A tumor immunotherapy composition based on specific immune cells, preparation method and application

Abstract

This disclosure relates to a tumor immunotherapy composition, preparation method, and application based on specific immune cells, particularly specific immune cells activated by attenuated Listeria monocytogenes carrying non-integrating antigenic peptide plasmids. The disclosure involves extracting T cells in vitro, co-culturing T cells with antigen-presenting cells activated by attenuated Listeria monocytogenes, and generating T cells with specific tumor antigenic peptides in vitro. These specific T cells are then reinfused into the body to generate a tumor-specific immune response. The technical solution of this disclosure can specifically activate tumor-specific T cells, thereby triggering a series of anti-tumor immune responses. Furthermore, the process does not require genetic modification of autologous cells, significantly improving both targeting and safety.

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