Immunohistochemical staining control device

Abstract

The utility model discloses an immunohistochemical staining control device, which belongs to the technical field of immunohistochemical staining, and adopts the technical scheme that the immunohistochemical staining control device comprises a device body, a sealing cover is arranged at the top of the device body, and six sliding frames are arranged in the device body; a plurality of protection mechanisms and a plurality of auxiliary mechanisms are arranged in the sliding frame; the protection mechanism comprises a placement frame, a limiting frame, a disinfection frame, a connecting pipe and a fixing plate, the bottom of the placement frame extends into the sliding frame and is in close contact with the interior of the sliding frame, the bottom of the limiting frame is magnetically attracted to the top of the placement frame, and the interior of the disinfection frame is fixedly connected with the interior of the placement frame. The problems that in the existing reagent distribution and sample treatment process, most immunohistochemical staining control devices disinfect reagents after staining and moving out, so that when the samples are moved, the risk of cross contamination exists among residual samples in the devices, and the accuracy of a detection result is influenced are solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of immunohistochemical staining technology, especially to an immunohistochemical staining control device. BACKGROUND

[0002] The immunohistochemical staining control device is a medical device for realizing automatic operation of immunohistochemical staining, which can locate, qualitatively and quantitatively detect antigens in tissues or cells, and provide important basis for pathological diagnosis and research.

[0003] Currently, the conventional process of automatic immunohistochemical staining products is to quickly heat the section sample by heating equipment, repair the sample protein in the repair liquid environment, and then clean the sample, add antibody reagent, and complete the staining of specific protein by developing reagent according to a specific process. In order to ensure the quality of protein repair in a high temperature environment, one method is to place the glass slide after the section is processed by pasting into the drawer-shaped wet box of the automatic product, close the wet box for subsequent repair, cleaning and other reagent addition, and all operations are performed in the drawer-shaped wet box darkroom. Another method is to place the glass slide on the heating device and place a specially designed cover plate on the glass slide, and press the cover plate and the glass slide by other devices, and provide a repair environment through the gap between the glass slide and the cover plate. In the subsequent process operation, the cover plate is pulled horizontally to add liquid and clean. In the immunohistochemical staining process, the sample area state information cannot be directly observed due to the obstruction of the components in both methods, which is not conducive to the system quality control of the staining result and the real-time operation of the glass slide. In addition, the horizontal pulling of the cover plate in the second method increases the space requirement of the module in the horizontal direction and increases the volume of the instrument.

[0004] The existing patent (publication number: CN217879220U) discloses an immunohistochemical staining control device, which includes a base, a driving assembly for providing power, a sample tray rack for placing a sample tray, a heating plate arranged on the sample tray rack, a lever guiding assembly for realizing a special linkage relationship, specifically including a first lever, a second lever, a guiding rod and a guiding block assembly, a fastening assembly for clamping the end of the cover plate, and a pressing assembly for pressing the cover plate. The utility model has a reasonable structure, and through the linkage design of the first lever and the second lever, the glass slide above is exposed most of the time during the immunohistochemical staining process, which facilitates effective quality control monitoring during the staining process. At the same time, the special linkage setting drives the cover plate to be pulled apart in the vertical direction, so that the other end of the cover plate slides on the glass slide, effectively shortening the length space of the device in the horizontal direction, and better meeting the space requirement.

[0005] In view of the above problems, the existing patent provides a solution, and the existing patent has certain limitations in use. During reagent distribution and sample processing, most of the immunohistochemical staining control devices are disinfected after the reagent staining is moved out. Therefore, when the sample is moved, there is a risk of cross contamination between the remaining samples in the device, which affects the accuracy of the detection result.

[0006] Therefore, an immunohistochemical staining control device is provided. Content of the utility model

[0007] The utility model discloses an immunohistochemical staining control device, which can solve the problem that most of the immunohistochemical staining control devices are disinfected after the reagent staining is moved out during reagent distribution and sample processing, which affects the accuracy of the detection result.

[0008] To achieve the above object, the utility model provides the following technical scheme: an immunohistochemical staining control device, comprising a device body, a cover is arranged on the top of the device body, six sliding frames are arranged in the device body, a plurality of protection mechanisms and a plurality of auxiliary mechanisms are arranged in the sliding frame.

