Calcium magnesium coenzyme Q10 hard capsule containing artificial breeding crocodile bone and deer bone extract and preparation method thereof

Abstract

The application discloses a calcium-magnesium coenzyme Q10 hard capsule containing artificial breeding crocodile bone and deer bone extracts and a preparation method thereof, and belongs to the technical field of health-care food. The product takes the certified artificial breeding crocodile bone and deer bone extracts as the core, and is compounded with calcium citrate, magnesium citrate, coenzyme Q10, vitamin D3, vitamin K2, hawthorn and pueraria extract, and is prepared into the hard capsule by being matched with microcrystalline cellulose and magnesium stearate. The application adopts the double animal bone compounding to form a natural calcium collagen system, and is matched with coenzyme Q10 and plant extract multiple synergies, and completely discloses a low-temperature extraction and gradient premix industrial process. The raw materials are legal and traceable, the product batches are stable, the active ingredient absorption and utilization rate is high, the product has the legal health-care functions of helping to improve bone density, relieve physical fatigue and maintain blood lipid health level, is suitable for the middle-aged and old people, people with easy fatigue and blood lipid metabolism imbalance, and the process can be scaled up for production.

Description

Technical Field

[0002] This invention belongs to the field of health food technology, specifically involving a hard capsule made from extracts of licensed artificially bred crocodile bone and deer bone as core functional ingredients, compounded with calcium citrate, magnesium citrate, coenzyme Q10, vitamin D3, and vitamin K2, and combined with extracts of hawthorn and kudzu root that are both food and medicine; the product has legally recognized health functions that help improve bone density, relieve physical fatigue, and help maintain healthy blood lipid levels, and its complete industrial preparation process is disclosed. Background Technology

[0003] As people age, they experience a continuous loss of calcium, which can lead to decreased bone density and limb weakness. At the same time, imbalances in blood lipid metabolism and insufficient energy supply to the heart muscle can easily cause sub-health problems such as fatigue and increased metabolic burden on blood vessels.

[0004] Crocodile bone and deer bone are rich in collagen, natural calcium and phosphorus, and various trace elements. The combination of these two bones can provide natural and complex bone nutrition. Coenzyme Q10 is a key nutrient for providing energy to myocardial cells. Calcium citrate and magnesium citrate, combined with vitamin D3 and vitamin K2, can synergistically enhance calcium absorption and reduce vascular calcification. Hawthorn and kudzu root extracts can help regulate blood lipid metabolism.

[0005] Existing health food products of the same type have obvious defects: 1) They only contain animal bone powder, resulting in a single source of calcium, unstable collagen content, and a high risk of excessive levels of heavy metals and microorganisms; 2) They are simply calcium supplements, lacking coenzyme Q10 and plant extracts to synergistically regulate blood lipids and relieve fatigue; 3) They lack a suitable low-temperature defatting extraction process for crocodile and deer bones, as high temperatures can easily destroy active bone collagen; 4) Their formula components are simple and cannot simultaneously meet the multiple health needs of improving bone density, relieving physical fatigue, and regulating blood lipids, leaving a technological gap in the industry.

[0006] This invention addresses the shortcomings of existing technologies by providing a compound health food hard capsule with legally sourced raw materials, synergistic formulation, stable process, and high absorption and utilization rate. Summary of the Invention

[0007] 1. Formula (parts by weight) 300 portions of bone extract from certified artificially bred crocodiles 200 portions of certified artificially bred deer bone extract Calcium citrate 60-100 parts Magnesium citrate 80-120 parts Coenzyme Q10 5-15 parts Vitamin D3 0.01–0.03 servings Vitamin K2 0.001–0.003 parts Hawthorn extract 30-60 parts 30-60 parts of kudzu root extract 30-60 parts of microcrystalline cellulose 3-7 parts magnesium stearate 2. Optimize the formulation ratio 300 parts of certified artificially bred crocodile bone extract, 200 parts of certified artificially bred deer bone extract, 80 parts of calcium citrate, 100 parts of magnesium citrate, 10 parts of coenzyme Q10, 0.02 parts of vitamin D3, 0.002 parts of vitamin K2, 50 parts of hawthorn extract, 50 parts of kudzu root extract, 47 parts of microcrystalline cellulose, and 5 parts of magnesium stearate.

