An internal circulation device for production scale polypeptide synthesis
By designing an internal circulation device and using a three-way solenoid valve to switch the circulating water pipeline, the temperature of the peptide synthesis reactor can be controlled, which solves the problems of high equipment cost and large space occupation, and optimizes equipment cost and space.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- CHENGDU GLAD TECH CO LTD
- Filing Date
- 2025-06-20
- Publication Date
- 2026-06-26
AI Technical Summary
Existing peptide synthesis reactors require two separate systems for cooling and heating, resulting in high equipment costs and large space requirements.
An internal circulation device is adopted, and the circulating water pipeline is switched through a three-way solenoid valve. The same set of water storage tanks and circulating water are used to achieve heating and cooling. Combined with a water chiller and heating tubes, the temperature of the reactor is controlled.
It reduced equipment costs, decreased equipment size, and optimized space utilization.
Smart Images
Figure CN224405095U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of peptide synthesis equipment technology, and more particularly to an internal circulation device for production peptide synthesis. Background Technology
[0002] Peptides are compounds formed by α-amino acids linked together by peptide bonds. They are intermediate products of protein hydrolysis. Peptides composed of three or more amino acid molecules are called polypeptides. In the synthesis of polypeptide products, the amino acid raw materials need to be stirred in a reaction vessel. The temperature conditions inside the reaction vessel need to be strictly controlled at each stage of the synthesis process. Currently, polypeptide synthesis reaction vessels require two separate systems for cooling and heating, which is not only costly but also bulky and space-consuming. Utility Model Content
[0003] The main objective of this application is to provide an internal circulation device for production-type peptide synthesis, which aims to solve the technical problem of high equipment cost caused by existing peptide synthesis reactors using two separate systems for cooling and heating.
[0004] To achieve the above objectives, this application provides an internal circulation device for the synthesis of production-type peptides, including a reaction vessel and a water jacket covering the reaction vessel. A cavity for filling with circulating water is formed between the reaction vessel and the water jacket. The device also includes a water storage tank for storing the circulating water. A heating pipe is installed inside the water storage tank. The water storage tank is connected to a pumping assembly, which is connected to a three-way solenoid valve. The three-way solenoid valve is connected to a first water pipe and a bypass pipe. The first water pipe is connected to a water chiller, which is connected to a second water pipe extending into the cavity. The other end of the bypass pipe is connected to the side wall of the second water pipe. A return water assembly is also connected to the bottom of the cavity. The return water assembly is used to return the circulating water in the cavity to the water storage tank.
[0005] Optionally, at least one annular cylinder is provided inside the reactor. The annular cylinder has an annular cavity inside. Multiple connecting pipes communicating with the annular cavity are connected to the side wall of the annular cylinder. The other end of each connecting pipe is connected to the cavity.
[0006] Optionally, a first thermometer is installed on the reactor, extending out of the water jacket, and a second thermometer is installed on the water storage tank. The first and second thermometers are electrically connected to a controller, and a three-way solenoid valve is electrically connected to the controller.
[0007] Optionally, an air vent valve is provided at the top of the water jacket, the air vent valve is connected to an air vent pipe, and an exhaust fan is provided inside the air vent pipe.
[0008] Optionally, the pumping assembly includes a pumping pipe extending into the water storage tank, the pumping pipe being connected to a first water pump, the first water pump being connected to a third water pipe, and the third water pipe being connected to a three-way solenoid valve.
[0009] Optionally, the water return assembly includes a fourth water pipe connected to the bottom of the cavity, the fourth water pipe being connected to a second water pump, the second water pump being connected to a fifth water pipe, and the fifth water pipe being connected to a water storage tank.
[0010] Optionally, multiple connecting columns connect the reactor to the water jacket.
[0011] Optionally, both the outer wall of the reactor and the inner wall of the water jacket are provided with a heat insulation layer.
