Method of controlling antibiotic resistant biofilms with bacteriophage in combination with deinococcus radiodurans

By combining bacteriophages with radiation-resistant cocci, antibiotic-resistant bacteria in antibiotic-resistant biofilms are targeted to lyse and ARGs are degraded, solving the problem of eliminating antibiotic-resistant bacteria in pipeline networks and achieving efficient and environmentally friendly biofilm control.

CN122187267APending Publication Date: 2026-06-12ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2026-05-12
Publication Date
2026-06-12

AI Technical Summary

Technical Problem

Existing technologies are insufficient for effectively targeting and eliminating antibiotic-resistant bacteria in pipeline networks, and there is a risk of spreading antibiotic resistance genes (ARGs). Traditional disinfection methods also produce byproducts and stimulate biofilm growth.

Method used

The combination of bacteriophage and Deinococcus radiodurans was used. The bacteriophage targeted and lysed antibiotic-resistant bacteria in antibiotic-resistant biofilms, while Deinococcus radiodurans degraded ARGs through extracellular nucleases, thus synergistically disrupting the biofilm structure.

Benefits of technology

It achieves efficient removal of biofilm biomass, kills antibiotic-resistant bacteria, reduces the risk of ARGs transmission, avoids the generation of chlorine disinfection byproducts, and provides a green and sustainable water treatment method.

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Abstract

The application discloses a method for controlling antibiotic-resistant biofilm by using bacteriophages and deinococcus radiodurans, and belongs to the field of environmental biological technology and water treatment. The method adds lytic bacteriophages and deinococcus radiodurans as a composite microbial agent into an environmental water body where antibiotic-resistant biofilm is located, targets and lysates antibiotic-resistant bacteria in the antibiotic-resistant biofilm, and degrades accumulated and released intracellular antibiotic-resistant genes. The application can be used for biological control of antibiotic-resistant biofilm in water distribution and supply pipe networks, and avoids by-products caused by excessive chlorine disinfection.
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