[0009] The protection mechanism comprises a placing rack, a limiting rack, a disinfection rack, a connecting pipe and a fixed plate, the bottom of the placing rack extends to the inside of the sliding frame and is in close contact with the inside of the sliding frame, the bottom of the limiting rack is magnetically attracted to the top of the placing rack, the inside of the disinfection rack is fixedly connected with the inside of the placing rack, the right side of the connecting pipe is fixedly communicated with the left side of the disinfection rack, and the bottom of the fixed plate is fixedly connected with the top of the limiting rack.

[0010] Preferably, the auxiliary mechanism comprises a support frame fixedly connected to the bottom of the limiting rack, and the bottom of the support frame is fixedly connected with a magnetic block.

[0011] Preferably, the right side of the fixed plate is provided with a moving plate, and the bottom of the moving plate is fixedly connected with a moving block.

[0012] Preferably, the right side of the moving block is fixedly connected with an iron block, and the bottom of the magnetic block is fixedly connected with a limiting plate.

[0013] Preferably, the inside of the limiting rack is fixedly connected with a mounting frame, and the inside of the mounting frame is slidingly connected with the surface of the moving block.

[0014] Preferably, a water tank is formed in the inside of the placing rack, the bottom of the placing rack is fixedly connected with a water inlet frame, and the top of the water inlet frame extends to the inside of the placing rack and is fixedly communicated with the inside of the water tank.

[0015] Preferably, the top of the device body is fixedly connected with two electric telescopic columns, and the top of the telescopic end of the electric telescopic column is fixedly connected with the bottom of the cover.

[0016] Preferably, the bottom of the cover is fixedly connected with a lifting frame, the surface of the device body is fixedly connected with a baffle, and the top of the baffle is in contact with the bottom of the lifting frame.

[0017] Compared with the prior art, the device has the advantages that:

[0018] 1. The water in the water inlet frame moves to the inside of the placement frame through the water tank, the inside of the placement frame is cleaned, and then the disinfectant mist in the connecting pipe moves to the inside of the placement frame through the disinfection frame, so that the inside of the placement frame is conveniently disinfected in time.

[0019] 2. When the sample is removed, the moving plate drives the moving block to move, the moving block drives the iron block to be magnetically attracted to the magnetic attraction block, so that the moving plate conveniently assists in sealing the inside of the placement frame. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is an overall structural diagram of the immunohistochemical staining control device.

[0021] Figure 2 It is a three-dimensional structural schematic diagram of the inside of the device body.

[0022] Figure 3 It is a three-dimensional connection schematic diagram of the placement frame and the sliding frame.

[0023] Figure 4 It is a three-dimensional connection schematic diagram of the protection mechanism.

[0024] Figure 5 It is a three-dimensional connection schematic diagram of the auxiliary mechanism.

[0025] Figure 6 It is a three-dimensional connection schematic diagram of the placement frame and the water inlet frame.

[0026] In the drawings, 1 is a device body, 2 is a cover, 3 is a lifting frame, 4 is a protection mechanism, 401 is a placement frame, 402 is a limiting frame, 403 is a disinfection frame, 404 is a connecting pipe, 405 is a fixed plate, 5 is an electric telescopic column, 6 is a baffle, 7 is a sliding frame, 8 is an auxiliary mechanism, 801 is a support frame, 802 is a limiting plate, 803 is a moving plate, 804 is a magnetic attraction block, 805 is an iron block, 806 is a moving block, 9 is a mounting frame, 10 is a water tank, and 11 is a water inlet frame. DETAILED DESCRIPTION

[0027] Clearly and completely describe the technical scheme in the embodiments of the utility model with the drawings in the embodiments of the utility model below, obviously, the described embodiments are only a part of the embodiments of the utility model, and not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by the ordinary skilled in the art without making creative labor belong to the scope of the utility model protection.

