A method for preparing a bacterial pathogen inactivated vaccine based on irradiation technology and application thereof
Electron beam irradiation technology was used to inactivate Aeromonas hydrophila, which solved the problems of antigen structure destruction and low inactivation efficiency in existing methods. This enabled the preparation of a highly efficient and safe vaccine, which is suitable for the immune control of freshwater fish such as largemouth bass and has significant immune protection and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI OCEAN UNIV
- Filing Date
- 2026-03-11
- Publication Date
- 2026-06-12
AI Technical Summary
Existing heat inactivation and formaldehyde inactivation methods for preparing Aeromonas hydrophila vaccines suffer from problems such as severe damage to antigen structure, insufficient immunoprotection, low inactivation efficiency, high safety risks, and long production cycles, making it difficult to meet the needs of aquaculture for high efficiency, safety, and high immunoprotection.
Electron beam irradiation technology is used to inactivate Aeromonas hydrophila. By irradiating the pathogen with a high-energy electron beam, its DNA and membrane structure are destroyed, achieving complete inactivation while preserving the antigen structure to the maximum extent. Combined with adjuvants, vaccines can be prepared, which are suitable for the immune control of freshwater fish such as largemouth bass.
It achieves rapid, safe, and thorough pathogen inactivation, significantly improves the immune induction and protective effects of vaccines, shortens the production cycle, reduces operational risks and chemical contamination, and is suitable for the preparation of vaccines for a variety of bacterial fish diseases, possessing broad application potential.
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