A sample pretreatment method and detection method suitable for the detection of cyclomethicone in cosmetics
By optimizing the sample pretreatment method for cosmetics, and utilizing a liquid-liquid extraction system with an equal volume mixture of cyclohexane and methylcyclohexane as solvents, along with gas chromatography-tandem mass spectrometry, the matrix effect problem in the detection of cyclodimethylsiloxane in cosmetics was solved, achieving high accuracy and high precision in detection.
Patent Information
- Application Number
- CN202610596303.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-30
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for detecting cyclodimethylsiloxanes in cosmetics suffer from matrix effects, leading to decreased accuracy and precision of detection results and making it difficult to simultaneously and effectively remove interfering components from the cosmetic matrix and extract the target analyte.
A liquid-liquid extraction system was developed using an equal volume mixture of cyclohexane and methylcyclohexane as solvent. By combining gas chromatography-tandem mass spectrometry with the control of the water content and solvent ratio of the polar solvent, the separation and purification of cyclopolydimethylsiloxane and interfering substances were achieved, thus optimizing the sample pretreatment method.
It effectively removes interfering substances from oil-based and wax-based cosmetics, improving the accuracy and precision of detection results. It enables the simultaneous detection of three cyclic polydimethylsiloxanes with a recovery rate of 90-110%, a matrix effect of 90-110%, a correlation coefficient greater than 0.998, a detection limit of 30 ng/mL, and a quantitation limit of 100 ng/mL.
Smart Images
Figure CN122409924A_ABST