[0028] Please refer to Figures 1-6 The utility model provides technical scheme:

[0029] An immunohistochemical staining control device, including device body 1, the top of device body 1 is provided with cover 2, the inside of device body 1 is provided with six sliding frames 7, the inside of sliding frame 7 is provided with several protection mechanisms 4 and several auxiliary mechanisms 8;

[0030] Protection mechanism 4 includes rack 401, limiting frame 402, disinfection frame 403, connecting pipe 404 and fixed plate 405, the bottom of rack 401 extends to the inside of sliding frame 7 and is in close contact with the inside of sliding frame 7, the bottom of limiting frame 402 is magnetically attracted to the top of rack 401, the inside of disinfection frame 403 is fixedly connected with the inside of rack 401, the right side of connecting pipe 404 is fixedly communicated with the left side of disinfection frame 403, and the bottom of fixed plate 405 is fixedly connected with the top of limiting frame 402.

[0031] In the embodiment: by making the bottom of fixed plate 405 and the bottom of limiting frame 402 fixedly connected, the sample can be conveniently moved to the inside of sliding frame 7, so that fixed plate 405 drives limiting frame 402 to limit the sample, so that the device body 1 can conveniently be dyed, when the sample is removed, the disinfectant fog in the connecting pipe 404 moves to the inside of rack 401 through disinfection frame 403, so that the inside of rack 401 can be conveniently disinfected in time, and the cross interference phenomenon between the inside of rack 401 and other samples in the inside of rack 401 can be reduced.

[0032] Specifically, as shown in Figure 4 , Figure 5 Auxiliary mechanism 8 includes support frame 801 fixedly connected to the bottom of limiting frame 402, and the bottom of support frame 801 is fixedly connected with a magnetic block 804.

[0033] Specifically, as shown in Figure 4 , Figure 5 The right side of fixed plate 405 is provided with a moving plate 803, and the bottom of moving plate 803 is fixedly connected with a moving block 806.

[0034] Specifically, as shown in Figure 5As shown, an iron block 805 is fixedly connected to the right side of the movable block 806, and a limit plate 802 is fixedly connected to the bottom of the magnetic block 804.

[0035] In this embodiment: by fixing the top of the magnetic block 804 to the top of the support frame 801, the support frame 801 can be easily fixed to the magnetic block 804 by the limiting frame 402, and the left side of the iron block 805 can be fixed to the right side of the moving block 806, thereby making it easy for the iron block 805 to limit the moving block 806 by the magnetic block 804, thus achieving the effect of limiting the moving block 806.

[0036] Specifically, such as Figure 4 , Figure 5 As shown, the mounting bracket 9 is fixedly connected inside the limiting bracket 402, and the interior of the mounting bracket 9 is slidably connected to the surface of the moving block 806.

[0037] Specifically, such as Figure 6 As shown, a water tank 10 is provided inside the placement rack 401, and a water inlet rack 11 is fixedly connected to the bottom of the placement rack 401. The top of the water inlet rack 11 extends into the interior of the placement rack 401 and is fixedly connected to the interior of the water tank 10.

[0038] In this embodiment: by fixing the surface of the mounting frame 9 to the inside of the limiting frame 402, the moving block 806 can be moved inside the mounting frame 9, and the top of the water inlet frame 11 can be fixedly connected to the bottom of the water tank 10, thereby facilitating the cleaning fluid to clean the inside of the placement frame 401 through the water tank 10, achieving the effect of facilitating the cleaning of the inside of the placement frame 401.

[0039] Specifically, such as Figure 1 , Figure 2 As shown, two electric telescopic columns 5 are fixedly connected to the top of the device body 1, and the top of the telescopic end of the electric telescopic column 5 is fixedly connected to the bottom of the cover 2.

[0040] Specifically, such as Figure 1 , Figure 2 As shown, a lifting frame 3 is fixedly connected to the bottom of the cover 2, and a baffle 6 is fixedly connected to the surface of the device body 1. The top of the baffle 6 is in contact with the bottom of the lifting frame 3.

[0041] In this embodiment: by fixing the top of the telescopic end of the electric telescopic column 5 to the bottom of the cover 2, the electric telescopic column 5 can easily drive the cover 2 to move, and the top of the lifting frame 3 can be fixedly connected to the bottom of the cover 2, thereby facilitating the contact between the interior of the lifting frame 3 and the surface of the device body 1, achieving the effect of facilitating the lifting frame 3 to limit the cover 2.