[0012] The beneficial effects that this application can achieve are as follows:
[0013] This application includes a reactor and a water jacket covering the reactor. A cavity for filling with circulating water is formed between the reactor and the water jacket. It also includes a water storage tank for storing the circulating water. A heating pipe is installed inside the water storage tank. The water storage tank is connected to a pumping assembly. The pumping assembly is connected to a three-way solenoid valve. The three-way solenoid valve is connected to a first water pipe and a bypass pipe. The first water pipe is connected to a water chiller. The water chiller is connected to a second water pipe that extends into the cavity. The other end of the bypass pipe is connected to the side wall of the second water pipe. A return water assembly is also connected to the bottom of the cavity. The return water assembly is used to return the circulating water in the cavity to the water storage tank. Based on the structure of this application, when the reactor needs to be heated, the three-way solenoid valve is connected only to the bypass pipe. At this time, the circulating water in the storage tank is heated to a certain temperature by the heating tube. The hot circulating water is then pumped out by the pumping assembly and enters the cavity through the bypass pipe and the second water pipe, thereby achieving the heating effect. When the reactor needs to be cooled, the three-way solenoid valve is connected only to the first water pipe. The circulating water is then directly pumped to the first water pipe and enters the water chiller, forming cold circulating water, which enters the cavity through the second water pipe, thereby achieving the cooling effect. When it is necessary to switch between heating and cooling modes, the circulating water in the cavity can be returned to the storage tank through the return water assembly, so that it can be drained back into the cavity after subsequent heating or cooling. This allows the heating and cooling modes to share a single storage tank and circulating water, reducing equipment costs and improving equipment size to reduce space occupation. Attached Figure Description
[0014] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.
[0015] Figure 1 This is a schematic diagram of the internal circulation device for production peptide synthesis in an embodiment of this application;
[0016] Figure 2This is a schematic diagram of the external structure of an internal circulation device for production peptide synthesis according to an embodiment of this application;
[0017] Figure 3 This is a schematic diagram (top view) of the connection structure between the annular cylinder and the connecting pipe in an embodiment of this application.
[0018] Figure 4 This is a three-dimensional structural diagram of the annular cylinder in an embodiment of this application.
[0019] Figure label:
[0020] 110-Reaction vessel, 120-Water jacket, 130-Cavity, 140-Water storage tank, 150-Heating tube, 160-Water pumping assembly, 161-Water pumping pipe, 162-First water pump, 163-Third water pipe, 170-Three-way solenoid valve, 180-First water pipe, 190-Bypass pipe, 210-Water chiller, 220-Second water pipe, 230-Return water assembly, 231-Fourth water pipe, 232-Second water pump, 233-Fifth water pipe, 240-Annular cylinder, 241-Annular cavity, 250-Connecting pipe, 260-First thermometer, 270-Second thermometer, 280-Controller, 290-Exhaust valve, 310-Exhaust pipe, 320-Exhaust fan, 330-Connecting column.
[0021] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation
[0022] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.
[0023] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a specific posture. If the specific posture changes, the directional indication will also change accordingly.
[0024] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral part; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.
[0025] Furthermore, if the embodiments of this application involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the meaning of "and / or" throughout the text includes three parallel solutions; for example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed in this application.
[0026] Example
[0027] Reference Figures 1-4 This embodiment provides an internal circulation device for production-type peptide synthesis, including a reaction vessel 110 and a water jacket 120 covering the reaction vessel 110. A cavity 130 for filling with circulating water is formed between the reaction vessel 110 and the water jacket 120. The device also includes a water storage tank 140 for storing the circulating water, with a heating pipe 150 installed inside the water storage tank 140. A water pumping assembly 160 is connected to the water storage tank 140, and a three-way valve is connected to the water pumping assembly 160. Solenoid valve 170, a three-way solenoid valve 170 is connected to a first water pipe 180 and a bypass pipe 190. The first water pipe 180 is connected to a water chiller 210. The water chiller 210 is connected to a second water pipe 220 that extends into the cavity 130. The other end of the bypass pipe 190 is connected to the side wall of the second water pipe 220. A return water assembly 230 is also connected to the bottom of the cavity 130. The return water assembly 230 is used to return the circulating water in the cavity 130 to the water storage tank 140.
