A bioceramic composite scaffold for repairing aging bone and a preparation method and application thereof
By designing a bioceramic composite scaffold with a hollow TCP core on the outer wall and an internal MnTCP ceramic rod, the problem of the single function of existing scaffolds is solved, and the synergistic effect of ROS clearance and NAD+ replenishment is achieved, promoting the efficient repair and regeneration of aging bone.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
- Filing Date
- 2026-04-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing bone tissue engineering scaffolds have limited functionality in repairing aging bone defects. They cannot effectively remove excess reactive oxygen species (ROS) and continuously replenish NAD+, leading to mitochondrial dysfunction and a decline in regenerative capacity, making it difficult to systematically reverse the complex pathological state of aging bone.
A bioceramic composite scaffold was designed, consisting of a hollow tricalcium phosphate scaffold on the outer wall and a porous manganese-doped tricalcium phosphate (MnTCP) ceramic rod loaded with β-nicotinamide mononucleotide (NMN) inside. The scaffold was prepared by 3D printing and calcination technology to achieve the synergistic effect of Mn ion scavenging of ROS and NMN conversion to NAD+, thereby restoring cellular energy metabolism and microenvironment homeostasis.
This composite scaffold can continuously release NMN to convert into NAD+, clear ROS, restore mitochondrial function, improve the cellular microenvironment, promote the repair of aging bone, enhance osteogenic differentiation capacity, and achieve efficient tissue regeneration.
Smart Images
Figure CN122399102A_ABST