A transdermal patch, its preparation method and use
By preparing a transdermal patch containing a support layer comprising a matrix, plasticizer, and penetration enhancer, the gastrointestinal symptoms caused by oral administration of compound 1 were resolved, the transdermal properties and stability of compound 1 were achieved, and the effective release and safety of the drug were ensured.
Patent Information
- Application Number
- CN202610743080.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2025-11-21
- Filing Date
- 2026-05-27
- Publication Date
- 2026-07-17
AI Technical Summary
In the prior art, the oral administration of compound 1 causes gastrointestinal symptoms, and there is a lack of specific formulations and efficacy evaluations for transdermal patches. There is an urgent need to study suitable formulations and compositions.
A transdermal patch comprising a support layer containing compound 1 or its derivatives is prepared. The support layer is composed of a matrix, a plasticizer, and a penetration enhancer, and is prepared through a specific ratio and process to ensure transdermal properties and stability.
It achieves excellent transdermal properties of compound 1 or its derivatives, stable release in vitro and in vivo, no skin irritation, stable pharmacodynamics and pharmacokinetics, and ensures long-term efficacy.
Smart Images
Figure CN122398762A_ABST
Abstract
Citation Information
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