humidity drying system, triggers a fault alarm when an abnormality is detected, and completes the uniform drying of the bioactive microplate by maintaining a clean environment with constant temperature and humidity in the drying chamber.

[0005] In some embodiments, the step of collecting real-time temperature and humidity parameters inside the drying chamber includes: deploying temperature and humidity acquisition nodes at multiple different locations inside the drying chamber, collecting real-time temperature and humidity data of the corresponding area through each temperature and humidity acquisition node; and performing outlier removal and smoothing filtering on the collected multiple sets of temperature and humidity data to obtain the overall real-time temperature and humidity parameters inside the drying chamber.

[0006] In some embodiments, the step of comparing the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment control commands includes: calculating the deviation value and deviation change rate between the real-time temperature and humidity parameters and the preset target temperature and humidity parameters; classifying the deviation value and deviation change rate based on preset fuzzy control rules, generating adjustment control commands that match the deviation level, and performing amplitude limiting processing on the adjustment control commands to avoid control overshoot.

[0007] In some embodiments, controlling the operating state of the processing fan according to the adjustment control command and adjusting the flow rate of the circulating air into the drying chamber body includes: adjusting the operating speed of the processing fan by stepless frequency conversion according to the adjustment control command, and correspondingly adjusting the air flow rate of the circulating air; adjusting the air distribution ratio and air supply duration of the circulating air according to the temperature and humidity deviation of different areas inside the drying chamber body, so as to ensure that the airflow field inside the drying chamber body is uniformly distributed.

[0008] In some embodiments, controlling the operating status of the dehumidifying rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment control command, and adjusting the dehumidification amount of the circulating air, includes: adjusting the rotation speed of the dehumidifying rotor, the operating air volume of the regeneration fan, and the heating output power of the regeneration heating device according to the adjustment control command; and achieving continuous linear adjustment of the dehumidification amount of the circulating air by matching the real-time adsorption load and regeneration desorption efficiency of the dehumidifying rotor, thereby ensuring that the dehumidification process is stable and controllable.

[0009] In some embodiments, the process of discharging the moisture adsorbed by the dehumidifying impeller through the regeneration airflow includes: heating the regeneration air to a preset regeneration temperature range using a regeneration heating device, and then driving the heated regeneration air to flow in the reverse direction through the regeneration area of ​​the dehumidifying impeller by a regeneration fan, so that the moisture adsorbed by the dehumidifying impeller is released from the adsorption material and discharged from the system with the regeneration airflow; and dynamically adjusting the heating temperature and circulation time of the regeneration air according to the real-time adsorption saturation of the dehumidifying impeller.

[0010] In some embodiments, controlling the operation of the cooling and temperature control unit according to the adjustment control command, and adjusting the dehumidified air to a set temperature before sending it into the drying chamber body, includes: adjusting the cooling or heating output power of the cooling and temperature control unit according to the adjustment control command, performing temperature compensation adjustment on the dehumidified air, so that the temperature of the treated air is stabilized within the set target temperature range; and dynamically adjusting the operating level of the cooling and temperature control unit according to the deviation between the real-time supply air temperature and the set temperature to avoid large fluctuations in the supply air temperature.

[0011] In some embodiments, the monitoring of the operating status of each component in the constant temperature and humidity drying system and the triggering of a fault alarm when an abnormal operation is detected includes: collecting real-time operating parameters of the processing fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit; comparing the real-time operating parameters with the corresponding preset normal operating range; when the operating parameters are detected to exceed the normal operating range, generating a fault signal of the corresponding level, triggering an alarm prompt of the corresponding level, recording the fault information, and generating a safety shutdown protection command when a serious fault is detected.

[0012] In some embodiments, the process of achieving uniform drying of bioactive microplates by maintaining a constant temperature and humidity clean environment in the drying chamber includes: dynamically adjusting the target temperature and humidity parameters inside the drying chamber according to a preset drying stage division throughout the drying process of the bioactive microplates; maintaining a constant temperature and humidity clean environment in the corresponding drying stage through closed-loop control; and adjusting the circulation frequency of the circulating airflow according to the real-time drying progress of the bioactive microplates to achieve gradient uniform drying of the bioactive microplates and avoid deactivation of bioactive substances on the microplates.

[0013] Secondly, this application provides a constant temperature and humidity drying system for drying bioactive microplates, which is used to implement the method provided in any embodiment of this application, including a drying chamber body, an air handling system, a rotary dehumidification system, a post-cooling temperature control unit, and a control and monitoring system; The air handling system includes a processing fan for driving a circulating airflow. The rotary dehumidification system includes a dehumidification rotor, a regeneration fan, and a regeneration heating device. The dehumidification rotor is used to dehumidify the circulating air. The regeneration fan and the regeneration heating device work together to generate a regeneration airflow to discharge the moisture adsorbed by the dehumidification rotor. The post-cooling temperature control unit is located on the processing air outlet side of the dehumidification rotor and is used to adjust the temperature of the dehumidified air before sending it into the drying chamber body. The control and monitoring system is electrically connected to the processing fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit, respectively. It is used to collect the temperature and humidity parameters inside the drying chamber, adjust the operating status of each component in a closed loop according to preset parameters, and has the functions of operating status monitoring and fault alarm.

[0014] This application collects real-time temperature and humidity parameters of the drying chamber and compares them with preset target parameters to generate adjustment and control commands. It synchronously and collaboratively controls the operation of the fan, rotary dehumidification system, and post-cooling temperature control unit, realizing coordinated closed-loop control of temperature and humidity in the drying chamber. This solves the problem that independent temperature and humidity control in the prior art is prone to coupling fluctuations and cannot maintain a stable constant temperature and humidity environment. It can keep the environment of the drying chamber within the temperature and humidity range that meets the drying requirements of bioactive microporous plates for a long time, avoiding the deactivation of bioactive substances caused by temperature and humidity fluctuations.

[0015] By synchronously and dynamically adjusting the circulating airflow, dehumidification capacity, and supply air temperature, the uniform distribution of airflow and temperature and humidity fields inside the drying chamber can be ensured, enabling uniform drying of large batches of bioactive microplates. This significantly reduces inter-well and batch-to-batch differences in microplates, improving product consistency and testing accuracy of biological testing products.

[0016] This method simultaneously monitors the operational status and alarms faults of all system components, enabling real-time identification of system malfunctions and triggering corresponding warnings. This avoids the scrapping of entire batches of products due to equipment malfunctions, significantly improving the stability and safety of the production process and meeting the needs of large-scale continuous production of biological testing products.

[0017] The control logic of this method is adapted to the special process requirements of bioactive microplate drying. It can be adapted to existing rotary dehumidification drying systems without high equipment modification costs, and balances drying efficiency and production economy while ensuring the stability of bioactive substances.

[0018] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic flowchart of the steps of a control method for a constant temperature and humidity drying system for drying bioactive microplates, provided in an embodiment of this application. Figure 2 This is a schematic block diagram of a constant temperature and humidity drying system for drying bioactive microplates provided in one embodiment of this application; Figure 3 This is a schematic block diagram of the structure of a constant temperature and humidity drying system provided in an embodiment of this application.

[0021] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Detailed Implementation

[0022] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0023] The flowchart shown in the attached diagram is for illustrative purposes only and does not necessarily include all content and operations / steps, nor does it necessarily have to be performed in the order described. For example, some operations / steps can be broken down, combined, or partially merged, so the actual execution order may change depending on the actual situation.

[0024] It should be understood that, in order to clearly describe the technical solutions of the embodiments of the present invention, the terms "first" and "second" are used in the embodiments of the present invention to distinguish identical or similar items with essentially the same function and effect. Those skilled in the art will understand that the terms "first" and "second" do not limit the quantity or execution order, and the terms "first" and "second" are not necessarily different.

[0025] It should be understood that the terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the scope of the application. As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural forms unless the context clearly indicates otherwise.

[0026] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0027] In the production of in vitro diagnostic bioassay products, bioactive microplates are the core detection carriers. The stability of the bioactive substances such as antigens, antibodies, and enzymes coated on their surface directly determines the sensitivity, accuracy, and batch consistency of the test products. In the microplate production process, the drying step is crucial for ensuring stable adhesion of bioactive substances and preventing inactivation. It places extremely high demands on the temperature, humidity, cleanliness, and airflow uniformity of the drying environment. Uniform drying must be achieved in a clean environment with constant temperature and humidity to avoid problems such as denaturation of bioactive substances and excessive drying differences between wells caused by temperature and humidity fluctuations.

[0028] Currently, the drying process for bioactive microplates is mostly achieved in the industry by using conventional oven drying, vacuum freeze drying, or ordinary industrial dehumidification drying equipment with simple control logic. Conventional oven drying can only achieve open-loop or semi-open-loop control of a single temperature, and cannot accurately coordinate and regulate the humidity of the drying environment. This can easily lead to problems such as low drying efficiency due to excessively high humidity and rapid dehydration and inactivation of bioactive substances due to excessively low humidity. Vacuum freeze drying equipment can ensure bioactivity, but it is expensive and has a long drying cycle, making it unsuitable for large-scale continuous production and difficult to achieve uniform drying of large batches of microporous plates. The control logic of ordinary industrial rotary dehumidifier drying equipment is mostly designed for the dehumidification scenarios of conventional industrial plants. It can only achieve dehumidification and temperature regulation with fixed parameters. It cannot coordinate and close-loop control of multiple actuators such as dehumidification, temperature regulation, and airflow circulation based on the real-time temperature and humidity parameters of the drying chamber. This can easily lead to coupled fluctuations in temperature and humidity, making it impossible to maintain a stable constant temperature and humidity clean environment for a long time. This results in large differences between the pores of the dried microporous plates, poor batch consistency, and even inactivation of bioactive substances and product scrap. Meanwhile, existing control methods for such drying equipment often lack real-time monitoring and abnormal protection mechanisms for the operating status of all system components. They cannot promptly identify abnormal component operation and trigger early warnings, which can easily lead to the loss of the entire batch of production materials, resulting in insufficient production stability and safety.

[0029] To solve the above problem, please refer to Figure 1 This application provides a control method for a constant temperature and humidity drying system for drying bioactive microplates, applicable to such a system. The provided control method for the constant temperature and humidity drying system for drying bioactive microplates includes steps S101 to S103. Details are as follows: Step S101. Collect real-time temperature and humidity parameters inside the drying chamber; compare the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment and control commands; control the operation status of the processing fan according to the adjustment and control commands, and adjust the flow rate of the circulating airflow into the drying chamber.