[0028] In this embodiment, when it is necessary to heat the reactor 110, the three-way solenoid valve 170 is connected only to the bypass pipe 190. At this time, the circulating water in the water storage tank 140 is heated to a certain temperature by the heating pipe 150. The hot circulating water is then drawn out by the pumping assembly 160 and enters the cavity 130 through the bypass pipe 190 and the second water pipe 220, thereby achieving the heating effect. If it is necessary to cool the reactor 110, the three-way solenoid valve 170 is connected only to the first water pipe 180. At this time, the circulating water is directly pumped to the first water pipe 180 by the pumping assembly 160. The water then enters the water chiller 210, forming cold circulating water that enters the cavity 130 through the second water pipe 220, thereby achieving a cooling effect. When it is necessary to switch between heating and cooling modes, the circulating water in the cavity 130 can be returned to the storage tank 140 through the return water component 230, so that it can be diverted back to the cavity 130 after subsequent heating or cooling. This allows the heating and cooling modes to share a single storage tank 140 and circulating water, enabling the circulating water to be recycled within the cavity 130, reducing equipment costs, and improving equipment size to reduce space occupation.
[0029] It should be noted that the water chiller 210 can reduce the circulating water to a preset temperature, which is existing technology and will not be described in detail here.
[0030] As an optional implementation, at least one annular cylinder 240 is provided inside the reactor 110. The annular cylinder 240 has an annular cavity 241 inside. Multiple connecting pipes 250 communicating with the annular cavity 241 are connected to the side wall of the annular cylinder 240. The other end of each connecting pipe 250 is connected to the cavity 130.
[0031] In this embodiment, after circulating into the cavity 130, it can enter the annular cylinder 240 through the connecting pipe 250. Since both the connecting pipe 250 and the annular cylinder 240 are located inside the reactor 110, they can penetrate deep into the middle position to contact the raw materials, thereby better cooling or heating the raw materials. In addition, the annular structure of the annular cylinder 240 can pass through the stirring assembly, which can avoid interference.
[0032] As an optional implementation, a first thermometer 260 is provided on the reactor 110, the first thermometer 260 extends out of the water jacket 120, a second thermometer 270 is provided on the water storage tank 140, the first thermometer 260 and the second thermometer 270 are electrically connected to a controller 280, and a three-way solenoid valve 170 is electrically connected to the controller 280.
[0033] In this embodiment, the first thermometer 260 can monitor the internal temperature of the reactor 110 in real time. After detecting the corresponding temperature, it sends a signal to the controller 280. The controller 280 determines whether to raise or lower the temperature based on the detected temperature, and then controls the three-way solenoid valve 170 to open different pipelines to introduce hot or cold circulating water into the cavity 130. At the same time, the second thermometer 270 can monitor the temperature of the circulating water in the water storage tank 140. After reaching the corresponding temperature, the pumping assembly 160 is started.
[0034] It should be noted that the controller 280 can use a PLC controller of model S7-200 to meet the usage requirements.
[0035] As an optional implementation, the top of the water jacket 120 is provided with an exhaust valve 290, the exhaust valve 290 is connected to an exhaust pipe 310, and an exhaust fan 320 is provided inside the exhaust pipe 310.
[0036] In this embodiment, when cooling is required, since the water chiller 210 needs a certain amount of time to cool the circulating water, the hot air in the cavity 130 (which has no circulating water at this time) can be discharged by opening the exhaust valve 290 and the exhaust fan 320. The air cooling plays a temporary transitional cooling role. When the cold circulating water can be used, the exhaust valve 290 and the exhaust fan 320 are closed to ensure continuous cooling.
[0037] It should be noted that if cooling is required and the cavity 130 has circulating water, the circulating water must first be recycled back to the water storage tank 140 through the water return component 230 before opening the exhaust valve 290 and the exhaust fan 320.
