Use of a human milk oligosaccharide in the manufacture of a product for improving intestinal homeostasis in aging
By regulating the aging gut microbiota through specific human milk oligosaccharides, the problems of aging gut barrier damage and dysbiosis are solved, and the functions of the gut barrier and stem cells are improved, resulting in significant health benefits for aging.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG GONGSHANG UNIVERSITY
- Filing Date
- 2026-05-29
- Publication Date
- 2026-07-17
AI Technical Summary
Aging leads to damage to the intestinal barrier and dysbiosis, which in turn triggers chronic diseases. Current technologies have failed to effectively utilize the probiotic effects of human milk oligosaccharides (HMOs) in the aging process.
By employing human milk oligosaccharides with specific structures, such as 3'-sialyl lactose (3'-SL) and lactose-N-neotetrasaccharide (LNnT), the aging gut microbiome is reshaped, the integrity of the intestinal physical and chemical barriers is enhanced, and the homeostasis and metabolic pathways of intestinal stem cells are regulated.
It significantly enhances intestinal barrier integrity, reduces permeability, regulates microbiota structure, improves intestinal epithelial and stem cell function, reduces chronic inflammation and the risk of carcinogenesis, and has potential preventive and therapeutic effects on metabolic syndrome and neurodegenerative diseases.
Smart Images
Figure CN122398825A_ABST