[0030] Specifically, this step is the core pre-processing stage for sensing and command generation in the entire closed-loop control system. It completes the entire process of "environmental status acquisition - deviation judgment - basic airflow adjustment," providing a reliable data foundation and airflow conditions for subsequent precise temperature and humidity control. Specifically, it includes the following steps: 1. Real-time temperature and humidity parameter acquisition in the drying room: After the system is powered on and initialized, the control and monitoring system continuously collects the real-time air temperature and relative humidity parameters inside the drying room through temperature and humidity acquisition elements deployed inside the drying room body, according to the preset acquisition frequency (default setting is once per second, which can be adjusted in the range of 0.2 seconds to 5 seconds according to production needs). The acquired analog signals are transmitted to the analog input module of the control and monitoring system through shielded signal cables. After being converted from analog to digital signals, they are stored in the register of the control unit, completing the acquisition of basic environmental data.

[0031] 2. Control Command Generation Stage: The control and monitoring system retrieves the currently collected real-time temperature and humidity parameters from the register, and simultaneously retrieves the user-preset target temperature and humidity parameters adapted to the drying requirements of the bioactive microplate from the storage unit (the typical target range is temperature 18℃-25℃, relative humidity 20%-40%, which can be adjusted according to the characteristics of different bioactive substances); the real-time parameters and target parameters are compared one by one to calculate the temperature deviation and humidity deviation values; based on the preset PID control logic, the corresponding direction and amplitude of the control command are generated according to the sign and magnitude of the deviation value. The commands are divided into three categories: fan adjustment commands, dehumidification system adjustment commands, and temperature control unit adjustment commands, which correspond to the subsequent execution components.

[0032] 3. Processing Fan and Circulating Airflow Regulation: The control and monitoring system sends the generated fan regulation commands to the variable frequency drive of the processing fan via a communication cable. The variable frequency drive adjusts the output frequency and voltage according to the commands, changing the operating state of the processing fan and correspondingly adjusting the total flow rate and air velocity of the circulating airflow into the drying chamber. Through the continuous delivery of circulating airflow, a stable circulating flow field is formed inside the drying chamber, ensuring that the clean air after subsequent dehumidification and temperature adjustment can be evenly diffused to all areas of the drying chamber, avoiding airflow dead zones, and providing basic airflow conditions for the uniform drying of the microporous plate.

[0033] Step S102. Control the operation status of the dehumidification rotor, regeneration fan and regeneration heating device of the rotary dehumidification system according to the adjustment control command, adjust the dehumidification amount of the circulating air, and discharge the moisture adsorbed by the dehumidification rotor through the regeneration airflow; control the operation status of the cooling temperature control unit according to the adjustment control command, adjust the dehumidified air to the set temperature and send it into the drying chamber body.

[0034] Specifically, this step is the core process execution link of the entire control method. Through the coordinated control of multiple components, it achieves precise coordinated regulation of the humidity and temperature of the circulating air, and outputs clean air with constant temperature and humidity that meets the drying requirements. It includes the following steps: 1. Rotary Dehumidification System Coordinated Control and Moisture Removal: The control and monitoring system synchronously sends the generated dehumidification system adjustment commands to the drive motor of the dehumidification rotor, the frequency converter driver of the regeneration fan, and the power controller of the regeneration heating device. First, the operating speed of the dehumidification rotor drive motor is adjusted according to the humidity deviation value. The higher the speed, the larger the effective area of ​​the rotor for adsorbing moisture, and the stronger the dehumidification capacity. Simultaneously, the operating air volume of the regeneration fan and the electric heating output power of the regeneration heating device are adjusted to heat the regeneration air to a suitable regeneration temperature. The hot air driven by the regeneration fan reverses and flushes the regeneration area of ​​the dehumidification rotor, causing the moisture adsorbed by the rotor to be desorbed from the molecular sieve / silica gel adsorbent material by heat and discharged from the system with the regeneration exhaust gas, realizing continuous regeneration and circulating dehumidification of the rotor. Through the coordinated matching of rotor speed, regeneration air volume, and heating power, the dehumidification volume of the circulating air is precisely adjusted, and the humidity of the circulating air is controlled within the target range.

[0035] 2. Temperature Compensation and Air Supply Regulation of the Post-Cooling Temperature Control Unit: The control and monitoring system sends the generated temperature control unit adjustment command to the cooling / heating controller of the post-cooling temperature control unit. The dehumidified air first flows through the heat exchange coil of the post-cooling temperature control unit. The control unit adjusts the operating frequency of the refrigeration compressor or the output power of the electric auxiliary heater of the post-cooling temperature control unit according to the deviation between the real-time value and the target value of the air supply temperature, and performs temperature compensation regulation to cool or heat the dehumidified air. After the temperature of the treated air is corrected to the set target temperature range, it is sent into the drying chamber through the air supply duct, so that the air entering the drying chamber simultaneously meets the preset temperature and humidity requirements, forming a circulating constant temperature and humidity clean airflow.

[0036] Step S103. Monitor the operating status of each component in the constant temperature and humidity drying system. Trigger a fault alarm when an abnormal operation is detected. By maintaining a clean environment with constant temperature and humidity in the drying chamber, the bioactive microplate is dried uniformly.

[0037] Specifically, this step is the safety guarantee and process closed-loop link of the entire control method. The core is to ensure the long-term stable operation of the system, and at the same time, to achieve uniform drying of the bioactive microplate through continuous closed-loop control. This includes the following environment: 1. System-wide Component Operation Monitoring and Fault Alarm Protection: Throughout the entire system operation cycle, the control and monitoring system continuously collects and processes real-time operating parameters of the fan, dehumidification rotor drive motor, regeneration fan, regeneration heating device, and post-cooling temperature control unit at a preset monitoring frequency. These parameters include operating current, operating voltage, motor speed, equipment surface temperature, and start / stop status. The collected real-time operating parameters are compared one by one with the corresponding normal operating ranges pre-stored in the control unit. When any parameter is detected to exceed the normal operating range, it is determined to be an operational anomaly, and a corresponding level of fault signal is generated based on the severity of the anomaly. For minor faults (such as slight parameter deviation or filter clogging warning), an on-site audible and visual alarm is triggered, and the fault code and fault description are displayed on the human-machine interface. For serious faults (such as fan overload shutdown, heating overheating, or component short circuit), in addition to triggering the highest level alarm, a safety shutdown protection command is immediately generated to cut off the power supply output of the corresponding dangerous component, preventing equipment damage and loss of production materials. At the same time, the fault information is stored in the system's fault log for subsequent traceability and troubleshooting.

[0038] 2. Constant Temperature and Humidity Environment Maintenance and Uniform Drying of Microplates: Under normal operating conditions without system failure, the control and monitoring system cyclically executes the entire process from step S101 to step S102, forming a continuous closed-loop control. This process corrects temperature and humidity deviations within the drying chamber in real time, maintaining a constant temperature, humidity, and clean environment within the drying chamber for an extended period. This allows the bioactive microplates placed on multiple drying racks within the drying chamber to slowly and uniformly complete the dehydration and drying process in a stable and uniform temperature and humidity environment. Through stable environmental control, drastic fluctuations in temperature and humidity or excessive local environmental differences are avoided, preventing uneven drying of the coating material between the microplate pores and denaturation and inactivation of bioactive substances. Ultimately, this process achieves the production of bioactive microplates that meet quality requirements.

[0039] In some embodiments, the step of collecting real-time temperature and humidity parameters inside the drying chamber includes: deploying temperature and humidity acquisition nodes at multiple different locations inside the drying chamber, collecting real-time temperature and humidity data of the corresponding area through each temperature and humidity acquisition node; and performing outlier removal and smoothing filtering on the collected multiple sets of temperature and humidity data to obtain the overall real-time temperature and humidity parameters inside the drying chamber.

[0040] This embodiment is used to solve the problems that single-point data acquisition cannot reflect the overall temperature and humidity status of the drying room, and that the acquired data has instantaneous interference and outliers that cause control deviations, thereby improving the accuracy and representativeness of temperature and humidity acquisition.

[0041] The data acquisition nodes are deployed in a three-dimensional distributed layout inside the drying chamber. Specifically, two data acquisition nodes are deployed in each of the upper (20cm from the top), middle (material placement height on the drying rack), and lower (20cm from the ground) layers of the drying chamber, and one data acquisition node is deployed at each of the air supply inlet and return air outlet of the drying chamber, for a total of eight data acquisition nodes. All data acquisition nodes use industrial-grade temperature and humidity transmitters with an accuracy of ±0.2℃ and ±2%RH, and are connected to the analog input module of the control and monitoring system via shielded twisted-pair cables to avoid electromagnetic interference.

[0042] Synchronous data acquisition involves sending synchronous acquisition commands to all acquisition nodes through the control and monitoring system. The eight acquisition nodes acquire real-time temperature and humidity data of the corresponding area at the same time, with the acquisition frequency set to once per second. All acquired data is synchronously uploaded to the storage register of the control and monitoring system.

[0043] Outlier removal is performed by using the Laida criterion (3σ criterion) to remove outliers from eight sets of temperature and humidity data collected at the same time through the control and monitoring system. Specifically, the mean and standard deviation of the eight sets of data are calculated, and data whose absolute difference from the mean is greater than three times the standard deviation are identified as outliers and removed, while the remaining valid data are retained.

[0044] The smoothing filtering process first calculates a weighted average of the valid data after removing outliers. The weight of the data collected in the middle material zone is set to 0.5, the weight of the data at the supply and return air points is set to 0.3, and the weight of the data at the upper and lower layers is set to 0.2 to obtain the weighted average. Then, the weighted average of the data from five consecutive collection cycles is filtered by a moving average to eliminate numerical jumps caused by instantaneous airflow fluctuations. Finally, the real-time temperature and humidity parameters that can truly reflect the overall environmental state inside the drying room are obtained and used for subsequent control logic judgment.

[0045] In some embodiments, the step of comparing the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment control commands includes: calculating the deviation value and deviation change rate between the real-time temperature and humidity parameters and the preset target temperature and humidity parameters; classifying the deviation value and deviation change rate based on preset fuzzy control rules, generating adjustment control commands that match the deviation level, and performing amplitude limiting processing on the adjustment control commands to avoid control overshoot.

[0046] This embodiment addresses the problems of slow response, easy overshoot, and large fluctuations in conventional PID control for temperature and humidity coupled systems, thereby improving the accuracy and stability of temperature and humidity control.

[0047] The deviation is calculated by acquiring the real-time temperature and humidity parameters of the drying room after processing through the control and monitoring system, comparing them with the preset target temperature and humidity parameters, and calculating the temperature deviation value eT and humidity deviation value eRH respectively. At the same time, the temperature deviation change rate eCT and humidity deviation change rate eRH are also calculated. The deviation change rate is the difference between the deviation value of the current cycle and the deviation value of the previous cycle, divided by the acquisition cycle time.

