RESPIRATORY VIRUS AGENTS AND METHODS OF USE

Abstract

Methods for inhibiting respiratory viruses (i.e., viruses associated with respiratory conditions, e.g., influenza A, influenza B, RSV, and the like) are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a target motif with an effective amount of an agent that specifically binds to the target motif to inhibit the respiratory virus. Methods for treating or preventing respiratory virus infection in a subject are also provided. Pharmaceutical compounds and compositions comprising an oligonucleotide sequence complementary to a target region of the vRNA used in the methods are also provided. The oligonucleotides provided may include a 5-methylcytosine.