A pathological image classification method based on dyeing perception intelligent feature modeling

By using multi-source decoupled edge attribute embedding and metadata feature modulation, combined with hierarchical cross-staining interaction and gating feedback mechanisms, the problems of feature confusion and incomplete data in multi-staining pathological images are solved, achieving more accurate and robust pathological image classification.

CN122657582APending Publication Date: 2026-08-28HENAN UNIV OF SCI & TECH
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Patent Information

Application Number
CN202610801772.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-04
Publication Date
2026-08-28

AI Technical Summary

Technical Problem

Existing graph neural network models cannot effectively distinguish the features of different staining modalities when processing multi-stained pathological images, ignoring the essential differences between modalities and leading to confusion in feature representation. At the same time, the models cannot dynamically adapt to the input dimension when processing incomplete data, resulting in a decline in classification performance.

Method used

We adopt a colorimetric-aware intelligent feature modeling method, which dynamically adjusts features to adapt to different colorimetric modalities through multi-source decoupling edge attribute embedding and metadata feature modulation mechanism, and improves the perceptual accuracy of the model through hierarchical cross-colorimetric interaction and gated feedback mechanism. At the same time, we introduce a robust conditional prototyping learning strategy to handle incomplete data.

Benefits of technology

It achieves accurate classification of multimodal pathological images, improves the stability and classification performance of the model under incomplete data, enhances the ability to discriminate tissue microenvironments, and maximizes the utilization value of incomplete data.

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Abstract

The application discloses a kind of pathological image classification methods based on dyeing perception intelligent feature modeling, belong to pathological image classification field, this method includes collecting the multi-staining full section image group data of different objects;Multi-staining full section image group data includes H&E dyeing image and several immunohistochemical dyeing images;Each multi-staining full section image group data is respectively preprocessed, obtains the several equal-size image blocks of each object;Based on the image block of each object, graph is constructed, and the multi-modal heterogeneous pathology graph of each object is obtained;With the multi-modal heterogeneous pathology graph of each object as training data, train pathological image classification model;The pathological image classification model of training completion is used to classify the pathological image to be measured.The application solves the problems of the existing method in processing digital pathology graph data, such as node category characteristics, edge information utilization, cross-staining interaction and non-perfect data processing.
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