[0008] 3. Complete and standardized preparation process (1) Preparation of extracts from crocodile bone and deer bone The raw materials were sourced from farms holding a "License for Artificial Breeding of Wild Animals" and accompanied by a special traceability label for wild animal products. Crocodile bones and deer bones were rinsed with clean water to remove blood and impurities, and degreased twice with warm water at 40°C for 1.5 hours each time. They were then pulverized at low temperature to 200-mesh bone powder, and extracted with 10 times the amount of purified water at 45°C for 3 hours. The extract was concentrated under reduced pressure to a relative density of 1.12, dried under vacuum at 50°C, and passed through an 80-mesh sieve to obtain dry powders of crocodile bone and deer bone extracts, respectively.

[0009] (2) Preparation of compound plant extracts Hawthorn and kudzu root were mixed, and extracted with 12 times the amount of purified water at 80°C for 2 hours. The mixture was then filtered. The residue was extracted a second time with 8 times the amount of water for 1 hour. The filtrates were combined. The mixture was concentrated to a relative density of 1.09. 95% ethanol was added to adjust the alcohol content to 60%. The mixture was precipitated at room temperature for 10 hours. The mixture was then filtered to remove impurities. After recovering the ethanol, the mixture was vacuum dried and pulverized through an 80-mesh sieve to obtain a dry powder of the compound plant extract.

[0010] (3) Gradient premixing All functional powders (crocodile bone, deer bone, calcium and magnesium, coenzyme Q10, vitamins, and plant extracts) were sieved through an 80-mesh sieve. An equal amount of microcrystalline cellulose was added and premixed with the functional powders at a low speed of 15 r / min for 10 min to ensure uniform dispersion of coenzyme Q10 and prevent the agglomeration of oil components.

[0011] (4) Total Blending and Powdering Add the remaining microcrystalline cellulose and magnesium stearate, mix in a three-dimensional mixer at 20 r / min for 20 min, and pass all the powder through a 60 mesh granulation sieve to obtain a uniform and loose filling powder.

[0012] (5) Capsule filling and post-processing The fully automatic #0 hard capsule filling machine is used to control the net weight of the contents of each capsule to 500mg; the capsules are polished and the residues are removed manually; they are sterilized by cobalt-60 irradiation at 4kGy and then sealed in light-proof aluminum-plastic packaging to obtain the finished hard capsules.

[0013] 4. Legally Regulated Health Benefits Description Animal function tests have verified that this product has three nationally recognized health care functions: 1) helps improve bone density; 2) relieves physical fatigue; 3) helps maintain healthy blood lipid levels; it can improve the sub-health state of middle-aged and elderly people, such as calcium loss, limb weakness, and heavy blood lipid metabolism burden.

[0014] 5. Raw Material and Product Safety Statement The crocodile and deer raw materials are all from regular and certified artificial breeding bases, and the products have a unified traceability label, which meets the food raw material safety standards; hawthorn and kudzu root are included in the list of food and medicine homology; calcium citrate, magnesium, coenzyme Q10 and vitamins are food nutritional fortifiers; microcrystalline cellulose and magnesium stearate are pharmaceutical and food-grade excipients with no harmful additives.

[0015] Suitable for: Middle-aged and elderly adults with decreased bone density, fatigue, and lipid metabolism imbalance; Not suitable for: people with gout, people with a history of kidney stones, people with coagulation disorders, pregnant women, and infants.

[0016] 6. Innovative Advantages of this Invention (1) The combination of crocodile bone and deer bone extracts, natural collagen, compound calcium and phosphorus combined with organic calcium and magnesium citrate, and vitamin D3 and K2 form a complete calcium absorption system, which significantly improves bone density and is superior to single bone powder products. (2) Coenzyme Q10, combined with hawthorn and kudzu root extracts, works synergistically to relieve physical fatigue on the one hand and help maintain healthy blood lipid levels on the other, achieving triple synergistic health care of bone protection, lipid regulation and anti-fatigue. (3) The whole process of low temperature extraction process fully preserves the activity of collagen; the gradient premixing process solves the problem of coenzyme Q10 oil components agglomeration and uneven mixing, and the hard capsules have high filling uniformity and strong batch stability. (4) Avoid the defects of heavy metal and microbial fluctuations in yak bone powder raw materials. The source of artificially bred animal raw materials is controllable and of uniform quality, which complies with the regulatory standards for health food. Detailed Implementation

[0017] Example 1 (Preferred Formula) Weigh out 300 parts of licensed artificially bred crocodile bone extract, 200 parts of licensed artificially bred deer bone extract, 80 parts of calcium citrate, 100 parts of magnesium citrate, 10 parts of coenzyme Q10, 0.02 parts of vitamin D3, 0.002 parts of vitamin K2, 50 parts of hawthorn extract, and 50 parts of kudzu root extract, and pass all through an 80-mesh sieve; add 47 parts of microcrystalline cellulose and 5 parts of magnesium stearate, and mix in a three-dimensional mixer at 20 r / min for 20 min, then granulate through a 60-mesh sieve; fill with #0 capsules, with a single capsule content of 500 mg; polish, sterilize by 4 kGy irradiation, and seal in a light-proof container to obtain the finished product.