[0038] As an optional implementation, the pumping assembly 160 includes a pumping pipe 161 extending into the water storage tank 140. The pumping pipe 161 is connected to a first water pump 162, which is connected to a third water pipe 163. The third water pipe 163 is connected to a three-way solenoid valve 170. When pumping is required, the first water pump 162 can pump circulating water through the pumping pipe 161 to the third water pipe 163. The first water pump 162 is electrically connected to the controller 280 for automated control.
[0039] As an optional implementation, the water return assembly 230 includes a fourth water pipe 231 connected to the bottom of the cavity 130. The fourth water pipe 231 is connected to a second water pump 232, and the second water pump 232 is connected to a fifth water pipe 233, which connects to a water storage tank 140. When the second water pump 232 starts, it can recover the circulating water in the cavity 130 to the water storage tank 140 through the fourth water pipe 231 and the fifth water pipe 233. Similarly, the second water pump 232 is electrically connected to the controller 280 for easy automated control.
[0040] As an optional implementation, a plurality of connecting columns 330 are connected between the reactor 110 and the water jacket 120. The connecting columns 330 support the reactor 110 within the water jacket 120, thereby forming an independent cavity 130.
[0041] As an optional implementation, both the outer wall of the reactor 110 and the inner wall of the water jacket 120 are provided with heat insulation layers, which can play a certain heat preservation role after heating.
[0042] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.
Claims
1. An internal circulation device for production scale polypeptide synthesis, characterized in that, The system includes a reactor and a water jacket covering the reactor. A cavity for filling with circulating water is formed between the reactor and the water jacket. The system also includes a water storage tank for storing the circulating water. A heating pipe is installed inside the water storage tank. The water storage tank is connected to a pumping assembly. The pumping assembly is connected to a three-way solenoid valve. The three-way solenoid valve is connected to a first water pipe and a bypass pipe. The first water pipe is connected to a water chiller. The water chiller is connected to a second water pipe that extends into the cavity. The other end of the bypass pipe is connected to the side wall of the second water pipe. A return water assembly is also connected to the bottom of the cavity. The return water assembly is used to return the circulating water in the cavity to the water storage tank.
2. An internal circulation device for production scale polypeptide synthesis as claimed in claim 1, wherein, The reactor contains at least one annular cylinder with an annular cavity inside. The side wall of the annular cylinder is connected to multiple connecting pipes that communicate with the annular cavity, and the other end of each connecting pipe is connected to the cavity.
3. An internal circulation device for the production phage display of a polypeptide according to claim 1 or 2, wherein, A first thermometer is installed on the reactor vessel, extending out of the water jacket. A second thermometer is installed on the water storage tank. Both the first and second thermometers are electrically connected to a controller. A three-way solenoid valve is electrically connected to the controller.
4. An internal circulation device for the production-scale synthesis of polypeptides according to claim 3, wherein, An air vent valve is installed at the top of the water jacket, and the air vent valve is connected to an air vent pipe, which contains an exhaust fan.
5. An internal circulation device for production scale polypeptide synthesis as defined in claim 1, wherein, The pumping assembly includes a pumping pipe that extends into the water storage tank, the pumping pipe is connected to a first water pump, the first water pump is connected to a third water pipe, and the third water pipe is connected to a three-way solenoid valve.
6. An internal circulation device for production scale polypeptide synthesis as defined in claim 1, wherein, The water return assembly includes a fourth water pipe connected to the bottom of the cavity, a second water pump connected to the fourth water pipe, a fifth water pipe connected to the second water pump, and a water storage tank.
7. An internal circulation device for production scale polypeptide synthesis as defined in claim 1, wherein, There are multiple connecting columns between the reactor and the water jacket.
8. An internal circulation device for production scale polypeptide synthesis as defined in claim 1, wherein, Both the outer wall of the reactor and the inner wall of the water jacket are equipped with heat insulation layers.