[0048] Fuzzy hierarchical judgment is achieved by pre-writing a fuzzy control rule table into the control and monitoring system, dividing the deviation value and deviation change rate into 5 levels: negative large, negative small, zero, positive small, and positive large. For different combinations of deviation level and deviation change rate levels, corresponding control output levels are preset. The control and monitoring system inputs the calculated deviation value and deviation change rate into the fuzzy control rule table, performs fuzzy inference and hierarchical judgment, and outputs the corresponding PID parameter correction values, including the adjustment amounts of the proportional coefficient, integral coefficient, and derivative coefficient.

[0049] The regulation and control command generation is achieved by the control and monitoring system calculating the regulation and control commands for the processing fan, rotary dehumidification system, and post-cooling temperature control unit based on the corrected PID parameters. The output amplitude of the command is matched with the deviation level; the larger the deviation, the larger the command output amplitude, achieving rapid correction; the smaller the deviation, the smaller the command output amplitude, achieving precise fine-tuning.

[0050] The amplitude limiting and overshoot prevention processing limits the output amplitude of the control command before outputting it, and pre-sets the maximum upper limit and minimum lower limit of the single-cycle command output. When the calculated command output amplitude exceeds the upper limit, only the command corresponding to the upper limit is output; when the command output amplitude is lower than the lower limit, only the command corresponding to the lower limit is output. This avoids excessive control output within a single cycle, which could lead to significant overshoot and oscillation in temperature and humidity, and achieves stable, overshoot-free closed-loop control.

[0051] In some embodiments, controlling the operating state of the processing fan according to the adjustment control command and adjusting the flow rate of the circulating air into the drying chamber body includes: adjusting the operating speed of the processing fan by stepless frequency conversion according to the adjustment control command, and correspondingly adjusting the air flow rate of the circulating air; adjusting the air distribution ratio and air supply duration of the circulating air according to the temperature and humidity deviation of different areas inside the drying chamber body, so as to ensure that the airflow field inside the drying chamber body is uniformly distributed.

[0052] This embodiment is used to solve the problem of uneven airflow distribution and large local temperature and humidity differences caused by fixed airflow, so as to ensure uniform airflow field inside the drying chamber and improve the drying consistency of microporous plates.

[0053] The stepless frequency conversion airflow regulation utilizes a three-phase asynchronous frequency conversion motor for the fan, equipped with a vector-type frequency conversion driver, and communicates with the control and monitoring system. Based on the generated regulation control commands, the control and monitoring system sends corresponding frequency control signals to the frequency conversion driver. The frequency adjustment range is 0-50Hz, corresponding to a fan speed of 0-1450 r / min, achieving stepless continuous adjustment of the fan speed. As the fan speed increases, the airflow increases linearly; as the fan speed decreases, the airflow decreases linearly, achieving precise regulation of the total circulating airflow.

[0054] The regional temperature and humidity deviation collection method acquires real-time temperature and humidity data of different areas inside the drying room through multiple data acquisition nodes, calculates the temperature and humidity deviation values ​​between different areas, and identifies areas with large temperature and humidity deviations.

[0055] Air supply distribution and duration adjustment are achieved by installing electrically adjustable dampers on the air supply ducts of the drying room, corresponding to different air supply areas. All dampers are electrically connected to the control and monitoring system. The control and monitoring system adjusts the opening of the corresponding air supply dampers based on the temperature and humidity deviations in different areas. Areas with large deviations have larger damper openings, increasing the air supply ratio; areas with small deviations have smaller damper openings, decreasing the air supply ratio. At the same time, the system dynamically adjusts the air supply duration for corresponding areas based on the magnitude of the deviations. Areas with large deviations have longer air supply durations, while areas with small deviations have shorter air supply durations. Through the dynamic adjustment of the air supply ratio and duration, the air exchange frequency and airflow velocity in all areas of the drying room tend to be consistent, eliminating airflow dead zones and local temperature and humidity deviations, and ensuring a uniform airflow field distribution within the drying room.

[0056] In some embodiments, controlling the operating status of the dehumidifying rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment control command, and adjusting the dehumidification amount of the circulating air, includes: adjusting the rotation speed of the dehumidifying rotor, the operating air volume of the regeneration fan, and the heating output power of the regeneration heating device according to the adjustment control command; and achieving continuous linear adjustment of the dehumidification amount of the circulating air by matching the real-time adsorption load and regeneration desorption efficiency of the dehumidifying rotor, thereby ensuring that the dehumidification process is stable and controllable.

[0057] This embodiment is used to solve the problems of large fluctuations in dehumidification capacity, mismatch between adsorption and regeneration, and low dehumidification efficiency caused by single parameter adjustment in rotary dehumidification systems, and to achieve continuous linear and stable adjustment of dehumidification capacity.

[0058] Multi-parameter synchronous adjustment is achieved through a control and monitoring system that outputs three control signals simultaneously based on humidity adjustment control commands. These signals correspond to the dehumidifier rotor drive motor, the regeneration fan inverter driver, and the regeneration heating device power controller, respectively. The dehumidifier rotor drive motor is a stepper motor with a control accuracy of 0.1 r / min and a speed adjustment range of 0-10 r / min. The regeneration fan is an inverter fan with an airflow adjustment range of 0-2000 m³ / min.3 / h; The regenerative heating device uses a silicon controlled rectifier power controller with a power adjustment range of 0-100% of the rated power.

[0059] The adsorption load and regeneration efficiency are matched through a built-in rotor adsorption-regeneration matching model in the control and monitoring system. Based on the real-time humidity deviation value, the target rotation speed of the dehumidifying rotor is first determined, corresponding to the real-time adsorption load of the rotor. Then, based on the target rotation speed of the rotor, the corresponding regeneration fan airflow and regeneration heating device output power are matched. Specifically: as the rotor speed increases, the adsorption load increases, and the regeneration fan airflow and heating power are increased simultaneously to improve the regeneration desorption efficiency; as the rotor speed decreases, the adsorption load decreases, and the regeneration fan airflow and heating power are decreased simultaneously to reduce energy consumption. Through the coordinated matching of these three factors, it is ensured that the moisture adsorbed by the rotor can be completely desorbed and regenerated, avoiding a decrease in dehumidification capacity due to rotor adsorption saturation.

[0060] The continuous linear adjustment of dehumidification capacity is achieved by synchronously and continuously adjusting the rotor speed, regeneration air volume, and heating power, so that the effective dehumidification capacity of the rotor changes continuously and linearly with the humidity deviation, realizing continuous linear adjustment of the dehumidification capacity of the circulating air within the rated range of 0-100%. This avoids the step fluctuation of dehumidification capacity caused by single parameter adjustment, ensuring that the dehumidification process is stable and controllable, and the humidity of the circulating air can be smoothly and accurately adjusted to the target range.

[0061] In some embodiments, the process of discharging the moisture adsorbed by the dehumidifying impeller through the regeneration airflow includes: heating the regeneration air to a preset regeneration temperature range using a regeneration heating device, and then driving the heated regeneration air to flow in the reverse direction through the regeneration area of ​​the dehumidifying impeller by a regeneration fan, so that the moisture adsorbed by the dehumidifying impeller is released from the adsorption material and discharged from the system with the regeneration airflow; and dynamically adjusting the heating temperature and circulation time of the regeneration air according to the real-time adsorption saturation of the dehumidifying impeller.

[0062] This embodiment is used to solve the problems of insufficient regeneration, excessive energy consumption, and shortened rotor life caused by fixed regeneration parameters, thereby improving regeneration efficiency and reducing operating energy consumption.

[0063] The regenerated air is heated and transported by passing through a pre-filter and then entering the heating chamber of the regeneration heating device. The control and monitoring system adjusts the output power of the electric heating tube of the regeneration heating device through a silicon controlled rectifier power controller to heat the regenerated air to the preset regeneration temperature range (the normal range is 100℃-140℃). The heated high-temperature regenerated air is driven by the regeneration fan and flows in the opposite direction to the processing air through the regeneration area of ​​the dehumidification impeller.

[0064] Moisture removal and discharge are achieved by bringing high-temperature regenerated air into full contact with the adsorbent material in the regeneration zone of the dehumidifying rotor, causing the adsorbed moisture in the adsorbent material to evaporate and be released. The released water vapor mixes with the regenerated air to form high-humidity exhaust gas, which is discharged from the system through the exhaust duct by the regeneration fan, thus completing the regeneration of the rotor and the removal of moisture.

[0065] The adsorption saturation level is determined in real time by a control and monitoring system that uses temperature and humidity sensors before and after the desiccant to collect the humidity difference between the air inlet and outlet of the desiccant. Combined with the desiccant's operating speed and cumulative operating time, the real-time adsorption saturation level of the dehumidifying desiccant is calculated. The smaller the humidity difference and the longer the cumulative operating time, the higher the adsorption saturation level.

[0066] The regeneration parameters are dynamically adjusted by a control and monitoring system based on the real-time adsorption saturation of the rotor. The heating temperature and circulation time of the regeneration air are adjusted accordingly. When the adsorption saturation is high, the regeneration heating temperature is increased to 120℃-140℃, and the continuous running time of the regeneration fan is extended to ensure sufficient moisture desorption. When the adsorption saturation is low, the regeneration heating temperature is decreased to 100℃-120℃, and the regeneration running time is shortened. This reduces heating and fan energy consumption and extends the service life of the rotor adsorption material while ensuring the regeneration effect.

[0067] In some embodiments, controlling the operation of the cooling and temperature control unit according to the adjustment control command, and adjusting the dehumidified air to a set temperature before sending it into the drying chamber body, includes: adjusting the cooling or heating output power of the cooling and temperature control unit according to the adjustment control command, performing temperature compensation adjustment on the dehumidified air, so that the temperature of the treated air is stabilized within the set target temperature range; and dynamically adjusting the operating level of the cooling and temperature control unit according to the deviation between the real-time supply air temperature and the set temperature to avoid large fluctuations in the supply air temperature.

[0068] This embodiment is used to solve the problems of large fluctuations in air temperature after dehumidification and low temperature control accuracy caused by fixed gear adjustment, and to avoid the impact of air supply temperature fluctuations on the stability of the drying room environment.

[0069] After temperature compensation and adjustment, the cooling and temperature control unit adopts an air-cooled chilled water coil with an electric auxiliary heating structure. The chilled water coil is connected to the variable frequency refrigeration compressor unit, and the electric auxiliary heating uses silicon controlled rectifier power control, both of which are electrically connected to the control and monitoring system. According to the temperature adjustment control command, the control and monitoring system adjusts the operating frequency of the refrigeration compressor or the output power of the electric auxiliary heating to perform temperature compensation and adjustment on the air flowing through the cooling and temperature control unit after dehumidification. When the temperature of the dehumidified air is higher than the target temperature, the cooling mode is activated to cool the air through the chilled water coil; when the temperature of the dehumidified air is lower than the target temperature, the heating mode is activated to heat the air through the electric auxiliary heating.