[0018] Comparative Example 1 (crocodile bone extract only, no deer bone) The deer bone extract was removed, and the crocodile bone extract was increased by an equal amount to 500 parts. The remaining raw materials, proportions, and processes were the same as in Example 1. Functional tests showed that the effect of improving bone density was reduced by 36%, proving that the combination of the two bone extracts had a synergistic effect.

[0019] Comparative Example 2 (without Coenzyme Q10, hawthorn and kudzu root) The product has been modified by removing Coenzyme Q10, hawthorn, and kudzu root extract, while keeping the rest of the formula and process unchanged. The product does not relieve physical fatigue or regulate blood lipids; it only has a single function of calcium supplementation.

[0020] Comparative Example 3 (No Gradient Premixing Process) The formula is the same as in Example 1, and all powders are directly mixed at one time; Coenzyme Q10 agglomerates and clumps appear in the powder, the capsule filling volume varies beyond the standard, and the batch stability is poor, which verifies the advantages of the gradient premixing process of the present invention.

Claims

1. A calcium, magnesium, and coenzyme Q10 hard capsule containing extracts from farmed crocodile and deer bones for bone and heart protection, characterized in that... Made from the following parts by weight of raw materials: Preliminary components: Calcium citrate 60-100 parts, magnesium citrate 80-120 parts, coenzyme Q10 5-15 parts, vitamin D3 0.01-0.03 parts, vitamin K2 0.001-0.003 parts, hawthorn extract 30-60 parts, kudzu root extract 30-60 parts, microcrystalline cellulose 30-60 parts, magnesium stearate 3-7 parts; Features: It also includes 300 portions of certified artificially bred crocodile bone extract and 200 portions of certified artificially bred deer bone extract; the certified artificially bred crocodile bone and deer bone extracts come from breeding bases with qualifications for artificial breeding of wild animals and are marked with special traceability labels for wild animal products.

2. The calcium-magnesium coenzyme Q10 hard capsule containing extracts from farmed crocodile and deer bones, as described in claim 1, is characterized in that... The mass fractions of each raw material are as follows: 300 parts of certified artificially bred crocodile bone extract, 200 parts of certified artificially bred deer bone extract, 80 parts of calcium citrate, 100 parts of magnesium citrate, 10 parts of coenzyme Q10, 0.02 parts of vitamin D3, 0.002 parts of vitamin K2, 50 parts of hawthorn extract, 50 parts of kudzu root extract, 47 parts of microcrystalline cellulose, and 5 parts of magnesium stearate.

3. The calcium, magnesium, and coenzyme Q10 hard capsule containing extracts from farmed crocodile and deer bones, as described in claim 1, is characterized in that... The dosage form is a #0 hard capsule, with a net weight of 500mg per capsule.

4. A method for preparing a calcium-magnesium coenzyme Q10 hard capsule containing extracts from farmed crocodile and deer bones, as described in any one of claims 1 to 3, characterized in that... Includes the following steps: (1) The artificially bred crocodile bones and deer bones were cleaned, degreased in 40°C warm water, pulverized at low temperature, extracted with water at 45°C, concentrated and vacuum dried to obtain double bone extract powder; hawthorn and kudzu root were extracted with water at 80°C, precipitated with ethanol, dried and sieved to obtain compound plant extract powder. (2) All the active ingredients were passed through an 80-mesh sieve and premixed with a portion of microcrystalline cellulose at a gradient of 15 r / min for 10 min to disperse coenzyme Q10; (3) Add the remaining microcrystalline cellulose and magnesium stearate, mix at 20 r / min for 20 min, and granulate through a 60 mesh. (4) The capsules are filled by a fully automatic capsule machine, polished, sterilized by 4kGy irradiation, and sealed in light-proof aluminum-plastic packaging to obtain finished hard capsules.

5. The application of the calcium-magnesium coenzyme Q10 hard capsule containing artificially bred crocodile and deer bone extracts as described in any one of claims 1 to 3 in the preparation of health foods with health functions that help improve bone density, relieve physical fatigue, and help maintain healthy blood lipid levels.