A method for correcting for concentration effect induced isotope ratio bias

By establishing a linear relationship model between concentration ratio and isotope ratio, the problem of isotope ratio deviation caused by concentration effect is solved, and high-precision isotope ratio correction is achieved. This model is applicable to various isotope systems, especially for accurate analysis of low-content samples.

CN122409807APending Publication Date: 2026-07-17INSTITUTE OF GEOLOGY AND GEOPHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INSTITUTE OF GEOLOGY AND GEOPHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2026-05-20
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies are unable to effectively correct isotope ratio deviations caused by concentration effects, especially in low-content samples where multiple concentration matchings cannot be performed, leading to inaccurate analytical results and limiting the widespread application of isotope analysis techniques.

Method used

By establishing a linear relationship model between concentration ratio and isotope ratio, the concentration ratio of sample to standard solution is measured using a mass spectrometer. The linear relationship equation is obtained by fitting the equation using the least squares method. The corrected isotope ratio is then calculated, and the corrected isotope composition data is output.

Benefits of technology

It achieves high-precision isotope ratio correction under large concentration gradients, ensuring the accuracy and scientific rigor of low-content sample analysis, filling the technological gap in low-content sample research, and is applicable to various isotope systems.

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Abstract

本申请提供了一种校正浓度效应引起同位素比值偏差的方法。该方法包括:获取样品溶液与标准溶液的目标元素浓度比值,记为P值;基于仪器分析获得样品的实测同位素比值;利用预先建立的浓度比与同位素比值之间的线性关系模型,计算得到校正后的同位素比值;输出校正后的同位素组成数据。本方法可以对± 20%浓度差引起的同位素偏差进行准确校正。该范围远大于浓度的分析误差,本发明的上述方法保证了低含量样品同位素分析数据的准确性。
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