[0070] Real-time monitoring of air supply temperature is achieved by installing high-precision temperature sensors inside the air supply duct and at the air outlet of the post-cooling temperature control unit to collect real-time temperature data of the air supply and upload it to the control and monitoring system.

[0071] Deviation grading and dynamic adjustment of the operating level: The control and monitoring system calculates the deviation between the real-time supply air temperature and the set target temperature, classifying the deviation into three levels: large deviation (absolute deviation ≥ 2℃), medium deviation (1℃ ≤ absolute deviation < 2℃), and small deviation (absolute deviation < 1℃). For different deviation levels, the operating level of the cooling temperature control unit is dynamically adjusted: for large deviations, full power operation is used to quickly bring the temperature back to the target range; for medium deviations, medium power operation is used to smoothly correct the temperature deviation; for small deviations, micro-power fine-tuning is used to precisely maintain temperature stability. Through graded dynamic adjustment, large fluctuations in the supply air temperature are avoided, ensuring that the processed supply air temperature remains stable within the set target temperature range, with a control accuracy of ±0.5℃.

[0072] In some embodiments, the monitoring of the operating status of each component in the constant temperature and humidity drying system and the triggering of a fault alarm when an abnormal operation is detected includes: collecting real-time operating parameters of the processing fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit; comparing the real-time operating parameters with the corresponding preset normal operating range; when the operating parameters are detected to exceed the normal operating range, generating a fault signal of the corresponding level, triggering an alarm prompt of the corresponding level, recording the fault information, and generating a safety shutdown protection command when a serious fault is detected.

[0073] This embodiment is used to solve the problem of untimely identification of system malfunctions and unnecessary downtime or equipment damage caused by the lack of graded fault protection, thereby improving the safety and reliability of system operation.

[0074] The real-time acquisition of operating parameters is achieved through the control and monitoring system using current transformers, voltage transmitters, speed sensors, temperature sensors, and other acquisition components. This system collects and processes real-time operating parameters of the fan, dehumidification wheel drive motor, regeneration fan, regeneration heating device, and post-cooling temperature control unit, including operating current, operating voltage, motor speed, equipment casing temperature, start / stop status, leakage current, etc. The acquisition frequency is twice per second.

[0075] The operation status comparison and judgment system compares the real-time operating parameters of each component collected by the control and monitoring system with the corresponding normal operating ranges of the component that are pre-stored in the system. When the parameter is within the normal operating range, it is judged as normal operation; when the parameter exceeds the normal operating range, it is judged as abnormal operation.

[0076] Fault Classification and Corresponding Handling: Based on the magnitude and risk level of parameters exceeding the normal range, faults are classified into two levels: **General Faults:** Parameters deviate slightly from the normal range, posing no equipment damage or safety risk, such as filter blockage warnings, minor fan overload, or slight temperature deviations. In this case, the control and monitoring system generates a general fault signal, triggering a yellow audible and visual alarm at the site. Simultaneously, the fault code, fault location, fault cause, and handling suggestions are displayed on the human-machine interface, and the fault information is written to the system fault log. The system continues normal operation, only prompting maintenance personnel for handling. **Severe Faults:** Parameters deviate significantly from the normal range, posing safety risks such as equipment damage, fire, and electric shock, such as fan short-circuit overload, heater overheating, compressor high-pressure protection, and leakage faults. In this case, the control and monitoring system generates a severe fault signal, triggering a red audible and visual alarm. Simultaneously, a safety shutdown protection command is immediately generated, cutting off the power output to the faulty component, shutting down the rotary dehumidifier and heating device, and only maintaining low-speed ventilation of the handling fan to prevent the fault from escalating. All operating parameters at the time of the fault are fully recorded for subsequent traceability.

[0077] In some embodiments, the process of achieving uniform drying of bioactive microplates by maintaining a constant temperature and humidity clean environment in the drying chamber includes: dynamically adjusting the target temperature and humidity parameters inside the drying chamber according to a preset drying stage division throughout the drying process of the bioactive microplates; maintaining a constant temperature and humidity clean environment in the corresponding drying stage through closed-loop control; and adjusting the circulation frequency of the circulating airflow according to the real-time drying progress of the bioactive microplates to achieve gradient uniform drying of the bioactive microplates and avoid deactivation of bioactive substances on the microplates.

[0078] This embodiment is used to solve the problems of inactivation of bioactive substances and uneven drying caused by drying at fixed temperature and humidity, while taking into account both drying efficiency and bioactivity stability, thereby improving product quality.

[0079] Based on the characteristics of the bioactive substances such as antigens, antibodies, and enzymes coated on the bioactive microplates, the drying process is pre-divided into three consecutive drying stages in the human-machine interface of the control and monitoring system: Initial drying stage: 0.5-1 hour, target temperature 20-22℃, target relative humidity 35%-40%; Stabilization drying stage: 2-4 hours, target temperature 22-24℃, target relative humidity 25%-30%; Final drying stage: 0.5-1 hour, target temperature 20-22℃, target relative humidity 20%-25%. Simultaneously, corresponding target temperature and humidity parameters are preset for each stage and stored in the system storage unit.

[0080] The phased target parameter dynamic adjustment is achieved by the control and monitoring system automatically switching the target temperature and humidity parameters corresponding to the current drying stage according to the preset drying stage division and duration throughout the drying process of the bioactive microplate; and by adjusting the operating status of each component of the system in real time through the closed-loop control logic of steps S101-S103 to maintain the constant temperature and humidity clean environment corresponding to the current drying stage.

[0081] Real-time monitoring of drying progress: The humidity sensor at the return air of the drying room collects the trend of return air humidity change. Combined with the cumulative drying time, the real-time drying progress of the bioactive microplate is determined. The smaller the return air humidity change rate and the longer the cumulative running time, the higher the drying progress.

[0082] Circulation frequency gradient adjustment: Based on the real-time drying progress of the bioactive microplate, the operating speed of the processing fan is dynamically adjusted, and the circulation frequency of the circulating airflow is adjusted accordingly. In the initial drying stage, the fan speed is increased to accelerate the circulation frequency and quickly remove free moisture from the surface. In the stable drying stage, a medium fan speed is maintained for smooth drying. In the final drying stage, the fan speed is reduced and the circulation frequency is slowed down to gently complete the final drying and avoid denaturation and inactivation of the spatial structure of the bioactive substances on the microplate due to rapid dehydration. Through gradient drying control, uniform drying of the bioactive microplate is achieved while ensuring the stability of the bioactive substances, thereby improving batch consistency and detection performance of the product.

[0083] In some embodiments, existing solutions only achieve indirect open-loop drying control based on the ambient temperature and humidity of the drying room. This cannot obtain the actual drying progress of the microplate itself and the difference in moisture content between the pores in real time, which can easily lead to the problem of "environmental parameters meeting the standards but the material is not dried enough / over-dried". At the same time, it cannot adapt to the changes in drying requirements caused by different batch coating amounts and initial humidity differences, which ultimately leads to the inactivation of bioactive substances and poor batch consistency. This embodiment constructs a dual closed-loop control of "ambient temperature and humidity - material drying state" to achieve adaptive and precise regulation based on the actual drying state of the microplate.

[0084] The in-situ drying state acquisition system is established by deploying two sets of non-contact detection elements on each layer of the stainless steel mesh drying rack in the drying chamber, corresponding to the placement position of the microplate: one set is a high-precision near-infrared moisture sensor with a detection accuracy of ±0.1%, used to collect the surface moisture content and moisture difference between the microplate pores in real time; the other set is a high-precision weighing module with a weighing accuracy of ±0.01g, used to collect the overall weight change of a single microplate in real time, and indirectly calculate the water loss rate and drying progress; all detection elements are connected to the control and monitoring system via industrial Ethernet, and the acquisition frequency is set to once every 5 seconds, corresponding to the parameter acquisition step S101.

[0085] The drying status data processing and target parameter adaptive correction are achieved by processing the collected in-situ moisture and weight data through the control and monitoring system to calculate the real-time drying progress, average water loss rate, and maximum inter-pore moisture difference of the microplate. The real-time drying progress is compared with the preset drying progress curve. When the actual progress lags behind the preset progress, the target humidity value of the drying room is automatically lowered and the upper limit of the target temperature is increased. When the actual progress is faster than the preset progress and the water loss rate exceeds the safety threshold of bioactive substances, the target humidity value of the drying room is automatically increased and the target temperature is decreased. The target temperature and humidity parameters in step S101 are corrected simultaneously to generate adjustment and control instructions adapted to the current material state.

[0086] The dual-closed-loop coordinated regulation and execution system synchronously sends the corrected regulation and control commands to the execution components through the control and monitoring system. This corresponds to the process regulation step S102: adjusting the speed of the processing fan and the air supply distribution according to the water loss rate; increasing the air supply ratio and circulation frequency at the corresponding locations for areas with large differences in moisture content between holes to reduce the differences between holes; adjusting the dehumidification capacity and regeneration efficiency of the rotary dehumidification system according to the drying progress to match the current moisture removal requirements; and adjusting the air supply temperature of the cooling unit according to the material surface temperature to avoid excessively high local temperatures that could lead to denaturation of biological activity.

[0087] The intelligent determination of the drying endpoint and the closed-loop termination correspond to the process execution step S103. When the moisture content and inter-pore difference of the microplate are detected to reach the preset qualified threshold and there is no significant change for three consecutive collection cycles, the drying endpoint is automatically determined and a drying completion signal is generated. Simultaneously, the rotary dehumidification system is switched to a low-load standby state, and the rear cooling temperature control unit is switched to a normal temperature maintenance state to avoid continued dehydration after drying, which would lead to the inactivation of biological activity. At the same time, the entire drying process data is stored in the material traceability database to complete the adaptive closed-loop control of the entire drying process.

[0088] In some embodiments, the drying of bioactive microplates needs to meet the cleanliness requirements of Class 10,000 / Class 100,000 under GMP specifications. Existing solutions do not couple cleanliness parameters with temperature, humidity, and dehumidification control. A fixed fresh air ratio is prone to two types of problems: first, insufficient fresh air volume leads to substandard cleanliness and cross-contamination from bioaerosols carried by return air; second, excessive fresh air volume leads to a surge in dehumidification load and excessive energy consumption, while also disrupting the temperature and humidity stability of the drying room. This embodiment achieves multi-objective synergistic optimization control of cleanliness, temperature and humidity, biosafety, and energy consumption, and is fully compatible with the compliance requirements of bioproduct production.

[0089] The parameter acquisition stage of step S101, which involves the construction of a multi-parameter acquisition and multi-objective control framework, involves deploying detection elements on the drying room body, air supply duct, return air duct, fresh air inlet, and exhaust outlet. These elements include a laser particle counter (detecting the concentration of suspended particles with diameters of 0.5μm and 5μm to determine the cleanliness level), a differential pressure sensor, a bioaerosol sampling sensor, and electrically adjustable dampers for fresh air / return air / exhaust air. All elements are electrically connected to the control and monitoring system. A multi-objective optimization control framework is constructed within the control unit, with the priority order as follows: biosafety > cleanliness compliance > temperature and humidity stability > energy consumption optimization.

