A highly stereoselective preparation of optically active alkenyl substituted allene compounds and methods for their construction
By using palladium catalyst and chiral phosphoramide ligand to catalyze the asymmetric cross-coupling reaction of propargyl alcohol derivatives with alkenyl borate esters, the problems of harsh reaction conditions and limited functional group compatibility in the synthesis of alkenyl substituted allenes in the prior art are solved, and the synthesis of optically active alkenyl substituted allenes is realized in a high-efficiency and simple manner.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI UNIV
- Filing Date
- 2026-04-30
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for synthesizing alkenyl-substituted allene compounds suffer from harsh reaction conditions, limited functional group compatibility, difficulty in obtaining chiral products, and low efficiency.
Optically active alkenyl-substituted allene compounds were constructed by using a complex formed by a palladium catalyst and a chiral phosphoramidite ligand to catalyze the asymmetric cross-coupling reaction of propargyl alcohol derivatives and alkenyl borate esters.
It achieves highly stereoselective and regioselective synthesis of alkenyl-substituted allenes, with a wide range of applicable substrates, strong functional group tolerance, mild reaction conditions, simple operation, low cost, and is suitable for laboratory and industrial-scale preparation.
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