[0042] Working principle: when the sample is dyed, the sample is moved to the inside of the sliding frame 7, the fixed plate 405 drives the limiting frame 402 to move to the top of the sample, the limiting frame 402 drives the limiting plate 802 to limit the sample, then the sliding frame 7 drives the sample to move to the inside of the device body 1 for dyeing, after dyeing, when the sample is removed, the moving plate 803 drives the moving block 806 to move, the moving block 806 drives the iron block 805 to be magnetically attracted to the magnetic attraction block 804, so as to facilitate the moving plate 803 to assist in sealing the inside of the placing frame 401, the water flow in the water inlet frame 11 moves to the inside of the placing frame 401 through the water tank 10, and the inside of the placing frame 401 is cleaned, then the disinfecting fog in the connecting pipe 404 moves to the inside of the placing frame 401 through the disinfecting frame 403, so as to conveniently disinfect the inside of the placing frame 401 in time, that is, the phenomenon that the inside of the placing frame 401 and other placing frames 401 are interfered with each other is reduced, and the problem that in the existing reagent distribution and sample processing process, most of the immunohistochemical dyeing control devices are disinfected after the reagent is dyed and removed, so that there is a risk of cross contamination between the remaining samples in the device when the sample is moved, and the accuracy of the detection result is affected.

[0043] The above is only a preferred embodiment of the present application, and is not used to limit the present application, and any modification, equivalent replacement and improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. An immunohistochemical staining control device comprising a device body (1), characterized in that: The top of the device body (1) is provided with a cover (2), the inside of the device body (1) is provided with six sliding frames (7), the inside of the sliding frame (7) is provided with a plurality of protection mechanisms (4) and a plurality of auxiliary mechanisms (8); The protection mechanism (4) comprises a placing frame (401), a limiting frame (402), a disinfection frame (403), a connecting pipe (404) and a fixed plate (405), the bottom of the placing frame (401) extends to the inside of the sliding frame (7) and is in close contact with the inside of the sliding frame (7), the bottom of the limiting frame (402) is magnetically attracted to the top of the placing frame (401), the inside of the disinfection frame (403) is fixedly connected with the inside of the placing frame (401), the right side of the connecting pipe (404) is fixedly communicated with the left side of the disinfection frame (403), and the bottom of the fixed plate (405) is fixedly connected with the top of the limiting frame (402).

2. An immunohistochemical staining control device according to claim 1, wherein: The auxiliary mechanism (8) comprises a supporting frame (801) fixedly connected to the bottom of the limiting frame (402), and the bottom of the supporting frame (801) is fixedly connected with a magnetic block (804).

3. An immunohistochemical staining control device according to claim 2, wherein: The right side of the fixed plate (405) is provided with a moving plate (803), and the bottom of the moving plate (803) is fixedly connected with a moving block (806).

4. An immunohistochemical staining control device according to claim 3, wherein: The right side of the moving block (806) is fixedly connected with an iron block (805), and the bottom of the magnetic block (804) is fixedly connected with a limiting plate (802).

5. The immunohistochemistry staining control device of claim 3, wherein: The inside of the limiting frame (402) is fixedly connected with a mounting frame (9), and the inside of the mounting frame (9) is in sliding connection with the surface of the moving block (806).

6. The immunohistochemistry staining control device of claim 1, wherein: The inside of the placing frame (401) is provided with a water groove (10), the bottom of the placing frame (401) is fixedly connected with a water inlet frame (11), and the top of the water inlet frame (11) extends to the inside of the placing frame (401) and is in fixed communication with the inside of the water groove (10).

7. The immunohistochemistry staining control device of claim 1, wherein: The top of the device body (1) is fixedly connected with two electric telescopic columns (5), and the top of the telescopic end of the electric telescopic column (5) is fixedly connected with the bottom of the cover (2).

8. The immunohistochemistry staining control device of claim 1, wherein: The bottom of the cover (2) is fixedly connected with a lifting frame (3), the surface of the device body (1) is fixedly connected with a baffle (6), and the top of the baffle (6) is in contact with the bottom of the lifting frame (3).

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