[0090] The cleanliness-fresh air ratio linkage adjustment logic collects the concentration of suspended particles and bioaerosols in the drying room in real time through the control and monitoring system, compares them with the preset cleanliness level threshold, and generates fresh air adjustment instructions. The instruction generation step corresponding to step S101 is as follows: when the particle concentration exceeds the cleanliness threshold or bioaerosols are detected, it is determined that the cleanliness is not up to standard. The opening of the fresh air electric valve is automatically increased and the opening of the return air valve is decreased to increase the fresh air ratio. At the same time, the exhaust valve is fully opened to discharge the polluted return air outside the system. When the cleanliness is consistently and stably up to standard, the opening of the fresh air valve is automatically reduced and the opening of the return air valve is increased. Under the premise of ensuring cleanliness, the recovery of the cold / heat of the return air is maximized, and the dehumidification and temperature control load is reduced.

[0091] In the process adjustment step S102, when the proportion of fresh air is adjusted, the control and monitoring system simultaneously calculates the temperature and humidity load changes brought by the fresh air: when the fresh air volume increases and the fresh air temperature and humidity are higher than the target values, the dehumidification capacity of the rotary dehumidification system is increased simultaneously, the regeneration heating power and the rotary speed are increased, and the dehumidification volume is increased; the cooling / heating power of the cooling and temperature control unit is adjusted simultaneously to compensate for the temperature fluctuations brought by the fresh air, ensuring that the supply air temperature and humidity remain stable within the target range; at the same time, the total supply air flow of the processing fan is adjusted to match the change in the total air volume of fresh air and return air, maintain the positive pressure gradient in the drying room, prevent unfiltered air from infiltrating, and ensure stable cleanliness.

[0092] The compliance monitoring and safety closed-loop protection corresponds to the monitoring and protection link in step S103. The control and monitoring system records the cleanliness, pressure difference, and fresh air ratio data in real time throughout the entire cycle, and automatically generates a cleanliness operation report that complies with GMP standards. When the concentration of bioaerosols exceeds the standard or the pressure difference of the HEPA filter exceeds the threshold, the highest level alarm is immediately triggered. At the same time, the return air valve is shut off, the fresh air and exhaust air valves are fully opened, and the system switches to a 100% fresh air and exhaust mode to avoid cross-contamination. When the positive pressure in the drying room is insufficient, the system automatically adjusts the fan air volume and the opening of the air valve to maintain a standard clean positive pressure of 10-15 Pa, thereby achieving closed-loop control of compliance and safety throughout the entire process.

[0093] In some embodiments, during large-scale production, it is often necessary to simultaneously dry bioactive microplates with different coating types (antigens / antibodies / enzymes), different specifications, and different drying process requirements in the same drying room. Existing solutions can only achieve uniform temperature and humidity control of the entire drying room, which cannot meet the differentiated drying needs of different materials and is prone to problems such as "insufficient drying of some materials and excessive inactivation of some materials". This embodiment realizes independent and coordinated control of multiple zones and multiple process curves in a single drying room, which greatly improves equipment utilization and adaptability to large-scale production.

[0094] The zoned drying system is constructed by dividing the interior of the drying chamber into 2-4 independent drying zones. Each zone corresponds to an independent supply air branch, return air branch, electrically adjustable damper, temperature and humidity acquisition node, and near-infrared moisture detection module. Different types of bioactive microporous plates can be placed independently in each zone. Each zone's supply air branch is equipped with an independent micro temperature control module and humidity fine-tuning module, which can perform secondary fine-tuning of the constant temperature and humidity air in the main supply air duct, realizing independent temperature and humidity control in each zone. All actuators and detection elements in all zones are connected to the control and monitoring system, constructing a control architecture of "unified dehumidification and temperature control of the main system + independent fine-tuning of each zone".

[0095] In step S101, which involves independent parameter acquisition and multi-instruction generation for each zone, the control and monitoring system acquires real-time temperature and humidity parameters and micro-perforated plate drying status parameters for each zone according to the preset drying process curve. The system then compares the real-time parameters of each zone with the independent target temperature and humidity parameters and drying progress curve for that zone, generating independent fine-tuning control instructions for each zone. At the same time, it generates unified basic adjustment control instructions for the main equipment of the drying system to ensure that the main air supply parameters meet the basic requirements of all zones.

[0096] The main system-zone coordinated adjustment process, corresponding to step S102, is divided into two levels: The main system-level adjustment uses the control and monitoring system to uniformly control the dehumidification capacity of the rotary dehumidifier, the main supply air temperature of the post-cooling temperature control unit, and the total supply air flow of the processing fan, based on the maximum dehumidification requirements and highest / lowest temperature requirements of all zones, providing all zones with constant temperature and humidity clean air that meets basic requirements. The zone-level fine-tuning uses the control and monitoring system to adjust the opening of the air valves in the corresponding zone's air supply branch and the output of the secondary temperature / humidity control module according to the independent fine-tuning instructions for each zone, precisely regulating the air entering that zone to ensure that the temperature and humidity within the zone accurately match the process requirements of the materials in that zone. Simultaneously, for the drying progress of each zone, the air circulation frequency and air supply duration of that zone are independently adjusted to achieve differentiated drying for different zones without interference. The independent timing control of each zone and the monitoring of the entire process correspond to the monitoring and execution stage of step S103. The control and monitoring system sets an independent drying sequence for each zone, which can independently start, pause, and end the drying process. When the material in a certain zone reaches the drying endpoint, the air supply branch of that zone is automatically shut down and switched to standby mode without affecting the normal drying of other zones. At the same time, the system monitors the operating status and material drying status of each zone in real time, and performs fault judgment and alarm independently for each zone. When a minor fault occurs in a single zone, only the corresponding zone is shut down without affecting the operation of the entire drying system, thus achieving efficient and coordinated control of large-scale multi-material drying.

[0097] In some embodiments, existing solutions employ fixed control parameters and rules, which cannot adapt to significant seasonal fluctuations in external environmental temperature and humidity (such as high temperature and humidity in summer and low temperature and humidity in winter). They also cannot compensate for performance degradation caused by long-term operation of equipment, such as aging of the dehumidification rotor adsorption performance, decrease in fan airflow, and reduced efficiency of heat exchanger scaling. This can easily lead to inconsistent drying effects across different seasons and equipment lifecycles. This embodiment uses a self-learning algorithm to achieve adaptive optimization of control parameters and equipment aging compensation, ensuring consistent drying quality throughout the system's entire lifecycle.

[0098] In the storage unit of the control and monitoring system, a full lifecycle operation database is constructed, storing data including: historical data of external environmental temperature and humidity, historical data of operating parameters of various equipment components, data on the temperature and humidity control effect of the drying room, quality inspection data of microporous plates after drying, and equipment maintenance and component replacement records. At the same time, a self-learning optimization model based on BP neural network is embedded in the control unit. The input of the model is external environmental parameters, equipment performance parameters, and target temperature and humidity parameters, and the output is the optimized control parameters (PID parameters, impeller speed-regeneration power matching parameters, post-cooling temperature adjustment compensation parameters, and fan air volume-air pressure matching parameters).

[0099] The environmental adaptive parameter optimization corresponds to the acquisition and instruction generation link of step S101. The control monitoring system is used to collect the ambient temperature, humidity, and atmospheric pressure parameters outside the drying room in real time and input them into the self-learning model. The model automatically optimizes and corrects the current control logic parameters according to the optimal control data under the same historical environmental conditions: for the high-temperature and high-humidity environment in summer, it automatically increases the regeneration temperature of the rotary wheel and extends the regeneration duration, optimizes the two-stage cooling logic of the post-cooling temperature control unit, and avoids air condensation after dehumidification; for the low-temperature and low-humidity environment in winter, it automatically reduces the dehumidification load of the rotary wheel, optimizes the compensation logic of the electric auxiliary heating, and avoids too low supply air temperature and too dry humidity; at the same time, it automatically corrects the proportional, integral, and differential parameters of the fuzzy PID control to adapt to the temperature and humidity control response characteristics under different environments and ensure the same control accuracy in different seasons.

[0100] The equipment aging performance compensation control corresponds to the process adjustment link of step S102. The control monitoring system is used to collect the characteristic parameters of the equipment operation in real time, including the humidity difference at the inlet and outlet of the dehumidification rotary wheel, the actual air volume at the rated speed of the fan, the heat transfer temperature difference of the post-cooling temperature control unit, and the heating rate of the regeneration heating. The performance decay rate of each component is calculated through the characteristic parameters to evaluate the degree of equipment aging. The performance decay rate is input into the self-learning model, and the model automatically generates compensation control parameters: when the adsorption performance of the rotary wheel decays, it automatically increases the rotary wheel speed and raises the regeneration heating power to compensate for the decline in dehumidification capacity; when the air volume of the fan decays, it automatically increases the fan operation frequency to compensate for the loss of supply air flow; when the heat transfer efficiency of the heat exchanger decreases, it automatically increases the refrigeration / heating output power to compensate for the decay of the temperature control ability, ensuring that the same temperature and humidity control effect as that of a new device can still be achieved after the equipment ages.

[0101] The full-life cycle closed-loop optimization and early warning correspond to the monitoring and protection link of step S103. After each drying process is completed, the control monitoring system feeds back the operation data and the microplate quality inspection data of this time to the self-learning model to iteratively optimize the model and continuously improve the control accuracy; at the same time, according to the change trend of the component performance decay rate, it predicts the remaining service life of the component, generates a maintenance early warning prompt in advance, and notifies the operation and maintenance personnel to replace the aging components to avoid sudden equipment failures; through continuous self-learning, self-adaptation, and self-compensation, the batch consistency and operation stability of the drying quality within the full life cycle of the system are achieved.

[0102] Please refer to Figure 2As shown in the figure, this application provides a constant temperature and humidity drying system for drying bioactive microplates, used to implement the method provided in any embodiment of this application. The system includes a drying chamber body 10, an air handling system 20, a rotary dehumidification system 30, a post-cooling temperature control unit 40, and a control and monitoring system 50. The air handling system includes a processing fan that drives the circulating airflow. The rotary dehumidification system includes a dehumidification rotor, a regeneration fan, and a regeneration heating device. The dehumidification rotor dehumidifies the circulating air, and the regeneration fan and regeneration heating device work together to generate a regeneration airflow to discharge the moisture adsorbed by the dehumidification rotor. The post-cooling temperature control unit is located on the processing air outlet side of the dehumidification rotor and is used to adjust the temperature of the dehumidified air before sending it into the drying chamber body. The control and monitoring system is electrically connected to the processing fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit, respectively, and is used to collect temperature and humidity parameters inside the drying chamber body, adjust the operating status of each component in a closed loop according to preset parameters, and has operating status monitoring and fault alarm functions.

[0103] Specifically, this system is a dedicated set of equipment designed for the drying process of bioactive microplates (ELISA plates, antigen / antibody coated microplates, chemiluminescence detection plates, etc.), and is adapted to the compliance requirements of in vitro diagnostic biopharmaceutical production. It addresses the pain points of existing drying equipment, such as low temperature and humidity control accuracy, substandard cleanliness, easy inactivation of bioactive substances, and poor batch consistency.

[0104] Through the coordinated operation of five core units—the drying chamber itself, the air handling system, the rotary dehumidification system, the post-cooling temperature control unit, and the control and monitoring system—a stable environment of constant temperature, constant humidity, positive pressure, and cleanliness can be maintained in the drying chamber for a long time. This achieves uniform and gentle drying of bioactive microplates, ensuring drying efficiency while maximizing the preservation of the structural stability and bioactivity of bioactive substances on the microplates, thus meeting the needs of large-scale continuous production.

[0105] The system can execute the control methods provided in all embodiments of this application. The core workflow is as follows: after the return air and fresh air in the drying room are mixed in proportion, they are sent to the rotary dehumidification system to complete deep dehumidification. The dehumidified air is precisely corrected to the target temperature by the post-cooling temperature control unit, and then pressurized and filtered by the processing fan of the air handling system before being sent into the drying room body. A uniform circulating airflow is formed in the drying chamber to complete the drying operation of the microporous plate. At the same time, the rotary dehumidification system continuously analyzes and discharges the moisture adsorbed by the rotary wheel through an independent regeneration air path to achieve continuous and stable dehumidification capacity. The control and monitoring system collects environmental and equipment parameters throughout the process, and adjusts the operating status of each unit in a closed loop to achieve fully automated control and safety protection.

[0106] The drying chamber is the core drying chamber of the system, providing a sealed, clean, dead-angle-free, temperature and humidity-uniform drying space for bioactive microplates. It is also equipped with material support, environmental monitoring, and safety protection structures. It is the basic carrier for achieving uniform drying of microplates and must meet the cleanliness and hygiene requirements of bioproduct production to avoid cross-contamination and environmental fluctuations.

[0107] The main body of the drying chamber is made of food-grade 304 stainless steel and welded together. The inner wall is mirror-polished and the weld seams are passivated and ground to eliminate dead corners and sharp edges, preventing dust accumulation and microbial growth. The outside of the chamber is covered with a polyurethane insulation layer with a thickness of not less than 50mm to isolate it from external temperature interference and reduce energy consumption. The chamber size is designed according to the production capacity of a single batch. A typical single batch can accommodate 100-500 standard 96-well microplates. The chamber volume is adapted to the circulating airflow path design to avoid airflow eddies and drying dead corners.

[0108] The cavity is equipped with multi-layer adjustable stainless steel mesh drying racks. The spacing between the layers can be freely adjusted according to the height of the material. Each drying rack is equipped with a 304 stainless steel tray with uniformly perforated holes. The microporous plate is placed horizontally on the tray to ensure that the circulating airflow can pass through each tray evenly and contact all the holes of the microporous plate to achieve uniform drying between the holes. The bottom of the drying rack is equipped with silent universal wheels, which can be pushed into / pull out of the cavity as a whole for easy loading and unloading of materials.

[0109] The cavity features double-sealed doors on the front, sealed with silicone rubber sealing strips and equipped with a double-door interlocking structure to prevent unfiltered air from seeping into the cavity during the drying process. Each door has an embedded anti-static tempered glass observation window, allowing real-time monitoring of the drying status of the materials inside. The top of the cavity has evenly distributed air diffusers, and the bottom side has return air vents, creating a vertical laminar airflow path of "top supply, bottom return," ensuring uniform distribution of airflow, temperature, and humidity within the cavity. The cavity is equipped with cleanroom explosion-proof LED lighting and an anti-static grounding device, meeting the safety requirements of a biological cleanroom. Temperature and humidity monitoring nodes, a laser particle counter, and differential pressure sensors are deployed in a three-dimensional distributed layout within the cavity to collect internal environmental parameters in real time and transmit them to the control and monitoring system. By adjusting the ratio of fresh air to return air, the cavity maintains a clean positive pressure of 10-15 Pa relative to the external environment, preventing unfiltered air from seeping into the cavity and ensuring a stable cleanliness of the drying environment.

[0110] The air handling system is the core of the entire system's airflow circulation power, responsible for driving the circulating airflow between the drying chamber and other units of the system. It also performs clean air filtration and dynamic adjustment of the fresh air / return air / exhaust air ratio, ensuring uniform airflow and meeting cleanliness standards within the drying chamber while reducing the system's dehumidification and temperature control load through return air circulation, balancing control precision and operating energy consumption. Its core components include the handling fan, supply air filter assembly, and fresh air / return air / exhaust air conditioning assembly.

[0111] The processing fan adopts a low-noise forward-curved multi-blade centrifugal variable frequency fan, equipped with a vector-type variable frequency drive, and electrically connected to the control and monitoring system; the fan's frequency adjustment range is 0-50Hz, corresponding to an air volume adjustment range of 1000-5000m³ / h. 3 / h, the total pressure meets the resistance loss requirements of pipelines and filters, and the speed can be continuously adjusted steplessly to adjust the airflow and wind speed of the circulating air; the fan base is equipped with rubber shock-absorbing pads, and the inlet and outlet are equipped with flexible connections to avoid the transmission of operating vibration to the cavity and reduce operating noise; the operating status, speed, current and other parameters of the fan are fed back to the control and monitoring system in real time to realize closed-loop regulation and fault monitoring. The air supply filtration system adopts a three-stage filtration architecture, fully meeting the requirements for biological cleanliness: a G4-level pre-filter is installed at the fresh air inlet to filter large particles of dust, hair, and other impurities in the air, protecting downstream equipment; an F8-level medium-efficiency filter is installed in the main air supply duct to further filter fine particles in the air, protecting the terminal high-efficiency filter; an H10-level high-efficiency filter is installed at the air supply terminal in the drying room, with a filtration efficiency of no less than 99.9% for suspended particles with a diameter of 0.5μm, ensuring that the air cleanliness supplied to the drying room reaches the 100,000 / 10,000-level standard, meeting the requirements for bioproduct production; each stage of the filter is equipped with a differential pressure sensor to monitor the differential pressure value across the filter in real time. When the differential pressure value exceeds a preset threshold, it is determined that the filter is blocked, and feedback is sent to the control and monitoring system to trigger a replacement warning.

[0112] Fresh air / return air / exhaust air regulation components: The fresh air inlet, return air duct, and exhaust air duct are each equipped with an electrically proportional regulating damper. The damper opening is continuously adjustable from 0-100%, and all dampers are electrically connected to the control and monitoring system. The control and monitoring system dynamically adjusts the opening of the three dampers based on the cleanliness, pressure difference, temperature, and humidity parameters in the drying room to achieve precise control of the fresh air, return air, and exhaust air ratios: When the cleanliness consistently meets the standards, the return air damper opening is increased, and the fresh air and exhaust air damper openings are decreased to maximize the recovery of the cold / heat energy of the return air and reduce the dehumidification and temperature control loads; when the cleanliness does not meet the standards or bioaerosols are detected, the fresh air and exhaust air damper openings are increased, the return air damper is closed, and the system switches to 100% fresh air mode to avoid cross-contamination and ensure production compliance.

[0113] The rotary dehumidifier system is the core dehumidification unit of the system. It employs a physical adsorption dehumidification principle, addressing the shortcomings of conventional compressor condensation dehumidifiers, such as low efficiency and inability to stably control low relative humidity under low humidity conditions. It can achieve deep and stable dehumidification of circulating air at room temperature, controlling relative humidity to below 10%, perfectly meeting the low humidity requirements of bioactive microporous plate drying. Through the coordinated operation of the dehumidification rotor, regeneration fan, and regeneration heating device, the system achieves continuous dehumidification of circulating air and continuous regeneration of the rotor, ensuring long-term stability of dehumidification capacity.

[0114] The dehumidification rotor is a honeycomb type with a silica gel-molecular sieve composite adsorbent. The rotor core is made of flame-retardant ceramic fiber substrate, and the adsorbent is uniformly attached to the inner wall of the honeycomb channels, featuring high moisture absorption capacity, fast desorption speed, and long service life. The rotor is installed in a heat-insulated and sealed stainless steel shell, and is divided into a 75% treatment zone and a 25% regeneration zone by a partition. The two zones are isolated by a high-temperature resistant silicone rubber sealing strip to prevent cross-contamination between treatment and regeneration air. The rotor is driven by a geared stepper motor with a speed adjustment range of 0-10 r / min. The drive motor is electrically connected to the control and monitoring system, which can steplessly adjust the rotor speed according to humidity deviation to adjust the dehumidification capacity. When the circulating air flows through the treatment zone of the rotor, the water vapor in the air is physically adsorbed by the adsorbent, achieving deep dehumidification of the air. The dried air then enters the rear cooling and temperature control unit.

[0115] The regeneration fan adopts a high-pressure centrifugal variable frequency fan, equipped with a variable frequency drive, and is electrically connected to the control and monitoring system. The air volume adjustment range matches the regeneration requirements of the rotor, and the operating air volume can be steplessly adjusted. The regeneration fan is responsible for driving the regeneration airflow through the regeneration heating device and the rotor regeneration zone, and discharging the desorbed water vapor out of the system to realize the regeneration of the rotor.

[0116] The regeneration heating device uses a stainless steel finned electric heater, equipped with a silicon controlled rectifier (SCR) power controller, to achieve continuous stepless adjustment of 0-100% rated power. The power controller is electrically connected to the control and monitoring system and can dynamically adjust the heating output power according to the regeneration temperature requirements, heating the regeneration air to the standard regeneration temperature range of 100-140℃. The heating device is equipped with dual over-temperature protection, including a PT100 temperature sensor and an over-temperature fuse protector. The temperature signal is fed back to the control and monitoring system in real time. When the temperature exceeds the safety threshold, the heating power is immediately cut off, triggering the over-temperature alarm and protection to avoid equipment damage.

[0117] A G4-grade pre-filter is installed at the regeneration air inlet to prevent dust from entering the heating device and rotor, thus avoiding blockage of the adsorbent pores. A check valve and silencer are installed in the regeneration exhaust duct to prevent backflow of outside air and reduce exhaust noise. During system operation, the heated, high-temperature regeneration air flows in reverse through the rotor's regeneration zone, causing the moisture in the adsorbent to evaporate and be discharged from the system with the regeneration exhaust gas. This achieves continuous regeneration of the rotor and ensures that it always maintains a stable dehumidification capacity.

[0118] The post-cooling temperature control unit is located on the air outlet side of the dehumidification rotor processing area. It is the core of the system's precise temperature control. Its core function is to compensate and regulate the temperature of the dehumidified air, solve the problem of air temperature rise during dehumidification, and accurately and stably control the supply air temperature within the target range. This achieves coordinated closed-loop control of temperature and humidity, avoids supply air temperature fluctuations from disrupting the environmental stability of the drying room, and ensures the safe drying of bioactive substances.

[0119] It adopts a combined temperature control structure of "variable frequency air-cooled refrigeration coil + thyristor electric auxiliary heating". The shell is made of 304 stainless steel and the inside is insulated to avoid heat / cold loss. The refrigeration coil is connected to a fully enclosed scroll variable frequency refrigeration compressor unit, which can realize stepless adjustment of cooling capacity. The electric auxiliary heating adopts a stainless steel finned electric heater, which can realize continuous power adjustment from 0-100% through a thyristor power controller. Both the refrigeration and heating units are electrically connected to the control and monitoring system, which can realize precise temperature adjustment within the range of 18-25℃, and the control accuracy can reach ±0.5℃.

[0120] The temperature control unit is equipped with high-precision PT100 temperature sensors at both the air inlet and outlet to collect the inlet temperature of the dehumidified air and the outlet temperature of the treated air in real time, and feed this data back to the control and monitoring system. When the outlet temperature is higher than the target temperature, the control and monitoring system starts the refrigeration compressor to cool the air through the chilled water coil. When the outlet temperature is lower than the target temperature, the electric auxiliary heating is activated to compensate for the temperature drop. At the same time, the system dynamically adjusts the cooling / heating output power according to the deviation between the outlet temperature and the target temperature. When the deviation is large, the system provides full power for rapid correction, and when the deviation is small, it provides micro-power for precise fine-tuning to avoid large fluctuations in the outlet temperature.

[0121] The temperature control unit is equipped with a condensate drip tray and an automatic drain valve at the bottom, which can promptly drain the condensate generated during the cooling process and prevent the condensate from being carried into the drying room, thus affecting the humidity control effect. The coil is equipped with a fan speed sensor, which triggers protection when the air volume is insufficient to prevent the coil from freezing and being damaged.

[0122] The control and monitoring system is the "brain" of the entire drying system and the core carrier for realizing all control methods in this application. It is responsible for parameter acquisition, logic operation, closed-loop control, operation monitoring, fault alarm and data traceability of the entire system. It can realize the coordinated closed-loop control of temperature and humidity in the drying room, and at the same time has the functions of monitoring the operating status of the entire equipment, hierarchical fault alarm, safety protection and production data traceability, which is fully compatible with the automation and compliance requirements of bioproduct production.

[0123] An industrial-grade programmable logic controller (PLC) is used as the control core, and it is equipped with analog input / output modules, digital input / output modules, and industrial Ethernet communication modules. The PLC is internally programmed with the control logic of all embodiments of this application, including algorithms such as temperature and humidity fuzzy PID closed-loop control, multi-parameter collaborative adjustment, self-learning optimization, multi-zone drying control, and graded fault protection. It can automatically generate adjustment control instructions based on the collected parameters, drive the operation of each actuator, and realize full-process automated control.

[0124] The data acquisition module is electrically connected to all sensors and detection elements in the system, including temperature and humidity sensors, laser particle counters, differential pressure sensors in the drying room, as well as current transformers, voltage transmitters, speed sensors, and temperature sensors in various equipment components. It collects all environmental parameters and equipment operating parameters in real time at a preset frequency, and after signal amplification, analog-to-digital conversion, and preprocessing, transmits the data to the core control unit, providing a reliable data foundation for closed-loop control.

[0125] The human-machine interface and remote monitoring unit adopts a 10-inch or larger industrial-grade touch screen, installed on the operating side of the drying room. The operating interface includes functional modules such as system process monitoring, parameter setting, real-time curves, historical curves, alarm interface, data query, and formula management. Operators can set target temperature and humidity, drying process curves, and operating parameters through the touch screen, and view the system's real-time operating status, historical operating data, and fault information. The system supports industrial Ethernet communication and can be connected to the factory's MES production management system to realize remote status monitoring, parameter setting, and data uploading, meeting the centralized management and control needs of large-scale production.

[0126] The execution drive module includes a frequency converter driver, a silicon controlled rectifier power controller, an electric damper driver, and a relay control module, which are electrically connected to the core control unit. It receives adjustment and control commands from the control unit and drives all execution components, such as the processing fan, regeneration fan, dehumidification wheel drive motor, refrigeration compressor, regeneration heating device, electric auxiliary heating, and electric regulating damper, to achieve closed-loop regulation of the system.

[0127] Fault Alarm and Data Storage Unit: Equipped with audible and visual alarms and industrial-grade data storage hard drives, the core control unit monitors the operating status of all components in real time. When operating parameters are detected to exceed the normal range, corresponding fault signals are generated based on the severity of the fault: minor faults trigger a yellow audible and visual warning, displaying fault information and handling suggestions on the touchscreen; severe faults trigger a red audible and visual alarm, simultaneously generating a safety shutdown protection command to cut off power to dangerous components, preventing equipment damage and material loss. All system operating parameters, process parameters, alarm information, and drying batch data are automatically and in real time stored for at least one year, supporting data export, printing, and traceability, fully complying with GMP requirements for biopharmaceutical production data management.

[0128] The system supports the storage and retrieval of no fewer than 100 drying process formulas. Operators can pre-store the corresponding staged drying process curves according to the drying requirements of different types of bioactive microplates, and call them up with one click during production to avoid repeated parameter settings. It also supports three-level permission management, divided into operator, administrator and engineer levels. Different permissions correspond to different operating scopes to prevent unauthorized personnel from modifying process parameters and ensure the compliance and traceability of production operations.

[0129] Initialization and parameter setting: The operator places the bioactive microplate to be dried on the drying rack in the drying room, closes the sealed door, selects the corresponding drying process formula on the human-machine interface, sets the target temperature and humidity parameters and drying time, and starts the system.

[0130] The parameter acquisition and command generation system collects temperature, humidity, cleanliness, and differential pressure parameters inside the drying room in real time through various acquisition nodes via the control and monitoring system. These parameters are compared with preset target parameters to calculate the deviation value and the rate of change of deviation. Based on the preset control logic, corresponding adjustment and control commands are generated.

[0131] The circulating airflow dehumidification and temperature regulation are achieved by mixing the return air and fresh air in the drying room in a certain proportion driven by the processing fan to form a circulating airflow. The airflow first flows through the processing area of ​​the dehumidification rotor to complete deep dehumidification. The dehumidified dry air flows through the cooling and temperature regulation unit and is precisely adjusted to the target temperature. After being filtered through three stages, the constant temperature and humidity air is evenly delivered into the drying room body through the air diffuser to uniformly dry the microporous plate.

[0132] The continuous regeneration of the dehumidifying rotor is achieved by a regeneration fan driving regeneration air through a regeneration heating device. After being heated to the preset regeneration temperature, the air flows in the opposite direction through the regeneration zone of the dehumidifying rotor, causing the moisture adsorbed by the rotor to be desorbed by heat and discharged from the system with the regeneration exhaust gas, thus realizing the continuous regeneration of the rotor and ensuring a continuous and stable dehumidification capacity.

[0133] Closed-loop control and safety protection continuously cycle through parameter acquisition, command generation, and component adjustment processes via the control and monitoring system, forming a closed-loop control of temperature and humidity to maintain a constant temperature and humidity clean environment in the drying room for extended periods. Simultaneously, it monitors the operating status of all components in real time, and immediately triggers corresponding alarms and protection measures when an abnormality is detected to avoid production losses.

[0134] Once the preset drying time is reached or the system detects that the microplate drying progress has met the standard, the system automatically completes the drying process, generates a drying completion prompt, and simultaneously stores the entire drying process data into the storage unit. The operator then retrieves the dried microplate, completing the entire drying operation.

[0135] It should be noted that those skilled in the art will clearly understand that, for the sake of convenience and brevity, the specific working process of the constant temperature and humidity drying system and its modules for drying bioactive microplates described above can be referred to the corresponding content in the various embodiments of the control method for the constant temperature and humidity drying system for drying bioactive microplates described above, and will not be repeated here.

[0136] The control method for the above-mentioned isothermal and humidity-controlled drying system for drying bioactive microplates can be implemented as a computer program, which can be used in various ways, such as... Figure 2It runs on the device shown.

[0137] Please see Figure 3 , Figure 3 This is a schematic block diagram of the constant temperature and humidity drying system provided in an embodiment of this application. The constant temperature and humidity drying system includes a processor, a memory, and a network interface connected via a device bus, wherein the memory may include a storage medium and internal memory.

[0138] The storage medium may store operating devices and computer programs. The computer program includes program instructions that, when executed, cause the processor to perform any control method for a constant temperature and humidity drying system used for drying bioactive microplates.

[0139] The processor provides computing and control capabilities to support the operation of the entire constant temperature and humidity drying system.

[0140] The internal memory provides an environment for the execution of computer programs in non-volatile storage media. When executed by a processor, the computer program enables the processor to perform any control method for a constant temperature and humidity drying system for drying bioactive microplates.

[0141] This network interface is used for network communication, such as sending assigned tasks. Those skilled in the art will understand that... Figure 3 The structure shown is merely a block diagram of a portion of the structure related to the present application and does not constitute a limitation on the terminal to which the present application is applied. A specific constant temperature and humidity drying system may include more or fewer components than those shown in the figure, or combine certain components, or have different component arrangements.

[0142] It should be understood that the processor can be a Central Processing Unit (CPU), but it can also be other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. Among these, a general-purpose processor can be a microprocessor or any conventional processor.

[0143] In one embodiment, the processor is configured to run a computer program stored in memory to perform the following steps: The system collects real-time temperature and humidity parameters inside the drying chamber; compares the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment and control commands; and controls the operation of the processing fan and adjusts the flow rate of the circulating air into the drying chamber according to the adjustment and control commands. The system controls the operation of the dehumidification rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment and control commands, adjusts the dehumidification amount of the circulating air, and discharges the moisture adsorbed by the dehumidification rotor through the regeneration airflow; the system also controls the operation of the cooling and temperature control unit according to the adjustment and control commands, adjusts the dehumidified air to the set temperature, and sends it into the drying chamber body. The system monitors the operating status of each component in the constant temperature and humidity drying system, triggers a fault alarm when an abnormality is detected, and completes the uniform drying of the bioactive microplate by maintaining a clean environment with constant temperature and humidity in the drying chamber.

[0144] In some embodiments, the step of collecting real-time temperature and humidity parameters inside the drying chamber includes: deploying temperature and humidity acquisition nodes at multiple different locations inside the drying chamber, collecting real-time temperature and humidity data of the corresponding area through each temperature and humidity acquisition node; and performing outlier removal and smoothing filtering on the collected multiple sets of temperature and humidity data to obtain the overall real-time temperature and humidity parameters inside the drying chamber.

[0145] In some embodiments, the step of comparing the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment control commands includes: calculating the deviation value and deviation change rate between the real-time temperature and humidity parameters and the preset target temperature and humidity parameters; classifying the deviation value and deviation change rate based on preset fuzzy control rules, generating adjustment control commands that match the deviation level, and performing amplitude limiting processing on the adjustment control commands to avoid control overshoot.

[0146] In some embodiments, controlling the operating state of the processing fan according to the adjustment control command and adjusting the flow rate of the circulating air into the drying chamber body includes: adjusting the operating speed of the processing fan by stepless frequency conversion according to the adjustment control command, and correspondingly adjusting the air flow rate of the circulating air; adjusting the air distribution ratio and air supply duration of the circulating air according to the temperature and humidity deviation of different areas inside the drying chamber body, so as to ensure that the airflow field inside the drying chamber body is uniformly distributed.

[0147] In some embodiments, controlling the operating status of the dehumidifying rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment control command, and adjusting the dehumidification amount of the circulating air, includes: adjusting the rotation speed of the dehumidifying rotor, the operating air volume of the regeneration fan, and the heating output power of the regeneration heating device according to the adjustment control command; and achieving continuous linear adjustment of the dehumidification amount of the circulating air by matching the real-time adsorption load and regeneration desorption efficiency of the dehumidifying rotor, thereby ensuring that the dehumidification process is stable and controllable.

[0148] In some embodiments, the process of discharging the moisture adsorbed by the dehumidifying impeller through the regeneration airflow includes: heating the regeneration air to a preset regeneration temperature range using a regeneration heating device, and then driving the heated regeneration air to flow in the reverse direction through the regeneration area of ​​the dehumidifying impeller by a regeneration fan, so that the moisture adsorbed by the dehumidifying impeller is released from the adsorption material and discharged from the system with the regeneration airflow; and dynamically adjusting the heating temperature and circulation time of the regeneration air according to the real-time adsorption saturation of the dehumidifying impeller.

[0149] In some embodiments, controlling the operation of the cooling and temperature control unit according to the adjustment control command, and adjusting the dehumidified air to a set temperature before sending it into the drying chamber body, includes: adjusting the cooling or heating output power of the cooling and temperature control unit according to the adjustment control command, performing temperature compensation adjustment on the dehumidified air, so that the temperature of the treated air is stabilized within the set target temperature range; and dynamically adjusting the operating level of the cooling and temperature control unit according to the deviation between the real-time supply air temperature and the set temperature to avoid large fluctuations in the supply air temperature.

[0150] In some embodiments, the monitoring of the operating status of each component in the constant temperature and humidity drying system and the triggering of a fault alarm when an abnormal operation is detected includes: collecting real-time operating parameters of the processing fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit; comparing the real-time operating parameters with the corresponding preset normal operating range; when the operating parameters are detected to exceed the normal operating range, generating a fault signal of the corresponding level, triggering an alarm prompt of the corresponding level, recording the fault information, and generating a safety shutdown protection command when a serious fault is detected.

[0151] In some embodiments, the process of achieving uniform drying of bioactive microplates by maintaining a constant temperature and humidity clean environment in the drying chamber includes: dynamically adjusting the target temperature and humidity parameters inside the drying chamber according to a preset drying stage division throughout the drying process of the bioactive microplates; maintaining a constant temperature and humidity clean environment in the corresponding drying stage through closed-loop control; and adjusting the circulation frequency of the circulating airflow according to the real-time drying progress of the bioactive microplates to achieve gradient uniform drying of the bioactive microplates and avoid deactivation of bioactive substances on the microplates.

[0152] This application also provides a computer-readable storage medium storing a computer program that, when executed by a processor, causes the processor to implement the steps of a control method for a constant temperature and humidity drying system for drying bioactive microplates as provided in any embodiment of this application.

[0153] The computer-readable storage medium can be an internal storage unit of the constant temperature and humidity drying system described in the foregoing embodiments, such as the hard disk or memory of the constant temperature and humidity drying system. Alternatively, the computer-readable storage medium can be an external storage device of the constant temperature and humidity drying system, such as a plug-in hard disk, SmartMediaCard (SMC), SecureDigital (SD) card, or FlashCard equipped on the constant temperature and humidity drying system.

[0154] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and these modifications or substitutions should all be covered within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A control method for a constant temperature and humidity drying system for drying bioactive microplates, characterized in that, include: By collecting real-time temperature and humidity parameters inside the drying chamber; The collected real-time temperature and humidity parameters are compared with the preset target temperature and humidity parameters to generate corresponding adjustment and control commands; the operation status of the processing fan is controlled according to the adjustment and control commands to adjust the flow rate of the circulating airflow into the drying chamber. The system controls the operation of the dehumidification rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to the adjustment and control commands, adjusts the dehumidification amount of the circulating air, and discharges the moisture adsorbed by the dehumidification rotor through the regeneration airflow; the system also controls the operation of the cooling and temperature control unit according to the adjustment and control commands, adjusts the dehumidified air to the set temperature, and sends it into the drying chamber body. The system monitors the operating status of each component in the constant temperature and humidity drying system, triggers a fault alarm when an abnormality is detected, and completes the uniform drying of the bioactive microplate by maintaining a clean environment with constant temperature and humidity in the drying chamber.

2. The method according to claim 1, characterized in that, The method of collecting real-time temperature and humidity parameters inside the drying chamber includes: Temperature and humidity acquisition nodes are set up at multiple different points inside the drying room, and real-time temperature and humidity data of the corresponding area are collected through each temperature and humidity acquisition node. Outlier removal and smoothing filtering were performed on the collected temperature and humidity data to obtain the overall real-time temperature and humidity parameters inside the drying room.

3. The method according to claim 1, characterized in that, The step of comparing the collected real-time temperature and humidity parameters with preset target temperature and humidity parameters to generate corresponding adjustment and control commands includes: Calculate the deviation and rate of change between the real-time temperature and humidity parameters and the preset target temperature and humidity parameters; Based on preset fuzzy control rules, the deviation value and the rate of change of deviation are classified and judged, and adjustment control commands matching the deviation level are generated. The adjustment control commands are then limited to avoid control overshoot.

4. The method according to claim 1, characterized in that, The process of controlling the operation of the fan according to the adjustment control command and adjusting the flow rate of the circulating airflow into the drying chamber includes: According to the adjustment and control command, the operating speed of the processing fan is adjusted by stepless frequency conversion, and the air flow rate of the circulating air is adjusted accordingly. Based on the temperature and humidity deviations in different areas inside the drying chamber, the air supply distribution ratio and duration of the circulating airflow are adjusted to ensure a uniform airflow distribution inside the drying chamber.

5. The method according to claim 1, characterized in that, The process of controlling the operating status of the dehumidification rotor, regeneration fan, and regeneration heating device of the rotary dehumidification system according to adjustment control commands, and adjusting the dehumidification capacity of the circulating air, includes: According to the adjustment and control commands, adjust the rotation speed of the dehumidification impeller, the operating air volume of the regeneration fan, and the heating output power of the regeneration heating device; By matching the real-time adsorption load and regeneration efficiency of the dehumidification impeller, continuous linear adjustment of the dehumidification capacity of the circulating air is achieved, ensuring a stable and controllable dehumidification process.

6. The method according to claim 5, characterized in that, The process of discharging the moisture adsorbed by the dehumidifying impeller through the regeneration airflow includes: After the regeneration air is heated to the preset regeneration temperature range by the regeneration heating device, the heated regeneration air is driven by the regeneration fan to flow in the reverse direction through the regeneration area of ​​the dehumidification wheel, so that the moisture adsorbed by the dehumidification wheel is desorbed from the adsorption material and discharged from the system with the regeneration airflow. The heating temperature and circulation time of the regenerated air are dynamically adjusted based on the real-time adsorption saturation of the dehumidification impeller.

7. The method according to claim 1, characterized in that, The process of controlling the operation of the cooling and temperature control unit according to the adjustment control command, adjusting the dehumidified air to the set temperature, and then sending it into the drying chamber body includes: According to the adjustment and control command, the cooling or heating output power of the cooling and heating unit is adjusted to compensate and regulate the temperature of the dehumidified air so that the temperature of the treated air is stabilized within the set target temperature range. Based on the deviation between the real-time supply air temperature and the set temperature, the operating level of the cooling temperature control unit is dynamically adjusted to avoid large fluctuations in the supply air temperature.

8. The method according to claim 1, characterized in that, The system monitors the operating status of each component in the constant temperature and humidity drying system and triggers a fault alarm when an abnormality is detected, including: The system collects and processes real-time operating parameters of the fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit, and compares the real-time operating parameters with the corresponding preset normal operating range. When the operating parameters are detected to be outside the normal operating range, a fault signal of the corresponding level is generated, an alarm of the corresponding level is triggered, the fault information is recorded, and a safe shutdown protection command is generated when a serious fault is detected.

9. The method according to claim 1, characterized in that, The process of maintaining a clean environment with constant temperature and humidity in the drying chamber to achieve uniform drying of the bioactive microplate includes: Throughout the drying process of the bioactive microplate, the target temperature and humidity parameters inside the drying chamber are dynamically adjusted according to the preset drying stages, and a constant temperature and humidity clean environment is maintained for the corresponding drying stages through closed-loop control. Based on the real-time drying progress of the bioactive microplate, the circulation frequency of the circulating airflow is adjusted to achieve gradient uniform drying of the bioactive microplate and avoid the deactivation of bioactive substances on the microplate.

10. A constant temperature and humidity drying system for drying bioactive microplates, characterized in that, The method for implementing any one of claims 1-9 includes a drying room body, an air handling system, a rotary dehumidification system, a post-cooling temperature control unit, and a control and monitoring system; The air handling system includes a processing fan for driving a circulating airflow. The rotary dehumidification system includes a dehumidification rotor, a regeneration fan, and a regeneration heating device. The dehumidification rotor is used to dehumidify the circulating air. The regeneration fan and the regeneration heating device work together to generate a regeneration airflow to discharge the moisture adsorbed by the dehumidification rotor. The post-cooling temperature control unit is located on the processing air outlet side of the dehumidification rotor and is used to adjust the temperature of the dehumidified air before sending it into the drying chamber body. The control and monitoring system is electrically connected to the processing fan, dehumidification rotor, regeneration fan, regeneration heating device, and post-cooling temperature control unit, respectively. It is used to collect the temperature and humidity parameters inside the drying chamber, adjust the operating status of each component in a closed loop according to preset parameters, and has the functions of operating status monitoring and fault alarm.

Images